{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:05:36Z","timestamp":1788807936851,"version":"build-2803163510"},"reference-count":149,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100006259","name":"Teva Pharmaceutical Industries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006259","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.jneuroim.2014.08.622","type":"journal-article","created":{"date-parts":[[2014,8,30]],"date-time":"2014-08-30T16:33:48Z","timestamp":1409416428000},"page":"9-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Immune surveillance of the central nervous system in multiple sclerosis \u2014 Relevance for therapy and experimental models"],"prefix":"10.1016","volume":"276","author":[{"given":"Rehana Z.","family":"Hussain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liat","family":"Hayardeny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra C.","family":"Cravens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Yarovinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd N.","family":"Eagar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamine","family":"Arellano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystin","family":"Deason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyd","family":"Castro-Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"St\u00fcve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2014.08.622_bb0115","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1084\/jem.20061931","article-title":"The fibrin-derived gamma377\u2013395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease","volume":"204","author":"Adams","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0165","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/nn.2887","article-title":"Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool","volume":"14","author":"Ajami","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0085","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.4049\/jimmunol.162.3.1685","article-title":"Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: evidence for an inhibitory loop involving endogenous IL-10","volume":"162","author":"Ajuebor","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0065","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/90609","article-title":"Toll-like receptors: critical proteins linking innate and acquired immunity","volume":"2","author":"Akira","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0290","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0167-5699(97)01102-X","article-title":"Th1\u2013Th2: reliable paradigm or dangerous dogma?","volume":"18","author":"Allen","year":"1997","journal-title":"Immunol. Today"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0010","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.4049\/jimmunol.160.10.4671","article-title":"Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 cell activation","volume":"160","author":"Aloisi","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0305","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1084\/jem.20061886","article-title":"CD4(+)CD25(\u2212)Foxp3(\u2212) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis","volume":"204","author":"Anderson","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0050","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/BF00931808","article-title":"Immunohistochemical characterization of the mononuclear cells in the brain of the rat with an experimental chronic Trypanosoma brucei gambiense infection","volume":"75","author":"Anthoons","year":"1989","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0300","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/eji.1830240513","article-title":"Flow cytometric determination of cytokines in activated murine T helper lymphocytes: expression of interleukin-10 in interferon-gamma and in interleukin-4-expressing cells","volume":"24","author":"Assenmacher","year":"1994","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0675","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.4049\/jimmunol.174.3.1424","article-title":"Rolling of Th1 cells via P-selectin glycoprotein ligand-1 stimulates LFA-1-mediated cell binding to ICAM-1","volume":"174","author":"Atarashi","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0350","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1084\/jem.192.3.393","article-title":"Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction","volume":"192","author":"Babbe","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0200","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1006\/exnr.2000.7618","article-title":"Turnover of rat brain perivascular cells","volume":"168","author":"Bechmann","year":"2001","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0170","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1084\/jem.20011794","article-title":"Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation","volume":"196","author":"Bellingan","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0635","doi-asserted-by":"crossref","first-page":"21453","DOI":"10.1074\/jbc.C200176200","article-title":"The immune modulator FTY720 targets sphingosine 1-phosphate receptors","volume":"277","author":"Brinkmann","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0075","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.4049\/jimmunol.174.4.2336","article-title":"Conditional macrophage ablation demonstrates that resident macrophages initiate acute peritoneal inflammation","volume":"174","author":"Cailhier","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0180","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1182\/blood-2005-03-1288","article-title":"A specific role of integrin Mac-1 in accelerated macrophage efflux to the lymphatics","volume":"106","author":"Cao","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0690","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.ceb.2003.08.003","article-title":"Integrin avidity regulation: are changes in affinity and conformation underemphasized?","volume":"15","author":"Carman","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0275","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMra052723","article-title":"The many roles of chemokines and chemokine receptors in inflammation","volume":"354","author":"Charo","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0520","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.clim.2011.02.011","article-title":"Immune mechanisms of new therapeutic strategies in MS: teriflunomide","volume":"142","author":"Claussen","year":"2012","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0650","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1056\/NEJMoa0907839","article-title":"Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis","volume":"362","author":"Cohen","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0585","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1016\/S0140-6736(12)61769-3","article-title":"Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing\u2013remitting multiple sclerosis: a randomised controlled phase 3 trial","volume":"380","author":"Cohen","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0590","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1056\/NEJMoa0802670","article-title":"Alemtuzumab vs. interferon beta-1a in early multiple sclerosis","volume":"359","author":"Coles","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0580","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/S0140-6736(12)61768-1","article-title":"Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial","volume":"380","author":"Coles","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0270","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1742-2094-8-73","article-title":"Lymph node-derived donor encephalitogenic CD4+ T cells in C57BL\/6 mice adoptive transfer experimental autoimmune encephalomyelitis highly express GM-CSF and T-bet","volume":"8","author":"Cravens","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0240","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1742-2094-10-67","article-title":"The neonatal CNS is not conducive for encephalitogenic Th1 T cells and B cells during experimental autoimmune encephalomyelitis","volume":"10","author":"Cravens","year":"2013","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0355","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1182\/blood-2003-11-4025","article-title":"High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay","volume":"103","author":"Crawford","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0575","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1365-2249.1992.tb06421.x","article-title":"Humanized monoclonal antibody CAMPATH-1H: myeloma cell expression of genomic constructs, nucleotide sequence of cDNA constructs and comparison of effector mechanisms of myeloma and Chinese hamster ovary cell-derived material","volume":"87","author":"Crowe","year":"1992","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0140","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1002\/eji.201141817","article-title":"A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation","volume":"41","author":"Davies","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0145","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1038\/ncomms2877","article-title":"Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation","volume":"4","author":"Davies","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0215","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.yexmp.2010.05.009","article-title":"FLT-3 expression and function on microglia in multiple sclerosis","volume":"89","author":"DeBoy","year":"2010","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0315","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4049\/jimmunol.150.2.353","article-title":"Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production","volume":"150","author":"Del Prete","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0265","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1179\/016164106X98107","article-title":"The role of CD4+ T-cells in the development of MS","volume":"28","author":"Delgado","year":"2006","journal-title":"Neurol. Res."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0755","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1128\/CMR.11.4.569","article-title":"Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection","volume":"11","author":"Denkers","year":"1998","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0470","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1006\/jaut.2000.0371","article-title":"Relapsing and remitting experimental autoimmune encephalomyelitis in B cell deficient mice","volume":"14","author":"Dittel","year":"2000","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0555","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1056\/NEJMc1211805","article-title":"PML in a patient treated with fumaric acid","volume":"368","author":"Ermis","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0450","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/ni833","article-title":"B cells regulate autoimmunity by provision of IL-10","volume":"3","author":"Fillatreau","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0245","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.4049\/jimmunol.166.4.2717","article-title":"Brain dendritic cells and macrophages\/microglia in central nervous system inflammation","volume":"166","author":"Fischer","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0120","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1006\/mcne.1993.1051","article-title":"Effects of TGF-betas and bFGF on astroglial cell growth and gene expression in vitro","volume":"4","author":"Flanders","year":"1993","journal-title":"Mol. Cell. Neurosci."},{"issue":"Suppl.","key":"10.1016\/j.jneuroim.2014.08.622_bb0525","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1097\/01.wco.0000413320.94715.e9","article-title":"New treatments and treatment goals for patients with relapsing\u2013remitting multiple sclerosis","volume":"25","author":"Fox","year":"2012","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0540","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1056\/NEJMoa1206328","article-title":"Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis","volume":"367","author":"Fox","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0360","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1056\/NEJMra052130","article-title":"Multiple sclerosis\u2014the plaque and its pathogenesis","volume":"354","author":"Frohman","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0765","doi-asserted-by":"crossref","first-page":"286","DOI":"10.4049\/jimmunol.146.1.286","article-title":"Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine","volume":"146","author":"Gazzinelli","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0760","doi-asserted-by":"crossref","first-page":"175","DOI":"10.4049\/jimmunol.149.1.175","article-title":"Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii","volume":"149","author":"Gazzinelli","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0320","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1084\/jem.183.6.2559","article-title":"Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10","volume":"183","author":"Gerosa","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0375","doi-asserted-by":"crossref","first-page":"368","DOI":"10.4049\/jimmunol.171.1.368","article-title":"Vulnerability of human neurons to T cell-mediated cytotoxicity","volume":"171","author":"Giuliani","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0335","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.4049\/jimmunol.178.3.1341","article-title":"T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity","volume":"178","author":"Gocke","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0535","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1056\/NEJMoa1114287","article-title":"Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis","volume":"367","author":"Gold","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0775","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20082108","article-title":"Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii-infected dendritic cells","author":"Goldszmid","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0295","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ni0603-503","article-title":"TH1\u2013TH2: a procrustean paradigm","volume":"4","author":"Gor","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0045","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nm1197","article-title":"Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis","volume":"11","author":"Greter","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0565","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1182\/blood.V62.4.873.873","article-title":"Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement","volume":"62","author":"Hale","year":"1983","journal-title":"Blood"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0330","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","article-title":"Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"Harrington","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0615","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1056\/NEJMoa0706383","article-title":"B-cell depletion with rituximab in relapsing\u2013remitting multiple sclerosis","volume":"358","author":"Hauser","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0205","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/ni.2680","article-title":"The skin-resident and migratory immune system in steady state and memory: innate lymphocytes, dendritic cells and T cells","volume":"14","author":"Heath","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0260","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2174\/1567202043480152","article-title":"Multiple sclerosis \u2014 a coordinated immune attack across the blood brain barrier","volume":"1","author":"Hemmer","year":"2004","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0030","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nm1177","article-title":"Experimental autoimmune encephalomyelitis repressed by microglial paralysis","volume":"11","author":"Heppner","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0035","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1126\/science.3276004","article-title":"Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo","volume":"239","author":"Hickey","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0455","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.4049\/jimmunol.161.9.4480","article-title":"B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization","volume":"161","author":"Hjelmstrom","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0740","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1093\/infdis\/172.6.1561","article-title":"Toxoplasma gondii comprises three clonal lineages: correlation of parasite genotype with human disease","volume":"172","author":"Howe","year":"1995","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0745","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1128\/jcm.35.6.1411-1414.1997","article-title":"Determination of genotypes of Toxoplasma gondii strains isolated from patients with toxoplasmosis","volume":"35","author":"Howe","year":"1997","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0040","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1084\/jem.172.4.1025","article-title":"Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages","volume":"172","author":"Huitinga","year":"1990","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0070","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nri1086","article-title":"NODs: intracellular proteins involved in inflammation and apoptosis","volume":"3","author":"Inohara","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0225","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/j.1460-9568.2010.07105.x","article-title":"Appearance of Cxcl10-expressing cell clusters is common for traumatic brain injury and neurodegenerative disorders","volume":"31","author":"Israelsson","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0345","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1093\/brain\/awf059","article-title":"Oligoclonal expansion of memory CD8+ T cells in cerebrospinal fluid from multiple sclerosis patients","volume":"125","author":"Jacobsen","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0220","doi-asserted-by":"crossref","first-page":"7196","DOI":"10.4049\/jimmunol.0901404","article-title":"Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood\u2013brain barrier during experimental autoimmune encephalomyelitis","volume":"184","author":"Jain","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0310","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1084\/jem.20062175","article-title":"Conventional T-bet(+)Foxp3(\u2212) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection","volume":"204","author":"Jankovic","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0185","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1164\/rccm.201011-1891OC","article-title":"Fas determines differential fates of resident and recruited macrophages during resolution of acute lung injury","volume":"184","author":"Janssen","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0655","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1056\/NEJMoa0909494","article-title":"A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis","volume":"362","author":"Kappos","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0110","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1152\/physrev.00011.2010","article-title":"Physiology of microglia","volume":"91","author":"Kettenmann","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0705","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1083\/jcb.200404160","article-title":"The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2","volume":"167","author":"Kim","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0230","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1182\/blood-2008-07-168575","article-title":"Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease","volume":"113","author":"King","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0160","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.4049\/jimmunol.0901089","article-title":"Alveolar macrophages transport pathogens to lung draining lymph nodes","volume":"183","author":"Kirby","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0055","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/ana.21379","article-title":"Localizing central nervous system immune surveillance: meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis","volume":"65","author":"Kivisakk","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0095","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.imlet.2007.07.017","article-title":"Resident peritoneal leukocytes are important sources of MMP-9 during zymosan peritonitis: superior contribution of macrophages over mast cells","volume":"113","author":"Kolaczkowska","year":"2007","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0090","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00005-009-0053-6","article-title":"Resident peritoneal macrophages and mast cells are important cellular sites of COX-1 and COX-2 activity during acute peritoneal inflammation","volume":"57","author":"Kolaczkowska","year":"2009","journal-title":"Arch. Immunol. Ther. Exp. (Warsz)"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0100","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0166-2236(96)10049-7","article-title":"Microglia: a sensor for pathological events in the CNS","volume":"19","author":"Kreutzberg","year":"1996","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0670","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.4049\/jimmunol.164.6.3301","article-title":"Leukocyte arrest during cytokine-dependent inflammation in vivo","volume":"164","author":"Kunkel","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0195","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/glia.440070106","article-title":"Bone marrow derived elements and resident microglia in brain inflammation","volume":"7","author":"Lassmann","year":"1993","journal-title":"Glia"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0155","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1136\/thx.2010.150318","article-title":"Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity","volume":"66","author":"Lauder","year":"2011","journal-title":"Thorax"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0175","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1084\/jem.20111009","article-title":"Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis","volume":"209","author":"Leuschner","year":"2012","journal-title":"J. Exp. Med."},{"issue":"Pt 20","key":"10.1016\/j.jneuroim.2014.08.622_bb0700","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1242\/jcs.113.20.3563","article-title":"Integrin cytoplasmic domain-binding proteins","volume":"113","author":"Liu","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0605","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1182\/blood.V70.5.1316.1316","article-title":"Flow cytometric analysis of human bone marrow. II. Normal B lymphocyte development","volume":"70","author":"Loken","year":"1987","journal-title":"Blood"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0665","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/ni1275","article-title":"Immune cell migration in inflammation: present and future therapeutic targets","volume":"6","author":"Luster","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0460","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1002\/(SICI)1521-4141(199911)29:11<3432::AID-IMMU3432>3.0.CO;2-2","article-title":"B cells are critical to induction of experimental allergic encephalomyelitis by protein but not by a short encephalitogenic peptide","volume":"29","author":"Lyons","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0480","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.4049\/jimmunol.178.6.3447","article-title":"B cell regulation of CD4+CD25+ T regulatory cells and IL-10 via B7 is essential for recovery from experimental autoimmune encephalomyelitis","volume":"178","author":"Mann","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0390","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1126\/science.3317824","article-title":"The T cell receptor","volume":"238","author":"Marrack","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0475","first-page":"3420","article-title":"Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression","volume":"118","author":"Matsushita","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0080","doi-asserted-by":"crossref","first-page":"L1245","DOI":"10.1152\/ajplung.00453.2001","article-title":"Role of resident alveolar macrophages in leukocyte traffic into the alveolar air space of intact mice","volume":"282","author":"Maus","year":"2002","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0135","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nm1202","article-title":"Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis","volume":"11","author":"McMahon","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0385","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0002-9440(10)61755-5","article-title":"Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes","volume":"159","author":"Medana","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0640","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1212\/01.wnl.0000327609.57688.ea","article-title":"FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis","volume":"71","author":"Mehling","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0645","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1212\/WNL.0b013e3181ebdd64","article-title":"Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis","volume":"75","author":"Mehling","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0500","doi-asserted-by":"crossref","first-page":"e17103","DOI":"10.1371\/journal.pone.0017103","article-title":"Rituximab therapy reduces organ-specific T cell responses and ameliorates experimental autoimmune encephalomyelitis","volume":"6","author":"Monson","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0280","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.4049\/jimmunol.136.7.2348","article-title":"Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins","volume":"136","author":"Mosmann","year":"1986","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0550","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1046\/j.1365-2133.1999.03034.x","article-title":"Treatment of severe psoriasis with fumaric acid esters: scientific background and guidelines for therapeutic use. The German Fumaric Acid Ester Consensus Conference","volume":"141","author":"Mrowietz","year":"1999","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0435","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-5728(92)90188-Q","article-title":"Synergy between encephalitogenic T cells and myelin basic protein-specific antibodies in the induction of experimental autoimmune encephalomyelitis","volume":"41","author":"Myers","year":"1992","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0370","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1126\/science.7624779","article-title":"Induction of MHC class I genes in neurons","volume":"269","author":"Neumann","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0515","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1056\/NEJMoa1014656","article-title":"Randomized trial of oral teriflunomide for relapsing multiple sclerosis","volume":"365","author":"O'Connor","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0465","doi-asserted-by":"crossref","first-page":"462","DOI":"10.4049\/jimmunol.171.1.462","article-title":"Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL\/6 mice","volume":"171","author":"Oliver","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0620","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jbspin.2011.11.002","article-title":"Progressive multifocal leukoencephalopathy in autoimmune diseases","volume":"79","author":"Palazzo","year":"2012","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0325","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.4049\/jimmunol.160.4.1804","article-title":"Identification of a T cell subset capable of both IFN-gamma and IL-10 secretion in patients with chronic Borrelia burgdorferi infection","volume":"160","author":"Pohl-Koppe","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0445","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1084\/jem.20090299","article-title":"Spontaneous relapsing\u2013remitting EAE in the SJL\/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells","volume":"206","author":"Pollinger","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0730","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1056\/NEJMoa044397","article-title":"A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis","volume":"354","author":"Polman","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0415","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.4049\/jimmunol.174.8.4678","article-title":"Gamma delta T cells regulate the extent and duration of inflammation in the central nervous system by a Fas ligand-dependent mechanism","volume":"174","author":"Ponomarev","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0420","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.4049\/jimmunol.173.3.1587","article-title":"Gamma delta T cell regulation of IFN-gamma production by central nervous system-infiltrating encephalitogenic T cells: correlation with recovery from experimental autoimmune encephalomyelitis","volume":"173","author":"Ponomarev","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0210","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00401-010-0774-y","article-title":"CD11c-expressing cells reside in the juxtavascular parenchyma and extend processes into the glia limitans of the mouse nervous system","volume":"121","author":"Prodinger","year":"2011","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0405","doi-asserted-by":"crossref","first-page":"941","DOI":"10.4049\/jimmunol.157.2.941","article-title":"A pathogenic role for gamma delta T cells in relapsing\u2013remitting experimental allergic encephalomyelitis in the SJL mouse","volume":"157","author":"Rajan","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0410","doi-asserted-by":"crossref","first-page":"5955","DOI":"10.4049\/jimmunol.160.12.5955","article-title":"The effect of gammadelta T cell depletion on cytokine gene expression in experimental allergic encephalomyelitis","volume":"160","author":"Rajan","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0400","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.4049\/jimmunol.164.4.2120","article-title":"Experimental autoimmune encephalomyelitis on the SJL mouse: effect of gamma delta T cell depletion on chemokine and chemokine receptor expression in the central nervous system","volume":"164","author":"Rajan","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0105","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.immunol.021908.132528","article-title":"Microglial physiology: unique stimuli, specialized responses","volume":"27","author":"Ransohoff","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0365","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jneuroim.2006.06.010","article-title":"Phenotypic characterization of autoreactive T cells in multiple sclerosis","volume":"178","author":"Ratts","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0505","article-title":"Requirement for safety monitoring for approved MS therapies \u2014 an overview","author":"Rommer","year":"2013","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0570","article-title":"Monoclonal antibodies in treatment of multiple sclerosis","author":"Rommer","year":"2013","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0150","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1189\/jlb.0809548","article-title":"The myeloid 7\/4-antigen defines recently generated inflammatory macrophages and is synonymous with Ly-6B","volume":"88","author":"Rosas","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0735","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMoa044396","article-title":"Natalizumab plus interferon beta-1a for relapsing multiple sclerosis","volume":"354","author":"Rudick","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0440","doi-asserted-by":"crossref","first-page":"4016","DOI":"10.4049\/jimmunol.139.12.4016","article-title":"A monoclonal antibody against a myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune disease","volume":"139","author":"Schluesener","year":"1987","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0545","first-page":"103","article-title":"Treatment of psoriasis vulgaris","volume":"13","author":"Schweckendieck","year":"1959","journal-title":"Med. Monatsschr."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0020","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1084\/jem.173.5.1235","article-title":"Major histocompatibility complex-expressing nonhematopoietic astroglial cells prime only CD8+ T lymphocytes: astroglial cells as perpetuators but not initiators of CD4+ T cell responses in the central nervous system","volume":"173","author":"Sedgwick","year":"1991","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0695","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1600-065X.1990.tb00563.x","article-title":"Roles of adhesion molecules in T-cell recognition: fundamental similarities between four integrins on resting human T cells (LFA-1, VLA-4, VLA-5, VLA-6) in expression, binding, and costimulation","volume":"114","author":"Shimizu","year":"1990","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0395","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1073\/pnas.90.3.923","article-title":"Clonal expansions of activated gamma\/delta T cells in recent-onset multiple sclerosis","volume":"90","author":"Shimonkevitz","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0005","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.4049\/jimmunol.157.5.1819","article-title":"The central nervous system as an immunocompetent organ: role of glial cells in antigen presentation","volume":"157","author":"Shrikant","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0750","first-page":"3","article-title":"Genetic basis of pathogenicity in toxoplasmosis","volume":"219","author":"Sibley","year":"1996","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0380","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1073\/pnas.0308689100","article-title":"Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood","volume":"101","author":"Skulina","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0130","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1172\/JCI13360","article-title":"Requirement for endocytic antigen processing and influence of invariant chain and H-2M deficiencies in CNS autoimmunity","volume":"108","author":"Slavin","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0680","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1084\/jem.20040424","article-title":"CXCR2- and E-selectin-induced neutrophil arrest during inflammation in vivo","volume":"200","author":"Smith","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0595","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.4049\/jimmunol.125.4.1678","article-title":"Characterization of a human B lymphocyte-specific antigen","volume":"125","author":"Stashenko","year":"1980","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0600","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1073\/pnas.78.6.3848","article-title":"Expression of cell surface markers after human B lymphocyte activation","volume":"78","author":"Stashenko","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0340","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nm1551","article-title":"A brief history of T(H)17, the first major revision in the T(H)1\/T(H)2 hypothesis of T cell-mediated tissue damage","volume":"13","author":"Steinman","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0710","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1527-3458.2007.00003.x","article-title":"Pharmacological properties, toxicology and scientific rationale for the use of natalizumab (Tysabri) in inflammatory diseases","volume":"13","author":"Stuve","year":"2007","journal-title":"CNS Drug Rev."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0025","doi-asserted-by":"crossref","first-page":"6720","DOI":"10.4049\/jimmunol.169.12.6720","article-title":"The role of the MHC class II transactivator in class II expression and antigen presentation by astrocytes and in susceptibility to central nervous system autoimmune disease","volume":"169","author":"Stuve","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0715","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/ana.20858","article-title":"Immune surveillance in multiple sclerosis patients treated with natalizumab","volume":"59","author":"Stuve","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0720","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1001\/archneur.63.10.1383","article-title":"Altered CD4+\/CD8+ T-cell ratios in cerebrospinal fluid of natalizumab-treated patients with multiple sclerosis","volume":"63","author":"Stuve","year":"2006","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0725","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1212\/01.wnl.0000327341.89587.76","article-title":"Immunologic, clinical, and radiologic status 14months after cessation of natalizumab therapy","volume":"72","author":"Stuve","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0060","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1146\/annurev.immunol.23.021704.115816","article-title":"Macrophage receptors and immune recognition","volume":"23","author":"Taylor","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0490","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/0161-5890(88)90047-8","article-title":"Heterogeneity in the B1 (CD20) cell surface molecule expressed by human B-lymphocytes","volume":"25","author":"Tedder","year":"1988","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0610","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/intimm\/dxh009","article-title":"Mouse CD20 expression and function","volume":"16","author":"Uchida","year":"2004","journal-title":"Int. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0125","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0306-4522(91)90082-Y","article-title":"Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system","volume":"44","author":"Unsicker","year":"1991","journal-title":"Neuroscience"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0685","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1172\/JCI12440","article-title":"Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels","volume":"108","author":"Vajkoczy","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0560","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1056\/NEJMc1215357","article-title":"PML in a patient treated with dimethyl fumarate from a compounding pharmacy","volume":"368","author":"van Oosten","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"Pt 1","key":"10.1016\/j.jneuroim.2014.08.622_bb0015","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/brain\/117.1.59","article-title":"Human astrocytes are only partially competent antigen presenting cells. Possible implications for lesion development in multiple sclerosis","volume":"117","author":"Weber","year":"1994","journal-title":"Brain"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0495","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/ana.22081","article-title":"B-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunity","volume":"68","author":"Weber","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0425","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0165-5728(83)90001-2","article-title":"Immunoglobulin-deficient rats fail to develop experimental allergic encephalomyelitis","volume":"5","author":"Willenborg","year":"1983","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0430","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.4049\/jimmunol.136.5.1676","article-title":"Immunoregulation of passively induced allergic encephalomyelitis","volume":"136","author":"Willenborg","year":"1986","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0485","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1084\/jem.184.6.2271","article-title":"Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice","volume":"184","author":"Wolf","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0770","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.immuni.2006.07.015","article-title":"Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4+ T cell response","volume":"25","author":"Yarovinsky","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0250","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.immuni.2012.05.025","article-title":"Dendritic cells ameliorate autoimmunity in the CNS by controlling the homeostasis of PD-1 receptor(+) regulatory T cells","volume":"37","author":"Yogev","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0190","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.immuni.2012.12.001","article-title":"Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis","volume":"38","author":"Yona","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0255","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1146\/annurev.iy.08.040190.003051","article-title":"The T lymphocyte in experimental allergic encephalomyelitis","volume":"8","author":"Zamvil","year":"1990","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.622_bb0235","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1523\/JNEUROSCI.2199-08.2009","article-title":"Intracerebral dendritic cells critically modulate encephalitogenic versus regulatory immune responses in the CNS","volume":"29","author":"Zozulya","year":"2009","journal-title":"J. Neurosci."}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572814008716?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572814008716?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:26:00Z","timestamp":1759047960000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165572814008716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":149,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0165572814008716"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2014.08.622","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immune surveillance of the central nervous system in multiple sclerosis \u2014 Relevance for therapy and experimental models","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2014.08.622","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}