{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:57:09Z","timestamp":1773658629459,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.jneuroim.2014.08.625","type":"journal-article","created":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T20:37:30Z","timestamp":1409603850000},"page":"104-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Brain parenchymal TNF-\u03b1 and IL-1\u03b2 induction in experimental pneumococcal meningitis"],"prefix":"10.1016","volume":"276","author":[{"given":"Kaywan","family":"Izadpanah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorette","family":"Freyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joerg R.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johann S.","family":"Braun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2014.08.625_bb0005","series-title":"Infections of the Central Nervous System","first-page":"341","article-title":"Pathogenesis and pathophysiology of bacterial infections","author":"Agyeman","year":"2014"},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0010","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jneuroim.2010.02.009","article-title":"TNF-\u03b1, IL-1\u03b2, IL-6, and cinc-1 levels in rat brain after meningitis induced by Streptococcus pneumoniae","volume":"221","author":"Barichello","year":"2010","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0015","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1172\/JCI23223","article-title":"Bacterial programmed cell death of cerebral endothelial cells involves dual death pathways","volume":"115","author":"Bermpohl","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0020","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0304-3940(97)00830-6","article-title":"Central nervous system TNFalpha-mRNA expression during rabbit experimental pneumococcal meningitis","volume":"237","author":"Bitsch","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0025","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1107\/S0907444903027720","article-title":"Expression, purification, crystallization and preliminary characterization of uridine 5\u2032-diphospho-N-acetylmuramoyl l-alanyl-d-glutamate:lysine ligase (MurE) from Streptococcus pneumoniae 110K\/70","volume":"60","author":"Blewett","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0030","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1111\/j.1471-4159.2004.02837.x","article-title":"Clindamycin is neuroprotective in experimental Streptococcus pneumoniae meningitis compared with ceftriaxone","volume":"91","author":"B\u00f6ttcher","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0035","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/6514","article-title":"Neuroprotection by a caspase inhibitor in pneumococcal meningitis","volume":"5","author":"Braun","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0040","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.1128\/IAI.67.8.3750-3756.1999","article-title":"Pneumolysin, a protein toxin of Streptococcus pneumoniae, induces NO production from macrophages","volume":"67","author":"Braun","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0045","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1086\/324013","article-title":"Apoptosis-inducing factor mediates microglial and neuronal apoptosis caused by pneumococcus","volume":"184","author":"Braun","year":"2001","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0050","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1172\/JCI12035","article-title":"Pneumococcal pneumolysin and H2O2 mediate brain cell apoptosis during meningitis","volume":"109","author":"Braun","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0055","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/BF00227734","article-title":"In situ hybridization with digoxigenin-labeled probes: sensitive and reliable detection method applied to myelinating rat brain","volume":"84","author":"Breitschopf","year":"1992","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0060","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.neuroscience.2005.01.031","article-title":"A quantitative in situ hybridization and polymerase chain reaction study of microglial-macrophage expression of interleukin-1beta mRNA following permanent middle cerebral artery occlusion in mice","volume":"132","author":"Clausen","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0065","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1046\/j.1365-2249.1997.4441343.x","article-title":"Haemophilus influenzae and Streptococcus pneumoniae induce different intracerebral mRNA cytokine patterns during the course of experimental bacterial meningitis","volume":"109","author":"Diab","year":"1997","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0070","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.4049\/jimmunol.163.8.4308","article-title":"Cerebral endothelial cells release TNF-alpha after stimulation with cell walls of Streptococcus pneumoniae and regulate inducible nitric oxide synthase and ICAM-1 expression via autocrine loops","volume":"163","author":"Freyer","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0075","article-title":"The causative pathogen determines the inflammatory probile in cerebrospinal fluid and outcome in patients with bacterial meningitis","volume":"312476","author":"Grandgirard","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0080","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/00004647-200001000-00009","article-title":"Microglia and macrophages are the major source of tumor necrosis factor in permanent middle cerebral artery occlusion in mice","volume":"20","author":"Gregersen","year":"2000","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0085","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1128\/IAI.01679-06","article-title":"Pneumococcal cell wall-induced meningitis impairs adult hippocampal neurogenesis","volume":"75","author":"Hoffmann","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0090","doi-asserted-by":"crossref","first-page":"6476","DOI":"10.4049\/jimmunol.178.10.6476","article-title":"TLR2 mediates neuroinflammation and neuronal damage","volume":"178","author":"Hoffmann","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0095","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1523\/JNEUROSCI.20-10-03612.2000","article-title":"IFN gamma enhances microglial reactions to hippocampal axonal degeneration","volume":"20","author":"Jensen","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0100","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.expneurol.2007.01.036","article-title":"Matrix metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal, glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis","volume":"205","author":"Kiaei","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0105","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.molbrainres.2004.06.009","article-title":"Expression of proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta in the brain during experimental group B streptococcal meningitis","volume":"128","author":"Kim","year":"2004","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0110","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/QCO.0b013e328337f49e","article-title":"New understandings on the pathophysiology of bacterial meningitis","volume":"23","author":"Koedel","year":"2010","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0115","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/0006-3002(60)90205-5","article-title":"A study of the genetic material determining an enzyme in pneumococcus","volume":"39","author":"Lacks","year":"1960","journal-title":"Acta Biochem. Biophys."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0120","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1128\/IAI.68.2.615-620.2000","article-title":"Matrix metalloproteinases contribute to brain damage in experimental pneumococcal meningitis","volume":"68","author":"Leib","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0125","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1086\/313922","article-title":"Matrix metalloproteinase (MMP)-8 and MMP-9 in cerebrospinal fluid during bacterial meningitis: association with blood\u2013brain barrier damage and neurological sequelae","volume":"31","author":"Leppert","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0130","series-title":"Neurology and Neurosurgery Illustrated","first-page":"490","article-title":"Acute bacterial meningitis","author":"Lindsay","year":"2011"},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0135","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1073\/pnas.0435928100","article-title":"Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection","volume":"100","author":"Malley","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0140","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/mdr.1997.3.19","article-title":"Biological properties of pneumolysin","volume":"3","author":"Mitchell","year":"1997","journal-title":"Microb. Drug Resist."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0145","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/00005072-199901000-00008","article-title":"Regulation of the gene encoding tumor necrosis factor alpha (TNF-alpha) in the rat brain and pituitary in response in different models of systemic immune challenge","volume":"58","author":"Nadeau","year":"1999","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0150","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1523\/JNEUROSCI.20-09-03456.2000","article-title":"Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and nuclear factor kappa B activity in the brain during endotoxemia","volume":"20","author":"Nadeau","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0155","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/00005072-199903000-00006","article-title":"Apoptosis of neurons in the dentate gyrus in humans suffering from bacterial meningitis","volume":"58","author":"Nau","year":"1999","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0160","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/ana.410440404","article-title":"Matrix metalloproteinases contribute to the blood\u2013brain barrier disruption during bacterial meningitis","volume":"44","author":"Paul","year":"1998","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0165","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1001\/archneur.1993.00540060015010","article-title":"Spectrum of complications during bacterial meningitis in adults. Results of a prospective clinical study","volume":"50","author":"Pfister","year":"1993","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0170","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0006-8993(85)91383-6","article-title":"Evidence for a \u2018paravascular\u2019 fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space","volume":"326","author":"Rennels","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0175","first-page":"431","article-title":"Rapid solute transport throughout the brain via paravascular fluid pathways","volume":"52","author":"Rennels","year":"1990","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0180","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1099\/00222615-43-1-37","article-title":"Dexamethasone treatment of lipopolysaccharide-induced meningitis in rabbits that mimics magnification of inflammation following antibiotic therapy","volume":"43","author":"Rooney","year":"1995","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0185","doi-asserted-by":"crossref","first-page":"10291","DOI":"10.1523\/JNEUROSCI.22-23-10291.2002","article-title":"Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model","volume":"22","author":"Ruscher","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0190","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0022-510X(01)00508-1","article-title":"Differential cellular expression of tumor necrosis factor-alpha and Type I tumor necrosis factor receptor after transient global forebrain ischemia","volume":"186","author":"Sairanen","year":"2001","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0195","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/infdis\/151.3.535","article-title":"The relative role of bacterial cell wall and capsule in the induction of inflammation in pneumococcal meningitis","volume":"151","author":"Tuomanen","year":"1985","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0200","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1084\/jem.170.3.959","article-title":"Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes","volume":"170","author":"Tuomanen","year":"1989","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2014.08.625_bb0205","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S1074-7613(03)00205-X","article-title":"Recognition of pneumococcal peptidoglycan: an expanded, pivotal role for LPS binding protein","volume":"19","author":"Weber","year":"2003","journal-title":"Immunity"}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572814008741?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572814008741?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:23:20Z","timestamp":1759047800000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165572814008741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":41,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0165572814008741"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2014.08.625","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain parenchymal TNF-\u03b1 and IL-1\u03b2 induction in experimental pneumococcal meningitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2014.08.625","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}