{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T20:31:25Z","timestamp":1779395485459,"version":"3.53.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100001214","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["A13-04262-001"],"award-info":[{"award-number":["A13-04262-001"]}],"id":[{"id":"10.13039\/100001214","id-type":"DOI","asserted-by":"publisher"}]},{"name":"VA Merit Review Award","award":["BX001996-01A1"],"award-info":[{"award-number":["BX001996-01A1"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.jneuroim.2014.10.010","type":"journal-article","created":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T05:52:45Z","timestamp":1414648365000},"page":"176-185","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["A role for Apolipoprotein A-I in the pathogenesis of multiple sclerosis"],"prefix":"10.1016","volume":"277","author":[{"given":"Lindsay","family":"Meyers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chassidy J.","family":"Groover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Douglas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangmin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Brand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5299-4869","authenticated-orcid":false,"given":"Lidia A.","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.jneuroim.2014.10.010_bb0005","doi-asserted-by":"crossref","first-page":"e27473","DOI":"10.1371\/journal.pone.0027473","article-title":"Increase in Th17 and T-reg lymphocytes and decrease of IL22 correlate with the recovery phase of acute EAE in rat","volume":"6","author":"Almolda","year":"2011","journal-title":"PLoS ONE"},{"issue":"6","key":"10.1016\/j.jneuroim.2014.10.010_bb0010","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1194\/jlr.P002816","article-title":"Effect of statins on HDL-C: a complex process unrelated to changes in LDL-C: analysis of the VOYAGER database","volume":"51","author":"Barter","year":"2010","journal-title":"J. Lipid Res."},{"issue":"2","key":"10.1016\/j.jneuroim.2014.10.010_bb0015","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s001090050092","article-title":"Myelin oligodendrocyte glycoprotein: a novel candidate autoantigen in multiple sclerosis","volume":"75","author":"Bernard","year":"1997","journal-title":"J. Mol. Med. (Berl)"},{"issue":"11","key":"10.1016\/j.jneuroim.2014.10.010_bb0020","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1172\/JCI118687","article-title":"Opposite regulation of human versus mouse apolipoprotein A-I by fibrates in human apolipoprotein A-I transgenic mice","volume":"97","author":"Berthou","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jneuroim.2014.10.010_bb0025","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.brainres.2007.02.078","article-title":"Fluoro-Jade C can specifically stain the degenerative neurons in the substantia nigra of the 1-methyl-4-phenyl-1,2,3,6-tetrahydro pyridine-treated C57BL\/6 mice","volume":"1150","author":"Bian","year":"2007","journal-title":"Brain Res."},{"issue":"1\u20132","key":"10.1016\/j.jneuroim.2014.10.010_bb0030","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S1568-9972(01)00018-0","article-title":"High-density lipoprotein-associated apolipoprotein A-I: the missing link between infection and chronic inflammation?","volume":"1","author":"Burger","year":"2002","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jneuroim.2014.10.010_bb0035","series-title":"The MS-STAT trial: high dose simvastatin demonstrates neuroprotection without immune-modulation in secondary progressive multiple sclerosis (SPMS) \u2014 a phase II trial. 28th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis","author":"Chataway","year":"2012"},{"key":"10.1016\/j.jneuroim.2014.10.010_bb0040","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/S0140-6736(13)62242-4","article-title":"Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomized, placebo-controlled, phase 2 trial","volume":"383","author":"Chataway","year":"2014","journal-title":"LANCET"},{"issue":"1","key":"10.1016\/j.jneuroim.2014.10.010_bb0045","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ncl.2004.10.003","article-title":"Gender issues","volume":"23","author":"Coyle","year":"2005","journal-title":"Neurol. Clin."},{"issue":"Pt 2","key":"10.1016\/j.jneuroim.2014.10.010_bb0050","first-page":"375","article-title":"Combined therapy with methylprednisolone and erythropoietin in a model of multiple sclerosis","volume":"128","author":"Diem","year":"2005","journal-title":"Brain"},{"issue":"11","key":"10.1016\/j.jneuroim.2014.10.010_bb0055","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1172\/JCI6886","article-title":"Resistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions","volume":"104","author":"Dubois","year":"1999","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.jneuroim.2014.10.010_bb0060","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1267\/ahc.09018","article-title":"Application of Fluoro-Jade C in acute and chronic neurodegeneration models: utilities and staining differences","volume":"42","author":"Ehara","year":"2009","journal-title":"Acta Histochem. Cytochem."},{"issue":"1","key":"10.1016\/j.jneuroim.2014.10.010_bb0065","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.taap.2008.03.013","article-title":"Cytogenetic status and oxidative DNA-damage induced by atorvastatin in human peripheral blood lymphocytes: standard and Fpg-modified comet assay","volume":"231","author":"Gajski","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"5","key":"10.1016\/j.jneuroim.2014.10.010_bb0070","doi-asserted-by":"crossref","first-page":"e10484","DOI":"10.1371\/journal.pone.0010484","article-title":"Novel approaches to detect serum biomarkers for clinical response to interferon-beta treatment in multiple sclerosis","volume":"5","author":"Gandhi","year":"2010","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.jneuroim.2014.10.010_bb0075","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/5532","article-title":"Identification of autoantibodies associated with myelin damage in multiple sclerosis","volume":"5","author":"Genain","year":"1999","journal-title":"Nat. Med."},{"issue":"11","key":"10.1016\/j.jneuroim.2014.10.010_bb0080","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1002\/eji.200526065","article-title":"Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis","volume":"35","author":"Haas","year":"2005","journal-title":"Eur. J. Immunol."},{"issue":"2","key":"10.1016\/j.jneuroim.2014.10.010_bb0085","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/msj.20246","article-title":"Axonal damage in multiple sclerosis","volume":"78","author":"Haines","year":"2011","journal-title":"Mt Sinai J. Med."},{"issue":"18","key":"10.1016\/j.jneuroim.2014.10.010_bb0090","doi-asserted-by":"crossref","first-page":"6449","DOI":"10.1073\/pnas.0502187102","article-title":"Induction of CD4+CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3","volume":"102","author":"Hong","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5609","key":"10.1016\/j.jneuroim.2014.10.010_bb0095","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.jneuroim.2014.10.010_bb0100","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nri1648","article-title":"New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions","volume":"5","author":"Hunter","year":"2005","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.jneuroim.2014.10.010_bb0105","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1172\/JCI28508","article-title":"The IL-23\/IL-17 axis in inflammation","volume":"116","author":"Iwakura","year":"2006","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.jneuroim.2014.10.010_bb0110","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1177\/1352458508097217","article-title":"An APOA1 promoter polymorphism is associated with cognitive performance in patients with multiple sclerosis","volume":"15","author":"Koutsis","year":"2009","journal-title":"Mult. Scler."},{"key":"10.1016\/j.jneuroim.2014.10.010_bb0115","doi-asserted-by":"crossref","DOI":"10.4172\/2155-9899.1000148","article-title":"Autoantibodies to non-myelin antigens as contributors to the pathogenesis of multiple sclerosis","volume":"4","author":"Levin","year":"2013","journal-title":"J. Clin. Cell. Immunol."},{"key":"10.1016\/j.jneuroim.2014.10.010_bb0120","series-title":"Degenerative Neuroimmunological and Neuromuscular Disease","first-page":"49","article-title":"Neurodegeneration in multiple sclerosis involves multiple pathogenic mechanisms","author":"Levin","year":"2014"},{"issue":"4","key":"10.1016\/j.jneuroim.2014.10.010_bb0125","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/glia.20769","article-title":"Lovastatin induces the formation of abnormal myelin-like membrane sheets in primary oligodendrocytes","volume":"57","author":"Maier","year":"2009","journal-title":"Glia"},{"issue":"22","key":"10.1016\/j.jneuroim.2014.10.010_bb0130","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1212\/01.wnl.0000349667.27301.c8","article-title":"Combining beta interferon and atorvastatin may increase disease activity in multiple sclerosis","volume":"72","author":"Markovic-Plese","year":"2009","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.jneuroim.2014.10.010_bb0135","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1194\/jlr.M200439-JLR200","article-title":"Impact of simvastatin, niacin, and\/or antioxidants on cholesterol metabolism in CAD patients with low HDL","volume":"44","author":"Matthan","year":"2003","journal-title":"J. Lipid Res."},{"issue":"1","key":"10.1016\/j.jneuroim.2014.10.010_bb0140","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.it.2005.10.003","article-title":"Understanding the IL-23\u2013IL-17 immune pathway","volume":"27","author":"McKenzie","year":"2006","journal-title":"Trends Immunol."},{"issue":"3","key":"10.1016\/j.jneuroim.2014.10.010_bb0145","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1124\/jpet.108.143271","article-title":"Novel peroxisome proliferator-activated receptor alpha agonists lower low-density lipoprotein and triglycerides, raise high-density lipoprotein, and synergistically increase cholesterol excretion with a liver X receptor agonist","volume":"327","author":"Mukherjee","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"25","key":"10.1016\/j.jneuroim.2014.10.010_bb0150","doi-asserted-by":"crossref","first-page":"8646","DOI":"10.1523\/JNEUROSCI.0885-14.2014","article-title":"Brain glycolipids suppress T helper cells and inhibit autoimmune demyelination","volume":"34","author":"Mycko","year":"2014","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.jneuroim.2014.10.010_bb0155","doi-asserted-by":"crossref","first-page":"e1928","DOI":"10.1371\/journal.pone.0001928","article-title":"Oral high-dose atorvastatin treatment in relapsing\u2013remitting multiple sclerosis","volume":"3","author":"Paul","year":"2008","journal-title":"PLoS ONE"},{"issue":"1\u20132","key":"10.1016\/j.jneuroim.2014.10.010_bb0160","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0165-5728(02)00224-2","article-title":"Sex differences in cytokine responses to myelin peptides in multiple sclerosis","volume":"130","author":"Pelfrey","year":"2002","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2014.10.010_bb0165","doi-asserted-by":"crossref","first-page":"e518","DOI":"10.1038\/cddis.2013.44","article-title":"HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway","volume":"4","author":"Qi","year":"2013","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.jneuroim.2014.10.010_bb0170","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jneumeth.2012.09.004","article-title":"An organotypic spinal cord slice culture model to quantify neurodegeneration","volume":"211","author":"Ravikumar","year":"2012","journal-title":"J. Neurosci. Methods"},{"issue":"2","key":"10.1016\/j.jneuroim.2014.10.010_bb0175","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1073\/pnas.88.2.434","article-title":"Expression of human apolipoprotein A-I in transgenic mice results in reduced plasma levels of murine apolipoprotein A-I and the appearance of two new high density lipoprotein size subclasses","volume":"88","author":"Rubin","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1\u20132","key":"10.1016\/j.jneuroim.2014.10.010_bb0180","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1159\/000119001","article-title":"Functional recovery and morphological changes after injury to the optic nerve","volume":"28","author":"Sabel","year":"1993","journal-title":"Neuropsychobiology"},{"issue":"1","key":"10.1016\/j.jneuroim.2014.10.010_bb0185","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1177\/019262330002800111","article-title":"Fluoro-Jade: novel fluorochromes for detecting toxicant-induced neuronal degeneration","volume":"28","author":"Schmued","year":"2000","journal-title":"Toxicol. Pathol."},{"issue":"3","key":"10.1016\/j.jneuroim.2014.10.010_bb0190","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1515\/CCLM.2000.030","article-title":"Interferon beta1a therapy changes lipoprotein metabolism in patients with multiple sclerosis","volume":"38","author":"Sena","year":"2000","journal-title":"Clin. Chem. Lab. Med."},{"issue":"10","key":"10.1016\/j.jneuroim.2014.10.010_bb0195","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1089\/hum.2011.052","article-title":"Systemic adeno-associated virus-mediated gene therapy preserves retinal ganglion cells and visual function in DBA\/2J glaucomatous mice","volume":"22","author":"Sullivan","year":"2011","journal-title":"Hum. Gene Ther."},{"issue":"2","key":"10.1016\/j.jneuroim.2014.10.010_bb0200","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF00966801","article-title":"Evidence for increased lipid peroxidation in multiple sclerosis","volume":"17","author":"Toshniwal","year":"1992","journal-title":"Neurochem. Res."},{"issue":"9","key":"10.1016\/j.jneuroim.2014.10.010_bb0205","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","article-title":"Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23\/IL-17 axis","volume":"182","author":"van der Fits","year":"2009","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.jneuroim.2014.10.010_bb0210","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/ana.20593","article-title":"APOA1 polymorphism influences risk for early-onset nonfamiliar AD","volume":"58","author":"Vollbach","year":"2005","journal-title":"Ann. Neurol."},{"issue":"8","key":"10.1016\/j.jneuroim.2014.10.010_bb0215","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/nm1620","article-title":"Type II monocytes modulate T cell-mediated central nervous system autoimmune disease","volume":"13","author":"Weber","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.jneuroim.2014.10.010_bb0220","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1742-2094-8-127","article-title":"Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis","volume":"8","author":"Weinstock-Guttman","year":"2011","journal-title":"J. Neuroinflammation"},{"issue":"9","key":"10.1016\/j.jneuroim.2014.10.010_bb0225","doi-asserted-by":"crossref","first-page":"6911","DOI":"10.1167\/iovs.11-7434","article-title":"Latency delay of visual evoked potential is a real measurement of demyelination in a rat model of optic neuritis","volume":"52","author":"You","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.jneuroim.2014.10.010_bb0230","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.clim.2011.08.014","article-title":"Administering human adipose-derived mesenchymal stem cells to prevent and treat experimental arthritis","volume":"141","author":"Zhou","year":"2011","journal-title":"Clin. Immunol."}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572814009448?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572814009448?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:24:13Z","timestamp":1759047853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165572814009448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":46,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0165572814009448"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2014.10.010","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A role for Apolipoprotein A-I in the pathogenesis of multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2014.10.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}