{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:03:18Z","timestamp":1759104198528,"version":"3.44.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.jneuroim.2015.08.004","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T02:00:25Z","timestamp":1439172025000},"page":"98-105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Impact of glatiramer acetate on paraclinical markers of neuroprotection in multiple sclerosis: A prospective observational clinical trial"],"prefix":"10.1016","volume":"287","author":[{"given":"Rainer","family":"Ehling","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Di Pauli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Lackner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn","family":"Rainer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktoria","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2833-6337","authenticated-orcid":false,"given":"Harald","family":"Hegen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Lutterotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Kuenz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"De Zordo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schocke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Glatzl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang N.","family":"L\u00f6scher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Deisenhammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Reindl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2015.08.004_bb0005","doi-asserted-by":"crossref","first-page":"14157","DOI":"10.1073\/pnas.2336171100","article-title":"Glatiramer acetate-specific T cells in the brain express T helper 2\/3 cytokines and brain-derived neurotrophic factor in situ","volume":"100","author":"Aharoni","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0010","doi-asserted-by":"crossref","first-page":"8217","DOI":"10.1523\/JNEUROSCI.1859-05.2005","article-title":"Neurogenesis and neuroprotection induced by peripheral immunomodulatory treatment of experimental autoimmune encephalomyelitis","volume":"25","author":"Aharoni","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0015","doi-asserted-by":"crossref","first-page":"19045","DOI":"10.1073\/pnas.0509438102","article-title":"The immunomodulator glatiramer acetate augments the expression of neurotrophic factors in brains of experimental autoimmune encephalomyelitis mice","volume":"102","author":"Aharoni","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0020","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jns.2005.08.019","article-title":"Multiple sclerosis-related cognitive changes: a review of cross-sectional and longitudinal studies","volume":"245","author":"Amato","year":"2006","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0025","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1007\/s00415-012-6678-0","article-title":"Treatment of cognitive impairment in multiple sclerosis: position paper","volume":"260","author":"Amato","year":"2013","journal-title":"J. Neurol."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0030","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jneuroim.2005.07.001","article-title":"Lower brain-derived neurotrophic factor in serum of relapsing remitting MS: reversal by glatiramer acetate","volume":"167","author":"Azoulay","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0035","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jneuroim.2008.01.010","article-title":"Low and dysregulated BDNF secretion from immune cells of MS patients is related to reduced neuroprotection","volume":"195","author":"Azoulay","year":"2008","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0040","doi-asserted-by":"crossref","first-page":"6303","DOI":"10.4049\/jimmunol.162.11.6303","article-title":"Cutting edge: clonally restricted production of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3 mRNA by human immune cells and Th1\/Th2-polarized expression of their receptors","volume":"162","author":"Besser","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0045","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/S1474-4422(08)70259-X","article-title":"Cognitive impairment in multiple sclerosis","volume":"7","author":"Chiaravalloti","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0050","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1590\/S0100-879X2011007500165","article-title":"Serum levels of brain-derived neurotrophic factor correlate with the number of T2 MRI lesions in multiple sclerosis","volume":"45","author":"Comini-Frota","year":"2012","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0055","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1093\/brain\/121.8.1469","article-title":"Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study","volume":"121","author":"De Stefano","year":"1998","journal-title":"Brain"},{"issue":"165\u2013166","key":"10.1016\/j.jneuroim.2015.08.004_bb0060","first-page":"168","article-title":"\u201cFatigue\u201d in multiple sclerosis. Development and validation of the \u201cW\u00fcrzburger Fatigue Inventory for MS\u201d","volume":"77","author":"Flachenecker","year":"2006","journal-title":"Nervenarzt"},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0065","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.neulet.2009.05.057","article-title":"Increased plasma levels of brain derived neurotrophic factor (BDNF) after multiple sclerosis relapse","volume":"460","author":"Frota","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0070","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/135245850100700208","article-title":"Disease specific quality of life instruments in multiple sclerosis: validation of the Hamburg Quality of Life Questionnaire in Multiple Sclerosis (HAQUAMS)","volume":"7","author":"Gold","year":"2001","journal-title":"Mult. Scler."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0075","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0165-5728(03)00121-8","article-title":"Basal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controls","volume":"138","author":"Gold","year":"2003","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0080","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1084\/jem.189.5.865","article-title":"Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation?","volume":"189","author":"Kerschensteiner","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0085","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS)","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology"},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0090","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jneuroim.2008.04.033","article-title":"Interferon-beta induces brain-derived neurotrophic factor in peripheral blood mononuclear cells of multiple sclerosis patients","volume":"197","author":"Lalive","year":"2008","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0095","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000345995","article-title":"Spinal cord brain-derived neurotrophic factor levels increase after Dexamethasone treatment in male rats with chronic inflammation","volume":"20","author":"Laste","year":"2013","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0100","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00401-011-0890-3","article-title":"Central nervous system rather than immune cell-derived BDNF mediates axonal protective effects early in autoimmune demyelination","volume":"123","author":"Lee","year":"2012","journal-title":"Acta Neuropathol."},{"issue":"133","key":"10.1016\/j.jneuroim.2015.08.004_bb0105","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1093\/brain\/awq179","article-title":"Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis","volume":"2010","author":"Linker","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0110","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0115","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1002\/jnr.22276","article-title":"Correlations between peripheral blood mononuclear cell production of BDNF, TNF-alpha, IL-6, IL-10 and cognitive performances in multiple sclerosis patients","volume":"88","author":"Patanella","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0120","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/ana.20703","article-title":"Diagnostic criteria for multiple sclerosis: 2005 revisions to the \u201cMcDonald Criteria\u201d","volume":"58","author":"Polman","year":"2005","journal-title":"Ann. Neurol."},{"year":"1990","series-title":"A manual for the brief repeatable battery of neuropsychological tests in multiple sclerosis","author":"Rao","key":"10.1016\/j.jneuroim.2015.08.004_bb0125"},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0130","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nrneurol.2013.118","article-title":"The spectrum of MOG autoantibody-associated demyelinating diseases","volume":"9","author":"Reindl","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0135","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0165-5728(02)00319-3","article-title":"Brain-derived neurotrophic factor in patients with multiple sclerosis","volume":"132","author":"Sarchielli","year":"2002","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0140","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1177\/1352458506070146","article-title":"Production of brain-derived neurotrophic factor by mononuclear cells of patients with multiple sclerosis treated with glatiramer acetate, interferon-beta 1a, and high doses of immunoglobulins","volume":"13","author":"Sarchielli","year":"2007","journal-title":"Mult. Scler."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0145","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1177\/1352458514525867","article-title":"Combined visual and motor evoked potentials predict multiple sclerosis disability after 20years","volume":"20","author":"Schlaeger","year":"2014","journal-title":"Mult. Scler."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0150","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/brain\/awf015","article-title":"BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells?","volume":"125","author":"Stadelmann","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0155","doi-asserted-by":"crossref","first-page":"9528","DOI":"10.1073\/pnas.88.21.9528","article-title":"Cross-reactions and specificities of monoclonal antibodies against myelin basic protein and against the synthetic copolymer 1","volume":"88","author":"Teitelbaum","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0160","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1177\/1352458507077622","article-title":"Anti-myelin antibodies predict the clinical outcome after a first episode suggestive of MS","volume":"13","author":"Tomassini","year":"2007","journal-title":"Mult. Scler."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0170","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jneuroim.2007.06.003","article-title":"Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis","volume":"188","author":"Weinstock-Guttman","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2015.08.004_bb0175","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1093\/brain\/awf252","article-title":"Glatiramer acetate-specific T-helper 1- and 2-type cell lines produce BDNF: implications for multiple sclerosis therapy. Brain-derived neurotrophic factor","volume":"125","author":"Ziemssen","year":"2002","journal-title":"Brain"}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572815300199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572815300199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:26:42Z","timestamp":1759048002000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165572815300199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":34,"alternative-id":["S0165572815300199"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2015.08.004","relation":{},"ISSN":["0165-5728"],"issn-type":[{"type":"print","value":"0165-5728"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of glatiramer acetate on paraclinical markers of neuroprotection in multiple sclerosis: A prospective observational clinical trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2015.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}