{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:20:33Z","timestamp":1780586433767,"version":"3.54.1"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.jneuroim.2015.09.010","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T17:11:57Z","timestamp":1443546717000},"page":"120-122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Serum interleukin-27 expression in patients with myasthenia gravis"],"prefix":"10.1016","volume":"288","author":[{"given":"Ha-Neul","family":"Jeong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hwan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bum Chun","family":"Suh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Chul","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2015.09.010_bb0005","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/ni1375","article-title":"Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells","volume":"7","author":"Batten","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0010","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1084\/jem.20100064","article-title":"IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells","volume":"207","author":"Batten","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0015","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jaut.2013.12.011","article-title":"Myasthenia gravis: a comprehensive review of immune dysregulation and etiological mechanisms","volume":"52","author":"Berrih-Aknin","year":"2014","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0020","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jaut.2014.01.003","article-title":"Diagnostic and clinical classification of autoimmune myasthenia gravis","volume":"48\u201349","author":"Berrih-Aknin","year":"2014","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0025","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jaut.2013.12.013","article-title":"Innate immunity in myasthenia gravis thymus: pathogenic effects of Toll-like receptor 4 signaling on autoimmunity","volume":"52","author":"Cordiglieri","year":"2014","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0030","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.4049\/jimmunol.0900735","article-title":"Differential effect of IL-27 on developing versus committed Th17 cells","volume":"183","author":"El-behi","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0035","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/cei.12408","article-title":"Human interleukin-27: wide individual variation in plasma levels and complex inter-relationships with interleukin-17A","volume":"178","author":"Forrester","year":"2014","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0040","first-page":"958","article-title":"Expression of IL-21 in the peripheral blood of myasthenia gravis patients and its correlation with anti-AChR-Ab class switch","volume":"35","author":"Hu","year":"2010","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0045","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00005-010-0098-6","article-title":"Interleukin-27: biological properties and clinical application","volume":"58","author":"Jankowski","year":"2010","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0050","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s10072-013-1460-3","article-title":"Serum IL-21 levels decrease with glucocorticoid treatment in myasthenia gravis","volume":"35","author":"Li","year":"2014","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0055","doi-asserted-by":"crossref","first-page":"737","DOI":"10.2310\/JIM.0b013e3181d88f7b","article-title":"Low level of serum interleukin 27 in patients with systemic lupus erythematosus","volume":"58","author":"Li","year":"2010","journal-title":"J. Investig. Med."},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0060","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1089\/jir.2010.0115","article-title":"Interleukin-27-mediated suppression of human Th17 cells is associated with activation of STAT1 and suppressor of cytokine signaling protein 1","volume":"31","author":"Liu","year":"2011","journal-title":"J. Interf. Cytokine Res."},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0065","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1084\/jem.20061440","article-title":"Regulation of IL-27 p28 gene expression in macrophages through MyD88- and interferon-gamma-mediated pathways","volume":"204","author":"Liu","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0070","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.4049\/jimmunol.175.4.2191","article-title":"A role for IL-27 in early regulation of Th1 differentiation","volume":"175","author":"Owaki","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0075","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S1074-7613(02)00324-2","article-title":"IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells","volume":"16","author":"Pflanz","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0080","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/art.30180","article-title":"Increased levels of interleukin-27 in patients with rheumatoid arthritis","volume":"63","author":"Shen","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0085","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/jid.2009.349","article-title":"Possible roles of IL-27 in the pathogenesis of psoriasis","volume":"130","author":"Shibata","year":"2010","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0090","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/ni1376","article-title":"Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system","volume":"7","author":"Stumhofer","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0095","doi-asserted-by":"crossref","first-page":"4886","DOI":"10.4049\/jimmunol.170.10.4886","article-title":"Cutting edge: role of IL-27\/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment","volume":"170","author":"Takeda","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0100","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jns.2014.11.035","article-title":"Decreased expression of IL-27 and its correlation with Th1 and Th17 cells in progressive multiple sclerosis","volume":"348","author":"Tang","year":"2015","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0105","series-title":"National Conference of Neurology and the 2nd Sino-French Joint Conference on Neurology","article-title":"The role of IL-27 in myasthenia gravis and its correlation with anti-AChR-IgG class switching","author":"Tian","year":"2009"},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0110","doi-asserted-by":"crossref","first-page":"R129","DOI":"10.1186\/ar3067","article-title":"Effects of inflammatory cytokine IL-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritis","volume":"12","author":"Wong","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0115","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3109\/03009742.2014.962080","article-title":"Interleukin-27 and interleukin-23 in patients with systemic lupus erythematosus: possible role in lupus nephritis","volume":"44","author":"Xia","year":"2015","journal-title":"Scand. J. Rheumatol."},{"key":"10.1016\/j.jneuroim.2015.09.010_bb0120","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.4049\/jimmunol.179.7.4415","article-title":"IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation","volume":"179","author":"Yoshimoto","year":"2007","journal-title":"J. Immunol."}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016557281530045X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016557281530045X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:27:01Z","timestamp":1759048021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016557281530045X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":24,"alternative-id":["S016557281530045X"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2015.09.010","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum interleukin-27 expression in patients with myasthenia gravis","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2015.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}