{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:52:24Z","timestamp":1773298344658,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.jneuroim.2015.11.007","type":"journal-article","created":{"date-parts":[[2015,11,14]],"date-time":"2015-11-14T08:46:52Z","timestamp":1447490812000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Thalidomide represses inflammatory response and reduces radiculopathic pain by inhibiting IRAK-1 and NF-\u03baB\/p38\/JNK signaling"],"prefix":"10.1016","volume":"290","author":[{"given":"Tieying","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunfeng","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunliang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengxu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruyv","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Ya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2015.11.007_bb0005","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1097\/BRS.0b013e318294edb1","article-title":"Regulation of nerve growth factor by anti-inflammatory drugs, a steroid, and a selective cyclooxygenase 2 inhibitor in human intervertebral disc cells stimulated with interleukin-1","volume":"38","author":"Alimasi","year":"2013","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0010","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.brainres.2012.02.033","article-title":"The thalidomide analgesic effect is associated with differential TNF-alpha receptor expression in the dorsal horn of the spinal cord as studied in a rat model of neuropathic pain","volume":"1450","author":"Andrade","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0015","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1517\/14740338.2013.775242","article-title":"Lenalidomide and thalidomide in the treatment of chronic pain","volume":"12","author":"Asher","year":"2013","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0020","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/01.brs.0000154619.38122.47","article-title":"Metabolism of the intervertebral disc: effects of low levels of oxygen, glucose, and pH on rates of energy metabolism of bovine nucleus pulposus cells","volume":"30","author":"Bibby","year":"2005","journal-title":"Spine (Phila Pa 1976)"},{"issue":"Suppl. 2","key":"10.1016\/j.jneuroim.2015.11.007_bb0025","first-page":"68","article-title":"Pathology and possible mechanisms of nervous system response to disc degeneration","volume":"88","author":"Brisby","year":"2006","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0030","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00210-011-0724-9","article-title":"Effect of dipyrone and thalidomide alone and in combination on STZ-induced diabetic neuropathic pain","volume":"385","author":"Chauhan","year":"2012","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0035","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/01.RHU.0000062620.10630.21","article-title":"Successful treatment with low-dose thalidomide in a patient with both Behcet's disease and complex regional pain syndrome type I: case report","volume":"9","author":"Ching","year":"2003","journal-title":"J. Clin. Rheumatol."},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0040","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.spinee.2007.10.005","article-title":"A systematic review of low back pain cost of illness studies in the United States and internationally","volume":"8","author":"Dagenais","year":"2008","journal-title":"Spine J."},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0045","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1097\/00007632-200107150-00004","article-title":"Influence of macrophage infiltration of herniated disc tissue on the production of matrix metalloproteinases leading to disc resorption","volume":"26","author":"Doita","year":"2001","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0050","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.gene.2012.06.004","article-title":"Toll-like receptor adaptor signaling molecule MyD88 on intervertebral disk homeostasis: in vitro, ex vivo studies","volume":"505","author":"Ellman","year":"2012","journal-title":"Gene"},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068273","article-title":"Axial low back pain: one painful area\u2014many perceptions and mechanisms","volume":"8","author":"Forster","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0060","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/rheumatology\/ken396","article-title":"The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain","volume":"48","author":"Freemont","year":"2009","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jor.21206","article-title":"Interleukin-17 synergizes with IFNgamma or TNFalpha to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells","volume":"29","author":"Gabr","year":"2011","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0070","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/01.brs.0000251651.61844.2d","article-title":"Autoimmune properties of nucleus pulposus: an experimental study in pigs","volume":"32","author":"Geiss","year":"2007","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0075","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S1097-2765(03)00053-4","article-title":"Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members","volume":"11","author":"Janssens","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0080","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1097\/BRS.0b013e318173298b","article-title":"Participation of 5-hydroxytryptamine in pain-related behavior induced by nucleus pulposus applied on the nerve root in rats","volume":"33","author":"Kato","year":"2008","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0085","doi-asserted-by":"crossref","first-page":"372","DOI":"10.22203\/eCM.v028a26","article-title":"Epigallocatechin 3-gallate suppresses interleukin-1beta-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats","volume":"28","author":"Krupkova","year":"2014","journal-title":"Eur. Cell. Mater."},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0090","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/path.1608","article-title":"Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc","volume":"204","author":"Le Maitre","year":"2004","journal-title":"J. Pathol."},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0095","doi-asserted-by":"crossref","first-page":"R732","DOI":"10.1186\/ar1732","article-title":"The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration","volume":"7","author":"Le Maitre","year":"2005","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0100","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1186\/ar2198","article-title":"Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration","volume":"9","author":"Le Maitre","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0105","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1517\/13543784.6.8.1105","article-title":"TNF-alpha antagonists: monoclonal antibodies, soluble receptors, thalidomide and other novel approaches","volume":"6","author":"Marriott","year":"1997","journal-title":"Expert. Opin. Investig. Drugs"},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0110","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1365-2249.1997.tb08310.x","article-title":"Thalidomide and derivatives: immunological investigations of tumour necrosis factor-alpha (TNF-alpha) inhibition suggest drugs capable of selective gene regulation","volume":"110","author":"McHugh","year":"1997","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0115","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0304-3959(93)90124-8","article-title":"Nitric oxide (NO) and nociceptive processing in the spinal cord","volume":"52","author":"Meller","year":"1993","journal-title":"Pain"},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0120","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1185\/03007995.2010.534446","article-title":"Pharmacotherapy of low back pain: targeting nociceptive and neuropathic pain components","volume":"27","author":"Morlion","year":"2011","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0125","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/01.brs.0000201324.45537.46","article-title":"Possible pathogenesis of painful intervertebral disc degeneration","volume":"31","author":"Peng","year":"2006","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0130","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s00482-003-0216-z","article-title":"Novel potential uses of thalidomide in the management of pain? A review of the literature","volume":"17","author":"Peuckmann","year":"2003","journal-title":"Schmerz"},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0135","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1684\/ecn.2013.0342","article-title":"Thalidomide distinctly affected TNF-alpha, IL-6 and MMP secretion by an ovarian cancer cell line (SKOV-3) and primary ovarian cancer cells","volume":"24","author":"Piura","year":"2013","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0140","first-page":"1033","article-title":"Intervertebral disc biology, degeneration and novel tissue engineering and regenerative medicine therapies","volume":"22","author":"Richardson","year":"2007","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047735","article-title":"Degenerate human nucleus pulposus cells promote neurite outgrowth in neural cells","volume":"7","author":"Richardson","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0150","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/01.brs.0000255097.18246.bc","article-title":"Anti-TNF-alpha antibody reduces pain-behavioral changes induced by epidural application of nucleus pulposus in a rat model depending on the timing of administration","volume":"32","author":"Sasaki","year":"2007","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0155","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1001\/archinte.163.12.1487","article-title":"Thalidomide has activity in treating complex regional pain syndrome","volume":"163","author":"Schwartzman","year":"2003","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0160","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1002\/art.27444","article-title":"Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues","volume":"62","author":"Shamji","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0165","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1097\/BRS.0b013e3181ebdb43","article-title":"Attenuation of inflammatory events in human intervertebral disc cells with a tumor necrosis factor antagonist","volume":"36","author":"Sinclair","year":"2011","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0170","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0304-3959(97)00154-1","article-title":"The effect of thalidomide treatment on vascular pathology and hyperalgesia caused by chronic constriction injury of rat nerve","volume":"74","author":"Sommer","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0175","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1097\/BRS.0b013e31815b757a","article-title":"p38 MAPK inhibition in nucleus pulposus cells: a potential target for treating intervertebral disc degeneration","volume":"32","author":"Studer","year":"2007","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0180","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/jor.20604","article-title":"p38 MAPK inhibition modulates rabbit nucleus pulposus cell response to IL-1","volume":"26","author":"Studer","year":"2008","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0185","first-page":"1009","article-title":"Immune cascades in human intervertebral disc: the pros and cons","volume":"6","author":"Sun","year":"2013","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0190","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1097\/BRS.0b013e3181696132","article-title":"Do corticosteroids produce additional benefit in nerve root infiltration for lumbar disc herniation?","volume":"33","author":"Tachihara","year":"2008","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0195","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.spinee.2012.02.027","article-title":"Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration","volume":"13","author":"Vo","year":"2013","journal-title":"Spine J."},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0200","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1055\/s-0033-1347299","article-title":"Inflammatory mediators in intervertebral disk degeneration and discogenic pain","volume":"3","author":"Wuertz","year":"2013","journal-title":"Global Spine J."},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0205","doi-asserted-by":"crossref","first-page":"E1373","DOI":"10.1097\/BRS.0b013e318221e655","article-title":"The red wine polyphenol resveratrol shows promising potential for the treatment of nucleus pulposus-mediated pain in vitro and in vivo","volume":"36","author":"Wuertz","year":"2011","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.jneuroim.2015.11.007_bb0210","doi-asserted-by":"crossref","first-page":"103","DOI":"10.22203\/eCM.v023a08","article-title":"Inflammatory and catabolic signalling in intervertebral discs: the roles of NF-kappaB and MAP kinases","volume":"23","author":"Wuertz","year":"2012","journal-title":"Eur. Cell. Mater."}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572815300746?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572815300746?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:25:14Z","timestamp":1759047914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165572815300746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":42,"alternative-id":["S0165572815300746"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2015.11.007","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thalidomide represses inflammatory response and reduces radiculopathic pain by inhibiting IRAK-1 and NF-\u03baB\/p38\/JNK signaling","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2015.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}