{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T23:40:29Z","timestamp":1769298029229,"version":"3.49.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Medical Scientific Research Foundation","award":["A2014123"],"award-info":[{"award-number":["A2014123"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.jneuroim.2015.12.010","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T19:45:59Z","timestamp":1450899959000},"page":"39-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Cytokines in cerebrospinal fluid of neurosyphilis patients: Identification of Urokinase plasminogen activator using antibody microarrays"],"prefix":"10.1016","volume":"293","author":[{"given":"Ping","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dao-Cheng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Mei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu-Jian","family":"Ke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu-Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Ying","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He-Ping","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2015.12.010_bb0005","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2174\/1568010054022097","article-title":"Chemokines and brain functions","volume":"4","author":"Banisadr","year":"2005","journal-title":"Curr. Drug Targets Inflamm. Allergy"},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0010","doi-asserted-by":"crossref","first-page":"5132","DOI":"10.4049\/jimmunol.164.10.5132","article-title":"Mechanisms of graft acceptance: evidence that plasminogen activator controls donor-reactive delayed-type hypersensitivity responses in cardiac allograft acceptor mice","volume":"164","author":"Bickerstaff","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0015","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.4049\/jimmunol.1101288","article-title":"Binding of anti-SSA antibodies to apoptotic fetal cardiocytes stimulates urokinase plasminogen activator (uPA)\/uPA receptor-dependent activation of TGF-beta and potentiates fibrosis","volume":"187","author":"Briassouli","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0020","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.ejpn.2011.05.008","article-title":"Concentration gradient of CXCL10 and CXCL11 between the cerebrospinal fluid and plasma in children with enteroviral aseptic meningitis","volume":"15","author":"Cavcic","year":"2011","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0025","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/ana.20076","article-title":"The urokinase receptor is overexpressed in the AIDS dementia complex and other neurological manifestations","volume":"55","author":"Cinque","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0030","first-page":"1","article-title":"Ham-Wasserman lecture: role of the plasminogen system in fibrin-homeostasis and tissue remodeling","author":"Collen","year":"2001","journal-title":"Hematology Am. Soc. Hematol. Educ. Program"},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0035","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/(SICI)1096-9098(199906)71:2<130::AID-JSO14>3.0.CO;2-9","article-title":"Urokinase plasminogen activator: a prognostic marker in multiple types of cancer","volume":"71","author":"Duffy","year":"1999","journal-title":"J. Surg. Oncol."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0040","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0165-5728(00)00368-4","article-title":"Lesion associated expression of urokinase-type plasminogen activator receptor (uPAR, CD87) in human cerebral malaria","volume":"111","author":"Fauser","year":"2000","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0045","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1093\/infdis\/jis446","article-title":"In enterovirus 71 encephalitis with cardio-respiratory compromise, elevated interleukin 1beta, interleukin 1 receptor antagonist, and granulocyte colony-stimulating factor levels are markers of poor prognosis","volume":"206","author":"Griffiths","year":"2012","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0050","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/1742-2094-10-124","article-title":"The plasminogen activator system: involvement in central nervous system inflammation and a potential site for therapeutic intervention","volume":"10","author":"Gur-Wahnon","year":"2013","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0055","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1172\/JCI118611","article-title":"Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoformans. A murine transgenic model","volume":"97","author":"Gyetko","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0060","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1111\/j.1462-5822.2006.00717.x","article-title":"Reciprocal upregulation of urokinase plasminogen activator and its inhibitor, PAI-2, by Borrelia burgdorferi affects bacterial penetration and host-inflammatory response","volume":"8","author":"Haile","year":"2006","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0065","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1182\/blood-2014-08-588442","article-title":"Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice","volume":"125","author":"Hijazi","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0075","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1086\/431600","article-title":"Urokinase-type plasminogen activator, an endogenous antibiotic","volume":"192","author":"Jin","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0080","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1128\/CMR.19.1.29-49.2006","article-title":"Biological basis for syphilis","volume":"19","author":"Lafond","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0085","series-title":"A manual of tests for syphilis","author":"Larsen","year":"1998"},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002528","article-title":"Regulatory T cells in peripheral blood and cerebrospinal fluid of syphilis patients with and without neurological involvement","volume":"7","author":"Li","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0095","doi-asserted-by":"crossref","first-page":"15862","DOI":"10.1038\/srep15862","article-title":"The Chemokine MIP-1alpha\/CCL3 impairs mouse hippocampal synaptic transmission, plasticity and memory","volume":"5","author":"Marciniak","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0100","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11908-009-0019-1","article-title":"Update on neurosyphilis","volume":"11","author":"Marra","year":"2009","journal-title":"Curr. Infect. Dis. Rep."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0105","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/OLQ.0b013e3181d877a1","article-title":"CXCL13 as a cerebrospinal fluid marker for neurosyphilis in HIV-infected patients with syphilis","volume":"37","author":"Marra","year":"2010","journal-title":"Sex. Transm. Dis."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0110","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1023\/A:1009095825561","article-title":"The urokinase plasminogen activator system in cancer: implications for tumor angiogenesis and metastasis","volume":"3","author":"Mazar","year":"1999","journal-title":"Angiogenesis"},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0115","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.pediatrneurol.2005.06.003","article-title":"TNF-alpha and IL-6 in the diagnosis of bacterial and aseptic meningitis in children","volume":"34","author":"Mukai","year":"2006","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0120","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/13550280802400692","article-title":"Expression of the urokinase plasminogen activator receptor (uPAR) and its ligand (uPA) in brain tissues of human immunodeficiency virus patients with opportunistic cerebral diseases","volume":"15","author":"Nebuloni","year":"2009","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0125","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1097\/OLQ.0000000000000024","article-title":"Elevated cerebrospinal fluid interleukin-17A and interferon-gamma levels in early asymptomatic neurosyphilis","volume":"40","author":"Pastuszczak","year":"2013","journal-title":"Sex. Transm. Dis."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0130","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1182\/blood.V83.3.808.808","article-title":"The receptor for urokinase-type plasminogen activator and urokinase is translocated from two distinct intracellular compartments to the plasma membrane on stimulation of human neutrophils","volume":"83","author":"Plesner","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0135","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S1286-4579(02)01638-6","article-title":"The immune response to infection with Treponema pallidum, the stealth pathogen","volume":"4","author":"Salazar","year":"2002","journal-title":"Microbes Infect."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003469","article-title":"A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection","volume":"9","author":"Sanderson-Smith","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0145","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1742-2094-8-86","article-title":"Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3\/NF-kappaB signaling pathway","volume":"8","author":"Schulz","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0150","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jneuroim.2004.08.038","article-title":"Expression of the urokinase plasminogen activator and its receptor in HIV-1-associated central nervous system disease","volume":"157","author":"Sidenius","year":"2004","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0155","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jneuroim.2005.02.013","article-title":"Evaluation of cerebrospinal fluid uPA, PAI-1, and soluble uPAR levels in HIV-infected patients","volume":"163","author":"Sporer","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0160","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1007\/s10753-014-9815-3","article-title":"Expression of CXCL2 in the serum and cerebrospinal fluid of patients with HIV and syphilis or neurosyphilis","volume":"37","author":"Tsai","year":"2014","journal-title":"Inflammation"},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0165","doi-asserted-by":"crossref","first-page":"5550","DOI":"10.4049\/jimmunol.177.8.5550","article-title":"Involvement of the urokinase kringle domain in lipopolysaccharide-induced acute lung injury","volume":"177","author":"Wang","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003004","article-title":"Increased interleukin-17 in peripheral blood and cerebrospinal fluid of neurosyphilis patients","volume":"8","author":"Wang","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.jneuroim.2015.12.010_bb0175","first-page":"1","article-title":"Sexually transmitted diseases treatment guidelines, 2010","volume":"59","author":"Workowski","year":"2010","journal-title":"MMWR Recomm. Rep."}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016557281530103X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016557281530103X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:11:39Z","timestamp":1762251099000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016557281530103X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":34,"alternative-id":["S016557281530103X"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2015.12.010","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytokines in cerebrospinal fluid of neurosyphilis patients: Identification of Urokinase plasminogen activator using antibody microarrays","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2015.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}