{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:44:07Z","timestamp":1790178247340,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401113"],"award-info":[{"award-number":["81401113"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010083","name":"Hunan Provincial Innovation Foundation for Postgraduate","doi-asserted-by":"crossref","award":["CX2013B099"],"award-info":[{"award-number":["CX2013B099"]}],"id":[{"id":"10.13039\/501100010083","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.jneuroim.2016.04.006","type":"journal-article","created":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T02:45:16Z","timestamp":1460601916000},"page":"41-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Quantitative profiling of neurotransmitter abnormalities in the hippocampus of rats treated with lipopolysaccharide: Focusing on kynurenine pathway and implications for depression"],"prefix":"10.1016","volume":"295-296","author":[{"given":"Yujin","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglou","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranyao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruili","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8360-7427","authenticated-orcid":false,"given":"Pei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2016.04.006_bb0005","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.euroneuro.2015.04.025","article-title":"Prefrontal cortical GABA abnormalities are associated with reduced hippocampal volume in major depressive disorder","volume":"25","author":"Abdallah","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0010","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bbr.2011.03.060","article-title":"Changes in behaviour and cytokine expression upon a peripheral immune challenge","volume":"222","author":"Bay-Richter","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0015","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bbi.2014.07.012","article-title":"A role for inflammatory metabolites as modulators of the glutamate N-methyl-d-aspartate receptor in depression and suicidality","volume":"43","author":"Bay-Richter","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0020","doi-asserted-by":"crossref","first-page":"271359","DOI":"10.1155\/2013\/271359","article-title":"Systemic immune activation leads to neuroinflammation and sickness behavior in mice","volume":"2013","author":"Biesmans","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0025","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bbi.2012.10.005","article-title":"Impairment of lithium chloride-induced conditioned gaping responses (anticipatory nausea) following immune system stimulation with lipopolysaccharide (LPS) occurs in both LPS tolerant and LPS non-tolerant rats","volume":"27","author":"Chan","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0030","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1006\/brbi.1995.1033","article-title":"Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-d-aspartate receptors","volume":"9","author":"Chao","year":"1995","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0035","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neulet.2008.06.007","article-title":"Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: a role for IFN-gamma?","volume":"441","author":"Connor","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0040","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1742-2094-7-93","article-title":"Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide","volume":"7","author":"Corona","year":"2010","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0045","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.bbi.2012.08.008","article-title":"Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX(3)CR1)-deficient mice","volume":"31","author":"Corona","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0050","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.psyneuen.2010.09.012","article-title":"Inflammation-associated depression: from serotonin to kynurenine","volume":"36","author":"Dantzer","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0055","doi-asserted-by":"crossref","first-page":"905","DOI":"10.3233\/JAD-2011-111097","article-title":"The role of indoleamine 2,3-dioxygenase in a mouse model of neuroinflammation-induced depression","volume":"28","author":"Dobos","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0060","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.pbb.2014.09.014","article-title":"Lipopolysaccharide repeated challenge followed by chronic mild stress protocol introduces a combined model of depression in rats: reversibility by imipramine and pentoxifylline","volume":"126","author":"Elgarf","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0065","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1038\/sj.npp.1301649","article-title":"Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system","volume":"33","author":"Godbout","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0070","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1016\/j.psyneuen.2013.03.017","article-title":"Stress and vitamin D: altered vitamin D metabolism in both the hippocampus and myocardium of chronic unpredictable mild stress exposed rats","volume":"38","author":"Jiang","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0075","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1007\/s00213-014-3440-6","article-title":"Dysregulation of vitamin D metabolism in the brain and myocardium of rats following prolonged exposure to dexamethasone","volume":"231","author":"Jiang","year":"2014","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0080","doi-asserted-by":"crossref","first-page":"6048","DOI":"10.3390\/nu6126048","article-title":"Neurochemical effects of chronic administration of calcitriol in rats","volume":"6","author":"Jiang","year":"2014","journal-title":"Nutrients"},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0085","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00406-014-0572-y","article-title":"Aberrant NMDA receptor DNA methylation detected by epigenome-wide analysis of hippocampus and prefrontal cortex in major depression","volume":"265","author":"Kaut","year":"2015","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0090","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.bbi.2013.01.001","article-title":"A new animal model of (chronic) depression induced by repeated and intermittent lipopolysaccharide administration for 4months","volume":"31","author":"Kubera","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0095","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/jnr.490400316","article-title":"Endotoxin administration stimulates cerebral catecholamine release in freely moving rats as assessed by microdialysis","volume":"40","author":"Lavicky","year":"1995","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0100","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1523\/JNEUROSCI.15-04-02920.1995","article-title":"Effect of bacterial endotoxin and interleukin-1 beta on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels: an in vivo microdialysis study","volume":"15","author":"Linthorst","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0105","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neulet.2010.03.050","article-title":"Effect of in vivo striatal perfusion of lipopolysaccharide on dopamine metabolites","volume":"475","author":"Maurino","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0110","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12974-015-0259-y","article-title":"Systemic lipopolysaccharide-mediated alteration of cortical neuromodulation involves increases in monoamine oxidase-A and acetylcholinesterase activity","volume":"12","author":"Ming","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0115","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1080\/10253890701754068","article-title":"A link between stress and depression: shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression","volume":"11","author":"Miura","year":"2008","journal-title":"Stress"},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0120","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1080\/10253890802252442","article-title":"Shifting the balance of brain tryptophan metabolism elicited by isolation housing and systemic administration of lipopolysaccharide in mice","volume":"12","author":"Miura","year":"2009","journal-title":"Stress"},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0125","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.euroneuro.2013.03.008","article-title":"Modulation of the inflammatory response in rats chronically treated with the antidepressant agomelatine","volume":"23","author":"Molteni","year":"2013","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0130","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S1734-1140(13)71067-3","article-title":"LPS-induced oxidative stress and inflammatory reaction in the rat striatum","volume":"65","author":"Noworyta-Sokolowska","year":"2013","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0135","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/sj.mp.4002148","article-title":"Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice","volume":"14","author":"O'Connor","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0140","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1742-2094-8-12","article-title":"Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice","volume":"8","author":"Park","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0145","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0006-8993(98)00402-8","article-title":"Cyclooxygenase 2 mRNA expression in rat brain after peripheral injection of lipopolysaccharide","volume":"802","author":"Quan","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0150","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.yhbeh.2012.03.010","article-title":"Indoleamine 2,3-dioxygenase mediates anhedonia and anxiety-like behaviors caused by peripheral lipopolysaccharide immune challenge","volume":"62","author":"Salazar","year":"2012","journal-title":"Horm. Behav."},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0155","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyu005","article-title":"Lipopolysaccharide-induced depressive-like behavior is associated with alpha(1)-adrenoceptor dependent downregulation of the membrane GluR1 subunit in the mouse medial prefrontal cortex and ventral tegmental area","volume":"18","author":"Sekio","year":"2015","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0160","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s00213-014-3725-9","article-title":"Individual differences in anhedonic and accumbal dopamine responses to chronic social stress and their link to cocaine self-administration in female rats","volume":"232","author":"Shimamoto","year":"2015","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0165","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.pnpbp.2012.10.006","article-title":"Immune changes and neurotransmitters: possible interactions in depression?","volume":"48","author":"Sperner-Unterweger","year":"2014","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0170","first-page":"347","article-title":"Brain maps: structure of the rat brain (2nd edn)","volume":"363","author":"Swanson","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0175","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/npp.2013.71","article-title":"NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL\/6J mice","volume":"38","author":"Walker","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0180","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1039\/C5AY00308C","article-title":"Simultaneous determination of multiple neurotransmitters and their metabolites in rat brain homogenates and microdialysates by LC\u2013MS\/MS","volume":"7","author":"Zhang","year":"2015","journal-title":"Anal. Methods"},{"key":"10.1016\/j.jneuroim.2016.04.006_bb0185","doi-asserted-by":"crossref","first-page":"10044","DOI":"10.1021\/ac3025202","article-title":"Quantitative analysis of neurochemical panel in rat brain and plasma by liquid chromatography\u2013tandem mass spectrometry","volume":"84","author":"Zheng","year":"2012","journal-title":"Anal. Chem."}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572816300765?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572816300765?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:27:30Z","timestamp":1759048050000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165572816300765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":37,"alternative-id":["S0165572816300765"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2016.04.006","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative profiling of neurotransmitter abnormalities in the hippocampus of rats treated with lipopolysaccharide: Focusing on kynurenine pathway and implications for depression","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2016.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}