{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T11:17:46Z","timestamp":1777807066450,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["\/ 573646\/2008-2"],"award-info":[{"award-number":["\/ 573646\/2008-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016235","name":"Instituto Nacional de Ci\u00eancia e Tecnologia Midas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016235","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["CBB-APQ-00075-09"],"award-info":[{"award-number":["CBB-APQ-00075-09"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ 00075-09"],"award-info":[{"award-number":["APQ 00075-09"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.jneuroim.2016.04.008","type":"journal-article","created":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T02:46:45Z","timestamp":1460602005000},"page":"122-129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Immune markers in the RASopathy neurofibromatosis type 1"],"prefix":"10.1016","volume":"295-296","author":[{"given":"Karen C.L.","family":"Torres","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giselle","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana C.","family":"Sim\u00f5es e Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabela","family":"Lubambo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz O.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiza","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e1tia D.","family":"Silveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9rica L.M.","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco A.","family":"Romano-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora M.","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2016.04.008_bb0005","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1067\/mai.2001.116436","article-title":"Molecular and cellular mechanisms of allergic disease","volume":"108","author":"Broide","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0010","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.immunol.20.091101.091806","article-title":"The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses","volume":"20","author":"Carreno","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jnen\/64.1.1","article-title":"Tumor suppressor mutations and growth factor signaling in the pathogenesis of NF1-associated peripheral nerve sheath tumors: II. The role of dysregulated growth factor signaling","volume":"64","author":"Carroll","year":"2005","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0020","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/gb-2005-6-6-223","article-title":"The B7 family of immune-regulatory ligands","volume":"6","author":"Collins","year":"2005","journal-title":"Genome Biol."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0025","doi-asserted-by":"crossref","first-page":"9914","DOI":"10.1073\/pnas.88.22.9914","article-title":"Identification and characterization of the neurofibromatosis type 1 protein product","volume":"88","author":"DeClue","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0030","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/ejhg.2011.113","article-title":"Mortality in neurofibromatosis 1: in North West England: an assessment of actuarial survival in a region of the UK since 1989","volume":"19","author":"Evans","year":"2011","journal-title":"Eur. J. Hum. Genet."},{"issue":"Suppl. 8","key":"10.1016\/j.jneuroim.2016.04.008_bb0035","doi-asserted-by":"crossref","first-page":"viii6","DOI":"10.1093\/annonc\/mds256","article-title":"Immuno-oncology: understanding the function and dysfunction of the immune system in cancer","volume":"23","author":"Finn","year":"2012","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0040","doi-asserted-by":"crossref","first-page":"D945","DOI":"10.1093\/nar\/gkq929","article-title":"COSMIC: mining complete cancer genomes in the catalogue of somatic mutations in cancer","volume":"39","author":"Forbes","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0045","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.semcancer.2012.05.004","article-title":"TGF-\u03b2-induced epithelial-mesenchymal transition: a link between cancer and inflammation","volume":"22","author":"Fuxe","year":"2012","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1227\/01.NEU.0000190651.45384.8B","article-title":"Molecular, genetic, and cellular pathogenesis of neurofibromas and surgical implications","volume":"58","author":"Gottfried","year":"2006","journal-title":"Neurosurgery"},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0055","doi-asserted-by":"crossref","DOI":"10.3171\/2009.11.FOCUS09221","article-title":"Neurofibromatosis type 1 and tumorigenesis: molecular mechanisms and therapeutic implications","volume":"28","author":"Gottfried","year":"2010","journal-title":"Neurosurg. Focus."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0060","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/jid.2012.390","article-title":"CD8(+) T cells mediate RAS-induced psoriasis-like skin inflammation through IFN-\u03b3","volume":"133","author":"Gunderson","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0065","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1001\/jama.1997.03550010065042","article-title":"The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2","volume":"278","author":"Gutmann","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0070","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1158\/2159-8290.CD-13-0146","article-title":"Identifying the ubiquitin ligase complex that regulates the NF1 tumor suppressor and Ras","volume":"3","author":"Hollstein","year":"2013","journal-title":"Cancer Discov."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0075","first-page":"33","article-title":"Malignancy in neurofibromatosis","volume":"29","author":"Hope","year":"1981","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0080","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s10555-006-9006-2","article-title":"Transforming growth factor-beta in cancer and metastasis","volume":"25","author":"Jakowlew","year":"2006","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0085","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/ajmg.a.30394","article-title":"Subcutaneous neurofibromas are associated with mortality in neurofibromatosis 1: a cohort study of 703 patients","volume":"132A","author":"Khosrotehrani","year":"2005","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0090","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1172\/JCI41443","article-title":"Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans","volume":"120","author":"Lasater","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0095","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1186\/1479-7364-5-6-623","article-title":"Neurofibromatosis type 1-associated tumours: their somatic mutational spectrum and pathogenesis","volume":"5","author":"Laycock-van Spyk","year":"2011","journal-title":"Hum. Genomics"},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2005.12.027","article-title":"Immune system evasion by peripheral nerve sheath tumor","volume":"397","author":"Lee","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0105","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2008.07.001","article-title":"TGFbeta in cancer","volume":"134","author":"Massagu\u00e9","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0110","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ccr.2009.05.009","article-title":"Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis","volume":"16","author":"McGillicuddy","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0115","doi-asserted-by":"crossref","first-page":"705","DOI":"10.4049\/jimmunol.176.2.705","article-title":"A case for regulatory B cells","volume":"176","author":"Mizoguchi","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0120","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.bbmt.2013.03.006","article-title":"CD19+CD5+ B cells and B1-like cells following allogeneic hematopoietic stem cell transplantation","volume":"19","author":"Moins-Teisserenc","year":"2013","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0125","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.molimm.2013.03.005","article-title":"The Ras GTPase-activating protein neurofibromin 1 promotes the positive selection of thymocytes","volume":"55","author":"Oliver","year":"2013","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0130","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1741-7015-11-109","article-title":"Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors","volume":"11","author":"Park","year":"2013","journal-title":"BMC Med."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0135","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-11-2612","article-title":"A comprehensive survey of Ras mutations in cancer","author":"Prior","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0140","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1086\/320121","article-title":"Mortality in neurofibromatosis 1: an analysis using U.S. death certificates","volume":"68","author":"Rasmussen","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0145","series-title":"Historical Background and Introduction. In Neurofibromatosis. Phenotype, Natural History, and Pathogenesis","author":"Riccardi","year":"1999"},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0150","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/S1470-2045(12)70414-X","article-title":"Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial","volume":"13","author":"Robertson","year":"2012","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0155","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cellimm.2012.06.014","article-title":"Anti-tumor immunity: myeloid leukocytes control the immune landscape","volume":"278","author":"Rutkowski","year":"2012","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0160","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1093\/carcin\/bgs297","article-title":"Transcriptional regulation of the interleukin-11 gene by oncogenic ras","volume":"33","author":"Shin","year":"2012","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0165","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1056\/NEJM198604173141603","article-title":"Long-term follow-up of von Recklinghausen neurofibromatosis. Survival and malignant neoplasms","volume":"314","author":"S\u00f8rensen","year":"1986","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0170","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.pnpbp.2008.11.011","article-title":"Expression of neuronal calcium sensor-1 (NCS-1) is decreased in leukocytes of schizophrenia and bipolar disorder patients","volume":"33","author":"Torres","year":"2009","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0175","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1212\/01.wnl.0000168830.79997.13","article-title":"Association between benign and malignant peripheral nerve sheath tumors in NF1","volume":"65","author":"Tucker","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0180","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0092-8674(90)90252-A","article-title":"Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus","volume":"62","author":"Viskochil","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0185","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/sj.bjc.6603227","article-title":"A prospective study of neurofibromatosis type 1 cancer incidence in the UK","volume":"95","author":"Walker","year":"2006","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0190","doi-asserted-by":"crossref","first-page":"4824","DOI":"10.4161\/cc.9.24.14322","article-title":"Alternative activation of tumor-associated macrophages by IL-4: priming for protumoral functions","volume":"9","author":"Wang","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0195","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/0959-4388(91)90070-N","article-title":"Identification and characterization of the gene for neurofibromatosis type 1","volume":"1","author":"White","year":"1991","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.jneuroim.2016.04.008_bb0200","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2340\/0001555575136140","article-title":"Life expectancy, mortality and prognostic factors in neurofibromatosis type 1. A twelve-year follow-up of an epidemiological study in G\u00f6teborg, Sweden","volume":"75","author":"Z\u00f6ller","year":"1995","journal-title":"Acta Derm. Venereol."}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572816300789?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572816300789?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:48:34Z","timestamp":1777495714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165572816300789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":40,"alternative-id":["S0165572816300789"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2016.04.008","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immune markers in the RASopathy neurofibromatosis type 1","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2016.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}