{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:28:10Z","timestamp":1790810890841,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.jneuroim.2016.08.003","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T23:47:35Z","timestamp":1470354455000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Latent toxoplasmosis is associated with neurocognitive impairment in young adults with and without chronic HIV infection"],"prefix":"10.1016","volume":"299","author":[{"given":"L.","family":"Ene","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.D.","family":"Marcotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Umlauf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Grancea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Temereanca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bharti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.L.","family":"Achim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Letendre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Ruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2016.08.003_bb0005","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1046\/j.1365-2249.2002.01941.x","article-title":"Temporary restoration of immune response against Toxoplasma gondii in HIV-infected individuals after HAART, as studied in the hu-PBMC-SCID mouse model","volume":"129","author":"Alfonzo","year":"2002","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0010","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1756-3305-5-13","article-title":"High seroprevalence of Toxoplasma gondii infection in a subset of Mexican patients with work accidents and low socioeconomic status","volume":"5","author":"Alvarado-Esquivel","year":"2012","journal-title":"Parasite Vectors"},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0015","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.biopsych.2006.09.034","article-title":"Antibodies to infectious agents in individuals at ultra-high risk for psychosis","volume":"61","author":"Amminger","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0020","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1097\/NMD.0b013e3181c29a23","article-title":"Toxoplasma gondii antibody titers and history of suicide attempts in patients with recurrent mood disorders","volume":"197","author":"Arling","year":"2009","journal-title":"J. Nerv. Ment. Dis."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0025","series-title":"Beck Depression Inventory Manual","author":"Beck","year":"1993"},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0030","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.neurobiolaging.2013.11.012","article-title":"Latent Toxoplasma gondii infection leads to deficits in goal-directed behavior in healthy elderly","volume":"35","author":"Beste","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0035","series-title":"19th International AIDS Conference. Washington DC, USA","article-title":"Latent toxoplasmosis may affect neurocognitive functioning in HIV-positive individuals","author":"Bharti","year":"2012"},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0040","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/13803390490510031","article-title":"Predictive validity of global deficit scores in detecting neuropsychological impairment in HIV infection","volume":"26","author":"Carey","year":"2004","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0045","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1093\/schbul\/sbm008","article-title":"Effects of Toxoplasma gondii infection on the brain","volume":"33","author":"Carruthers","year":"2007","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0050","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s11904-014-0221-0","article-title":"HIV associated neurocognitive disorders in the modern antiviral treatment era: prevalence, characteristics, biomarkers, and effects of treatment","volume":"11","author":"Chan","year":"2014","journal-title":"Curr. HIV\/AIeDS Rep."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0055","first-page":"147","article-title":"Epidemiological data on toxoplasmosis. The aspects of congenital toxoplasmosis","volume":"43","author":"Crucerescu","year":"1998","journal-title":"Bacteriol. Virusol. Parazitol. Epidemiol."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0060","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/NMD.0000000000000166","article-title":"Antibodies to Toxoplasma gondii and cognitive functioning in schizophrenia, bipolar disorder, and nonpsychiatric controls","volume":"202","author":"Dickerson","year":"2014","journal-title":"J. Nerv. Ment. Dis."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0065","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1017\/S0031182013001509","article-title":"Epidemiological review of toxoplasmosis in humans and animals in Romania","volume":"141","author":"Dubey","year":"2014","journal-title":"Parasitology"},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0070","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1097\/QAI.0000000000000384","article-title":"Association between latent toxoplasmosis and psychiatric disorders in HIV-infected subjects","volume":"68","author":"El Lakkis","year":"2015","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0075","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s13365-014-0275-1","article-title":"Neurocognitive functioning in a Romanian cohort of young adults with parenterally-acquired HIV-infection during childhood","volume":"20","author":"Ene","year":"2014","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0080","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.pt.2013.01.007","article-title":"How and why toxoplasma makes us crazy","volume":"29","author":"Flegr","year":"2013","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0085","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0301-0511(00)00034-X","article-title":"Correlation of duration of latent Toxoplasma gondii infection with personality changes in women","volume":"53","author":"Flegr","year":"2000","journal-title":"Biol. Psychol."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0090","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1097\/QAD.0b013e3283136d68","article-title":"Restoration of Toxoplasma gondii-specific immune responses in patients with AIDS starting HAART","volume":"22","author":"Furco","year":"2008","journal-title":"AIDS"},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0095","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bbi.2013.11.019","article-title":"Toxoplasma gondii impairs memory in infected seniors","volume":"36","author":"Gajewski","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0100","article-title":"Association between latent toxoplasmosis and cognition in adults: a cross-sectional study","volume":"1-9","author":"Gale","year":"2014","journal-title":"Parasitology"},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0105","doi-asserted-by":"crossref","first-page":"285","DOI":"10.14411\/fp.2014.038","article-title":"Association between latent toxoplasmosis and major depression, generalised anxiety disorder and panic disorder in human adults","volume":"61","author":"Gale","year":"2014","journal-title":"Folia Parasitol."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0110","doi-asserted-by":"crossref","first-page":"939","DOI":"10.4049\/jimmunol.120.3.939","article-title":"Aging and the immune response. I. Antibody formation and chronic infection in Toxoplasma gondii-infected mice","volume":"120","author":"Gardner","year":"1978","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0115","series-title":"Psychological Assessment Resources","article-title":"Frontal systems behavior scale: professional manual","author":"Grace","year":"2001"},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2011.01.004","article-title":"Prenatal depression and anxiety in Toxoplasma gondii-positive women","volume":"204","author":"Groer","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0125","first-page":"28","article-title":"Features of epidemiology and diagnostics of toxoplasmosis during HIV-infection","author":"Gubareva","year":"2010","journal-title":"Zh. Mikrobiol. Epidemiol. Immunobiol."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0130","doi-asserted-by":"crossref","first-page":"93","DOI":"10.14411\/fp.2012.014","article-title":"Does Toxoplasma gondii infection affect cognitive function? A case control study","volume":"59","author":"Guenter","year":"2012","journal-title":"Folia Parasitol."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0135","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1017\/S0031182001007624","article-title":"Decrease of psychomotor performance in subjects with latent \u2018asymptomatic\u2019 toxoplasmosis","volume":"122","author":"Havlicek","year":"2001","journal-title":"Parasitology"},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0140","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.arr.2013.04.003","article-title":"The impact of ageing on natural killer cell function and potential consequences for health in older adults","volume":"12","author":"Hazeldine","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0145","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1212\/WNL.0b013e318200d727","article-title":"HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER study","volume":"75","author":"Heaton","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0150","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/COH.0000000000000104","article-title":"Interactions between ageing and NeuroAIDS","volume":"9","author":"Hellmuth","year":"2014","journal-title":"Curr. Opin. HIV AIDS"},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0155","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1093\/schbul\/sbm010","article-title":"A controlled prospective study of Toxoplasma gondii infection in individuals with schizophrenia: beyond seroprevalence","volume":"33","author":"Hinze-Selch","year":"2007","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0160","doi-asserted-by":"crossref","first-page":"129","DOI":"10.14411\/fp.2010.016","article-title":"The diagnosis of a personality disorder increases the likelihood for seropositivity to Toxoplasma gondii in psychiatric patients","volume":"57","author":"Hinze-Selch","year":"2010","journal-title":"Folia Parasitol."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0165","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.4269\/ajtmh.14-0013","article-title":"Toxoplasma gondii seroprevalence in the United States 2009\u20132010 and comparison with the past two decades","volume":"90","author":"Jones","year":"2014","journal-title":"Am.J.Trop. Med. Hyg."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0170","first-page":"52237","article-title":"3-D imaging and analysis of neurons infected in vivo with Toxoplasma gondii","volume":"9","author":"Koshy","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0175","series-title":"19th Conference of Retroviruses and Opportunistic Infections. Seattle, US","article-title":"Higher CMV antibody concentrations are associated with older age, lower nadir CD4+ cell counts, and worse global neurocognitive functioning in people with HIV disease","author":"Letendre","year":"2012"},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0180","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/expr.1999.4421","article-title":"Toxoplasma gondii in primary rat CNS cells: differential contribution of neurons, astrocytes, and microglial cells for the intracerebral development and stage differentiation","volume":"93","author":"Luder","year":"1999","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0185","doi-asserted-by":"crossref","first-page":"e892","DOI":"10.1016\/j.ijid.2013.03.017","article-title":"Incidence and clinical and immunological characteristics of primary Toxoplasma gondii infection in HIV-infected patients","volume":"17","author":"Machala","year":"2013","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0190","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.bbi.2014.12.006","article-title":"Immediate rather than delayed memory impairment in older adults with latent toxoplasmosis","volume":"45","author":"Mendy","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0195","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1017\/S0031182015000505","article-title":"Toxoplasma gondii seropositivity and cognitive functions in school-aged children","volume":"142","author":"Mendy","year":"2015","journal-title":"Parasitology"},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0200","series-title":"Proceedings of the 6th Annual Meeting of the National Cooperative Vaccine Development Group for AIDS: Alexandria, VA, USA","article-title":"The risk assessment battery (RAB): validity and reliability","author":"Metzger","year":"1993"},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0205","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neulet.2010.03.057","article-title":"The probable relation between Toxoplasma gondii and Parkinson's disease","volume":"475","author":"Miman","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0210","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1093\/schbul\/sbs125","article-title":"Neurotropic infectious agents and cognitive impairment in schizophrenia","volume":"38","author":"Nimgaonkar","year":"2012","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0215","series-title":"The Neurobiological Basis of Suicide. Boca Raton (FL)","article-title":"Toxoplasma gondii, the immune system, and suicidal behavior","author":"Okusaga","year":"2012"},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0220","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.schres.2011.08.006","article-title":"Toxoplasma gondii antibody titers and history of suicide attempts in patients with schizophrenia","volume":"133","author":"Okusaga","year":"2011","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0225","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1089\/aid.1993.9.99","article-title":"The epidemic of human immunodeficiency virus infection in Romanian children","volume":"9","author":"Patrascu","year":"1993","journal-title":"AIDS Res. Hum. Retrovir."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0230","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s00127-014-0820-5","article-title":"The association of Toxoplasma gondii infection with neurocognitive deficits in a population-based analysis","volume":"49","author":"Pearce","year":"2014","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023866","article-title":"The neurotropic parasite Toxoplasma gondii increases dopamine metabolism","volume":"6","author":"Prandovszky","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0240","first-page":"15","article-title":"Substance abuse, hepatitis C, and aging in HIV: common cofactors that contribute to neurobehavioral disturbances","volume":"2012","author":"Schuster","year":"2012","journal-title":"Neurobehav. HIV Med."},{"issue":"Suppl. 20","key":"10.1016\/j.jneuroim.2016.08.003_bb0245","first-page":"22","article-title":"The mini-international neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0250","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/msb.2013.62","article-title":"Metabolic reconstruction identifies strain-specific regulation of virulence in Toxoplasma gondii","volume":"9","author":"Song","year":"2013","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0255","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1645\/GE-2760.1","article-title":"Dopamine stimulates propagation of Toxoplasma gondii tachyzoites in human fibroblast and primary neonatal rat astrocyte cell cultures","volume":"98","author":"Strobl","year":"2012","journal-title":"J. Parasitol."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0260","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1017\/S0022172400063191","article-title":"Prevalence of toxoplasma antibodies according to age with comments on the risk of prenatal infection","volume":"85","author":"van der Veen","year":"1980","journal-title":"J. Hyg. (Lond.)"},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0265","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.forsciint.2010.02.020","article-title":"May Toxoplasma gondii increase suicide attempt-preliminary results in Turkish subjects?","volume":"199","author":"Yagmur","year":"2010","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0270","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.forsciint.2005.11.002","article-title":"Is Toxoplasma gondii a potential risk for traffic accidents in Turkey?","volume":"163","author":"Yereli","year":"2006","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.jneuroim.2016.08.003_bb0275","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.4088\/JCP.11m07532","article-title":"Toxoplasma gondii immunoglobulin G antibodies and nonfatal suicidal self-directed violence","volume":"73","author":"Zhang","year":"2012","journal-title":"J. Clin. Psychiatry"}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572816301813?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572816301813?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:27:31Z","timestamp":1759048051000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165572816301813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":55,"alternative-id":["S0165572816301813"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2016.08.003","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Latent toxoplasmosis is associated with neurocognitive impairment in young adults with and without chronic HIV infection","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2016.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}