{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:06:00Z","timestamp":1790643960185,"version":"4.1.0"},"reference-count":220,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T00:00:00Z","timestamp":1590105600000},"content-version":"am","delay-in-days":356,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Italian Multiple Sclerosis Association","award":["2010\/R\/31"],"award-info":[{"award-number":["2010\/R\/31"]}]},{"name":"Italian Multiple Sclerosis Association","award":["2014\/PMS\/4"],"award-info":[{"award-number":["2014\/PMS\/4"]}]},{"DOI":"10.13039\/100000005","name":"United States Department of Defense","doi-asserted-by":"publisher","award":["MS140019"],"award-info":[{"award-number":["MS140019"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Italian Ministry of Health","award":["GR08-7"],"award-info":[{"award-number":["GR08-7"]}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["260511-SEM_SEM"],"award-info":[{"award-number":["260511-SEM_SEM"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UK Regenerative Medicine Platform Acellular Hub","award":["69889"],"award-info":[{"award-number":["69889"]}]},{"DOI":"10.13039\/501100004282","name":"Evelyn Trust","doi-asserted-by":"publisher","award":["69865"],"award-info":[{"award-number":["69865"]}],"id":[{"id":"10.13039\/501100004282","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bascule Charitable Trust","award":["RG 75149"],"award-info":[{"award-number":["RG 75149"]}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust Research","doi-asserted-by":"crossref","award":["RRZA\/05"],"award-info":[{"award-number":["RRZA\/05"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust Research","doi-asserted-by":"crossref","award":["RG79423"],"award-info":[{"award-number":["RG79423"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NINDS\/NIH"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.jneuroim.2016.12.005","type":"journal-article","created":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T13:01:38Z","timestamp":1481806898000},"page":"11-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Modulation of host immune responses following non-hematopoietic stem cell transplantation: Translational implications in progressive multiple sclerosis"],"prefix":"10.1016","volume":"331","author":[{"given":"Giulio","family":"Volpe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Bernstock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Peruzzotti-Jametti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6267-9472","authenticated-orcid":false,"given":"Stefano","family":"Pluchino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2016.12.005_bb0005","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1182\/blood-2004-04-1559","article-title":"Human mesenchymal stem cells modulate allogeneic immune cell responses","volume":"105","author":"Aggarwal","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003145","article-title":"Neuroprotective effect of transplanted human embryonic stem cell-derived neural precursors in an animal model of multiple sclerosis","volume":"3","author":"Aharonowiz","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0015","doi-asserted-by":"crossref","first-page":"914","DOI":"10.5966\/sctm.2015-0381","article-title":"Concise Review: Bridging the Gap: Novel Neuroregenerative and Neuroprotective Strategies in Spinal Cord Injury","volume":"5","author":"Ahuja","year":"2016","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0020","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1097\/00001756-200408260-00007","article-title":"expression after human neural stem cell transplantation to brain contused rats","volume":"15","author":"Al Nimer","year":"2004","journal-title":"Neuroreport"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0025","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nri1786","article-title":"Lymphoid neogenesis in chronic inflammatory diseases","volume":"6","author":"Aloisi","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0030","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1161\/STROKEAHA.110.606368","article-title":"The CCR2\/CCL2 interaction mediates the transendothelial recruitment of intravascularly delivered neural stem cells to the ischemic brain","volume":"42","author":"Andres","year":"2011","journal-title":"Stroke J. Cereb. Circ."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0035","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nbt.2816","article-title":"Mesenchymal stem cells: immune evasive, not immune privileged","volume":"32","author":"Ankrum","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0040","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2217\/imt.12.41","article-title":"The potential of mesenchymal stromal cells as a novel cellular therapy for multiple sclerosis","volume":"4","author":"Auletta","year":"2012","journal-title":"Immunotherapy"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0045","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1093\/brain\/awp174","article-title":"Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms","volume":"132","author":"Bacigaluppi","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0050","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/glia.20841","article-title":"Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis","volume":"57","author":"Bai","year":"2009","journal-title":"Glia"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0055","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nn.3109","article-title":"Hepatocyte growth factor mediates mesenchymal stem cell-induced recovery in multiple sclerosis models","volume":"15","author":"Bai","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0060","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1634\/stemcells.2006-0709","article-title":"Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow","volume":"25","author":"Baksh","year":"2007","journal-title":"Stem Cells"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0065","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/ana.20501","article-title":"Autologous mesenchymal stem cell transplantation in stroke patients","volume":"57","author":"Bang","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0070","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/74710","article-title":"Gene therapy of experimental brain tumors using neural progenitor cells","volume":"6","author":"Benedetti","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0075","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jns.2007.05.007","article-title":"Immunomodulation by neural stem cells","volume":"265","author":"Ben-Hur","year":"2008","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0080","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/glia.10159","article-title":"Transplanted multipotential neural precursor cells migrate into the inflamed white matter in response to experimental autoimmune encephalomyelitis","volume":"41","author":"Ben-Hur","year":"2003","journal-title":"Glia"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0085","first-page":"211","article-title":"Typical and atypical stem cell niches of the adult Nervous System in health and inflammatory brain and spinal cord diseases","author":"Bernstock","year":"2014","journal-title":"Adult Stem Cell Niches."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0090","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nm.3028","article-title":"The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine","volume":"19","author":"Bianco","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0095","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2174\/157488812804484648","article-title":"Autologous mesenchymal stem cell therapy in progressive multiple sclerosis: an open label study","volume":"7","author":"Bonab","year":"2012","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0100","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/bmt.2011.208","article-title":"Autologous hematopoietic cell transplantation following high-dose immunosuppressive therapy for advanced multiple sclerosis: long-term results","volume":"47","author":"Bowen","year":"2012","journal-title":"Bone Marrow Transplant."},{"issue":"43","key":"10.1016\/j.jneuroim.2016.12.005_bb0105","article-title":"Restrained Th17 response and myeloid cell infiltration into the central nervous system by human decidua-derived mesenchymal stem cells during experimental autoimmune encephalomyelitis","volume":"7","author":"Bravo","year":"2016","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0110","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1182\/blood-2003-03-0877","article-title":"Hematopoietic stem cell transplantation for progressive multiple sclerosis: failure of a total body irradiation-based conditioning regimen to prevent disease progression in patients with high disability scores","volume":"102","author":"Burt","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0115","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ccr.2006.11.020","article-title":"A perivascular niche for brain tumor stem cells","volume":"11","author":"Calabrese","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0120","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1006\/exnr.2002.7981","article-title":"Differentiation of engrafted neuronal-restricted precursor cells is inhibited in the traumatically injured spinal cord","volume":"177","author":"Cao","year":"2002","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0000373","article-title":"Neurosphere-derived cells exert a neuroprotective action by changing the ischemic microenvironment","volume":"2","author":"Capone","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0130","doi-asserted-by":"crossref","first-page":"17384","DOI":"10.1073\/pnas.1103650108","article-title":"Mesenchymal stem cells impair in vivo T-cell priming by dendritic cells","volume":"108","author":"Chiesa","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0135","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1007\/s13311-011-0066-9","article-title":"Cell-based therapy for neural disorders\u2013anticipating challenges","volume":"8","author":"Chiu","year":"2011","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0140","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1093\/brain\/aws189","article-title":"Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis","volume":"135","author":"Choi","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0145","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jns.2012.12.009","article-title":"Mesenchymal stem cell transplantation in multiple sclerosis","volume":"333","author":"Cohen","year":"2013","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0150","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1056\/NEJMoa0907839","article-title":"Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis","volume":"362","author":"Cohen","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0155","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1177\/1352458513502572","article-title":"Disease-modifying treatments for progressive multiple sclerosis","volume":"19","author":"Comi","year":"2013","journal-title":"Mult. Scler."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0160","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/S0140-6736(02)08220-X","article-title":"Multiple sclerosis","volume":"359","author":"Compston","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0165","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S1474-4422(11)70305-2","article-title":"Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study","volume":"11","author":"Connick","year":"2012","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0170","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1002\/stem.194","article-title":"Adipose-derived mesenchymal stem cells ameliorate chronic experimental autoimmune encephalomyelitis","volume":"27","author":"Constantin","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0175","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00441-012-1341-8","article-title":"New perspectives of tissue remodelling with neural stem and progenitor cell-based therapies","volume":"349","author":"Cossetti","year":"2012","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0180","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/brain\/awr339","article-title":"Transplanted neural stem\/precursor cells instruct phagocytes and reduce secondary tissue damage in the injured spinal cord","volume":"135","author":"Cusimano","year":"2012","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0185","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1161\/STROKEAHA.109.573691","article-title":"Human neural stem cell grafts modify microglial response and enhance axonal sprouting in neonatal hypoxic-ischemic brain injury","volume":"41","author":"Daadi","year":"2010","journal-title":"Stroke J. Cereb. Circ."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0190","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1460-9568.2007.05702.x","article-title":"Survival, migration and neuronal differentiation of human fetal striatal and cortical neural stem cells grafted in stroke-damaged rat striatum","volume":"26","author":"Darsalia","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0195","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3727\/096368910X536473","article-title":"Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells","volume":"20","author":"Deuse","year":"2011","journal-title":"Cell Transplant."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0200","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1182\/blood.V99.10.3838","article-title":"Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli","volume":"99","author":"Di Nicola","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0205","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.06.011","article-title":"Reparative therapy for acute ischemic stroke with allogeneic mesenchymal stem cells from adipose tissue: a safety assessment: a phase II randomized, double-blind, placebo-controlled, single-center, pilot clinical trial","volume":"23","author":"Diez-Tejedor","year":"2014","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0210","article-title":"Conditioned medium derived from neural progenitor cells induces long-term post-ischemic neuroprotection, sustained neurological recovery, neurogenesis, and angiogenesis","author":"Doeppner","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0215","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0896-6273(02)01133-9","article-title":"EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells","volume":"36","author":"Doetsch","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0220","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0225","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.3727\/096368914X685104","article-title":"Human Wharton's jelly-derived stem cells display immunomodulatory properties and transiently improve rat experimental autoimmune encephalomyelitis","volume":"24","author":"Donders","year":"2015","journal-title":"Cell Transplant."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0230","first-page":"24","article-title":"Mesenchymal stem cells in multiple sclerosis - translation to clinical trials","volume":"8","author":"Dulamea","year":"2015","journal-title":"J. Med. Life"},{"issue":"Suppl. 1","key":"10.1016\/j.jneuroim.2016.12.005_bb0235","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1191\/1352458504ms1025oa","article-title":"Natural history of primary progressive multiple sclerosis","volume":"10","author":"Ebers","year":"2004","journal-title":"Mult. Scler."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0240","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.mcn.2003.08.009","article-title":"Intraventricular transplantation of neural precursor cell spheres attenuates acute experimental allergic encephalomyelitis","volume":"24","author":"Einstein","year":"2003","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0245","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.expneurol.2005.11.007","article-title":"Transplanted neural precursor cells reduce brain inflammation to attenuate chronic experimental autoimmune encephalomyelitis","volume":"198","author":"Einstein","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0250","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/ana.21033","article-title":"Neural precursors attenuate autoimmune encephalomyelitis by peripheral immunosuppression","volume":"61","author":"Einstein","year":"2007","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0255","doi-asserted-by":"crossref","first-page":"15694","DOI":"10.1523\/JNEUROSCI.3364-09.2009","article-title":"Transplanted neural precursors enhance host brain-derived myelin regeneration","volume":"29","author":"Einstein","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0260","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1182\/blood-2005-03-1004","article-title":"Allogeneic marrow stromal cells are immune rejected by MHC class I- and class II-mismatched recipient mice","volume":"106","author":"Eliopoulos","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0265","doi-asserted-by":"crossref","first-page":"729","DOI":"10.3727\/096368913X664540","article-title":"Autologous bone marrow-derived cell therapy combined with physical therapy induces functional improvement in chronic spinal cord injury patients","volume":"23","author":"El-Kheir","year":"2014","journal-title":"Cell Transplant."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0270","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.pneurobio.2005.04.002","article-title":"Adult neurogenesis and repair of the adult CNS with neural progenitors, precursors, and stem cells","volume":"75","author":"Emsley","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0275","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.mcn.2008.07.007","article-title":"Neural precursor cells inhibit multiple inflammatory signals","volume":"39","author":"Fainstein","year":"2008","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0280","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0127805","article-title":"The parallel analysis of phase sensitive inversion recovery (PSIR) and double inversion recovery (DIR) images significantly improves the detection of cortical lesions in multiple sclerosis (MS) since clinical onset","volume":"10","author":"Favaretto","year":"2015","journal-title":"PLoS One"},{"issue":"Suppl. 5","key":"10.1016\/j.jneuroim.2016.12.005_bb0285","doi-asserted-by":"crossref","first-page":"v16","DOI":"10.1007\/s00415-005-5004-5","article-title":"evidence for multiple sclerosis as a diffuse disease of the central nervous system","volume":"252","author":"Filippi","year":"2005","journal-title":"J. Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0290","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S1474-4422(15)00393-2","article-title":"MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines","volume":"15","author":"Filippi","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0295","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3005568","article-title":"Cell-based therapeutics: the next pillar of medicine","volume":"5","author":"Fischbach","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0300","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s12031-012-9805-6","article-title":"Transplantation of placenta-derived mesenchymal stem cells in the EAE mouse model of MS.","volume":"48","author":"Fisher-Shoval","year":"2012","journal-title":"J. Mol. Neurosci.: MN"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0305","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/jcb.22775","article-title":"Teratomas from pluripotent stem cells: A clinical hurdle","volume":"111","author":"Fong","year":"2010","journal-title":"J. Cell. Biochem."},{"issue":"Suppl:S11\u20139","key":"10.1016\/j.jneuroim.2016.12.005_bb0310","article-title":"New treatments and treatment goals for patients with relapsing-remitting multiple sclerosis","volume":"25","author":"Fox","year":"2012","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0315","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1177\/1352458512458169","article-title":"Setting a research agenda for progressive multiple sclerosis: the International Collaborative on Progressive MS.","volume":"18","author":"Fox","year":"2012","journal-title":"Mult. Scler."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0320","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/nbt0112-12","article-title":"Embryonic stem cell pioneer Geron exits field, cuts losses","volume":"30","author":"Frantz","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0325","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.tibtech.2006.01.010","article-title":"Fat tissue: an underappreciated source of stem cells for biotechnology","volume":"24","author":"Fraser","year":"2006","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0330","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1177\/1352458509359727","article-title":"The therapeutic potential of mesenchymal stem cell transplantation as a treatment for multiple sclerosis: consensus report of the International MSCT Study Group","volume":"16","author":"Freedman","year":"2010","journal-title":"Mult. Scler."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0335","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/00007890-197404000-00001","article-title":"Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo","volume":"17","author":"Friedenstein","year":"1974","journal-title":"Transplantation"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0340","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1002\/med.21322","article-title":"The gap between the physiological and therapeutic roles of mesenchymal stem cells","volume":"34","author":"Galderisi","year":"2014","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0345","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1038\/nbt0915-890","article-title":"suspends first clinical trial involving induced pluripotent stem cells","volume":"33","author":"Garber","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0350","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-1-62703-574-3_6","article-title":"Culturing and expansion of \u201cclinical grade\u201d precursors cells from the fetal human central nervous system","volume":"1059","author":"Gelati","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0355","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/ana.21076","article-title":"Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis","volume":"61","author":"Gerdoni","year":"2007","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0360","doi-asserted-by":"crossref","first-page":"51068","DOI":"10.1074\/jbc.M205121200","article-title":"The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner","volume":"277","author":"Getting","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0365","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1002\/stem.1079","article-title":"Lumbar intraspinal injection of neural stem cells in patients with amyotrophic lateral sclerosis: results of a phase I trial in 12 patients","volume":"30","author":"Glass","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0370","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0139008","article-title":"Disparate effects of mesenchymal stem cells in experimental autoimmune encephalomyelitis and cuprizone-induced demyelination","volume":"10","author":"Glenn","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0375","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neulet.2008.10.040","article-title":"Human mesenchymal stem cells abrogate experimental allergic encephalomyelitis after intraperitoneal injection, and with sparse CNS infiltration","volume":"448","author":"Gordon","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0380","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1097\/NEN.0b013e3181f97392","article-title":"Human mesenchymal stem cells infiltrate the spinal cord, reduce demyelination, and localize to white matter lesions in experimental autoimmune encephalomyelitis","volume":"69","author":"Gordon","year":"2010","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0385","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.expneurol.2011.02.021","article-title":"Variable behavior and complications of autologous bone marrow mesenchymal stem cells transplanted in experimental autoimmune encephalomyelitis","volume":"230","author":"Grigoriadis","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0390","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1159\/000351450","article-title":"Human mesenchymal stem cells upregulate CD1dCD5(+) regulatory B cells in experimental autoimmune encephalomyelitis","volume":"20","author":"Guo","year":"2013","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0395","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3004373","article-title":"Neural stem cell engraftment and myelination in the human brain","volume":"4","author":"Gupta","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0400","doi-asserted-by":"crossref","first-page":"536","DOI":"10.5966\/sctm.2012-0015","article-title":"Characterization of autologous mesenchymal stem cell-derived neural progenitors as a feasible source of stem cells for central nervous system applications in multiple sclerosis","volume":"1","author":"Harris","year":"2012","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0405","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.84.14_supplement.P7.200","article-title":"Interim analysis of a phase I clinical trial investigating intrathecal administration of mesenchymal stem cell-neural progenitors in multiple sclerosis (P7.200)","volume":"84","author":"Harris","year":"2015","journal-title":"Neurology"},{"issue":"12","key":"10.1016\/j.jneuroim.2016.12.005_bb0410","article-title":"Different populations and sources of human mesenchymal stem cells (MSC): a comparison of adult and neonatal tissue-derived MSC","volume":"9","author":"Hass","year":"2011","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0415","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/ana.24009","article-title":"Multiple sclerosis: prospects and promise","volume":"74","author":"Hauser","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0420","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1093\/brain\/awr063","article-title":"Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke","volume":"134","author":"Honmou","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0425","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3389\/fimmu.2013.00144","article-title":"Mesenchymal stem cells: are we ready for clinical application in transplantation and tissue regeneration?","volume":"4","author":"Hoogduijn","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0430","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1634\/stemcells.2004-0058","article-title":"Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta","volume":"22","author":"In 't Anker","year":"2004","journal-title":"Stem Cells"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0435","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.1182\/blood-2004-02-0586","article-title":"Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells","volume":"105","author":"Jiang","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0440","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S1474-4422(10)70131-9","article-title":"Lamotrigine for neuroprotection in secondary progressive multiple sclerosis: a randomised, double-blind, placebo-controlled, parallel-group trial","volume":"9","author":"Kapoor","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0445","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1001\/archneurol.2010.248","article-title":"Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis","volume":"67","author":"Karussis","year":"2010","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0450","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1001\/archneur.65.6.753","article-title":"Neuroprotection and immunomodulation with mesenchymal stem cells in chronic experimental autoimmune encephalomyelitis","volume":"65","author":"Kassis","year":"2008","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0455","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.imlet.2013.06.002","article-title":"Mesenchymal stem cells (MSC) derived from mice with experimental autoimmune encephalomyelitis (EAE) suppress EAE and have similar biological properties with MSC from healthy donors","volume":"154","author":"Kassis","year":"2013","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0460","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1365-2990.2010.01122.x","article-title":"Fusion between human mesenchymal stem cells and rodent cerebellar Purkinje cells","volume":"37","author":"Kemp","year":"2011","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0465","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1002\/jnr.22050","article-title":"Soluble mediators from human neural stem cells play a critical role in suppression of T-cell activation and proliferation","volume":"87","author":"Kim","year":"2009","journal-title":"J. Neurosci. Res."},{"issue":"317","key":"10.1016\/j.jneuroim.2016.12.005_bb0470","article-title":"Intravenous transplantation of mesenchymal stem cells preconditioned with early phase stroke serum: current evidence and study protocol for a randomized trial","volume":"14","author":"Kim","year":"2013","journal-title":"Trials"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0475","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1177\/1352458507082604","article-title":"Autologous stem-cell transplantation in malignant multiple sclerosis: a case with a favorable long-term outcome","volume":"14","author":"Kimiskidis","year":"2008","journal-title":"Mult. Scler."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0480","doi-asserted-by":"crossref","first-page":"140170","DOI":"10.1155\/2015\/140170","article-title":"Intravenous administration of bone marrow-derived mesenchymal stem cells induces a switch from classical to atypical symptoms in experimental autoimmune encephalomyelitis","volume":"2015","author":"Kurte","year":"2015","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0485","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1093\/brain\/awh641","article-title":"Cortical demyelination and diffuse white matter injury in multiple sclerosis","volume":"128","author":"Kutzelnigg","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0490","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1523\/JNEUROSCI.5360-06.2007","article-title":"Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain","volume":"27","author":"Lalancette-Hebert","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0495","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047559","article-title":"Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials","volume":"7","author":"Lalu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0500","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1089\/scd.2009.0385","article-title":"Mouse mesenchymal stem cells suppress antigen-specific TH cell immunity independent of indoleamine 2,3-dioxygenase 1 (IDO1)","volume":"19","author":"Lanz","year":"2010","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0505","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1111\/j.1471-4159.2009.06268.x","article-title":"Neuroprotective mesenchymal stem cells are endowed with a potent antioxidant effect in vivo","volume":"110","author":"Lanza","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0510","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1093\/brain\/aws260","article-title":"Cortical lesions in multiple sclerosis: inflammation versus neurodegeneration","volume":"135","author":"Lassmann","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0515","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1750-3639.2007.00064.x","article-title":"The immunopathology of multiple sclerosis: an overview","volume":"17","author":"Lassmann","year":"2007","journal-title":"Brain Pathol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0520","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nrneurol.2012.168","article-title":"Progressive multiple sclerosis: pathology and pathogenesis","volume":"8","author":"Lassmann","year":"2012","journal-title":"Nat. Rev. Neurol."},{"issue":"2597","key":"10.1016\/j.jneuroim.2016.12.005_bb0525","article-title":"iPSC-derived neural precursors exert a neuroprotective role in immune-mediated demyelination via the secretion of LIF","volume":"4","author":"Laterza","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0530","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0301-472X(03)00110-3","article-title":"HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells","volume":"31","author":"Le Blanc","year":"2003","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0535","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1046\/j.1365-3083.2003.01176.x","article-title":"Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex","volume":"57","author":"Le Blanc","year":"2003","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0540","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/S0140-6736(08)60690-X","article-title":"Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study","volume":"371","author":"Le Blanc","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0545","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/sj.clpt.6100386","article-title":"Autologous mesenchymal stem cell therapy delays the progression of neurological deficits in patients with multiple system atrophy","volume":"83","author":"Lee","year":"2008","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0550","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/brain\/awm306","article-title":"Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke","volume":"131","author":"Lee","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0555","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1002\/stem.430","article-title":"A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke","volume":"28","author":"Lee","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0560","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/ana.23612","article-title":"A randomized trial of mesenchymal stem cells in multiple system atrophy","volume":"72","author":"Lee","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0565","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1634\/stemcells.2008-0146","article-title":"Mesenchymal stem cells alter migratory property of T and dendritic cells to delay the development of murine lethal acute graft-versus-host disease","volume":"26","author":"Li","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0570","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.stem.2013.07.001","article-title":"Genetic and epigenetic variations in iPSCs: potential causes and implications for application","volume":"13","author":"Liang","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0575","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.pharmtox.44.101802.121631","article-title":"Neurogenesis in the adult brain: new strategies for central nervous system diseases","volume":"44","author":"Lie","year":"2004","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0580","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113936","article-title":"Randomized placebo-controlled phase II trial of autologous mesenchymal stem cells in multiple sclerosis","volume":"9","author":"Llufriu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0585","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1212\/WNL.46.4.907","article-title":"Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis","volume":"46","author":"Lublin","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0590","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1212\/WNL.0000000000000560","article-title":"Defining the clinical course of multiple sclerosis: The 2013 revisions","volume":"83","author":"Lublin","year":"2014","journal-title":"Neurology"},{"issue":"65","key":"10.1016\/j.jneuroim.2016.12.005_bb0595","article-title":"Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells","volume":"4","author":"Luz-Crawford","year":"2013","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0600","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1093\/brain\/awm038","article-title":"Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology","volume":"130","author":"Magliozzi","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0605","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/ana.22230","article-title":"A gradient of neuronal loss and meningeal inflammation in multiple sclerosis","volume":"68","author":"Magliozzi","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0610","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1177\/1352458510371959","article-title":"Characterization of in vitro expanded bone marrow-derived mesenchymal stem cells from patients with multiple sclerosis","volume":"16","author":"Mallam","year":"2010","journal-title":"Mult. Scler."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0615","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2015.02.003","article-title":"The role of immune cells, glia and neurons in white and gray matter pathology in multiple sclerosis","volume":"127\u2013128","author":"Mallucci","year":"2015","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0620","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S1474-4422(08)70138-8","article-title":"Autologous haematopoietic stem-cell transplantation in multiple sclerosis","volume":"7","author":"Mancardi","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0625","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1191\/1352458505ms1181cr","article-title":"Autologous stem cell transplantation as rescue therapy in malignant forms of multiple sclerosis","volume":"11","author":"Mancardi","year":"2005","journal-title":"Mult. Scler."},{"issue":"134","key":"10.1016\/j.jneuroim.2016.12.005_bb0630","article-title":"Mesenchymal properties of SJL mice-stem cells and their efficacy as autologous therapy in a relapsing-remitting multiple sclerosis model","volume":"5","author":"Marin-Banasco","year":"2014","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0635","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/nrn1908","article-title":"The therapeutic potential of neural stem cells","volume":"7","author":"Martino","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0640","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1152\/physrev.00032.2010","article-title":"Brain regeneration in physiology and pathology: the immune signature driving therapeutic plasticity of neural stem cells","volume":"91","author":"Martino","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0645","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1523\/JNEUROSCI.4608-03.2004","article-title":"Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice","volume":"24","author":"Maslov","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0650","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jneuroim.2007.07.025","article-title":"Stem cells ameliorate EAE via an indoleamine 2,3-dioxygenase (IDO) mechanism","volume":"193","author":"Matysiak","year":"2008","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0655","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jneuroim.2010.12.004","article-title":"Immunoregulatory function of bone marrow mesenchymal stem cells in EAE depends on their differentiation state and secretion of PGE2","volume":"233","author":"Matysiak","year":"2011","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0660","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jneuroim.2008.05.006","article-title":"Differences in mesenchymal stem cell cytokine profiles between MS patients and healthy donors: implication for assessment of disease activity and treatment","volume":"199","author":"Mazzanti","year":"2008","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0665","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.expneurol.2009.08.007","article-title":"Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: a phase I clinical trial","volume":"223","author":"Mazzini","year":"2010","journal-title":"Exp. Neurol."},{"issue":"17","key":"10.1016\/j.jneuroim.2016.12.005_bb0670","article-title":"Human neural stem cell transplantation in ALS: initial results from a phase I trial","volume":"13","author":"Mazzini","year":"2015","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0675","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/14653240701218540","article-title":"Subsets of mesenchymal stromal cells","volume":"9","author":"McNiece","year":"2007","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0680","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/ana.20890","article-title":"lineage cells in the inflammatory central nervous system environment: migration, maintenance, local antibody production, and therapeutic modulation","volume":"59","author":"Meinl","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0685","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jns.2008.06.032","article-title":"Compartmentalization of inflammation in the CNS: a major mechanism driving progressive multiple sclerosis","volume":"274","author":"Meinl","year":"2008","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0690","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nature09262","article-title":"Mesenchymal and haematopoietic stem cells form a unique bone marrow niche","volume":"466","author":"Mendez-Ferrer","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0695","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/scrt516","article-title":"Safety and neurological assessments after autologous transplantation of bone marrow mesenchymal stem cells in subjects with chronic spinal cord injury","volume":"5","author":"Mendonca","year":"2014","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0700","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.expneurol.2004.07.011","article-title":"Immortalized neural stem cells differ from nonimmortalized cortical neurospheres and cerebellar granule cell progenitors","volume":"194","author":"Mi","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0705","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1042\/BST0340446","article-title":"TSG-6: a pluripotent inflammatory mediator?","volume":"34","author":"Milner","year":"2006","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0710","first-page":"12041","article-title":"Evaluation of locomotor function and microscopic structure of the spinal cord in a mouse model of experimental autoimmune encephalomyelitis following treatment with syngeneic mesenchymal stem cells","volume":"8","author":"Mitra","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"3","key":"10.1016\/j.jneuroim.2016.12.005_bb0715","article-title":"The therapeutic effect of mesenchymal stem cell transplantation in experimental autoimmune encephalomyelitis is mediated by peripheral and central mechanisms","volume":"3","author":"Morando","year":"2012","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0720","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1038\/nn.3233","article-title":"Neural progenitor cells regulate microglia functions and activity","volume":"15","author":"Mosher","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0725","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1634\/stemcells.2005-0568","article-title":"Adhesive interactions between human neural stem cells and inflamed human vascular endothelium are mediated by integrins","volume":"24","author":"Mueller","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0730","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nrn1829","article-title":"Gene therapy: can neural stem cells deliver?","volume":"7","author":"Muller","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0735","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.4049\/jimmunol.177.4.2080","article-title":"Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cells","volume":"177","author":"Nauta","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0740","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1182\/blood-2005-11-011650","article-title":"Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting","volume":"108","author":"Nauta","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0745","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2004.11.016","article-title":"Low immunogenicity of in vitro-expanded human neural cells despite high MHC expression","volume":"161","author":"Odeberg","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0750","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1227\/NEU.0000000000001056","article-title":"A phase III clinical trial showing limited efficacy of autologous mesenchymal stem cell therapy for spinal cord injury","volume":"78","author":"Oh","year":"2016","journal-title":"Neurosurgery"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0755","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nature05934","article-title":"Generation of germline-competent induced pluripotent stem cells","volume":"448","author":"Okita","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0760","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1634\/stemcells.22-3-377","article-title":"Mesenchymal stem cells can be differentiated into endothelial cells in vitro","volume":"22","author":"Oswald","year":"2004","journal-title":"Stem Cells"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0765","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.3727\/096368912X657620","article-title":"Distinct immunomodulatory and migratory mechanisms underpin the therapeutic potential of human mesenchymal stem cells in autoimmune demyelination","volume":"22","author":"Payne","year":"2013","journal-title":"Cell Transplant."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0770","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3005090","article-title":"Pluripotent stem cells: immune to the immune system?","volume":"4","author":"Pearl","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0775","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1007\/s12015-011-9338-3","article-title":"Human endometrial-derived mesenchymal stem cells suppress inflammation in the central nervous system of EAE mice","volume":"8","author":"Peron","year":"2012","journal-title":"Stem Cell Rev."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0780","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1001\/jamaneurol.2015.4321","article-title":"Safety and clinical effects of mesenchymal stem cells Secreting neurotrophic factor transplantation in patients with amyotrophic Lateral sclerosis: results of phase 1\/2 and 2a clinical trials","volume":"73","author":"Petrou","year":"2016","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0785","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/glia.22500","article-title":"How stem cells speak with host immune cells in inflammatory brain diseases","volume":"61","author":"Pluchino","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0790","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jns.2007.07.020","article-title":"The therapeutic plasticity of neural stem\/precursor cells in multiple sclerosis","volume":"265","author":"Pluchino","year":"2008","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0795","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nature01552","article-title":"Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis","volume":"422","author":"Pluchino","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0800","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/nature03889","article-title":"Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism","volume":"436","author":"Pluchino","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0805","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/ana.21745","article-title":"Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates","volume":"66","author":"Pluchino","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0810","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005959","article-title":"Immune regulatory neural stem\/precursor cells protect from central nervous system autoimmunity by restraining dendritic cell function","volume":"4","author":"Pluchino","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0815","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1038\/mt.2009.157","article-title":"Allogeneic mesenchymal stem cells for treatment of experimental autoimmune encephalomyelitis","volume":"17","author":"Rafei","year":"2009","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0820","doi-asserted-by":"crossref","first-page":"5994","DOI":"10.4049\/jimmunol.0803962","article-title":"Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th17 T cells in a CC chemokine ligand 2-dependent manner","volume":"182","author":"Rafei","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0825","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1634\/stemcells.2007-0416","article-title":"Human mesenchymal stem cells inhibit neutrophil apoptosis: a model for neutrophil preservation in the bone marrow niche","volume":"26","author":"Raffaghello","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0830","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/01.tp.0000244572.24780.54","article-title":"Mesenchymal stem cells inhibit dendritic cell differentiation and function by preventing entry into the cell cycle","volume":"83","author":"Ramasamy","year":"2007","journal-title":"Transplantation"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0835","doi-asserted-by":"crossref","first-page":"470949","DOI":"10.1155\/2012\/470949","article-title":"Ethical implications in the use of embryonic and adult neural stem cells","volume":"2012","author":"Ramos-Zuniga","year":"2012","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0840","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.stem.2013.01.010","article-title":"Public private partnerships: a marriage of necessity","volume":"12","author":"Rao","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0845","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1126\/science.1553558","article-title":"Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system","volume":"255","author":"Reynolds","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0850","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1523\/JNEUROSCI.12-11-04565.1992","article-title":"multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes","volume":"12","author":"Reynolds","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0855","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/sj.cdd.4402078","article-title":"Human neural progenitor cells display limited cytotoxicity and increased oligodendrogenesis during inflammation","volume":"14","author":"Ricci-Vitiani","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0860","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(13)61810-3","article-title":"Cell therapy for multiple sclerosis: an evolving concept with implications for other neurodegenerative diseases","volume":"382","author":"Rice","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0865","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1227\/NEU.0b013e31825ca05f","article-title":"Intraspinal stem cell transplantation in amyotrophic lateral sclerosis: a phase I safety trial, technical note, and lumbar safety outcomes","volume":"71","author":"Riley","year":"2012","journal-title":"Neurosurgery"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0870","doi-asserted-by":"crossref","first-page":"939","DOI":"10.2967\/jnumed.113.131698","article-title":"Vivo detection of diffuse Inflammation in secondary progressive multiple sclerosis using PET imaging and the radioligand (1)(1)C-PK11195","volume":"55","author":"Rissanen","year":"2014","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0875","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nrn3430","article-title":"The changing scene of amyotrophic lateral sclerosis","volume":"14","author":"Robberecht","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0880","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1177\/1352458507085129","article-title":"Large-scale, multicentre, quantitative MRI study of brain and cord damage in primary progressive multiple sclerosis","volume":"14","author":"Rovaris","year":"2008","journal-title":"Mult. Scler."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0885","doi-asserted-by":"crossref","DOI":"10.5966\/sctm.2015-0243","article-title":"Human mesenchymal stem cells impact Th17 and Th1 responses through a prostaglandin E2 and myeloid-dependent mechanism","author":"Rozenberg","year":"2016","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0890","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pneurobio.2013.11.001","article-title":"Induced neural stem cells: methods of reprogramming and potential therapeutic applications","volume":"114","author":"Ruggieri","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0895","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1002\/stem.1982","article-title":"Establishing criteria for human mesenchymal stem cell potency","volume":"33","author":"Samsonraj","year":"2015","journal-title":"Stem Cells"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0900","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/493310b","article-title":"Stem cells: surf the waves of reprogramming","volume":"493","author":"Sancho-Martinez","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0905","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1136\/jnnp-2012-304333","article-title":"Onset of secondary progressive phase and long-term evolution of multiple sclerosis","volume":"85","author":"Scalfari","year":"2014","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0910","doi-asserted-by":"crossref","first-page":"797","DOI":"10.5966\/sctm.2013-0026","article-title":"Age of the donor reduces the ability of human adipose-derived stem cells to alleviate symptoms in the experimental autoimmune encephalomyelitis mouse model","volume":"2","author":"Scruggs","year":"2013","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0915","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3171\/2013.3.PEDS12397","article-title":"Central nervous system stem cell transplantation for children with neuronal ceroid lipofuscinosis","volume":"11","author":"Selden","year":"2013","journal-title":"J. Neurosurg. Pediatr."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0920","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1750-3639.2004.tb00049.x","article-title":"Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis","volume":"14","author":"Serafini","year":"2004","journal-title":"Brain Pathol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0925","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/iub.1469","article-title":"Adipose-derived mesenchymal stem cells modulate the immune response in chronic experimental autoimmune encephalomyelitis model","volume":"68","author":"Shalaby","year":"2016","journal-title":"IUBMB Life."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0930","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1021\/bi701892f","article-title":"Biochemical basis for the functional switch that regulates hepatocyte growth factor receptor tyrosine kinase activation","volume":"47","author":"Sheth","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0935","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.exphem.2012.07.003","article-title":"Autologous hematopoietic stem cell transplantation with reduced-intensity conditioning in multiple sclerosis","volume":"40","author":"Shevchenko","year":"2012","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0940","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.4049\/jimmunol.1501457","article-title":"Conditioned medium from the stem cells of human exfoliated deciduous teeth ameliorates experimental autoimmune encephalomyelitis","volume":"196","author":"Shimojima","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0945","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nbt0716-677","article-title":"Neural stem cell trailblazer StemCells folds","volume":"34","author":"Smalley","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0950","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.neuroscience.2004.07.031","article-title":"Adult neural stem cells from the mouse subventricular zone are limited in migratory ability compared to progenitor cells of similar origin","volume":"128","author":"Soares","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0955","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1182\/blood-2005-07-2775","article-title":"Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation","volume":"107","author":"Spaggiari","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0960","doi-asserted-by":"crossref","first-page":"5302120","DOI":"10.1155\/2016\/5302120","article-title":"Clinical application of autologous adipose stem cells in patients with multiple sclerosis: preliminary results","volume":"2016","author":"Stepien","year":"2016","journal-title":"Mediat. Inflamm."},{"issue":"77","key":"10.1016\/j.jneuroim.2016.12.005_bb0965","article-title":"Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke","volume":"8","author":"Sun","year":"2010","journal-title":"J. Transl. Med."},{"issue":"118","key":"10.1016\/j.jneuroim.2016.12.005_bb0970","article-title":"Mesenchymal stem cells can modulate longitudinal changes in cortical thickness and its related cognitive decline in patients with multiple system atrophy","volume":"6","author":"Sunwoo","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0975","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.neuroscience.2014.07.013","article-title":"Inactive GSK3beta is disturbed in the spinal cord during experimental autoimmune encephalomyelitis, but rescued by stem cell therapy","volume":"277","author":"Tafreshi","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0980","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0985","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0990","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.stem.2012.03.003","article-title":"Direct conversion of fibroblasts into stably expandable neural stem cells","volume":"10","author":"Thier","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb0995","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.stem.2015.06.007","article-title":"Stem cell therapies in clinical trials: progress and challenges","volume":"17","author":"Trounson","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb1000","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/01.TP.0000045055.63901.A9","article-title":"Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation","volume":"75","author":"Tse","year":"2003","journal-title":"Transplantation"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb1005","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1007\/s13311-011-0063-z","article-title":"Cell therapy for spinal cord injury by neural stem\/progenitor cells derived from iPS\/ES cells","volume":"8","author":"Tsuji","year":"2011","journal-title":"Neurotherapeutics"},{"issue":"102","key":"10.1016\/j.jneuroim.2016.12.005_bb1010","article-title":"Clinical translation of human neural stem cells","volume":"4","author":"Tsukamoto","year":"2013","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb1015","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1002\/eji.200636416","article-title":"Immunoregulatory function of mesenchymal stem cells","volume":"36","author":"Uccelli","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb1020","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nri2395","article-title":"Mesenchymal stem cells in health and disease","volume":"8","author":"Uccelli","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb1025","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.metabol.2003.11.012","article-title":"Comparison of proliferation and differentiation capacity of human adipocyte precursor cells from the omental and subcutaneous adipose tissue depot of obese subjects","volume":"53","author":"Van Harmelen","year":"2004","journal-title":"Metabolism"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb1030","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.expneurol.2008.11.017","article-title":"Neural stem\/progenitor cells modulate immune responses by suppressing T lymphocytes with nitric oxide and prostaglandin E2","volume":"216","author":"Wang","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb1035","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.stemcr.2014.04.020","article-title":"Human ESC-derived MSCs outperform bone marrow MSCs in the treatment of an EAE model of multiple sclerosis","volume":"3","author":"Wang","year":"2014","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb1040","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/aps.2013.50","article-title":"Mesenchymal stem cells: a new trend for cell therapy","volume":"34","author":"Wei","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb1045","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.4103\/1673-5374.165525","article-title":"Stem Cell Ophthalmology Treatment Study (SCOTS) for retinal and optic nerve diseases: a case report of improvement in relapsing auto-immune optic neuropathy","volume":"10","author":"Weiss","year":"2015","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb1050","doi-asserted-by":"crossref","first-page":"982","DOI":"10.4103\/1673-5374.158365","article-title":"Stem Cell Ophthalmology Treatment Study (SCOTS) for retinal and optic nerve diseases: a preliminary report","volume":"10","author":"Weiss","year":"2015","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb1055","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/1097-4547(20000815)61:4<364::AID-JNR2>3.0.CO;2-C","article-title":"Adult rat and human bone marrow stromal cells differentiate into neurons","volume":"61","author":"Woodbury","year":"2000","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb1060","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jneuroim.2010.07.013","article-title":"Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot study","volume":"227","author":"Yamout","year":"2010","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb1065","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/jcb.24427","article-title":"Stem cells as promising therapeutic options for neurological disorders","volume":"114","author":"Yoo","year":"2013","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb1070","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.intimp.2013.07.016","article-title":"Comparison of in vivo immunomodulatory effects of intravenous and intraperitoneal administration of adipose-tissue mesenchymal stem cells in experimental autoimmune encephalomyelitis (EAE)","volume":"17","author":"Yousefi","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb1075","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.imlet.2016.02.016","article-title":"In vivo immunomodulatory effects of adipose-derived mesenchymal stem cells conditioned medium in experimental autoimmune encephalomyelitis","volume":"172","author":"Yousefi","year":"2016","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb1080","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/s12031-013-9992-9","article-title":"Characterization of in vitro expanded bone marrow-derived mesenchymal stem cells isolated from experimental autoimmune encephalomyelitis mice","volume":"51","author":"Zacharaki","year":"2013","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb1085","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1182\/blood-2005-04-1496","article-title":"Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy","volume":"106","author":"Zappia","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb1090","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/nbt1201-1129","article-title":"vitro differentiation of transplantable neural precursors from human embryonic stem cells","volume":"19","author":"Zhang","year":"2001","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jneuroim.2016.12.005_bb1095","article-title":"Transplantation of autologous adipose stem cells lacks therapeutic efficacy in the experimental autoimmune encephalomyelitis model","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jneuroim.2016.12.005_bb1100","article-title":"Treatment of multiple sclerosis by transplantation of neural stem cells derived from induced pluripotent stem cells","author":"Zhang","year":"2016","journal-title":"Sci. China Life Sci."}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572816303125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572816303125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:33:24Z","timestamp":1759048404000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165572816303125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":220,"alternative-id":["S0165572816303125"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2016.12.005","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of host immune responses following non-hematopoietic stem cell transplantation: Translational implications in progressive multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2016.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}