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Biol."},{"key":"10.1016\/j.jneuroim.2017.02.012_bb0555","doi-asserted-by":"crossref","first-page":"1007S","DOI":"10.1093\/jn\/130.4.1007S","article-title":"Glutamate as a neurotransmitter in the brain: review of physiology and pathology","volume":"130","author":"Meldrum","year":"2000","journal-title":"J. Nutr."},{"key":"10.1016\/j.jneuroim.2017.02.012_bb0560","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1152\/jn.1997.78.1.539","article-title":"Role of group I metabotropic glutamate receptors in the patterning of epileptiform activities in vitro","volume":"78","author":"Merlin","year":"1997","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.jneuroim.2017.02.012_bb0565","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1152\/jn.1995.74.2.896","article-title":"Role of metabotropic glutamate receptor subtypes in the patterning of epileptiform activities in vitro","volume":"74","author":"Merlin","year":"1995","journal-title":"J. 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Virol."},{"key":"10.1016\/j.jneuroim.2017.02.012_bb0650","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1128\/CMR.17.1.174-207.2004","article-title":"Theiler's virus infection: a model for multiple sclerosis","volume":"17","author":"Oleszak","year":"2004","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jneuroim.2017.02.012_bb0655","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jneuroim.2010.09.026","article-title":"Plasma cells in the central nervous system in the Theiler's virus model of multiple sclerosis","volume":"232","author":"Pachner","year":"2011","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2017.02.012_bb0660","doi-asserted-by":"crossref","first-page":"6543","DOI":"10.4049\/jimmunol.162.11.6543","article-title":"Potential role of CD4+ T cell-mediated apoptosis of activated astrocytes in Theiler's virus-induced demyelination","volume":"162","author":"Palma","year":"1999","journal-title":"J. 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