{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:35:11Z","timestamp":1792784111821,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1118"],"award-info":[{"award-number":["SFB1118"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dietmar Hopp Foundation"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.jneuroim.2017.03.008","type":"journal-article","created":{"date-parts":[[2017,3,11]],"date-time":"2017-03-11T11:30:43Z","timestamp":1489231843000},"page":"76-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["STZ causes depletion of immune cells in sciatic nerve and dorsal root ganglion in experimental diabetes"],"prefix":"10.1016","volume":"306","author":[{"given":"Asa S.","family":"Hidmark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter P.","family":"Nawroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2017.03.008_bb0005","doi-asserted-by":"crossref","first-page":"15185","DOI":"10.1074\/jbc.M115.644476","article-title":"Streptozotocin stimulates the ion channel TRPA1 directly: involvement of peroxynitrite","volume":"290","author":"Andersson","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0010","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1523\/JNEUROSCI.1447-08.2008","article-title":"Requirement of myeloid cells for axon regeneration","volume":"28","author":"Barrette","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0015","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/nm.2750","article-title":"Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy","volume":"18","author":"Bierhaus","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0020","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1172\/JCI18058","article-title":"Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily","volume":"114","author":"Bierhaus","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0025","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1744-8069-7-52","article-title":"Streptozotocin-induced early thermal hyperalgesia is independent of glycemic state of rats: role of transient receptor potential vanilloid 1(TRPV1) and inflammatory mediators","volume":"7","author":"Bishnoi","year":"2011","journal-title":"Mol. Pain"},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0030","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1383-5742(02)00044-3","article-title":"Genotoxicity of streptozotocin","volume":"512","author":"Bolz\u00e1n","year":"2002","journal-title":"Mutat. Res."},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0035","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.2337\/diabetes.53.7.1824","article-title":"Direct insulin signalling of neurons reverses diabetic neuropathy","volume":"53","author":"Brussee","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0040","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00401-014-1369-9","article-title":"Collagen VI regulates peripheral nerve regeneration by modulating macrophage recruitment and polarization","volume":"129","author":"Chen","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0045","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/nrn3053","article-title":"Repertoire of microglial and macrophage responses after spinal cord injury","volume":"12","author":"David","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0050","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neuroscience.2014.09.027","article-title":"The neuroimmunology of degeneration and regeneration in the peripheral nervous system","volume":"302","author":"DeFrancesco-Lisowitz","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0055","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1083\/jcb.200502078","article-title":"Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor","volume":"171","author":"DeVries-Seimon","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0060","article-title":"Methylglyoxal activates nociceptors through TRPA1 - a possible mechanism of metabolic neuropathies","author":"Eberhardt","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0065","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.tins.2016.10.003","article-title":"Nitroxidative signaling mechanisms in pathological pain","volume":"39","author":"Grace","year":"2016","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0070","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1189\/jlb.0303114","article-title":"Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification","volume":"75","author":"Guillemin","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0075","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","article-title":"A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia","volume":"32","author":"Hargreaves","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0080","doi-asserted-by":"crossref","first-page":"213","DOI":"10.7555\/JBR.28.20130105","article-title":"Class A scavenger receptor activation inhibits endoplasmic reticulum stress-induced autophagy in macrophage","volume":"28","author":"Huang","year":"2014","journal-title":"J. Biomed. Res."},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0085","doi-asserted-by":"crossref","first-page":"931","DOI":"10.2337\/db12-0632","article-title":"RAGE deficiency improves postinjury sciatic nerve regeneration in type 1 diabetic mice","volume":"62","author":"Juranek","year":"2012","journal-title":"Diabetes"},{"issue":"Pt 1","key":"10.1016\/j.jneuroim.2017.03.008_bb0090","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1093\/brain\/123.10.2118","article-title":"The regenerative deficit of peripheral nerves in experimental diabetes: its extent, timing and possible mechanisms","volume":"123","author":"Kennedy","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0095","doi-asserted-by":"crossref","first-page":"13435","DOI":"10.1523\/JNEUROSCI.3257-09.2009","article-title":"Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord","volume":"29","author":"Kigerl","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0100","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.phrs.2011.10.006","article-title":"Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy","volume":"65","author":"Koivisto","year":"2012","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0105","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuron.2006.03.042","article-title":"TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction","volume":"50","author":"Kwan","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0110","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1742-2094-2-20","article-title":"Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration","volume":"2","author":"Mander","year":"2005","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0115","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1182\/blood-2012-06-436212","article-title":"Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences","volume":"121","author":"Martinez","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0120","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0165-0270(01)00483-6","article-title":"Unilateral hot plate test: a simple and sensitive method for detecting central and peripheral hyperalgesia in mice","volume":"113","author":"Men\u00e9ndez","year":"2002","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/251204","article-title":"Neurotrauma and inflammation: CNS and PNS responses","volume":"2015","author":"Mietto","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0130","doi-asserted-by":"crossref","first-page":"8793","DOI":"10.1016\/j.biomaterials.2012.08.050","article-title":"Effect of modulating macrophage phenotype on peripheral nerve repair","volume":"33","author":"Mokarram","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0135","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.ajpath.2013.06.034","article-title":"Phenotypic transitions of macrophages orchestrate tissue repair","volume":"183","author":"Novak","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0140","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1124\/mol.107.041707","article-title":"Direct role of streptozotocin in inducing thermal hyperalgesia by enhanced expression of transient receptor potential vanilloid 1 in sensory neurons","volume":"73","author":"Pabbidi","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0145","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1744-8069-4-9","article-title":"Influence of TRPV1 on diabetes-induced alterations in thermal pain sensitivity","volume":"4","author":"Pabbidi","year":"2008","journal-title":"Mol. Pain"},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0150","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s12974-016-0735-z","article-title":"Adoptive transfer of M2 macrophages reduces neuropathic pain via opioid peptides","volume":"13","author":"Pannell","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0155","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/jnen\/62.3.260","article-title":"Insulin deficiency rather than hyperglycemia accounts for impaired neurotrophic responses and nerve fiber regeneration in type 1 diabetic neuropathy","volume":"62","author":"Pierson","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0160","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/glia.20763","article-title":"Endogenous signals initiating inflammation in the injured nervous system","volume":"57","author":"Pineau","year":"2009","journal-title":"Glia"},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0165","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0969-9961(02)00008-6","article-title":"Complement-receptor-3 and scavenger-receptor-AI\/II mediated myelin phagocytosis in microglia and macrophages","volume":"12","author":"Reichert","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0170","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1085-9489.2004.009204.x","article-title":"Relevance of hyperglycemia to early mechanical hyperalgesia in streptozotocin-induced diabetes","volume":"9","author":"Romanovsky","year":"2004","journal-title":"J. Peripher. Nerv. Syst."},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0175","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1742-2094-8-109","article-title":"Wallerian degeneration: the innate-immune response to traumatic nerve injury","volume":"8","author":"Rotshenker","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0180","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.4049\/jimmunol.0900890","article-title":"Neuron-interacting satellite glial cells in human trigeminal ganglia have an APC phenotype","volume":"183","author":"van Velzen","year":"2009","journal-title":"J. Immunol."},{"issue":"Suppl","key":"10.1016\/j.jneuroim.2017.03.008_bb0185","first-page":"83","article-title":"Glucose transporter 2 expression: prevention of streptozotocin-induced reduction in beta-cells with 5-thio-d-glucose","volume":"103","author":"Wang","year":"1995","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.jneuroim.2017.03.008_bb0190","doi-asserted-by":"crossref","first-page":"8231","DOI":"10.1074\/jbc.M110.145888","article-title":"Caveolae-dependent endocytosis is required for class a macrophage scavenger receptor-mediated apoptosis in macrophages","volume":"286","author":"Zhu","year":"2011","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016557281630248X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016557281630248X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:29:57Z","timestamp":1759048197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016557281630248X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":38,"alternative-id":["S016557281630248X"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2017.03.008","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"STZ causes depletion of immune cells in sciatic nerve and dorsal root ganglion in experimental diabetes","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2017.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}