{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:22:58Z","timestamp":1793064178078,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471222"],"award-info":[{"award-number":["81471222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Taishan Scholars Construction Engineering of Shandong Province","award":["ts20130914"],"award-info":[{"award-number":["ts20130914"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.jneuroim.2017.08.005","type":"journal-article","created":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T16:08:43Z","timestamp":1503072523000},"page":"71-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["ONX-0914, a selective inhibitor of immunoproteasome, ameliorates experimental autoimmune myasthenia gravis by modulating humoral response"],"prefix":"10.1016","volume":"311","author":[{"given":"Ru-Tao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-Tao","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Sheng","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2017.08.005_bb0005","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1136\/annrheumdis-2014-206016","article-title":"The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus","volume":"74","author":"Alexander","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0010","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.4049\/jimmunol.180.4.2132","article-title":"Ex vivo generated regulatory T cells modulate experimental autoimmune myasthenia gravis","volume":"180","author":"Aricha","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0015","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.4049\/jimmunol.172.4.2697","article-title":"Breakdown of tolerance to a self-peptide of acetylcholine receptor alpha-subunit induces experimental myasthenia gravis in rats","volume":"172","author":"Baggi","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0020","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1084\/jem.186.3.385","article-title":"Interferon gamma (IFN-gamma) is necessary for the genesis of acetylcholine receptor-induced clinical experimental autoimmune myasthenia gravis in mice","volume":"186","author":"Balasa","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0025","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.4049\/jimmunol.1301284","article-title":"B cell antigen presentation in the initiation of follicular helper T cell and germinal center differentiation","volume":"192","author":"Barnett","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0030","doi-asserted-by":"crossref","first-page":"634","DOI":"10.4049\/jimmunol.0903182","article-title":"Prevention of experimental colitis by a selective inhibitor of the immunoproteasome","volume":"185","author":"Basler","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0035","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/emmm.201303543","article-title":"Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis","volume":"6","author":"Basler","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0040","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4049\/jimmunol.128.1.105","article-title":"Binding affinities of anti-acetylcholine receptor autoantibodies in myasthenia gravis","volume":"128","author":"Bray","year":"1982","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0045","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1084\/jem.192.11.1545","article-title":"Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production","volume":"192","author":"Breitfeld","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0050","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0165-5728(88)90003-3","article-title":"Clonotypic analysis of the antibody response to the acetylcholine receptor in experimental autoimmune myasthenia gravis","volume":"19","author":"Brown","year":"1988","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0055","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.immuni.2014.10.004","article-title":"T follicular helper cell differentiation, function, and roles in disease","volume":"41","author":"Crotty","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0060","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.7717.1","article-title":"The germinal center antibody response in health and disease","volume":"5","author":"DeFranco","year":"2016","journal-title":"F1000Res"},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0065","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1007\/PL00000760","article-title":"Regulation of transcription factors by protein degradation","volume":"57","author":"Desterro","year":"2000","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0070","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nature13300","article-title":"Clonal selection in the germinal centre by regulated proliferation and hypermutation","volume":"509","author":"Gitlin","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0075","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.4049\/jimmunol.1002539","article-title":"Proteasome inhibition with bortezomib depletes plasma cells and autoantibodies in experimental autoimmune myasthenia gravis","volume":"186","author":"Gomez","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0080","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1084\/jem.187.1.97","article-title":"Immunoproteasome assembly: cooperative incorporation of interferon gamma (IFN-gamma)-inducible subunits","volume":"187","author":"Griffin","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0085","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.4049\/jimmunol.0903003","article-title":"Unexpected role for the immunoproteasome subunit LMP2 in antiviral humoral and innate immune responses","volume":"184","author":"Hensley","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0090","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1182\/blood-2010-05-284737","article-title":"Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis","volume":"117","author":"Hirai","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0095","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/art.33333","article-title":"Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells","volume":"64","author":"Ichikawa","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0100","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.4049\/jimmunol.1201183","article-title":"Immunoproteasome subunit LMP7 deficiency and inhibition suppresses Th1 and Th17 but enhances regulatory T cell differentiation","volume":"189","author":"Kalim","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0105","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.immuni.2011.03.024","article-title":"Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone","volume":"34","author":"Kerfoot","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0110","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/35056572","article-title":"Antigen processing by the proteasome","volume":"2","author":"Kloetzel","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0115","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1212\/WNL.26.11.1054","article-title":"Antibody to acetylcholine receptor in myasthenia gravis. Prevalence, clinical correlates, and diagnostic value","volume":"26","author":"Lindstrom","year":"1976","journal-title":"Neurology"},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0120","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1096\/fj.201601147R","article-title":"PR-957, a selective inhibitor of immunoproteasome subunit low-MW polypeptide 7, attenuates experimental autoimmune neuritis by suppressing Th17-cell differentiation and regulating cytokine production","volume":"31","author":"Liu","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0125","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1084\/jem.20120994","article-title":"The origins, function, and regulation of T follicular helper cells","volume":"209","author":"Ma","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0130","doi-asserted-by":"crossref","first-page":"827480","DOI":"10.1155\/2012\/827480","article-title":"Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis","volume":"2012","author":"Ma","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0135","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1158\/0008-5472.CAN-06-2258","article-title":"Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition","volume":"67","author":"Meister","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0140","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1196\/annals.1254.032","article-title":"T cells and cytokines in the pathogenesis of acquired myasthenia gravis","volume":"998","author":"Milani","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0145","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1002\/eji.201040620","article-title":"Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice","volume":"40","author":"Moebius","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0150","doi-asserted-by":"crossref","first-page":"e826","DOI":"10.1111\/j.1365-2567.2009.03089.x","article-title":"Disequilibrium of T helper type 1, 2 and 17 cells and regulatory T cells during the development of experimental autoimmune myasthenia gravis","volume":"128","author":"Mu","year":"2009","journal-title":"Immunology"},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0155","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nm.1978","article-title":"A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis","volume":"15","author":"Muchamuel","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0160","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1365-2249.2012.04578.x","article-title":"Prophylactic and therapeutic efficacies of a selective inhibitor of the immunoproteasome for Hashimoto's thyroiditis, but not for Graves' hyperthyroidism, in mice","volume":"168","author":"Nagayama","year":"2012","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0165","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1126\/science.1237572","article-title":"B cells use mechanical energy to discriminate antigen affinities","volume":"340","author":"Natkanski","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0170","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1182\/blood-2005-08-3494","article-title":"Proteasome inhibitor bortezomib modulates TLR4-induced dendritic cell activation","volume":"108","author":"Nencioni","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0175","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nm1763","article-title":"The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis","volume":"14","author":"Neubert","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0180","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1002\/eji.200425032","article-title":"Expression of housekeeping and immunoproteasome subunit genes is differentially regulated in positively and negatively selecting thymic stroma subsets","volume":"34","author":"Nil","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0185","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.1182\/blood-2005-08-3531","article-title":"Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells","volume":"107","author":"Obeng","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0190","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cyto.2014.04.002","article-title":"Deviated balance between Th1 and Th17 cells exacerbates acute graft-versus-host disease in mice","volume":"68","author":"Pan","year":"2014","journal-title":"Cytokine"},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0195","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0022-1759(86)90268-1","article-title":"Antibody avidity determination by ELISA using thiocyanate elution","volume":"86","author":"Pullen","year":"1986","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0200","first-page":"128","article-title":"Bortezomib-induced polyneuropathy","volume":"71","author":"Rampen","year":"2013","journal-title":"Neth. J. Med."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0205","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/1074-7613(95)90030-6","article-title":"The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression","volume":"2","author":"Read","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0210","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jneuroim.2005.09.001","article-title":"Altered expression of chemokine receptor CXCR5 on T cells of myasthenia gravis patients","volume":"170","author":"Saito","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0215","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/j.celrep.2015.05.042","article-title":"CD8alpha(\u2212) dendritic cells induce antigen-specific T follicular helper cells generating efficient humoral immune responses","volume":"11","author":"Shin","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0220","doi-asserted-by":"crossref","first-page":"5729","DOI":"10.4049\/jimmunol.164.11.5729","article-title":"Identification of murine germinal center B cell subsets defined by the expression of surface isotypes and differentiation antigens","volume":"164","author":"Shinall","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0225","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/art.25032","article-title":"Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus","volume":"62","author":"Simpson","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0230","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.4049\/jimmunol.1502641","article-title":"IL-17 augments B cell activation in ocular surface autoimmunity","volume":"197","author":"Subbarayal","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0235","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13075-015-0551-3","article-title":"Long-lived plasma cells are early and constantly generated in New Zealand Black\/New Zealand White F1 mice and their therapeutic depletion requires a combined targeting of autoreactive plasma cells and their precursors","volume":"17","author":"Taddeo","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0240","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/jlb.56.5.571","article-title":"Role of proteasomes modified by interferon-gamma in antigen processing","volume":"56","author":"Tanaka","year":"1994","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0245","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s12016-016-8558-3","article-title":"Thymic germinal centers and corticosteroids in myasthenia gravis: an immunopathological study in 1035 cases and a critical review","volume":"52","author":"Truffault","year":"2017","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0250","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.cell.2010.10.032","article-title":"Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter","volume":"143","author":"Victora","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0255","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nri916","article-title":"Unravelling the pathogenesis of myasthenia gravis","volume":"2","author":"Vincent","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0260","doi-asserted-by":"crossref","first-page":"7072","DOI":"10.4049\/jimmunol.178.11.7072","article-title":"C57BL\/6 mice genetically deficient in IL-12\/IL-23 and IFN-gamma are susceptible to experimental autoimmune myasthenia gravis, suggesting a pathogenic role of non-Th1 cells","volume":"178","author":"Wang","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0265","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12974-015-0334-4","article-title":"Caspase-1 inhibitor ameliorates experimental autoimmune myasthenia gravis by innate dendric cell IL-1-IL-17 pathway","volume":"12","author":"Wang","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0270","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1146\/annurev.immunol.25.022106.141557","article-title":"IL-17 family cytokines and the expanding diversity of effector T cell lineages","volume":"25","author":"Weaver","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0275","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.clim.2013.05.009","article-title":"ATRA alters humoral responses associated with amelioration of EAMG symptoms by balancing Tfh\/Tfr helper cell profiles","volume":"148","author":"Xie","year":"2013","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0280","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.immuni.2009.05.001","article-title":"Plasticity of CD4+ T cell lineage differentiation","volume":"30","author":"Zhou","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.jneuroim.2017.08.005_bb0285","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/eji.200939914","article-title":"Ectopic GC in the thymus of myasthenia gravis patients show characteristics of normal GC","volume":"40","author":"Zuckerman","year":"2010","journal-title":"Eur. J. Immunol."}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572817301820?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572817301820?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:30:20Z","timestamp":1759048220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165572817301820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":57,"alternative-id":["S0165572817301820"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2017.08.005","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ONX-0914, a selective inhibitor of immunoproteasome, ameliorates experimental autoimmune myasthenia gravis by modulating humoral response","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2017.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}