{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T01:43:58Z","timestamp":1785807838626,"version":"3.56.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.jneuroim.2018.05.013","type":"journal-article","created":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T12:40:36Z","timestamp":1527511236000},"page":"41-48","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Decitabine induces regulatory T cells, inhibits the production of IFN-gamma and IL-17 and exerts preventive and therapeutic efficacy in rodent experimental autoimmune neuritis"],"prefix":"10.1016","volume":"321","author":[{"given":"Paolo","family":"Fagone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Mazzon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinatin","family":"Chikovani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Saraceno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santa","family":"Mammana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Colletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Mangano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Placido","family":"Bramanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando","family":"Nicoletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2018.05.013_bb0005","doi-asserted-by":"crossref","first-page":"6","DOI":"10.2169\/internalmedicine.31.6","article-title":"Immunosuppressive effect of FK506 on experimental allergic neuritis in Lewis rats: change of T cell subsets","volume":"31","author":"Adachi","year":"1992","journal-title":"Intern. Med."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0010","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1182\/blood-2012-02-413526","article-title":"Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia","volume":"120","author":"Aslam","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0015","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1177\/096120339600500209","article-title":"In vitro type-1 and type-2 cytokine production in systemic lupus erythematosus: lack of relationship with clinical disease activity","volume":"5","author":"Barcellini","year":"1996","journal-title":"Lupus"},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0020","doi-asserted-by":"crossref","first-page":"248","DOI":"10.2119\/molmed.2013.00159","article-title":"Low-dose 5-aza-2\u2032-deoxycytidine pretreatment inhibits experimental autoimmune encephalomyelitis by induction of regulatory T cells","volume":"20","author":"Chan","year":"2014","journal-title":"Mol. Med."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0025","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jneuroim.2007.09.034","article-title":"Abnormality of circulating CD4(+)CD25(+) regulatory T cell in patients with Guillain-Barr\u00e9 syndrome","volume":"192","author":"Chi","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0030","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jneuroim.2007.09.034","article-title":"Abnormality of circulating CD4(+)CD25(+) regulatory T cell in patients with Guillain-Barr\u00e9 syndrome","volume":"192","author":"Chi","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0035","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.3324\/haematol.2012.074823","article-title":"The effects of 5-azacytidine on the function and number of regulatory T cells and T-effectors in myelodysplastic syndrome","volume":"98","author":"Costantini","year":"2013","journal-title":"Haematologica"},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0040","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/679813","article-title":"Autoimmune hepatitis in Brazilian children: IgE and genetic polymorphisms in associated genes","volume":"2015","author":"de Oliveira","year":"2015","journal-title":"J Immunol Res"},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0045","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.2174\/138161211798157621","article-title":"Manipulating thymic apoptosis for future therapy of autoimmune diseases","volume":"17","author":"Delfino","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0050","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1046\/j.1365-2567.1999.00749.x","article-title":"Suppression of chronic experimental autoimmune neuritis by nasally administered recombinant rat interleukin-6","volume":"97","author":"Deretzi","year":"1999","journal-title":"Immunology"},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0055","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1006\/jaut.1999.0317","article-title":"Amelioration of experimental allergic neuritis by sodium fusidate (fusidin): suppression of IFN-gamma and TNF-alpha and enhancement of IL-10","volume":"13","author":"Di Marco","year":"1999","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0060","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jaut.2009.06.003","article-title":"Treatment with rapamycin ameliorates clinical and histological signs of protracted relapsing experimental allergic encephalomyelitis in Dark Agouti rats and induces expansion of peripheral CD4+CD25+Foxp3+ regulatory T cells","volume":"33","author":"Donia","year":"2009","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0065","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.nbd.2004.04.007","article-title":"CCR5 deficiency does not prevent P0 peptide 180\u2013199 immunized mice from experimental autoimmune neuritis","volume":"16","author":"Duan","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11899-017-0363-4","article-title":"Hypomethylating agents as a therapy for AML","volume":"12","author":"Gardin","year":"2017","journal-title":"Curr. Hematol. Malig. Rep."},{"issue":"2","key":"10.1016\/j.jneuroim.2018.05.013_bb4000","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0165-5728(97)00115-X","article-title":"Modulation of experimental autoimmune neuritis in Lewis rats by oral application of myelin antigens","volume":"79","author":"Gaupp","year":"1997","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0075","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1182\/blood-2011-09-377044","article-title":"Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML)","volume":"119","author":"Goodyear","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0080","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.jocn.2007.09.016","article-title":"Increased levels of activated T-cells and reduced levels of CD4\/CD25+ cells in peripheral blood of Guillain-Barr\u00e9 syndrome patients compared to controls","volume":"15","author":"Harness","year":"2008","journal-title":"J. Clin. Neurosci."},{"issue":"11","key":"10.1016\/j.jneuroim.2018.05.013_bb2000","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1080\/1744666X.2016.1193006","article-title":"Guillain-Barr\u00e9 syndrome: causes, immunopathogenic mechanisms and treatment","volume":"12","author":"Jasti","year":"2016","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0085","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/jnr.10879","article-title":"Biphasic form of experimental autoimmune neuritis in dark Agouti rats and its oral therapy by antigen-specific tolerization","volume":"75","author":"Jung","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0090","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jneuroim.2013.10.011","article-title":"Intravenous immunoglobulin preparation attenuates neurological signs in rat experimental autoimmune neuritis with the suppression of macrophage inflammatory protein -1\u03b1 expression","volume":"266","author":"Kajii","year":"2014","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0095","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/imm.12261","article-title":"Impact of 5-aza-2\u2032-deoxycytidine and epigallocatechin-3-gallate for induction of human regulatory T cells","volume":"142","author":"Kehrmann","year":"2014","journal-title":"Immunology"},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0100","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0165-5728(93)90255-W","article-title":"Antibody responses to P0 and P2 myelin proteins in Guillain-Barr\u00e9 syndrome and chronic idiopathic demyelinating polyradiculoneuropathy","volume":"46","author":"Khalili-Shirazi","year":"1993","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0105","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/740947","article-title":"Circulating Th17, Th22, and Th1 cells are elevated in the Guillain-Barr\u00e9 syndrome and downregulated by IVIg treatments","volume":"2014","author":"Li","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0110","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ctrv.2017.01.004","article-title":"Clinical and biological effects of demethylating agents on solid tumours \u2013 a systematic review","volume":"54","author":"Linnekamp","year":"2017","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0115","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jaut.2012.12.003","article-title":"T-regs in autoimmune hepatitis-systemic lupus erythematosus\/mixed connective tissue disease overlap syndrome are functionally defective and display a Th1 cytokine profile","volume":"41","author":"Longhi","year":"2013","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0120","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s12026-014-8580-6","article-title":"Intravenous immunoglobulin exerts reciprocal regulation of Th1\/Th17 cells and regulatory T cells in Guillain-Barr\u00e9 syndrome patients","volume":"60","author":"Maddur","year":"2014","journal-title":"Immunol. Res."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0125","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jneuroim.2008.03.008","article-title":"Preventive and curative effects of cyclophosphamide in an animal model of Guillain Barr\u00e8 syndrome","volume":"196","author":"Mangano","year":"2008","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0130","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1002\/jcp.24641","article-title":"Hypomethylating agent 5-aza-2\u2032-deoxycytidine (DAC) ameliorates multiple sclerosis in mouse models","volume":"229","author":"Mangano","year":"2014","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0135","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1002\/jcp.24641","article-title":"Hypomethylating agent 5-aza-2\u2032-deoxycytidine (DAC) ameliorates multiple sclerosis in mouse models","volume":"229","author":"Mangano","year":"2014","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0140","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1136\/jnnp.65.2.266","article-title":"Sodium fusidate in Gillain-Barr\u00e9 syndrome: a case report","volume":"65","author":"Nicoletti","year":"1998","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"1-2","key":"10.1016\/j.jneuroim.2018.05.013_bb3000","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jneuroim.2005.07.019","article-title":"Macrophage migration inhibitory factor (MIF) seems crucially involved in Guillain-Barr\u00e9 syndrome and experimental allergic neuritis","volume":"168","author":"Nicoletti","year":"2005","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0145","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/758639","article-title":"Role of cytokines and Toll-like receptors in the immunopathogenesis of Guillain-Barr\u00e9 syndrome","volume":"2014","author":"Nyati","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0150","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1080\/10428190701471981","article-title":"Decitabine and its role in the treatment of hematopoietic malignancies","volume":"48","author":"Plimack","year":"2007","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0155","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jneuroim.2006.12.002","article-title":"Reduced circulating CD4+CD25+ cell populations in Guillain\u2013Barr\u00e9 syndrome","volume":"183","author":"Pritchard","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0160","first-page":"807","article-title":"Decitabine in the treatment of myelodysplastic syndromes","volume":"3","author":"Saba","year":"2007","journal-title":"Ther. Clin. Risk Manag."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0165","doi-asserted-by":"crossref","first-page":"667","DOI":"10.3109\/08916930903140907","article-title":"Circulating subsets and CD4 + CD25 + regulatory T cell function in chronic inflammatory demyelinating polyradiculoneuropathy","volume":"42","author":"Sanvito","year":"2009","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0170","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a026948","article-title":"DNA Hypomethylating drugs in cancer therapy","volume":"7","author":"Sato","year":"2017","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0175","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-017-1001-8","article-title":"Novel pathomechanisms in inflammatory neuropathies","volume":"14","author":"Schafflick","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0180","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1038\/leu.2013.64","article-title":"Salvage therapy with azacitidine increases regulatory T cells in peripheral blood of patients with AML or MDS and early relapse after allogeneic blood stem cell transplantation","volume":"27","author":"Schroeder","year":"2013","journal-title":"Leukemia"},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0185","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1517\/14656566.2011.564160","article-title":"The role of immunotherapy in Guillain-Barr\u00e9 syndrome: understanding the mechanism of action","volume":"12","author":"Shahrizaila","year":"2011","journal-title":"Expert. Opin. Pharmacother."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0190","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-016-0678-4","article-title":"Mapping autoantigen epitopes: molecular insights into autoantibody-associated disorders of the nervous system","volume":"13","author":"Sinmaz","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0195","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/ilar\/ilt054","article-title":"Animal models of autoimmune neuropathy","volume":"54","author":"Soliven","year":"2014","journal-title":"ILAR J."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0200","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/sji.12201","article-title":"Mitigated Tregs and augmented Th17 cells and cytokines are associated with severity of experimental autoimmune neuritis","volume":"80","author":"Wang","year":"2014","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0205","doi-asserted-by":"crossref","first-page":"56802","DOI":"10.18632\/oncotarget.18063","article-title":"Decitabine inhibits T cell proliferation via a novel TET2-dependent mechanism and exerts potent protective effect in mouse auto- and allo-immunity models","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0210","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s00109-007-0235-9","article-title":"The different effects of indirubin on effector and CD4+CD25+ regulatory T cells in mice: potential implication for the treatment of autoimmune diseases","volume":"85","author":"Zhang","year":"2007","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0215","article-title":"Attenuated EAN in TNF-\u03b1 deficient mice is associated with an altered balance of M1\/M2 macrophages","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0220","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s00109-009-0530-8","article-title":"Induction of Foxp3 demethylation increases regulatory CD4+CD25+ T cells and prevents the occurrence of diabetes in mice","volume":"87","author":"Zheng","year":"2009","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0225","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1006\/clin.1997.4356","article-title":"Cytokine dichotomy in peripheral nervous system influences the outcome of experimental allergic neuritis: dynamics of mRNA expression for IL-1 beta, IL-6, IL-10, IL-12, TNF-alpha, TNF-beta, and cytolysin","volume":"84","author":"Zhu","year":"1997","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.jneuroim.2018.05.013_bb0230","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1006\/exnr.2001.7662","article-title":"Suppression of autoimmune neuritis in IFN-\u03b3 receptor-deficient mice","volume":"169","author":"Zhu","year":"2001","journal-title":"Exp. Neurol."}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572818301863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572818301863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:31:53Z","timestamp":1759048313000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165572818301863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":49,"alternative-id":["S0165572818301863"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2018.05.013","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Decitabine induces regulatory T cells, inhibits the production of IFN-gamma and IL-17 and exerts preventive and therapeutic efficacy in rodent experimental autoimmune neuritis","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2018.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}