{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:24:59Z","timestamp":1792016699511,"version":"4.4.0"},"reference-count":93,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["00271-13"],"award-info":[{"award-number":["00271-13"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["475735\/2013-7"],"award-info":[{"award-number":["475735\/2013-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["467220\/2014-0"],"award-info":[{"award-number":["467220\/2014-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011094","name":"Academia Brasileira de Ci\u00eancias","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011094","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.jneuroim.2020.577380","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T11:16:09Z","timestamp":1598872569000},"page":"577380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"special_numbering":"C","title":["Inflammation in Huntington's disease: A few new twists on an old tale"],"prefix":"10.1016","volume":"348","author":[{"given":"Priscila Aparecida Costa","family":"Valad\u00e3o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00edvia Barretos S.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talita H\u00e9len","family":"Ferreira e Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago","family":"Macedo e Cordeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Lucio","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Guatimosim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Silva","family":"de Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jneuroim.2020.577380_bb0005","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1006\/nbdi.2002.0562","article-title":"Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression","volume":"11","author":"Andreassen","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0010","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1136\/jnnp.72.6.726","article-title":"Autonomic nervous system function in Huntington's disease","volume":"72","author":"Andrich","year":"2002","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0015","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1111\/j.1468-1331.2010.02973.x","article-title":"Autonomic symptoms in patients and pre-manifest mutation carriers of Huntington's disease","volume":"17","author":"Aziz","year":"2010","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0020","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1038\/ejhg.2016.36","article-title":"22 years of predictive testing for Huntington's disease: the experience of the UK Huntington's prediction consortium","volume":"24","author":"Baig","year":"2016","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0025","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/j.1468-1331.2008.02173.x","article-title":"Cardiovagal modulation upon postural change is altered in Huntington's disease","volume":"15","author":"B\u00e4r","year":"2008","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0030","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF00286586","article-title":"The current state of research with peripheral tissues in Huntington disease","volume":"66","author":"Beverstock","year":"1984","journal-title":"Hum. Genet."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0035","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1084\/jem.20080178","article-title":"A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease","volume":"205","author":"Bj\u00f6rkqvist","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0040","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1365-2826.2009.01898.x","article-title":"Huntington's disease does not appear to increase the risk of diabetes mellitus","volume":"21","author":"Boesgaard","year":"2009","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0045","doi-asserted-by":"crossref","first-page":"18259","DOI":"10.1523\/JNEUROSCI.4008-12.2012","article-title":"Cannabinoid receptor 2 signaling in peripheral immune cells modulates disease onset and severity in mouse models of Huntington's disease","volume":"32","author":"Bouchard","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0050","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1750-3639.1999.tb00216.x","article-title":"Oxidative stress in Huntington's disease","volume":"9","author":"Browne","year":"2006","journal-title":"Brain Pathol."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0055","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/0024-3205(78)90616-1","article-title":"Neuroendocrine function in Huntington's disease: dopaminergic regulation of prolactin release","volume":"22","author":"Caine","year":"1978","journal-title":"Life Sci."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0060","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1210\/jcem-44-5-870","article-title":"Altered growth hormone and prolactin responses to dopaminergic stimulation in huntington's chorea","volume":"44","author":"Caraceni","year":"1977","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0070","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bbi.2014.09.011","article-title":"Plasma inflammatory biomarkers for Huntington's disease patients and mouse model","volume":"44","author":"Chang","year":"2015","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.jneuroim.2020.577380_bb2005","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.bbrc.2007.05.093","article-title":"Increased oxidative damage and mitochondrial abnormalities in the peripheral blood of Huntington's disease patients","volume":"359","author":"Chen","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0075","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1038\/sj.cdd.4401967","article-title":"Increased apoptosis, Huntingtin inclusions and altered differentiation in muscle cell cultures from Huntington's disease subjects","volume":"13","author":"Ciammola","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0080","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/mds.23258","article-title":"Low anaerobic threshold and increased skeletal muscle lactate production in subjects with Huntington's disease","volume":"26","author":"Ciammola","year":"2011","journal-title":"Mov. Disord."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2019.01.006","article-title":"Stem cells in animal models of Huntington disease: a systematic review","author":"Colpo","year":"2019","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0090","article-title":"Immunomodulatory strategies for Huntington's disease treatment","volume":"16","author":"Colpo","year":"2017","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0095","article-title":"Promises and pitfalls of immune-based strategies for huntington's disease","author":"Colpo","year":"2017","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0100","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/263244a0","article-title":"Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea","volume":"263","author":"Coyle","year":"1976","journal-title":"Nature"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0105","doi-asserted-by":"crossref","DOI":"10.1001\/archneur.62.7.1043-a","article-title":"Insulin resistance and cognitive impairment: a view through the prism of epidemiology","author":"Craft","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0110","series-title":"The Choreography of Neuroinflammation in Huntington's Disease","author":"Crotti","year":"2015"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0115","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1136\/jnnp-2018-318854","article-title":"Platelet abnormalities in Huntington's disease","volume":"90","author":"Denis","year":"2019","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0120","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1084\/jem.20160776","article-title":"Potential biomarkers to follow the progression and treatment response of huntington's disease","volume":"213","author":"Disatnik","year":"2016","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/541259","article-title":"The role of the immune system in Huntington's disease","volume":"2013","author":"Ellrichmann","year":"2013","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0130","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1399-0004.1985.tb00185.x","article-title":"Diabetes mellitus in Huntington disease","volume":"27","author":"Farrer","year":"2008","journal-title":"Clin. Genet."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0135","doi-asserted-by":"crossref","first-page":"a007476","DOI":"10.1101\/cshperspect.a007476","article-title":"Huntington's disease","volume":"3","author":"Finkbeiner","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0140","series-title":"Gene Targeting in Mice: Functional Analysis of the Mammalian Genome for the Twenty-First Century","author":"Genetics, M.C.-N.R","year":"2005"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0145","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1111\/j.1460-9568.2008.06310.x","article-title":"Mechanisms of neurodegeneration in Huntington's disease","volume":"27","author":"Gil","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0150","doi-asserted-by":"crossref","first-page":"6182","DOI":"10.1523\/JNEUROSCI.0857-08.2008","article-title":"Full-length human mutant huntingtin with a stable Polyglutamine repeat can elicit progressive and selective Neuropathogenesis in BACHD mice","volume":"28","author":"Gray","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.tibs.2006.06.009","article-title":"Huntington's disease: seeing the pathogenic process through a genetic lens","author":"Gusella","year":"2006","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0160","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0968-0004(03)00168-3","article-title":"The hunt for huntingtin function: interaction partners tell many different stories","volume":"28","author":"Harjes","year":"2003","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0165","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0140-6736(77)90608-0","article-title":"Impaired prolactin release in Huntington's Chorea. Evidence for dopaminergic excess","volume":"310","author":"Hayden","year":"1977","journal-title":"Lancet"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0170","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/febs.14706","article-title":"Increased oxidative stress and CaMKII activity contribute to electro-mechanical defects in cardiomyocytes from a murine model of Huntington's disease","volume":"286","author":"Joviano-Santos","year":"2019","journal-title":"FEBS J."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0175","doi-asserted-by":"crossref","first-page":"726","DOI":"10.2174\/18715273113126660170","article-title":"A friend in need may not be a friend indeed: role of microglia in neurodegenerative diseases","volume":"12","author":"Kaushik","year":"2013","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0180","doi-asserted-by":"crossref","first-page":"7999","DOI":"10.1523\/JNEUROSCI.2675-04.2004","article-title":"Activation of the I\u03baB kinase complex and nuclear factor-\u03baB contributes to mutant huntingtin neurotoxicity","volume":"24","author":"Khoshnan","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0185","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1002\/mds.21550","article-title":"Myopathy as a first symptom of Huntington's disease in a marathon runner","volume":"22","author":"Kosinski","year":"2007","journal-title":"Mov. Disord."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0190","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1001\/archneur.65.4.476","article-title":"Glucose homeostasis in Huntington disease: abnormalities in insulin sensitivity and early-phase insulin secretion","volume":"65","author":"Lali\u0107","year":"2008","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0195","doi-asserted-by":"crossref","DOI":"10.1038\/sj.embor.7400250","article-title":"Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series","author":"Landles","year":"2004","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0200","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1136\/jnnp.44.5.414","article-title":"Studies of hypothalamic function in Huntington's chorea","volume":"44","author":"Lavin","year":"1981","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0205","series-title":"Wild-Type Huntingtin Reduces the Cellular Toxicity of Mutant Huntingtin in Vivo","author":"Leavitt","year":"2001"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0210","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0022-510X(95)00114-H","article-title":"Serum dehydroepiandrosterone and cortisol measurements in Huntington's chorea","volume":"132","author":"Leblhuber","year":"1995","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0215","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tig.2004.01.008","article-title":"Huntingtin\u2013protein interactions and the pathogenesis of Huntington's disease","volume":"20","author":"Li","year":"2004","journal-title":"Trends Genet."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0220","series-title":"Oral Treatment with Herbal Formula B307 Alleviates Cardiac Failure in Aging R6\/2 Mice with Huntington's Disease via Suppressing Oxidative Stress, Inflammation","author":"Lin","year":"2015"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0225","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","author":"MacDonald","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0230","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2006.09.025","article-title":"Drosophila in the study of neurodegenerative disease","author":"Marsh","year":"2006","journal-title":"Neuron."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0240","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1038\/ejhg.2014.281","article-title":"Huntington's disease biomarker progression profile identified by transcriptome sequencing in peripheral blood","volume":"23","author":"Mastrokolias","year":"2015","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0049838","article-title":"Comprehensive behavioral and molecular characterization of a new Knock-in mouse model of Huntington's disease: ZQ175","volume":"7","author":"Menalled","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0250","series-title":"Cardiac Dysfunction in the R6\/2 Mouse Model of Huntington's Disease","author":"Mihm","year":"2007"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0255","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141793","article-title":"Mutant huntingtin does not affect the intrinsic phenotype of human Huntington's disease T lymphocytes","volume":"10","author":"Miller","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0260","doi-asserted-by":"crossref","DOI":"10.1186\/s12862-015-0534-7","article-title":"A comparison of human and mouse gene co-expression networks reveals conservation and divergence at the tissue, pathway and disease levels genome evolution and evolutionary systems biology","volume":"15","author":"Monaco","year":"2015","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/currents.RRN1205","article-title":"Optimization of an HTRF assay for the detection of soluble mutant huntingtin in human buffy coats: a potential biomarker in blood for Huntington disease","volume":"2","author":"Moscovitch-Lopatin","year":"2010","journal-title":"PLoS Curr."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0270","series-title":"BAC to the Future: The Use of Bac Transgenic Mice for Neuroscience Research","author":"Neuroscience, N.H.-N.R","year":"2001"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1471-4159.2003.02009.x","article-title":"Inclusion formation in Huntington's disease R6\/2 mouse muscle cultures","volume":"87","author":"Orth","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0280","doi-asserted-by":"crossref","first-page":"13318","DOI":"10.1073\/pnas.231476398","article-title":"Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death","volume":"98","author":"Parker","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0285","doi-asserted-by":"crossref","first-page":"821","DOI":"10.4161\/auto.6502","article-title":"Protein misfolding and cardiac disease: establishing cause and effect","volume":"4","author":"Pattison","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0290","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1161\/CIRCULATIONAHA.107.750232","article-title":"Cardiomyocyte expression of a polyglutamine preamyloid oligomer causes heart failure","volume":"117","author":"Pattison","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0295","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1074\/mcp.M500090-MCP200","article-title":"Proteomic analysis of protein expression and oxidative modification in R6\/2 transgenic mice: a model of Huntington disease","volume":"4","author":"Perluigi","year":"2005","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0300","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1042\/cs0500551","article-title":"Plasma growth hormone concentrations in Huntington's chorea","volume":"50","author":"Phillipson","year":"1976","journal-title":"Clin. Sci."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0305","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.nbd.2015.08.011","article-title":"Increased central microglial activation associated with peripheral cytokine levels in premanifest Huntington's disease gene carriers","volume":"83","author":"Politis","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0310","doi-asserted-by":"crossref","DOI":"10.1590\/1516-4446-2013-1157","article-title":"Animal models of neurodegenerative diseases","volume":"35","author":"Ribeiro","year":"2013","journal-title":"Rev. Bras. Psiquiatr."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0315","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1523\/JNEUROSCI.20-10-03705.2000","article-title":"Wild-type huntingtin protects from apoptosis upstream of caspase-3","volume":"20","author":"Rigamonti","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0320","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1111\/j.1468-1331.2006.01319.x","article-title":"Weight changes in Huntington's disease","volume":"13","author":"Robbins","year":"2006","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0325","series-title":"Neuroimmunology of Huntington's Disease: Revisiting Evidence from Human Studies","author":"Rocha","year":"2016"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0330","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1750-1172-5-40","article-title":"Huntington's disease: a clinical review","volume":"5","author":"Roos","year":"2010","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0335","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/bpa.12426","article-title":"Huntington's disease (HD): the neuropathology of a multisystem neurodegenerative disorder of the human brain","volume":"26","author":"R\u00fcb","year":"2016","journal-title":"Brain Pathol."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004962","article-title":"Neuroendocrine disturbances in Huntington's disease","volume":"4","author":"Saleh","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0345","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1179\/1743132812Y.0000000073","article-title":"Oxidative stress and inflammation biomarkers in the blood of patients with Huntington's disease","volume":"34","author":"S\u00e1nchez-L\u00f3pez","year":"2012","journal-title":"Neurol. Res."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0350","series-title":"Huntington's Disease: The Current State of Research with Peripheral Tissues","author":"Sassone","year":"2009"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0355","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.1999.0447","article-title":"Transgenic models of Huntington'sdisease","volume":"354","author":"Sathasivam","year":"1999","journal-title":"Philos. Trans. R. Soc. London B Biol. Sci."},{"key":"10.1016\/j.jneuroim.2020.577380_bb2000","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3233\/JHD-130049","article-title":"A critical evaluation of inflammatory markers in Huntington\u2019s Disease plasma","volume":"2","author":"Silajd\u017ei\u0107","year":"2013","journal-title":"J. Huntingtons. Dis."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0360","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1002\/glia.20526","article-title":"Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease","volume":"55","author":"Simmons","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0365","article-title":"Modeling Huntington's disease in cells, flies, and mice","author":"Sipione","year":"2001","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0370","series-title":"Selective Striatal Neuronal Loss in a YAC128 Mouse Model of Huntington Disease","author":"Slow","year":"2003"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0375","series-title":"The Role of Immunity in Huntington's Disease","author":"Soulet","year":"2011"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0380","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/ng1193-259","article-title":"Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues","volume":"5","author":"Strong","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0385","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1093\/brain\/awm044","article-title":"Microglial activation in presymptomatic Huntington's disease gene carriers","volume":"130","author":"Tai","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0390","series-title":"Characterisation of Immune Cell Function in Fragment and Full-Length Huntington's Disease Mouse Models","author":"Tr\u00e4ger","year":"2015"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0395","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/ejn.13510","article-title":"Muscle atrophy is associated with cervical spinal motoneuron loss in BACHD mouse model for Huntington's disease","volume":"45","author":"Valad\u00e3o","year":"2017","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116653","article-title":"Inflammatory changes in peripheral organs in the BACHD murine model of Huntington's disease","volume":"232","author":"Valad\u00e3o","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0405","series-title":"Beyond the Brain: Widespread Pathology in Huntington's Disease","author":"van der Burg","year":"2009"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0410","series-title":"Testicular Degeneration in Huntington Disease","author":"Van Raamsdonk","year":"2007"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0415","series-title":"Neuropathological Classification of Huntinqton's Disease","author":"Vonsattel","year":"1985"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0420","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00005072-199805000-00001","article-title":"Huntington disease","volume":"57","author":"Vonsattel","year":"1998","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0425","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntinton's disease_Lancet 2007","volume":"369","author":"Walker","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0430","doi-asserted-by":"crossref","DOI":"10.1038\/nrg1045","article-title":"Modelling brain diseases in mice: the challenges of design and analysis","author":"Watase","year":"2003","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0435","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/nature01262","article-title":"Initial sequencing and comparative analysis of the mouse genome","volume":"420","author":"Waterston","year":"2002","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.jneuroim.2020.577380_bb0440","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1172\/JCI64565","article-title":"Mutant Huntingtin fragmentation in immune cells tracks Huntington's disease progression","volume":"122","author":"Weiss","year":"2012","journal-title":"Am. Soc. Clin. Investig."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0445","doi-asserted-by":"crossref","DOI":"10.1371\/currents.RRN1231","article-title":"Abnormal peripheral chemokine profile in Huntington's disease","author":"Wild","year":"2011","journal-title":"PLoS Curr."},{"key":"10.1016\/j.jneuroim.2020.577380_bb0450","series-title":"Mouse Models for Validating Preclinical Candidates for Huntington's Disease, Neurobiology of Huntington's Disease: Applications to Drug Discovery","author":"William Yang","year":"2011"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0455","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)80623-6","article-title":"Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease","volume":"101","author":"Yamamoto","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.jneuroim.2020.577380_bb0460","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1152\/physrev.00041.2009","article-title":"Molecular mechanisms and potential therapeutical targets in Huntington's disease","volume":"90","author":"Zuccato","year":"2010","journal-title":"Physiol. Rev."}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572820305191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572820305191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:49:02Z","timestamp":1777495742000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165572820305191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":93,"alternative-id":["S0165572820305191"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2020.577380","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammation in Huntington's disease: A few new twists on an old tale","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2020.577380","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"577380"}}