{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T23:07:57Z","timestamp":1791673677506,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jni-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimmunology"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.jneuroim.2022.577978","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T11:13:33Z","timestamp":1665141213000},"page":"577978","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Enrichment of serum IgG4 in MuSK myasthenia gravis patients"],"prefix":"10.1016","volume":"373","author":[{"given":"Dana L.E.","family":"Vergoossen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabel M.","family":"Ruiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin R.","family":"Keene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik H.","family":"Niks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn R.","family":"Tannemaat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Strijbos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander F.","family":"Lipka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Els C. Jol","family":"van der Zijde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten J.D.","family":"van Tol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap A.","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte A.","family":"Wevers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Westerberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00facia S.","family":"Borges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia C.","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Richman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Illa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Rostedt","family":"Punga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Evoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silv\u00e8re M.","family":"van der Maarel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan J.","family":"Verschuuren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maartje G.","family":"Huijbers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jneuroim.2022.577978_bb0005","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0022-1759(84)90376-4","article-title":"Measurement of serum IgG4 levels by a competitive immunoenzymatic assay with monoclonal antibodies","volume":"74","author":"Aucouturier","year":"1984","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jneuroim.2022.577978_bb0010","doi-asserted-by":"crossref","first-page":"9646209","DOI":"10.1155\/2018\/9646209","article-title":"Serological immunoglobulin-free light chain profile in myasthenia gravis patients","volume":"2018","author":"Basile","year":"2018","journal-title":"J Immunol Res"},{"issue":"17","key":"10.1016\/j.jneuroim.2022.577978_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22179142","article-title":"Laboratory investigation of hybrid IgG4 k\/lambda in MuSK positive myasthenia gravis","volume":"22","author":"Basile","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.jneuroim.2022.577978_bb0020","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/apm.12845","article-title":"IgG4-related disease: review of the histopathologic features, differential diagnosis, and therapeutic approach","volume":"126","author":"Bledsoe","year":"2018","journal-title":"APMIS"},{"key":"10.1016\/j.jneuroim.2022.577978_bb0025","first-page":"1","article-title":"Elevated serum IgG4 defines specific clinical phenotype of rheumatoid arthritis","volume":"2014","author":"Chen","year":"2014","journal-title":"Mediat. Inflamm."},{"issue":"4","key":"10.1016\/j.jneuroim.2022.577978_bb0030","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/ar3904","article-title":"Immunoglobulin class-switch recombination deficiencies","volume":"14","author":"Durandy","year":"2012","journal-title":"Arthritis Research & Therapy"},{"key":"10.1016\/j.jneuroim.2022.577978_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.785247","article-title":"Anti-neuronal IgG4 autoimmune diseases and IgG4-related diseases may not be part of the same spectrum: a comparative study","volume":"12","author":"Endmayr","year":"2022","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.jneuroim.2022.577978_bb0040","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1111\/j.1365-2133.2012.11144.x","article-title":"Enrichment of total serum IgG4 in patients with pemphigus","volume":"167","author":"Funakoshi","year":"2012","journal-title":"Br. J. Dermatol."},{"issue":"2","key":"10.1016\/j.jneuroim.2022.577978_bb0045","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.anai.2020.03.018","article-title":"Immunoglobulin G and immunoglobulin G subclass concentrations differ according to sex and race","volume":"125","author":"Harkness","year":"2020","journal-title":"Ann. Allergy Asthma Immunol."},{"issue":"4","key":"10.1016\/j.jneuroim.2022.577978_bb0050","first-page":"728","article-title":"Annexin A11 is targeted by IgG4 and IgG1 autoantibodies in IgG4-related disease","volume":"67","author":"Hubers","year":"2018","journal-title":"Gut"},{"issue":"8","key":"10.1016\/j.jneuroim.2022.577978_bb0055","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1111\/ene.12758","article-title":"The expanding field of IgG4-mediated neurological autoimmune disorders","volume":"22","author":"Huijbers","year":"2015","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.jneuroim.2022.577978_bb0060","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jneuroim.2015.12.016","article-title":"Longitudinal epitope mapping in MuSK myasthenia gravis: implications for disease severity","volume":"291","author":"Huijbers","year":"2016","journal-title":"J. Neuroimmunol."},{"issue":"2","key":"10.1016\/j.jneuroim.2022.577978_bb0065","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1507\/endocrj.EJ13-0407","article-title":"Prednisolone markedly reduced serum IgG4 along with improvement of pituitary mass and anterior pituitary function in a patient with IgG4-related infundibulophypophysitis","volume":"61","author":"Iseda","year":"2014","journal-title":"Endocr. J."},{"key":"10.1016\/j.jneuroim.2022.577978_bb0070","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1136\/jnnp.55.5.404","article-title":"Congenital oculo-bulbar palsy","volume":"55","author":"Jennekens","year":"1992","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jneuroim.2022.577978_bb0075","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1034\/j.1398-9995.2003.00230.x","article-title":"Role and interpretation of total serum IgE measurements in the diagnosis of allergic airway disease in adults","volume":"58","author":"Kerkhof","year":"2003","journal-title":"Allergy"},{"issue":"5","key":"10.1016\/j.jneuroim.2022.577978_bb0080","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00005-019-00556-3","article-title":"Clinical and immunological features of 78 adult patients with primary selective IgG subclass deficiencies","volume":"67","author":"Khokar","year":"2019","journal-title":"Arch. Immunol. Ther. Exp."},{"issue":"Pt 4","key":"10.1016\/j.jneuroim.2022.577978_bb0085","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1093\/brain\/aws025","article-title":"Muscle-specific kinase myasthenia gravis IgG4 autoantibodies cause severe neuromuscular junction dysfunction in mice","volume":"135","author":"Klooster","year":"2012","journal-title":"Brain"},{"issue":"10","key":"10.1016\/j.jneuroim.2022.577978_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102646","article-title":"Update on IgG4-mediated autoimmune diseases: new insights and new family members","volume":"19","author":"Koneczny","year":"2020","journal-title":"Autoimmun. Rev."},{"issue":"3","key":"10.1016\/j.jneuroim.2022.577978_bb0095","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1055\/s-0036-1584322","article-title":"The immunobiology of immunoglobulin G4","volume":"36","author":"Lighaam","year":"2016","journal-title":"Semin. Liver Dis."},{"issue":"10","key":"10.1016\/j.jneuroim.2022.577978_bb0100","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3109\/00207454.2011.596293","article-title":"Evaluation of serum IgG subclass concentrations in myasthenia gravis patients","volume":"121","author":"Liu","year":"2011","journal-title":"Int J Neurosci"},{"key":"10.1016\/j.jneuroim.2022.577978_bb0105","series-title":"Human IgG Subclasses: Useful Diagnostic Markers for Immunocompetence","author":"Meulenbroek","year":"2008"},{"issue":"2","key":"10.1016\/j.jneuroim.2022.577978_bb0115","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/mus.21642","article-title":"Pre- and postsynaptic neuromuscular junction abnormalities in musk myasthenia","volume":"42","author":"Niks","year":"2010","journal-title":"Muscle Nerve"},{"issue":"1\u20132","key":"10.1016\/j.jneuroim.2022.577978_bb0110","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jneuroim.2008.01.013","article-title":"Clinical fluctuations in MuSK myasthenia gravis are related to antigen-specific IgG4 instead of IgG1","volume":"195","author":"Niks","year":"2008","journal-title":"J. Neuroimmunol."},{"issue":"3","key":"10.1016\/j.jneuroim.2022.577978_bb0120","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1002\/hep.24487","article-title":"Utility of serum immunoglobulin G4 in distinguishing immunoglobulin G4-associated cholangitis from cholangiocarcinoma","volume":"54","author":"Oseini","year":"2011","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jneuroim.2022.577978_bb0125","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jbspin.2013.06.001","article-title":"IgG4-related disease","volume":"81","author":"Palazzo","year":"2014","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.jneuroim.2022.577978_bb0130","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jneuroim.2017.02.004","article-title":"Is MuSK myasthenia gravis linked to IgG4-related disease?","volume":"305","author":"Raibagkar","year":"2017","journal-title":"J. Neuroimmunol."},{"issue":"11","key":"10.1016\/j.jneuroim.2022.577978_bb0135","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1212\/01.WNL.0000128048.23930.1D","article-title":"Are MuSK antibodies the primary cause of myasthenic symptoms?","volume":"62","author":"Selcen","year":"2004","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.jneuroim.2022.577978_bb0140","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/mus.23951","article-title":"Interleukin-10 producing-B cells and their association with responsiveness to rituximab in myasthenia gravis","volume":"49","author":"Sun","year":"2014","journal-title":"Muscle Nerve"},{"issue":"2","key":"10.1016\/j.jneuroim.2022.577978_bb0145","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2169\/internalmedicine.50.4321","article-title":"Serial changes of elevated serum IgG4 levels in IgG4-related systemic disease","volume":"50","author":"Tabata","year":"2011","journal-title":"Intern. Med."},{"issue":"5","key":"10.1016\/j.jneuroim.2022.577978_bb0150","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1046\/j.1365-2141.2003.04355.x","article-title":"Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the international myeloma working group","volume":"121","author":"The International Myeloma Working Group","year":"2003","journal-title":"Br. J. Haematol."},{"issue":"2","key":"10.1016\/j.jneuroim.2022.577978_bb0155","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.clim.2014.02.012","article-title":"Preferential production of IgG1, IL-4 and IL-10 in MuSK-immunized mice","volume":"151","author":"Ulusoy","year":"2014","journal-title":"Clin. Immunol."},{"issue":"5\u20136","key":"10.1016\/j.jneuroim.2022.577978_bb0160","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3109\/08916931003602130","article-title":"Clinical aspects of myasthenia explained","volume":"43","author":"Verschuuren","year":"2010","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jneuroim.2022.577978_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2014.00520","article-title":"IgG subclasses and allotypes: from structure to effector functions","volume":"5","author":"Vidarsson","year":"2014","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.jneuroim.2022.577978_bb0170","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/ejhg.2013.40","article-title":"Heterogeneous clinical presentation in ICF syndrome: correlation with underlying gene defects","volume":"21","author":"Weemaes","year":"2013","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.jneuroim.2022.577978_bb0175","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jaut.2013.12.005","article-title":"Characterization of CD4 and CD8 T cell responses in MuSK myasthenia gravis","volume":"52","author":"Yi","year":"2014","journal-title":"J. Autoimmun."},{"issue":"4","key":"10.1016\/j.jneuroim.2022.577978_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0123546","article-title":"Differential cytokine changes in patients with myasthenia gravis with antibodies against AChR and MuSK","volume":"10","author":"Yilmaz","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jneuroim.2022.577978_bb0185","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3109\/08916934.2014.992517","article-title":"B cells produce less IL-10, IL-6 and TNF-alpha in myasthenia gravis","volume":"48","author":"Yilmaz","year":"2015","journal-title":"Autoimmunity"},{"issue":"11","key":"10.1016\/j.jneuroim.2022.577978_bb0190","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1016\/j.jid.2017.05.032","article-title":"Pivotal role of Lesional and perilesional T\/B lymphocytes in pemphigus pathogenesis","volume":"137","author":"Yuan","year":"2017","journal-title":"J. Investig. Dermatol."},{"issue":"2","key":"10.1016\/j.jneuroim.2022.577978_bb0195","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000000387","article-title":"Serum IgG subclasses in autoimmune diseases","volume":"94","author":"Zhang","year":"2015","journal-title":"Medicine (Baltimore)"}],"container-title":["Journal of Neuroimmunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572822001734?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165572822001734?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:42:25Z","timestamp":1759048945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165572822001734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":39,"alternative-id":["S0165572822001734"],"URL":"https:\/\/doi.org\/10.1016\/j.jneuroim.2022.577978","relation":{},"ISSN":["0165-5728"],"issn-type":[{"value":"0165-5728","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enrichment of serum IgG4 in MuSK myasthenia gravis patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Neuroimmunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jneuroim.2022.577978","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"577978"}}