{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:07:11Z","timestamp":1791493631536,"version":"4.3.4"},"reference-count":56,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H06277"],"award-info":[{"award-number":["16H06277"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K09139"],"award-info":[{"award-number":["17K09139"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K10515"],"award-info":[{"award-number":["20K10515"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K10494"],"award-info":[{"award-number":["22K10494"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of nutrition, health and aging"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jnha.2023.100013","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T16:34:09Z","timestamp":1705509249000},"page":"100013","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Low mitochondrial DNA copy number in peripheral blood mononuclear cells is associated with future mortality risk: a long-term follow-up study from Japan"],"prefix":"10.1016","volume":"28","author":[{"given":"Genki","family":"Mizuno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroya","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Tsuboi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Munetsuna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirai","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Ando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itsuki","family":"Kageyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Nouchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Teshigawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Hamajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jnha.2023.100013_bib0005","article-title":"Life span extension research and public debate: societal considerations","volume":"1","author":"de","year":"2007","journal-title":"Stud Ethics Law Technol."},{"issue":"2","key":"10.1016\/j.jnha.2023.100013_bib0010","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/0014-4827(55)90108-7","article-title":"A component promoting oxidative phosphorylation, released from mitochondria during aging","volume":"9","author":"Ernster","year":"1955","journal-title":"Exp Cell Res."},{"key":"10.1016\/j.jnha.2023.100013_bib0015","doi-asserted-by":"crossref","first-page":"5386","DOI":"10.1074\/jbc.R117.809194","article-title":"Mitochondrial energy generation disorders: genes, mechanisms, and clues to pathology","volume":"294","author":"Frazier","year":"2019","journal-title":"J Biol Chem."},{"issue":"23","key":"10.1016\/j.jnha.2023.100013_bib0020","doi-asserted-by":"crossref","first-page":"6828","DOI":"10.1111\/febs.16121","article-title":"Reducing embryonic mtDNA copy number alters epigenetic profile of key hepatic lipolytic genes and causes abnormal lipid accumulation in adult mice","volume":"288","author":"Wang","year":"2021","journal-title":"FEBS J."},{"issue":"3","key":"10.1016\/j.jnha.2023.100013_bib0025","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.tibs.2007.01.003","article-title":"Mitochondrial transcription and its regulation in mammalian cells","volume":"32","author":"Asin-Cayuela","year":"2007","journal-title":"Trends Biochem Sci."},{"issue":"8","key":"10.1016\/j.jnha.2023.100013_bib0030","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/em.22319","article-title":"Mitochondrial DNA: epigenetics and environment","volume":"60","author":"Sharma","year":"2019","journal-title":"Environ Mol Mutagen."},{"issue":"3","key":"10.1016\/j.jnha.2023.100013_bib0035","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/jb\/mvy058","article-title":"An overview of mammalian mitochondrial DNA replication mechanisms","volume":"164","author":"Yasukawa","year":"2018","journal-title":"J Biochem."},{"key":"10.1016\/j.jnha.2023.100013_bib0040","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.mito.2020.06.004","article-title":"Thinking outside the nucleus: mitochondrial DNA copy number in health and disease","volume":"53","author":"Castellani","year":"2020","journal-title":"Mitochondrion."},{"issue":"6","key":"10.1016\/j.jnha.2023.100013_bib0045","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.mito.2013.08.007","article-title":"Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics","volume":"13","author":"Guha","year":"2013","journal-title":"Mitochondrion."},{"issue":"9","key":"10.1016\/j.jnha.2023.100013_bib0050","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s00439-014-1458-9","article-title":"Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly","volume":"133","author":"Mengel-From","year":"2014","journal-title":"Hum Genet."},{"issue":"1","key":"10.1016\/j.jnha.2023.100013_bib0055","doi-asserted-by":"crossref","DOI":"10.1186\/s12864-017-4287-0","article-title":"Independent impacts of aging on mitochondrial DNA quantity and quality in humans","volume":"18","author":"Zhang","year":"2017","journal-title":"BMC Genomics."},{"issue":"2","key":"10.1016\/j.jnha.2023.100013_bib0060","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/ajcn\/nqy286","article-title":"Fruit and vegetable consumption, cigarette smoke, and leukocyte mitochondrial DNA copy number","volume":"109","author":"Wu","year":"2019","journal-title":"Am J Clin Nutr."},{"issue":"8","key":"10.1016\/j.jnha.2023.100013_bib0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0237235","article-title":"Lifestyle and behavioral factors and mitochondrial DNA copy number in a diverse cohort of mid-life and older adults","volume":"15","author":"Vyas","year":"2020","journal-title":"PLoS One."},{"issue":"6","key":"10.1016\/j.jnha.2023.100013_bib0070","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/mc.22373","article-title":"Lower mitochondrial DNA copy number in peripheral blood leukocytes increases the risk of endometrial cancer","volume":"55","author":"Sun","year":"2016","journal-title":"Mol Carcinog."},{"issue":"11","key":"10.1016\/j.jnha.2023.100013_bib0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0206003","article-title":"Association between mitochondrial DNA copy number and cardiovascular disease: current evidence based on a systematic review and meta-analysis","volume":"13","author":"Yue","year":"2018","journal-title":"PLoS One."},{"issue":"15","key":"10.1016\/j.jnha.2023.100013_bib0080","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000003323","article-title":"Decreased peripheral mitochondrial DNA copy number is associated with the risk of heart failure and long-term outcomes","volume":"95","author":"Huang","year":"2016","journal-title":"Medicine."},{"issue":"5","key":"10.1016\/j.jnha.2023.100013_bib0085","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s12265-019-09943-9","article-title":"mtDNA copy number contributes to all-cause mortality of lacunar infarct in a Chinese prospective stroke population","volume":"13","author":"Song","year":"2020","journal-title":"J Cardiovasc Transl Res."},{"issue":"2","key":"10.1016\/j.jnha.2023.100013_bib0090","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00109-014-1233-3","article-title":"Association of mitochondrial DNA levels with frailty and all-cause mortality","volume":"93","author":"Ashar","year":"2015","journal-title":"J Mol Med (Berl)."},{"issue":"5","key":"10.1016\/j.jnha.2023.100013_bib0095","doi-asserted-by":"crossref","first-page":"805","DOI":"10.2105\/AJPH.87.5.805","article-title":"Socioeconomic status and racial and ethnic differences in functional status associated with chronic diseases","volume":"87","author":"Kington","year":"1997","journal-title":"Am J Public Health."},{"issue":"2","key":"10.1016\/j.jnha.2023.100013_bib0100","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1001\/jama.2013.285112","article-title":"Tobacco control and the reduction in smoking-related premature deaths in the United States, 1964-2012","volume":"311","author":"Holford","year":"2014","journal-title":"JAMA."},{"issue":"9927","key":"10.1016\/j.jnha.2023.100013_bib0105","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/S0140-6736(13)62247-3","article-title":"Alcohol and mortality in Russia: prospective observational study of 151,000 adults","volume":"383","author":"Zaridze","year":"2014","journal-title":"Lancet."},{"issue":"12","key":"10.1016\/j.jnha.2023.100013_bib0110","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.5551\/jat.43570","article-title":"Relationship between long interspersed nuclear element-1 DNA methylation in leukocytes and dyslipidemia in the Japanese general population","volume":"25","author":"Tsuboi","year":"2018","journal-title":"J Atheroscler Thromb."},{"issue":"3","key":"10.1016\/j.jnha.2023.100013_bib0115","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1507\/endocrj.EJ21-0339","article-title":"DNA methylation level of the gene encoding thioredoxin-interacting protein in peripheral blood cells is associated with metabolic syndrome in the Japanese general population","volume":"69","author":"Yamazaki","year":"2022","journal-title":"Endocr J."},{"issue":"3-4","key":"10.1016\/j.jnha.2023.100013_bib0120","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/07435800.2022.2121967","article-title":"Association between the extent of peripheral blood DNA methylation of HIF3A and accumulation of adiposity in community-dwelling women: the Yakumo Study","volume":"47","author":"Mizuno","year":"2022","journal-title":"Endocr Res."},{"issue":"9","key":"10.1016\/j.jnha.2023.100013_bib0125","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1136\/jech-2020-215382","article-title":"Global DNA hypermethylation in peripheral blood mononuclear cells and cardiovascular disease risk: a population-based propensity score-matched cohort study","volume":"75","author":"Tsuboi","year":"2021","journal-title":"J Epidemiol Community Health."},{"key":"10.1016\/j.jnha.2023.100013_bib0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.canep.2022.102162","article-title":"Increased risk of cancer mortality by smoking-induced aryl hydrocarbon receptor repressor DNA hypomethylation in Japanese population: a long-term cohort study","volume":"78","author":"Tsuboi","year":"2022","journal-title":"Cancer Epidemiol."},{"key":"10.1016\/j.jnha.2023.100013_bib0135","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.lfs.2016.02.020","article-title":"Fructose consumption induces hypomethylation of hepatic mitochondrial DNA in rats","volume":"149","author":"Yamazaki","year":"2016","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.jnha.2023.100013_bib0140","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1524-4741.2010.00908.x","article-title":"Mitochondrial DNA content as a potential marker to predict response to anthracycline in breast cancer patients","volume":"16","author":"Hsu","year":"2010","journal-title":"Breast J."},{"issue":"3","key":"10.1016\/j.jnha.2023.100013_bib0145","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u201cEZR\u201d for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant."},{"issue":"6","key":"10.1016\/j.jnha.2023.100013_bib0150","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell."},{"issue":"16","key":"10.1016\/j.jnha.2023.100013_bib0155","doi-asserted-by":"crossref","first-page":"6829","DOI":"10.18632\/aging.204248","article-title":"New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary","volume":"14","author":"Schmauck-Medina","year":"2022","journal-title":"Aging (Albany NY)"},{"issue":"12","key":"10.1016\/j.jnha.2023.100013_bib0160","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1038\/s41591-019-0673-2","article-title":"Undulating changes in human plasma proteome profiles across the lifespan","volume":"25","author":"Lehallier","year":"2019","journal-title":"Nat Med."},{"issue":"10","key":"10.1016\/j.jnha.2023.100013_bib0165","doi-asserted-by":"crossref","first-page":"11431","DOI":"10.1096\/fj.201901072R","article-title":"Maternal fructose\u2013induced oxidative stress occurs via Tfam and Ucp5 epigenetic regulation in offspring hippocampi","volume":"33","author":"Yamada","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.jnha.2023.100013_bib0170","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.nutres.2021.06.002","article-title":"Maternal fructose consumption downregulates hippocampal catalase expression via DNA methylation in rat offspring","volume":"92","author":"Mizuno","year":"2021","journal-title":"Nutr Res."},{"issue":"10","key":"10.1016\/j.jnha.2023.100013_bib0175","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.jacc.2003.12.047","article-title":"The pathophysiology of cigarette smoking And cardiovascular disease: an update","volume":"43","author":"Ambrose","year":"2004","journal-title":"J Am Coll Cardiol."},{"key":"10.1016\/j.jnha.2023.100013_bib0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101544","article-title":"Oxidative stress-based therapeutics in COPD","volume":"33","author":"Barnes","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.jnha.2023.100013_bib0185","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.nutres.2022.12.010","article-title":"High-fructose corn syrup intake increases hepatic mitochondrial DNA copy number and methylation in adolescent rats","volume":"110","author":"Mizuno","year":"2023","journal-title":"Nutr Res."},{"key":"10.1016\/j.jnha.2023.100013_bib0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112449","article-title":"DMEP induces mitochondrial damage regulated by inhibiting Nrf2 and SIRT1\/PGC-1\u03b1 signaling pathways in HepG2 cells","volume":"221","author":"Liu","year":"2021","journal-title":"Ecotoxicol Environ Saf."},{"issue":"1","key":"10.1016\/j.jnha.2023.100013_bib0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054059","article-title":"Mitochondrial DNA damage and dysfunction, and oxidative stress are associated with endoplasmic reticulum stress, protein degradation and apoptosis in high fat diet-induced insulin resistance mice","volume":"8","author":"Yuzefovych","year":"2013","journal-title":"PLoS One."},{"issue":"12","key":"10.1016\/j.jnha.2023.100013_bib0200","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1080\/10715760310001621342","article-title":"Oxidative stress-related alteration of the copy number of mitochondrial DNA in human leukocytes","volume":"37","author":"Liu","year":"2003","journal-title":"Free Radic Res."},{"issue":"4","key":"10.1016\/j.jnha.2023.100013_bib0205","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.biocel.2004.09.010","article-title":"Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress","volume":"37","author":"Lee","year":"2005","journal-title":"Int J Biochem Cell Biol."},{"issue":"10","key":"10.1016\/j.jnha.2023.100013_bib0210","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1038\/oby.2012.32","article-title":"Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3","volume":"20","author":"Valdecantos","year":"2012","journal-title":"Obesity (Silver Spring)."},{"issue":"3","key":"10.1016\/j.jnha.2023.100013_bib0215","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.bbalip.2014.12.013","article-title":"\u03b1-Lipoic acid treatment increases mitochondrial biogenesis and promotes beige adipose features in subcutaneous adipocytes from overweight\/obese subjects","volume":"1851","author":"Fern\u00e1ndez-Galilea","year":"2015","journal-title":"Biochim Biophys Acta."},{"issue":"4","key":"10.1016\/j.jnha.2023.100013_bib0220","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12773","article-title":"Restoring mitochondrial DNA copy number preserves mitochondrial function and delays vascular aging in mice","volume":"17","author":"Foote","year":"2018","journal-title":"Aging Cell."},{"issue":"5733","key":"10.1016\/j.jnha.2023.100013_bib0225","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.1112125","article-title":"Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging","volume":"309","author":"Kujoth","year":"2005","journal-title":"Science."},{"issue":"5","key":"10.1016\/j.jnha.2023.100013_bib0230","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1083\/jcb.201010024","article-title":"Mitochondrial DNA mutations in disease and aging","volume":"193","author":"Park","year":"2011","journal-title":"J Cell Biol."},{"issue":"3","key":"10.1016\/j.jnha.2023.100013_bib0235","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.18632\/aging.102722","article-title":"Mitochondria and aging in older individuals: an analysis of DNA methylation age metrics, leukocyte telomere length, and mitochondrial DNA copy number in the VA normative aging study","volume":"12","author":"Dolcini","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.jnha.2023.100013_bib0240","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.exger.2015.04.002","article-title":"Association of telomere length and mitochondrial DNA copy number in a community sample of healthy adults","volume":"66","author":"Tyrka","year":"2015","journal-title":"Exp Gerontol."},{"issue":"1","key":"10.1016\/j.jnha.2023.100013_bib0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.xgen.2021.100006","article-title":"Association of mitochondrial DNA copy number with cardiometabolic diseases","volume":"1","author":"Liu","year":"2021","journal-title":"Cell genomics"},{"issue":"1","key":"10.1016\/j.jnha.2023.100013_bib0250","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-31122-0","article-title":"Mitochondrial DNA copy number is associated with psychosis severity and anti-psychotic treatment","volume":"8","author":"Kumar","year":"2018","journal-title":"Sci Rep"},{"issue":"10","key":"10.1016\/j.jnha.2023.100013_bib0255","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317736643","article-title":"Cell-free mitochondrial DNA copy number variation in head and neck squamous cell carcinoma: a study of non-invasive biomarker from Northeast India","volume":"39","author":"Kumar","year":"2017","journal-title":"Tumour Biol."},{"issue":"1","key":"10.1016\/j.jnha.2023.100013_bib0260","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13283","article-title":"Mitochondrial DNA in extracellular vesicles declines with age","volume":"20","author":"Lazo","year":"2021","journal-title":"Aging Cell."},{"issue":"1","key":"10.1016\/j.jnha.2023.100013_bib0265","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12890-021-01437-2","article-title":"Plasma mitochondrial DNA levels are associated with acute lung injury and mortality in septic patients","volume":"21","author":"Mao","year":"2021","journal-title":"BMC Pulm Med."},{"issue":"4","key":"10.1016\/j.jnha.2023.100013_bib0270","article-title":"Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19","volume":"6","author":"Scozzi","year":"2021","journal-title":"JCI Insight."},{"issue":"5","key":"10.1016\/j.jnha.2023.100013_bib0275","first-page":"419","article-title":"Release of mitochondrial DNA is associated with mortality in severe acute heart failure","volume":"9","author":"Krychtiuk","year":"2020","journal-title":"Eur Heart J Acute Cardiovasc Care."},{"issue":"3","key":"10.1016\/j.jnha.2023.100013_bib0280","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3390\/cells10030537","article-title":"Cell death and inflammation: the role of mitochondria in health and disease","volume":"10","author":"Picca","year":"2021","journal-title":"Cells."}],"container-title":["The Journal of nutrition, health and aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1279770723023758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1279770723023758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T13:09:38Z","timestamp":1761138578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1279770723023758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S1279770723023758"],"URL":"https:\/\/doi.org\/10.1016\/j.jnha.2023.100013","relation":{},"ISSN":["1279-7707"],"issn-type":[{"value":"1279-7707","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low mitochondrial DNA copy number in peripheral blood mononuclear cells is associated with future mortality risk: a long-term follow-up study from Japan","name":"articletitle","label":"Article Title"},{"value":"The Journal of nutrition, health and aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnha.2023.100013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Masson SAS on behalf of SERDI Publisher.","name":"copyright","label":"Copyright"}],"article-number":"100013"}}