{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T02:06:42Z","timestamp":1793498802381,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of nutrition, health and aging"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.jnha.2024.100299","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T18:47:47Z","timestamp":1719254867000},"page":"100299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["The potential of cannabinoids in managing cancer-related anorexia in older adults: a systematic review of the literature"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5064-1672","authenticated-orcid":false,"given":"Chiara","family":"Ceolin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"De Rui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6345-6836","authenticated-orcid":false,"given":"Adele","family":"Ravelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1579-2202","authenticated-orcid":false,"given":"Mario Virgilio","family":"Papa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5899-8000","authenticated-orcid":false,"given":"Maria","family":"Devita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9757-856X","authenticated-orcid":false,"given":"Giuseppe","family":"Sergi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1687-4493","authenticated-orcid":false,"given":"Alessandra","family":"Coin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jnha.2024.100299_bib0005","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3390\/nu8020069","article-title":"Anorexia of aging: risk factors, consequences, and potential treatments","volume":"8","author":"Landi","year":"2016","journal-title":"Nutrients."},{"issue":"2","key":"10.1016\/j.jnha.2024.100299_bib0010","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/jcsm.13186","article-title":"Association of anorexia\/appetite loss with malnutrition and mortality in older populations: a systematic literature review","volume":"14","author":"Fielding","year":"2023","journal-title":"J Cachexia Sarcopenia Muscle."},{"issue":"3","key":"10.1016\/j.jnha.2024.100299_bib0015","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1017\/S1368980019002271","article-title":"Malnutrition and related risk factors in older adults from different health-care settings: an enable study","volume":"23","author":"Kiesswetter","year":"2020","journal-title":"Public Health Nutr."},{"key":"10.1016\/j.jnha.2024.100299_bib0020","doi-asserted-by":"crossref","first-page":"j4208","DOI":"10.1136\/bmj.j4208","article-title":"Development and validation of QMortality risk prediction algorithm to estimate short term risk of death and assess frailty: cohort study","volume":"358","author":"Hippisley-Cox","year":"2017","journal-title":"BMJ."},{"issue":"5","key":"10.1016\/j.jnha.2024.100299_bib0025","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1002\/jcsm.12571","article-title":"Association between anorexia of ageing and sarcopenia among Japanese older adults","volume":"11","author":"Tsutsumimoto","year":"2020","journal-title":"J Cachexia Sarcopenia Muscle."},{"issue":"4","key":"10.1016\/j.jnha.2024.100299_bib0030","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jamda.2009.12.088","article-title":"Anorexia, physical function, and incident disability among the frail elderly population: results from the ilSIRENTE study","volume":"11","author":"Landi","year":"2010","journal-title":"J Am Med Dir Assoc."},{"issue":"2","key":"10.1016\/j.jnha.2024.100299_bib0035","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s12603-019-1297-4","article-title":"Association of dietary variety and appetite with sleep quality in urban-dwelling older Japanese adults","volume":"24","author":"Yamamoto","year":"2020","journal-title":"J Nutr Health Aging."},{"issue":"4","key":"10.1016\/j.jnha.2024.100299_bib0040","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1093\/ageing\/afaa014","article-title":"New horizons in appetite and the anorexia of ageing","volume":"49","author":"Cox","year":"2020","journal-title":"Age Ageing."},{"issue":"1","key":"10.1016\/j.jnha.2024.100299_bib0045","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/MCO.0b013e328359efd7","article-title":"Pathophysiology of the anorexia of aging","volume":"16","author":"Morley","year":"2013","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"1","key":"10.1016\/j.jnha.2024.100299_bib0050","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s40266-013-0134-4","article-title":"Recommendations to prescribe in complex older adults: results of the CRIteriato assess appropriate Medication use among Elderly complex patients (CRIME) project","volume":"31","author":"Onder","year":"2014","journal-title":"Drugs Aging."},{"issue":"5","key":"10.1016\/j.jnha.2024.100299_bib0055","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s12603-012-0061-9","article-title":"Anorexia of aging: a true geriatric syndrome","volume":"16","author":"Morley","year":"2012","journal-title":"J Nutr Health Aging"},{"issue":"1","key":"10.1016\/j.jnha.2024.100299_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0195-6663(88)80017-5","article-title":"Effects of smoked marijuana on food intake and body weight of humans living in a residential laboratory","volume":"11","author":"Foltin","year":"1988","journal-title":"Appetite."},{"issue":"5","key":"10.1016\/j.jnha.2024.100299_bib0065","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/QAI.0b013e31811ed205","article-title":"Dronabinol and marijuana in HIV-positive marijuana smokers. Caloric intake, mood, and sleep","volume":"45","author":"Haney","year":"2007","journal-title":"J Acquir Immune Defic Syndr."},{"issue":"2","key":"10.1016\/j.jnha.2024.100299_bib0070","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.3747\/co.23.3099","article-title":"Integrating cannabis into clinical cancer care","volume":"23","author":"Abrams","year":"2016","journal-title":"Curr Oncol"},{"key":"10.1016\/j.jnha.2024.100299_bib0075","first-page":"18","article-title":"The effects of dosage-controlled cannabis capsules on cancer-related cachexia and anorexia syndrome in advanced cancer patients: pilot study","author":"Bar-Sela","year":"2019","journal-title":"Integr Cancer Ther."},{"issue":"7303","key":"10.1016\/j.jnha.2024.100299_bib0080","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/bmj.323.7303.16","article-title":"Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review","volume":"323","author":"Tram\u00e8r","year":"2001","journal-title":"BMJ."},{"key":"10.1016\/j.jnha.2024.100299_bib0085","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.jnha.2024.100299_bib0090","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1200\/JCO.2002.20.2.567","article-title":"Dronabinol versus megestrol acetate versus combination therapy for cancer-associated anorexia: A North Central Cancer Treatment Group study","volume":"20","author":"Jatoi","year":"2002","journal-title":"J Clin Oncol."},{"issue":"4","key":"10.1016\/j.jnha.2024.100299_bib0095","first-page":"317","article-title":"Improving quality of life with nabilone during radiotherapy treatments for head and neck cancers: a randomized double-blind placebo-controlled trial","volume":"125","author":"C\u00f4t\u00e9","year":"2016","journal-title":"Ann OtolRhinolLaryngol."},{"issue":"9","key":"10.1016\/j.jnha.2024.100299_bib0100","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1093\/annonc\/mdq727","article-title":"Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized, double-blind, placebo-controlled pilot trial","volume":"22","author":"Brisbois","year":"2011","journal-title":"Ann Oncol Off J Eur Soc Med Oncol."},{"issue":"21","key":"10.1016\/j.jnha.2024.100299_bib0105","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.1200\/JCO.2005.05.1847","article-title":"Comparison of orally administered Cannabis extract and delta-9- tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannab","volume":"24","author":"Strasser","year":"2006","journal-title":"J Clin Oncol."},{"issue":"10","key":"10.1016\/j.jnha.2024.100299_bib0110","doi-asserted-by":"crossref","first-page":"S360","DOI":"10.1016\/j.jtho.2018.08.328","article-title":"MA02.08 The effect of nabilone on appetite, nutritional status, and quality of life in lung cancer patients: a randomized, double-blind clinical trial","volume":"13","author":"Turcott","year":"2018","journal-title":"J Thorac Oncol."},{"issue":"5","key":"10.1016\/j.jnha.2024.100299_bib0115","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.neuropharm.2005.04.017","article-title":"Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus","volume":"49","author":"Gamber","year":"2005","journal-title":"Neuropharmacology."},{"issue":"3","key":"10.1016\/j.jnha.2024.100299_bib0120","doi-asserted-by":"crossref","first-page":"e1797","DOI":"10.1371\/journal.pone.0001797","article-title":"The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system","volume":"3","author":"Kola","year":"2008","journal-title":"PLoS One."},{"key":"10.1016\/j.jnha.2024.100299_bib0125","unstructured":"Comprehensive Cancer Information - NCI [Internet]. [access 2024 Jan 2]. Available from: https:\/\/www.cancer.gov\/."},{"issue":"6","key":"10.1016\/j.jnha.2024.100299_bib0130","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1016\/j.clnu.2021.02.016","article-title":"Cancer-associated anorexia: validity and performance overtime of different appetite tools among patients at their first cancer diagnosis","volume":"40","author":"Molfino","year":"2021","journal-title":"Clin Nutr."},{"issue":"2","key":"10.1016\/j.jnha.2024.100299_bib0135","first-page":"154","article-title":"Cancer anorexia - cachexia syndrome","volume":"44","author":"Muliawati","year":"2012","journal-title":"Acta Med Indones."},{"issue":"4","key":"10.1016\/j.jnha.2024.100299_bib0140","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.smhs.2020.10.003","article-title":"Development and progression of cancer cachexia: perspectives from bench to bedside","volume":"2","author":"Lim","year":"2020","journal-title":"Sport Med Heal Sci [Internet]"},{"issue":"6","key":"10.1016\/j.jnha.2024.100299_bib0145","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1002\/jcsm.12633","article-title":"Cancer cachexia and skeletal muscle atrophy in clinical studies: what do we really know?","volume":"11","author":"Dolly","year":"2020","journal-title":"J Cachexia Sarcopenia Muscle."},{"issue":"3","key":"10.1016\/j.jnha.2024.100299_bib0150","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1089\/can.2020.0105","article-title":"The effects of cannabinoids on pro- and anti-inflammatory cytokines: a systematic review of in vivo studies","volume":"6","author":"Henshaw","year":"2021","journal-title":"Cannabis Cannabinoid Res"},{"issue":"3","key":"10.1016\/j.jnha.2024.100299_bib0155","first-page":"207","article-title":"Adherence to long-term therapies: evidence for action","volume":"35","author":"Burkhart","year":"2003","journal-title":"J Nurs Scholarsh an Off Publ Sigma Theta Tau Int Honor Soc Nurs."},{"issue":"9","key":"10.1016\/j.jnha.2024.100299_bib0160","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1080\/10410236.2013.815111","article-title":"Understanding social support burden among family caregivers","volume":"29","author":"Wittenberg-Lyles","year":"2014","journal-title":"Health Commun."},{"issue":"10","key":"10.1016\/j.jnha.2024.100299_bib0165","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s40266-021-00882-2","article-title":"Safety and tolerability of natural and synthetic cannabinoids in older adults: a systematic review and meta-analysis of open-label trials and observational studies","volume":"38","author":"Pisani","year":"2021","journal-title":"Drugs Aging."},{"key":"10.1016\/j.jnha.2024.100299_bib0170","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.957665","article-title":"Cannabinoids for behavioral symptoms in severe dementia: safety and feasibility in a long-term pilot observational study in nineteen patients","volume":"14","author":"Pautex","year":"2022","journal-title":"Front Aging Neurosci."},{"issue":"2","key":"10.1016\/j.jnha.2024.100299_bib0175","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/ajcn.70.2.183","article-title":"Geriatric cachexia: the role of cytokines","volume":"70","author":"Yeh","year":"1999","journal-title":"Am J Clin Nutr [Internet]"},{"issue":"2","key":"10.1016\/j.jnha.2024.100299_bib0180","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/jcsm.12380","article-title":"Cachexia and advanceddementia","volume":"10","author":"Minaglia","year":"2019","journal-title":"J CachexiaSarcopenia Muscle."}],"container-title":["The Journal of nutrition, health and aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1279770724003865?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1279770724003865?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T22:56:52Z","timestamp":1727132212000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1279770724003865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S1279770724003865"],"URL":"https:\/\/doi.org\/10.1016\/j.jnha.2024.100299","relation":{},"ISSN":["1279-7707"],"issn-type":[{"value":"1279-7707","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The potential of cannabinoids in managing cancer-related anorexia in older adults: a systematic review of the literature","name":"articletitle","label":"Article Title"},{"value":"The Journal of nutrition, health and aging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnha.2024.100299","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Masson SAS on behalf of SERDI Publisher.","name":"copyright","label":"Copyright"}],"article-number":"100299"}}