{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:54:44Z","timestamp":1780102484455,"version":"3.54.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010822","name":"Chengdu Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014857","name":"National Natural Science Foundation of China-Guangdong Joint Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the National Medical Association"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.jnma.2020.05.006","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T01:32:55Z","timestamp":1593653575000},"page":"567-577","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Bioinformatic analysis reveals that the OAS family may play an important role in lupus nephritis"],"prefix":"10.1016","volume":"112","author":[{"given":"Yiling","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhua","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanxin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jnma.2020.05.006_bib1","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.4049\/jimmunol.0802626","article-title":"CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis","volume":"183","author":"Steinmetz","year":"2009","journal-title":"J\u00a0Immunol"},{"issue":"8","key":"10.1016\/j.jnma.2020.05.006_bib2","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nrneph.2017.85","article-title":"Redefining lupus nephritis: clinical implications of pathophysiologic subtypes","volume":"13","author":"Yu","year":"2017","journal-title":"Nat Rev Nephrol"},{"issue":"3","key":"10.1016\/j.jnma.2020.05.006_bib3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/BOR.0000000000000381","article-title":"Treatment of lupus nephritis","volume":"29","author":"Dall'Era","year":"2017","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.jnma.2020.05.006_bib4","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jad.2017.04.061","article-title":"A\u00a0comprehensive regional analysis of genome-wide expression profiles for major depressive disorder","volume":"218","author":"Forero","year":"2017","journal-title":"J\u00a0Affect Disord"},{"issue":"6","key":"10.1016\/j.jnma.2020.05.006_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156234","article-title":"Common marker genes identified from various sample types for systemic lupus erythematosus","volume":"11","author":"Bing","year":"2016","journal-title":"PloS One"},{"issue":"12","key":"10.1016\/j.jnma.2020.05.006_bib6","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1681\/ASN.2010050472","article-title":"Updates on the treatment of lupus nephritis","volume":"21","author":"Bomback","year":"2010","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"3","key":"10.1016\/j.jnma.2020.05.006_bib7","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","article-title":"Affy--analysis of Affymetrix GeneChip data at the probe level","volume":"20","author":"Gautier","year":"2004","journal-title":"Bioinformatics"},{"issue":"7","key":"10.1016\/j.jnma.2020.05.006_bib8","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"10.1016\/j.jnma.2020.05.006_bib9","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"issue":"11","key":"10.1016\/j.jnma.2020.05.006_bib10","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"issue":"Suppl 4","key":"10.1016\/j.jnma.2020.05.006_bib11","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1186\/1752-0509-8-S4-S11","article-title":"cytoHubba: identifying hub objects and sub-networks from complex interactome","volume":"8","author":"Chin","year":"2014","journal-title":"BMC Syst Biol"},{"issue":"Suppl 4","key":"10.1016\/j.jnma.2020.05.006_bib12","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1186\/1752-0509-8-S4-S11","article-title":"cytoHubba: identifying hub objects and subnetworks from complex interactome","volume":"8","author":"Chia-Hao Chin","year":"2014","journal-title":"BMC Syst Biol"},{"key":"10.1016\/j.jnma.2020.05.006_bib13","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.clim.2016.08.001","article-title":"Lupus nephritis biomarkers","volume":"185","author":"Soliman","year":"2017","journal-title":"Clin Immunol"},{"issue":"2","key":"10.1016\/j.jnma.2020.05.006_bib14","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/rheumatology\/kem321","article-title":"Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus","volume":"47","author":"Miyagawa","year":"2008","journal-title":"Rheumatology"},{"issue":"10","key":"10.1016\/j.jnma.2020.05.006_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074821","article-title":"Dysregulation of complement system and CD4+ T cell activation pathways implicated in allergic response","volume":"8","author":"Couto Alves","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.jnma.2020.05.006_bib16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3389\/fgene.2017.00187","article-title":"The AGE-RAGE Axis: implications for age-associated arterial diseases","volume":"8","author":"Senatus","year":"2017","journal-title":"Front Genet"},{"issue":"1","key":"10.1016\/j.jnma.2020.05.006_bib17","doi-asserted-by":"crossref","first-page":"F107","DOI":"10.1152\/ajprenal.00434.2017","article-title":"Contribution of myo-inositol oxygenase in AGE:RAGE-mediated renal tubulointerstitial injury in the context of diabetic nephropathy","volume":"314","author":"Sharma","year":"2018","journal-title":"Am J Physiol Ren Physiol"},{"issue":"1","key":"10.1016\/j.jnma.2020.05.006_bib18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s10067-014-2799-4","article-title":"Identification of interferon-inducible genes as diagnostic biomarker for systemic lupus erythematosus","volume":"34","author":"Feng","year":"2015","journal-title":"Clin Rheumatol"},{"issue":"4","key":"10.1016\/j.jnma.2020.05.006_bib19","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3899\/jrheum.100214","article-title":"Increased expression of B cell activation factor supports the abnormal expansion of transitional B cells in systemic lupus erythematosus","volume":"38","author":"Landolt-Marticorena","year":"2011","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.jnma.2020.05.006_bib20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jaut.2017.03.003","article-title":"MicroRNA-302d targets IRF9 to regulate the IFN-induced gene expression in SLE","volume":"79","author":"Smith","year":"2017","journal-title":"J\u00a0Autoimmun"},{"issue":"9","key":"10.1016\/j.jnma.2020.05.006_bib21","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1136\/ard.2008.093146","article-title":"Lack of association between the interferon-alpha signature and longitudinal changes in disease activity in systemic lupus erythematosus","volume":"68","author":"Landolt-Marticorena","year":"2009","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"10.1016\/j.jnma.2020.05.006_bib22","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1177\/0961203308089694","article-title":"Increased expression of the type I interferon-inducible gene, lymphocyte antigen 6 complex locus E, in peripheral blood cells is predictive of lupus activity in a large cohort of Chinese lupus patients","volume":"17","author":"Tang","year":"2008","journal-title":"Lupus"},{"issue":"2","key":"10.1016\/j.jnma.2020.05.006_bib23","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.clim.2013.12.002","article-title":"A\u00a0T cell gene expression panel for the diagnosis and monitoring of disease activity in patients with systemic lupus erythematosus","volume":"150","author":"Grammatikos","year":"2014","journal-title":"Clin Immunol"},{"issue":"8","key":"10.1016\/j.jnma.2020.05.006_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074550","article-title":"Spleen tyrosine kinase (Syk) regulates systemic lupus erythematosus (SLE) T cell signaling","volume":"8","author":"Grammatikos","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.jnma.2020.05.006_bib25","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.imlet.2016.12.002","article-title":"Gender differences of B cell signature related to estrogen-induced IFI44L\/BAFF in systemic lupus erythematosus","volume":"181","author":"Fan","year":"2017","journal-title":"Immunol Lett"},{"issue":"2","key":"10.1016\/j.jnma.2020.05.006_bib26","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s10067-006-0260-z","article-title":"Could 2'5'-oligoadenylate synthetase isoforms be biomarkers to differentiate between disease flare and infection in lupus patients? A pilot study","volume":"26","author":"Ye","year":"2007","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.jnma.2020.05.006_bib27","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.3389\/fimmu.2017.01992","article-title":"Gene expression analysis reveals novel shared gene signatures and candidate molecular mechanisms between pemphigus and systemic lupus erythematosus in CD4(+) T cells","volume":"8","author":"Sezin","year":"2017","journal-title":"Front Immunol"},{"issue":"12","key":"10.1016\/j.jnma.2020.05.006_bib28","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1093\/ndt\/gfw214","article-title":"Urinary soluble CD163 level reflects glomerular inflammation in human lupus nephritis","volume":"31","author":"Endo","year":"2016","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.jnma.2020.05.006_bib29","doi-asserted-by":"crossref","first-page":"12987","DOI":"10.1038\/srep12987","article-title":"miR-744 enhances type I interferon signaling pathway by targeting PTP1B in primary human renal mesangial cells","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.jnma.2020.05.006_bib30","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.smim.2011.01.009","article-title":"The type I interferon system in the development of lupus","volume":"23","author":"Ronnblom","year":"2011","journal-title":"Semin Immunol"},{"issue":"3","key":"10.1016\/j.jnma.2020.05.006_bib31","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/sji.12330","article-title":"Systemic lupus erythematosus--a disease with a dysregulated type I interferon system","volume":"82","author":"Hagberg","year":"2015","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.jnma.2020.05.006_bib32","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.antiviral.2016.04.009","article-title":"Induction of OAS gene family in HIV monocyte infected patients with high and low viral load","volume":"131","author":"Fagone","year":"2016","journal-title":"Antivir Res"}],"container-title":["Journal of the National Medical Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027968419301324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027968419301324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T06:18:23Z","timestamp":1758435503000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0027968419301324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S0027968419301324"],"URL":"https:\/\/doi.org\/10.1016\/j.jnma.2020.05.006","relation":{},"ISSN":["0027-9684"],"issn-type":[{"value":"0027-9684","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bioinformatic analysis reveals that the OAS family may play an important role in lupus nephritis","name":"articletitle","label":"Article Title"},{"value":"Journal of the National Medical Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnma.2020.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by the National Medical Association. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}