{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:09:14Z","timestamp":1789135754661,"version":"build-2803163510"},"reference-count":22,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the National Medical Association"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jnma.2026.07.003","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:36:07Z","timestamp":1784129767000},"page":"971-976","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does Tranexamic acid fix all bleeding in surgery?"],"prefix":"10.1016","volume":"118","author":[{"given":"Taylor","family":"Lonjin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Prasanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jnma.2026.07.003_bib0001","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3109\/00365528709089756","article-title":"Clinical pharmacology of tranexamic acid","volume":"22","author":"Astedt","year":"1987","journal-title":"Scand J Gastroenterol Suppl"},{"issue":"2","key":"10.1016\/j.jnma.2026.07.003_bib0002","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/ejh.13348","article-title":"The many roles of tranexamic acid: an overview of the clinical indications for TXA in medical and surgical patients","volume":"104","author":"Cai","year":"2020","journal-title":"Eur J Haematol"},{"issue":"2","key":"10.1016\/j.jnma.2026.07.003_bib0003","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.thromres.2014.11.012","article-title":"Tranexamic acid \u2013 an old drug still going strong and making a revival","volume":"135","author":"Tengborn","year":"2015","journal-title":"Thromb Res Res"},{"issue":"1","key":"10.1016\/j.jnma.2026.07.003_bib0004","article-title":"Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion","author":"Henry","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"issue":"36","key":"10.1016\/j.jnma.2026.07.003_bib0005","article-title":"Tranexamic acid blood loss after cardiac surgery: systematic review meta-analysis","volume":"96","author":"Mei","year":"2017","journal-title":"Medicine"},{"issue":"14","key":"10.1016\/j.jnma.2026.07.003_bib0006","first-page":"1379","article-title":"Tranexamic acid cardiac surgery postoperative seizures: double-blind, placebo-controlled, randomized study","volume":"368","author":"Sigaut","year":"2013","journal-title":"N Engl J Med"},{"issue":"19","key":"10.1016\/j.jnma.2026.07.003_bib0007","first-page":"1893","article-title":"Tranexamic acid in patients undergoing coronary-artery surgery","volume":"376","author":"Myles","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jnma.2026.07.003_bib0008","article-title":"Comparison different tranexamic acid administration regimens cardiac surgery: systematic review meta-analysis","volume":"18","author":"Hui","year":"2018","journal-title":"BMC Anesth"},{"issue":"11","key":"10.1016\/j.jnma.2026.07.003_bib0009","first-page":"1055","article-title":"Tranexamic acid high-risk patients undergoing cardiac surgery","volume":"325","author":"Myles","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.jnma.2026.07.003_bib0010","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3389\/fped.2019.00181","article-title":"Efficacy and safety of tranexamic acid in pediatric patients undergoing cardiac surgery: a single-center experience","volume":"7","author":"Zhang","year":"2019","journal-title":"Front Pediatr"},{"issue":"2","key":"10.1016\/j.jnma.2026.07.003_bib0011","first-page":"126","article-title":"Systematic review and meta-analysis of tranexamic acid and epsilon aminocaproic acid in pediatric heart surgery","volume":"21","author":"Szarpak","year":"2024","journal-title":"Kardiochir Torakochirurgia Pol"},{"key":"10.1016\/j.jnma.2026.07.003_bib0012","doi-asserted-by":"crossref","DOI":"10.3389\/fsurg.2021.759937","article-title":"Effects of tranexamic acid on bleeding in pediatric surgeries: a systematic review and meta-analysis","volume":"8","author":"Wei","year":"2021","journal-title":"Front Surg"},{"issue":"10","key":"10.1016\/j.jnma.2026.07.003_bib0013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta17100","article-title":"The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients","volume":"17","author":"Roberts","year":"2013","journal-title":"Health Technol Assess"},{"issue":"2","key":"10.1016\/j.jnma.2026.07.003_bib0014","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1056\/NEJMoa2215457","article-title":"Prehospital tranexamic acid for severe trauma","volume":"389","author":"Gruen","year":"2023","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.jnma.2026.07.003_bib0015","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13049-024-01188-z","article-title":"Therapeutic efficacy of tranexamic acid on traumatic brain injury: a systematic review and meta-analysis","volume":"32","author":"Song","year":"2024","journal-title":"Scand J Trauma Resusc Emerg Med"},{"issue":"10269","key":"10.1016\/j.jnma.2026.07.003_bib0016","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0140-6736(20)32518-6","article-title":"Ultra-early tranexamic acid after subarachnoid haemorrhage (ULTRA): a randomised controlled trial","volume":"397","author":"Post","year":"2021","journal-title":"Lancet"},{"issue":"10135","key":"10.1016\/j.jnma.2026.07.003_bib0017","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1016\/S0140-6736(18)31033-X","article-title":"Tranexamic acid for hyperacute primary IntraCerebral haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial","volume":"391","author":"Sprigg","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.jnma.2026.07.003_bib0018","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jor.2024.08.004","article-title":"Impact of tranexamic acid use in total hip replacement patients: a systematic review and meta-analysis","volume":"60","author":"Liu","year":"2025","journal-title":"J Orthop"},{"issue":"12","key":"10.1016\/j.jnma.2026.07.003_bib0019","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1302\/0301-620X.93B12.26989","article-title":"Tranexamic acid in total knee replacement","volume":"93-B","author":"Alshryda","year":"2011","journal-title":"J Bone Jt Surg Br"},{"issue":"1","key":"10.1016\/j.jnma.2026.07.003_bib0020","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1186\/s13018-023-03929-9","article-title":"Efficacy and safety of single- and double-dose intravenous tranexamic acid in hip and knee arthroplasty: a systematic review and meta-analysis","volume":"18","author":"Yang","year":"2023","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.jnma.2026.07.003_bib0021","article-title":"Tranexamic acid: an exceedingly rare cause of anaphylaxis during anaesthesia","volume":"2016","author":"Bansal","year":"2016","journal-title":"Case Rep Immunol"},{"issue":"1","key":"10.1016\/j.jnma.2026.07.003_bib0022","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.arth.2019.08.015","article-title":"Tranexamic acid administration is not associated with an increase in complications in high-risk patients undergoing primary total knee or total hip arthroplasty: a retrospective case-control study of 38,220 patients","volume":"35","author":"Porter","year":"2020","journal-title":"J Arthroplasty"}],"container-title":["Journal of the National Medical Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027968426001264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027968426001264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:32:08Z","timestamp":1789133528000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0027968426001264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0027968426001264"],"URL":"https:\/\/doi.org\/10.1016\/j.jnma.2026.07.003","relation":{},"ISSN":["0027-9684"],"issn-type":[{"value":"0027-9684","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Does Tranexamic acid fix all bleeding in surgery?","name":"articletitle","label":"Article Title"},{"value":"Journal of the National Medical Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jnma.2026.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc. on behalf of National Medical Association.","name":"copyright","label":"Copyright"}]}}