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Physiol."},{"key":"10.1016\/j.jns.2004.11.050_bib75","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF02740634","article-title":"Nicotinic acetylcholine receptors in health and disease","volume":"15","author":"Lindstrom","year":"1997","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jns.2004.11.050_bib76","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1124\/mol.61.6.1416","article-title":"First and second transmembrane segments of alpha3, alpha4, beta2, and beta4 nicotinic acetylcholine receptor subunits influence the efficacy and potency of nicotine","volume":"61","author":"Rush","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.jns.2004.11.050_bib77","first-page":"311","article-title":"Alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors","volume":"286","author":"Gerzanich","year":"1998","journal-title":"J. Pharmacol. Exp. 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