{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:50:49Z","timestamp":1791046249954,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.jns.2007.01.048","type":"journal-article","created":{"date-parts":[[2007,3,24]],"date-time":"2007-03-24T07:05:45Z","timestamp":1174719945000},"page":"105-113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["High b-value diffusion imaging of dementia: Application to vascular dementia and alzheimer disease"],"prefix":"10.1016","volume":"257","author":[{"given":"Orna","family":"Mayzel-Oreg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaniv","family":"Assaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariela","family":"Gigi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafna","family":"Ben-Bashat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Verchovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mordohovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Graif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talma","family":"Hendler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos","family":"Korczyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoram","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2007.01.048_bib1","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s003300000608","article-title":"Imaging dementias","volume":"11","author":"Savoiardo","year":"2001","journal-title":"Eur Radiol"},{"key":"10.1016\/j.jns.2007.01.048_bib2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1212\/WNL.54.1.83","article-title":"Diffusion-weighted MRI in vascular dementia","volume":"54","author":"Choi","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2007.01.048_bib3","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1161\/01.STR.0000024432.34557.10","article-title":"Is mild cognitive impairment prodromal for vascular dementia like Alzheimer's disease?","volume":"33","author":"Meyer","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2007.01.048_bib4","first-page":"283","article-title":"MR Signal abnormalities in memory disorder and dementia","volume":"11","author":"Bowen","year":"1990","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/j.jns.2007.01.048_bib5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0925-4927(03)00005-2","article-title":"Prognostic significance of white matter changes in memory clinic population","volume":"122","author":"Bronge","year":"2003","journal-title":"Psychiat Res-Neuroim"},{"key":"10.1016\/j.jns.2007.01.048_bib6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1034\/j.1600-0404.2002.1o148.x","article-title":"Diagnostic patterns of regional atrophy on MRI and regional cerebral blood flow change on SPECT in young onset patients with Alzheimer's disease, frontotemporal dementia and vascular dementia","volume":"105","author":"Varma","year":"2002","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.jns.2007.01.048_bib7","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1212\/WNL.54.4.838","article-title":"White matter volumes and periventricular white matter hyperintensities in aging and dementia","volume":"54","author":"Smith","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2007.01.048_bib8","series-title":"Magnetic Resonance Imaging","author":"Stark","year":"1999"},{"key":"10.1016\/j.jns.2007.01.048_bib9","first-page":"1","article-title":"Molecular diffusion nuclear magnetic resonance imaging","volume":"7","author":"LeBihan","year":"1991","journal-title":"Magn Reson Q"},{"key":"10.1016\/j.jns.2007.01.048_bib10","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/nbm.798","article-title":"From the diffusion coefficient to the diffusion tensor","volume":"15","author":"LeBihan","year":"2002","journal-title":"NMR Biomed"},{"key":"10.1016\/j.jns.2007.01.048_bib11","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/nbm.787","article-title":"Application of diffusion-weighted and diffusion tensor MRI to white matter diseases \u2014 a review","volume":"15","author":"Horsfield","year":"2002","journal-title":"NMR Biomed"},{"key":"10.1016\/j.jns.2007.01.048_bib12","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1161\/01.STR.30.2.393","article-title":"Characterization of white matter damage in ischemic leukoaraiosis with diffusion tensor MRI","volume":"30","author":"Jones","year":"1999","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2007.01.048_bib13","first-page":"441","article-title":"Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoraraiosis","volume":"75","author":"O'Sullivan","year":"2004","journal-title":"JNNP"},{"key":"10.1016\/j.jns.2007.01.048_bib14","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1136\/jnnp.69.4.528","article-title":"Loss of connectivity in Alzheimer's disease: an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging","volume":"69","author":"Rose","year":"2000","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jns.2007.01.048_bib15","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1136\/jnnp.72.6.742","article-title":"White matter damage in Alzheimer's disease assessed in vivo using diffusion tensor magnetic resonance imaging","volume":"72","author":"Bozzali","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jns.2007.01.048_bib16","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1159\/000017099","article-title":"Diffusion-weighted magnetic resonance imaging in Alzheimer's disease","volume":"10","author":"Sandson","year":"1999","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.jns.2007.01.048_bib17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0304-3940(02)00914-X","article-title":"Selective reduction of diffusion anisotropy in white matter of Alzheimer disease brains measured by 3.0 Tesla magnetic resonance imaging","volume":"332","author":"Takahashi","year":"2002","journal-title":"Neurosci lett"},{"key":"10.1016\/j.jns.2007.01.048_bib18","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S1053-8119(03)00342-2","article-title":"High b-value diffusion-weighted imaging is more sensitive to white matter degeneration in Alzheimer's disease","volume":"20","author":"Yoshihura","year":"2003","journal-title":"NeuroImage"},{"key":"10.1016\/j.jns.2007.01.048_bib19","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/mrm.1910140218","article-title":"Early detection of regional cerebral ischemia in cats: comparison of diffusion-weighted and T2-weighted MRI and spectroscopy","volume":"14","author":"Moseley","year":"1990","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jns.2007.01.048_bib20","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/nbm.1940080708","article-title":"Diffusion-weighted NMR imaging: application to experimental focal cerebral ischemia","volume":"8","author":"Hoehn-Berlage","year":"1995","journal-title":"NMR Biomed"},{"key":"10.1016\/j.jns.2007.01.048_bib21","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/mrm.1910360607","article-title":"Biexponential diffusion attenuation in various stats of brain tissue: implication for diffusion-weighted imaging","volume":"36","author":"Niendorf","year":"1996","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jns.2007.01.048_bib22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1006\/jmrb.1996.0125","article-title":"Detection of different water populations in brain tissue using 2H single-and double-quantum-filtered diffusion NMR spectroscopy","volume":"112","author":"Assaf","year":"1996","journal-title":"J Magn Reson Ser B"},{"key":"10.1016\/j.jns.2007.01.048_bib23","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1006\/jmre.1997.1313","article-title":"Non-mono-exponential atteunuation of water and N-acetyl aspartate signals due to diffusion in brain tissue","volume":"131","author":"Assaf","year":"1998","journal-title":"J Magn Reson"},{"key":"10.1016\/j.jns.2007.01.048_bib24","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/(SICI)1522-2594(200002)43:2<191::AID-MRM5>3.0.CO;2-B","article-title":"Assignment of the water slow-diffusing component in the central nervous system using q-space diffusion MRS: implication for fiber tract imaging","volume":"43","author":"Assaf","year":"2000","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jns.2007.01.048_bib25","first-page":"555","article-title":"The sources of diffusion components in neuronal tissue: application to white matter disorders","volume":"7","author":"Assaf","year":"1999","journal-title":"Proc Int Soc Magn Res Med"},{"key":"10.1016\/j.jns.2007.01.048_bib26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/(SICI)1099-1492(199902)12:1<51::AID-NBM546>3.0.CO;2-E","article-title":"Multi-component apparent diffusion coefficients in human brain","volume":"12","author":"Mulkern","year":"1999","journal-title":"NMR Biomed"},{"key":"10.1016\/j.jns.2007.01.048_bib27","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/mrm.10268","article-title":"High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity","volume":"48","author":"Tuch","year":"2002","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jns.2007.01.048_bib28","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/nbm.778","article-title":"High b-value q-space analyzed diffusion-weighted MRS and MRI in neuronal tissues \u2014 a technical review","volume":"15","author":"Cohen","year":"2002","journal-title":"NMR Biomed"},{"key":"10.1016\/j.jns.2007.01.048_bib29","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/mrm.1910140303","article-title":"Measurement of translational displacement probabilities by NMR: an indicator of compartmentation","volume":"14","author":"Cory","year":"1990","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jns.2007.01.048_bib30","series-title":"Principles of Nuclear Magnetic Resonance Microscopy","author":"Callaghan","year":"1991"},{"key":"10.1016\/j.jns.2007.01.048_bib31","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/1522-2594(200011)44:5<713::AID-MRM9>3.0.CO;2-6","article-title":"Displacement imaging of spinal cord using q-space diffusion-weighted MRI","volume":"44","author":"Assaf","year":"2000","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jns.2007.01.048_bib32","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0014-4886(03)00274-7","article-title":"Hypertension and neuronal degeneration in excised rat spinal cord studied by high-b-value q-space diffusion magnetic resonance imaging","volume":"184","author":"Assaf","year":"2003","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jns.2007.01.048_bib33","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0730-725X(02)00470-8","article-title":"q-Space high b-value diffusion MRI of hemi-crush in rat spinal cord: evidence for spontaneous regeneration","volume":"20","author":"Nossin-Manor","year":"2002","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.jns.2007.01.048_bib34","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/mrm.10040","article-title":"High b-value q-space analyzed diffusion-weighted MRI: aplication to multiple sclerosis","volume":"47","author":"Assaf","year":"2002","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jns.2007.01.048_bib35","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.expneurol.2005.06.011","article-title":"Improved detectibility of experimental allergic encephalomyelitis in excised swine spinal cord by high b-value q-space DWI","volume":"195","author":"Biton","year":"2005","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jns.2007.01.048_bib36","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/mrm.1910390610","article-title":"A simplified method to measure diffusion tensor from seven MR images","volume":"39","author":"Basser","year":"1998","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jns.2007.01.048_bib37","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-Mental \/state\u201d: a practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psych Res"},{"key":"10.1016\/j.jns.2007.01.048_bib38","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0895-4356(97)00060-7","article-title":"Community screening for dementia: the Mini-Mental State Exam (MMSE) and Modified Mini-Mental State Exam (3MS) compared","volume":"50","author":"McDowell","year":"1977","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.jns.2007.01.048_bib39","series-title":"The Canadian Alzheimer Disease Review","article-title":"The Mini-Mental State Examination: strengths and weaknesses of a clinical instrument","author":"Simard","year":"1998"},{"key":"10.1016\/j.jns.2007.01.048_bib40","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0022-510X(02)00297-6","article-title":"High b-value q space-analyzed diffusion MRI in vascular dementia","volume":"203\u2013204","author":"Assaf","year":"2002","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.jns.2007.01.048_bib41","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.mri.2005.04.008","article-title":"White matter changes in multiple sclerosis: correlation of q-space diffusion MRI and 1H MRS","volume":"23","author":"Assaf","year":"2005","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.jns.2007.01.048_bib42","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1212\/WNL.57.12.2307","article-title":"Normal-appearing white matter in ischemic leukoaraiosis: a diffusion tensor MRI study","volume":"57","author":"O'Sullivan","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2007.01.048_bib43","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000057698","article-title":"Postmortem MRI and histopathology of white matter changes in Alzheimer brains","volume":"13","author":"Bronge","year":"2002","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.jns.2007.01.048_bib44","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000066021","article-title":"Comparative diagnostic utility of different MR modalities in mild cognitive impairment and Alzheimer's disease","volume":"14","author":"Kantarci","year":"2002","journal-title":"Dement Geriatr Cogn Disord"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X0700055X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X0700055X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T15:37:36Z","timestamp":1758382656000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X0700055X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":44,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0022510X0700055X"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2007.01.048","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High b-value diffusion imaging of dementia: Application to vascular dementia and alzheimer disease","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2007.01.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}