{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:35:37Z","timestamp":1790213737736,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000887","name":"Huntington's Disease Society of America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000887","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.jns.2007.05.035","type":"journal-article","created":{"date-parts":[[2007,7,26]],"date-time":"2007-07-26T07:19:24Z","timestamp":1185434364000},"page":"70-74","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Is brain lactate increased in Huntington's disease?"],"prefix":"10.1016","volume":"263","author":[{"given":"W.R. Wayne","family":"Martin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marguerite","family":"Wieler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Hanstock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2007.05.035_bib1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington's disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.jns.2007.05.035_bib2","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","author":"Huntington's Disease Collaborative Research Group","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.jns.2007.05.035_bib3","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1111\/j.1471-4159.1985.tb07192.x","article-title":"Regional mitochondrial respiratory activity in Huntington's disease brain","volume":"44","author":"Brennan","year":"1985","journal-title":"J Neurochem"},{"key":"10.1016\/j.jns.2007.05.035_bib4","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/0140-6736(90)92242-A","article-title":"Mitochondrial function and parental sex effect in Huntington's disease","volume":"336","author":"Mann","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.jns.2007.05.035_bib5","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1212\/WNL.40.8.1231","article-title":"Evidence for a defect in NADH: ubiquinone oxidoreductase (complex I) in Huntington's disease","volume":"40","author":"Parker","year":"1990","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2007.05.035_bib6","first-page":"21","article-title":"3-nitropropionic acid decreases cellular energy levels and causes neuronal degeneration in cortical explants","volume":"1","author":"Ludolph","year":"1992","journal-title":"Neurodegeneration"},{"key":"10.1016\/j.jns.2007.05.035_bib7","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1111\/j.1471-4159.1993.tb03633.x","article-title":"Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate","volume":"61","author":"Beal","year":"1993","journal-title":"J Neurochem"},{"key":"10.1016\/j.jns.2007.05.035_bib8","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1111\/j.1471-4159.1991.tb08258.x","article-title":"Aminooxyacetic acid results in excitotoxin lesions by a novel indirect mechanism","volume":"57","author":"Beal","year":"1991","journal-title":"J Neurochem"},{"key":"10.1016\/j.jns.2007.05.035_bib9","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1212\/WNL.43.12.2689","article-title":"Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy","volume":"43","author":"Jenkins","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2007.05.035_bib10","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1212\/WNL.50.4.1033","article-title":"Quantitative proton-decoupled 31P MRS and 1H MRS in the evaluation of Huntington's and Parkinson's diseases","volume":"50","author":"Hoang","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2007.05.035_bib11","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mds.870110204","article-title":"The Unified Huntington's Disease Rating Scale: reliability and consistency","volume":"11","author":"Huntington Study Group","year":"1996","journal-title":"Mov Disord"},{"key":"10.1016\/j.jns.2007.05.035_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1212\/WNL.29.1.1","article-title":"Huntington's disease: clinical care and evaluation","volume":"29","author":"Shoulson","year":"1979","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2007.05.035_bib13","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1002\/mrm.1910290613","article-title":"Automatic, localized in vivo adjustment of all first- and second-order shim coils","volume":"29","author":"Gruetter","year":"1993","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jns.2007.05.035_bib14","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1098\/rspa.1975.0104","article-title":"Critical factors in design of sensitive high-resolution nuclear magnetic-resonance spectrometers","volume":"344","author":"Hoult","year":"1975","journal-title":"Proc R Soc Lond A"},{"key":"10.1016\/j.jns.2007.05.035_bib15","series-title":"Proceedings of the Society of Magnetic Resonance in Medicine","first-page":"1964","article-title":"Segmentation of brain from a PRESS localised single volume using double inversion recovery for simultaneous T1 nulling","author":"Hanstock","year":"2000"},{"key":"10.1016\/j.jns.2007.05.035_bib16","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/0896-6273(95)90345-3","article-title":"Widespread expression of the Huntington's disease gene (IT-15) protein product","volume":"14","author":"Sharp","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.jns.2007.05.035_bib17","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/ana.410420411","article-title":"Huntington localization in brains of normal and Huntington's disease patients","volume":"42","author":"Sapp","year":"1997","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jns.2007.05.035_bib18","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/mds.870130214","article-title":"Increasing striatal iron content associated with normal aging","volume":"13","author":"Martin","year":"1998","journal-title":"Mov Disord"},{"key":"10.1016\/j.jns.2007.05.035_bib19","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/1097-4547(20000615)60:6<779::AID-JNR10>3.0.CO;2-M","article-title":"Proton magnetic resonance spectroscopy of cerebrospinal fluid in neurodegenerative disease: indication of glial energy impairment in Huntington chorea, but not Parkinson disease","volume":"60","author":"Garseth","year":"2000","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.jns.2007.05.035_bib20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0304-3940(93)90168-K","article-title":"CSF and serum metabolic profile of patients with Huntington's chorea: A study by high resolution proton NMR spectroscopy and HPLC","volume":"154","author":"Nicoli","year":"1993","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jns.2007.05.035_bib21","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1073\/pnas.85.6.1821","article-title":"Spatially localised 1H NMR of metabolites in the human brain","volume":"85","author":"Hanstock","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jns.2007.05.035_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1136\/jnnp.62.1.27","article-title":"Decreased N-acetyl-aspartate\/choline ratio and increased lactate in the frontal lobe of patients with Huntington's disease: a proton magnetic resonance spectroscopy study","volume":"62","author":"Harms","year":"1997","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jns.2007.05.035_bib23","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1023\/B:NERE.0000014824.04728.dd","article-title":"The energetics of Huntington's disease","volume":"29","author":"Browne","year":"2004","journal-title":"Neurochem Res"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X07003930?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X07003930?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T15:38:21Z","timestamp":1758382701000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X07003930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":23,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S0022510X07003930"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2007.05.035","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is brain lactate increased in Huntington's disease?","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2007.05.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}