{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:24:28Z","timestamp":1791336268413,"version":"4.3.1"},"reference-count":66,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1016\/j.jns.2007.09.008","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T09:15:12Z","timestamp":1196154912000},"page":"84-88","source":"Crossref","is-referenced-by-count":15,"title":["Human embryonic stem cells: An experimental and therapeutic resource for neurological disease"],"prefix":"10.1016","volume":"265","author":[{"given":"A.J.","family":"Joannides","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Chandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2007.09.008_bib1","series-title":"McAlpine's multiple sclerosis","year":"2005"},{"key":"10.1016\/j.jns.2007.09.008_bib2","unstructured":"Chandran S, Hunt D, Joannides A, et al. Myelin repair: the role of stem and precursor cells in multiple sclerosis. Philos Trans R Soc Lond B Biol Sci. (in press)."},{"key":"10.1016\/j.jns.2007.09.008_bib3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0002-9440(10)64537-3","article-title":"Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions","volume":"157","author":"Kornek","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jns.2007.09.008_bib4","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/1097-4547(20000801)61:3<288::AID-JNR6>3.0.CO;2-#","article-title":"Transplanted glial cells migrate over a greater distance and remyelinate demyelinated lesions more rapidly than endogenous remyelinating cells","volume":"61","author":"Blakemore","year":"2000","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.jns.2007.09.008_bib5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1191\/1352458502ms842oa","article-title":"New insights into remyelination failure in multiple sclerosis: implications for glial cell transplantation","volume":"8","author":"Chari","year":"2002","journal-title":"Mult Scler"},{"issue":"Pt 1","key":"10.1016\/j.jns.2007.09.008_bib6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1046\/j.1469-7580.1997.19010023.x","article-title":"Transplanting oligodendrocyte progenitors into the adult CNS","volume":"190","author":"Franklin","year":"1997","journal-title":"J Anat"},{"key":"10.1016\/j.jns.2007.09.008_bib7","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.mcn.2003.08.009","article-title":"Intraventricular transplantation of neural precursor cell spheres attenuates acute experimental allergic encephalomyelitis","volume":"24","author":"Einstein","year":"2003","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.jns.2007.09.008_bib8","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nature01552","article-title":"Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis","volume":"422","author":"Pluchino","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jns.2007.09.008_bib9","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/nature03889","article-title":"Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism","volume":"436","author":"Pluchino","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jns.2007.09.008_bib10","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.expneurol.2005.11.007","article-title":"Transplanted neural precursor cells reduce brain inflammation to attenuate chronic experimental autoimmune encephalomyelitis","volume":"198","author":"Einstein","year":"2006","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jns.2007.09.008_bib11","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/nrn1908","article-title":"The therapeutic potential of neural stem cells","volume":"7","author":"Martino","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.jns.2007.09.008_bib12","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/35075141","article-title":"Cell culture. Progenitor cells from human brain after death","volume":"411","author":"Palmer","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.jns.2007.09.008_bib13","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1016\/j.yexcr.2006.03.012","article-title":"Human progenitor cells isolated from the developing cortex undergo decreased neurogenesis and eventual senescence following expansion in vitro","volume":"312","author":"Wright","year":"2006","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jns.2007.09.008_bib14","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1046\/j.1460-9568.2000.00137.x","article-title":"Porcine neural progenitors require commitment to the oligodendrocyte lineage prior to transplantation in order to achieve significant remyelination of demyelinated lesions in the adult CNS","volume":"12","author":"Smith","year":"2000","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.jns.2007.09.008_bib15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nm974","article-title":"Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brain","volume":"10","author":"Windrem","year":"2004","journal-title":"Nat Med"},{"key":"10.1016\/j.jns.2007.09.008_bib16","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1089\/scd.2006.15.61","article-title":"Derivation of three clones from human embryonic stem cell lines by FACS sorting and their characterization","volume":"15","author":"Sidhu","year":"2006","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.jns.2007.09.008_bib17","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/(SICI)1097-4547(19971015)50:2<146::AID-JNR4>3.0.CO;2-F","article-title":"Emergence of oligodendrocytes from human neural spheres","volume":"50","author":"Murray","year":"1997","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.jns.2007.09.008_bib18","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/(SICI)1097-4547(19990901)57:5<590::AID-JNR2>3.0.CO;2-X","article-title":"Lineage restriction of neuroepithelial precursor cells from fetal human spinal cord","volume":"57","author":"Quinn","year":"1999","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.jns.2007.09.008_bib19","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/glia.20011","article-title":"Differential generation of oligodendrocytes from human and rodent embryonic spinal cord neural precursors","volume":"47","author":"Chandran","year":"2004","journal-title":"Glia"},{"key":"10.1016\/j.jns.2007.09.008_bib20","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic stem cell lines derived from human blastocysts","volume":"282","author":"Thomson","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jns.2007.09.008_bib21","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/nbt1102","article-title":"Characterization and culture of human embryonic stem cells","volume":"23","author":"Hoffman","year":"2005","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jns.2007.09.008_bib22","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature05142","article-title":"Human embryonic stem cell lines derived from single blastomeres","volume":"444","author":"Klimanskaya","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jns.2007.09.008_bib23","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.jns.2007.09.008_bib24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nature05934","article-title":"Generation of germline-competent induced pluripotent stem cells","volume":"448","author":"Okita","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jns.2007.09.008_bib25","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nature05944","article-title":"In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state","volume":"448","author":"Wernig","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jns.2007.09.008_bib26","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1634\/stemcells.22-5-770","article-title":"LIF\/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells","volume":"22","author":"Daheron","year":"2004","journal-title":"Stem Cells"},{"key":"10.1016\/j.jns.2007.09.008_bib27","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1634\/stemcells.2006-0277","article-title":"Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells","volume":"25","author":"Rajesh","year":"2007","journal-title":"Stem Cells"},{"key":"10.1016\/j.jns.2007.09.008_bib28","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.brainresbull.2005.08.022","article-title":"Neural differentiation of mouse embryonic stem cells in chemically defined medium","volume":"68","author":"Bouhon","year":"2005","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.jns.2007.09.008_bib29","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/jnr.20036","article-title":"Differentiation of embryonic stem cells to a neural fate: a route to re-building the nervous system?","volume":"76","author":"Lang","year":"2004","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.jns.2007.09.008_bib30","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1634\/stemcells.2006-0031","article-title":"Embryonic stem cell-derived neural progenitors display temporal restriction to neural patterning","volume":"24","author":"Bouhon","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.jns.2007.09.008_bib31","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.cbpa.2006.10.002","article-title":"Stem cell neural differentiation: a model for chemical biology","volume":"10","author":"Krencik","year":"2006","journal-title":"Curr Opin Chem Biol"},{"key":"10.1016\/j.jns.2007.09.008_bib32","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/76536","article-title":"Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells","volume":"18","author":"Lee","year":"2000","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jns.2007.09.008_bib33","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0092-8674(02)00835-8","article-title":"Directed differentiation of embryonic stem cells into motor neurons","volume":"110","author":"Wichterle","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.jns.2007.09.008_bib34","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/nbt1088","article-title":"Migration and differentiation of neural precursors derived from human embryonic stem cells in the rat brain","volume":"23","author":"Tabar","year":"2005","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jns.2007.09.008_bib35","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/jnr.21022","article-title":"Human embryonic stem cell-derived neural precursors develop into neurons and integrate into the host brain","volume":"84","author":"Guillaume","year":"2006","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.jns.2007.09.008_bib36","doi-asserted-by":"crossref","first-page":"18644","DOI":"10.1073\/pnas.0509315102","article-title":"Development of functional human embryonic stem cell-derived neurons in mouse brain","volume":"102","author":"Muotri","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jns.2007.09.008_bib37","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1634\/stemcells.2005-0393","article-title":"Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: effect of in vitro differentiation on graft survival and teratoma formation","volume":"24","author":"Brederlau","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.jns.2007.09.008_bib38","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1038\/nm1495","article-title":"Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes","volume":"12","author":"Roy","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.jns.2007.09.008_bib39","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1111\/j.1471-4159.2006.03841.x","article-title":"Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation","volume":"97","author":"Chung","year":"2006","journal-title":"J Neurochem"},{"key":"10.1016\/j.jns.2007.09.008_bib40","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1634\/stemcells.2006-0540","article-title":"Selection of embryonic stem cell-derived enhanced green fluorescent protein-positive dopamine neurons using the tyrosine hydroxylase promoter is confounded by reporter gene expression in immature cell populations","volume":"25","author":"Hedlund","year":"2007","journal-title":"Stem Cells"},{"key":"10.1016\/j.jns.2007.09.008_bib41","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nm1533","article-title":"Derivation of engraftable skeletal myoblasts from human embryonic stem cells","volume":"13","author":"Barberi","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.jns.2007.09.008_bib42","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/nbt1201-1134","article-title":"Neural progenitors from human embryonic stem cells","volume":"19","author":"Reubinoff","year":"2001","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jns.2007.09.008_bib43","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1006\/exnr.2001.7832","article-title":"Enrichment of neurons and neural precursors from human embryonic stem cells","volume":"172","author":"Carpenter","year":"2001","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jns.2007.09.008_bib44","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0006-8993(01)02776-7","article-title":"Induced neuronal differentiation of human embryonic stem cells","volume":"913","author":"Schuldiner","year":"2001","journal-title":"Brain Res"},{"key":"10.1016\/j.jns.2007.09.008_bib45","doi-asserted-by":"crossref","first-page":"12543","DOI":"10.1073\/pnas.0404700101","article-title":"Derivation of midbrain dopamine neurons from human embryonic stem cells","volume":"101","author":"Perrier","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jns.2007.09.008_bib46","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1634\/stemcells.22-5-669","article-title":"Generation of tyrosine hydroxylase positive neurons from human embryonic stem cells after coculture with cellular substrates and exposure to GDNF","volume":"22","author":"Buytaert-Hoefen","year":"2004","journal-title":"Stem Cells"},{"key":"10.1016\/j.jns.2007.09.008_bib47","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1634\/stemcells.22-6-925","article-title":"Dopaminergic differentiation of human embryonic stem cells","volume":"22","author":"Zeng","year":"2004","journal-title":"Stem Cells"},{"key":"10.1016\/j.jns.2007.09.008_bib48","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nbt1063","article-title":"Specification of motoneurons from human embryonic stem cells","volume":"23","author":"Li","year":"2005","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jns.2007.09.008_bib49","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1634\/stemcells.2004-0365","article-title":"Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells","volume":"23","author":"Yan","year":"2005","journal-title":"Stem Cells"},{"key":"10.1016\/j.jns.2007.09.008_bib50","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1634\/stemcells.2005-0432","article-title":"Establishing standards for the characterization of embryonic stem cell lines","volume":"24","author":"Loring","year":"2005","journal-title":"Stem Cells"},{"key":"10.1016\/j.jns.2007.09.008_bib51","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nm1181","article-title":"Human embryonic stem cells express an immunogenic nonhuman sialic acid","volume":"11","author":"Martin","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.jns.2007.09.008_bib52","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/nbt1201-1129","article-title":"In vitro differentiation of transplantable neural precursors from human embryonic stem cells","volume":"19","author":"Zhang","year":"2001","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jns.2007.09.008_bib53","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mcn.2005.05.004","article-title":"Derivation of neural precursors from human embryonic stem cells in the presence of noggin","volume":"30","author":"Itsykson","year":"2005","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.jns.2007.09.008_bib54","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1634\/stemcells.2005-0243","article-title":"Automated mechanical passaging: a novel and efficient method for human embryonic stem cell expansion","volume":"24","author":"Joannides","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.jns.2007.09.008_bib55","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1634\/stemcells.2006-0562","article-title":"A scaleable and defined system for generating neural stem cells from human embryonic stem cells","volume":"25","author":"Joannides","year":"2007","journal-title":"Stem Cells"},{"key":"10.1016\/j.jns.2007.09.008_bib56","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nbt780","article-title":"Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture","volume":"21","author":"Ying","year":"2003","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jns.2007.09.008_bib57","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1093\/brain\/awm070","article-title":"Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells","volume":"130","author":"Joannides","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.jns.2007.09.008_bib58","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/glia.20127","article-title":"Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation","volume":"49","author":"Nistor","year":"2004","journal-title":"Glia"},{"key":"10.1016\/j.jns.2007.09.008_bib59","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1038\/sj.npp.1301125","article-title":"An in vitro model of human dopaminergic neurons derived from embryonic stem cells: MPP+ toxicity and GDNF neuroprotection","volume":"31","author":"Zeng","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jns.2007.09.008_bib60","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/hmg\/ddm008","article-title":"Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation","volume":"16","author":"Schneider","year":"2007","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jns.2007.09.008_bib61","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.1523\/JNEUROSCI.23-12-04967.2003","article-title":"Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: a novel role for oligodendrocyte-derived glial cell line-derived neurotrophic factor","volume":"23","author":"Wilkins","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.jns.2007.09.008_bib62","first-page":"608","article-title":"Biology of disease. Analysis of autoimmune demyelination: its impact upon multiple sclerosis","volume":"50","author":"Raine","year":"1984","journal-title":"Lab Invest"},{"key":"10.1016\/j.jns.2007.09.008_bib63","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/ana.20913","article-title":"How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis","volume":"60","author":"Steinman","year":"2006","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jns.2007.09.008_bib64","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/brain\/awl075","article-title":"Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70\u00a0years of merits and culprits in experimental autoimmune encephalomyelitis research","volume":"129","author":"Gold","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.jns.2007.09.008_bib65","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0165-5728(90)90019-J","article-title":"Induction of chronic relapsing experimental allergic encephalomyelitis in Biozzi mice","volume":"28","author":"Baker","year":"1990","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.jns.2007.09.008_bib66","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/35003583","article-title":"Cannabinoids control spasticity and tremor in a multiple sclerosis model","volume":"404","author":"Baker","year":"2000","journal-title":"Nature"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X07006259?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X07006259?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,5]],"date-time":"2019-05-05T02:59:25Z","timestamp":1557025165000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X07006259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":66,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S0022510X07006259"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2007.09.008","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}