{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:17:26Z","timestamp":1776449846555,"version":"3.51.2"},"reference-count":27,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.jns.2008.06.039","type":"journal-article","created":{"date-parts":[[2008,8,10]],"date-time":"2008-08-10T04:09:50Z","timestamp":1218341390000},"page":"93-98","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Differential patterns of evolution in acute middle cerebral artery infarction with perfusion\u2013diffusion mismatch: Atherosclerotic vs. cardioembolic occlusion"],"prefix":"10.1016","volume":"273","author":[{"given":"Hye-Jin","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Cheol","family":"Yun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung-Hee","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A-Hyun","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun U.","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong S.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Wha","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2008.06.039_bib1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/ana.10407","article-title":"New perspectives on developing acute stroke therapy","volume":"53","author":"Fisher","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jns.2008.06.039_bib2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1161\/01.STR.0000149938.08731.2c","article-title":"The desmoteplase in acute ischemic stroke trial (DIAS). A phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase","volume":"36","author":"Hacke","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2008.06.039_bib3","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1161\/01.STR.30.8.1583","article-title":"Combined diffusion and perfusion MRI with correlation to single-photon emission CT in acute ischemic stroke. Ischemic penumbra predicts infarct growth","volume":"30","author":"Karonen","year":"1999","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2008.06.039_bib4","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1161\/01.STR.30.8.1591","article-title":"Diffusion- and perfusion-weighted MRI. The DWI\/PWI mismatch region in acute stroke","volume":"30","author":"Neumann-Haefelin","year":"1999","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2008.06.039_bib5","first-page":"557","article-title":"The cerebral ischemic penumbra","volume":"14","author":"Hakim","year":"1987","journal-title":"Can J Neurol Sci"},{"key":"10.1016\/j.jns.2008.06.039_bib6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000015955","article-title":"Mapping the ischaemic penumbra with PET: implications for acute stroke treatment","volume":"9","author":"Baron","year":"1999","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.jns.2008.06.039_bib7","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/ana.410360404","article-title":"Viability thresholds and the penumbra of focal ischemia","volume":"36","author":"Hossmann","year":"1994","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jns.2008.06.039_bib8","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/ana.410360402","article-title":"The ischemic penumbra, injury thresholds, and the therapeutic window for acute stroke","volume":"36","author":"Ginsberg","year":"1994","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jns.2008.06.039_bib9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1161\/01.STR.0000106482.31425.D1","article-title":"Effect of incomplete (spontaneous and postthrombolytic) recanalization after middle cerebral artery occlusion: a magnetic resonance imaging study","volume":"35","author":"Neumann-Haefelin","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2008.06.039_bib10","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1212\/WNL.43.4.728","article-title":"Brain infarction severity differs according to cardiac or arterial embolic source","volume":"43","author":"Timsit","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2008.06.039_bib11","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1212\/WNL.50.6.1699","article-title":"Arterial territories of the human brain: cerebral hemispheres","volume":"50","author":"Tatu","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2008.06.039_bib12","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1001\/archneur.64.1.50","article-title":"Early recurrent ischemic lesions on diffusion-weighted imaging in symptomatic intracranial atherosclerosis","volume":"64","author":"Kang","year":"2007","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jns.2008.06.039_bib13","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/ana.20617","article-title":"An evidence-based causative classification system for acute ischemic stroke","volume":"58","author":"Ay","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jns.2008.06.039_bib14","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/biomet\/44.3-4.470","article-title":"Tests for rank correlation coefficients. I","volume":"44","author":"Fieller","year":"1957","journal-title":"Biometrika"},{"key":"10.1016\/j.jns.2008.06.039_bib15","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1161\/01.STR.0000177486.85508.4d","article-title":"Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging","volume":"36","author":"Bardutzky","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2008.06.039_bib16","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1161\/01.STR.0000217223.72193.98","article-title":"Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging","volume":"37","author":"Henninger","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2008.06.039_bib17","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1161\/01.STR.28.2.311","article-title":"Atrial fibrillation and stroke. Mortality and causes of death after the first acute ischemic stroke","volume":"28","author":"Kaarisalo","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2008.06.039_bib18","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1161\/01.STR.20.12.1653","article-title":"Nonvalvular atrial fibrillation as a cause of fatal massive cerebral infarction in the elderly","volume":"20","author":"Yamanouchi","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2008.06.039_bib19","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1161\/01.STR.20.7.864","article-title":"Measurements of acute cerebral infarction: a clinical examination scale","volume":"20","author":"Brott","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2008.06.039_bib20","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1161\/01.STR.30.2.293","article-title":"Infarct volume as a surrogate or auxiliary outcome measure in ischemic stroke clinical trials. The RANTTAS investigators","volume":"30","author":"Saver","year":"1999","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2008.06.039_bib21","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1161\/01.STR.31.12.2912","article-title":"Effect of intravenous recombinant tissue plasminogen activator on ischemic stroke lesion size measured by computed tomography. NINDS; The National Institute of Neurological Disorders and Stroke (NINDS) rt-PA stroke study group","volume":"31","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2008.06.039_bib22","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1161\/01.STR.0000251792.76080.45","article-title":"The real estate factor: quantifying the impact of infarct location on stroke severity","volume":"38","author":"Menezes","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2008.06.039_bib23","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1161\/01.STR.21.6.923","article-title":"Functional impairment due to white matter ischemia after middle cerebral artery occlusion in cats","volume":"21","author":"Graf","year":"1990","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2008.06.039_bib24","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1001\/archneur.61.11.1682","article-title":"Factors affecting the angiographic recanalization and early clinical improvement in middle cerebral artery territory infarction after thrombolysis","volume":"61","author":"Kwon","year":"2004","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jns.2008.06.039_bib25","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1161\/01.STR.0000189999.19948.14","article-title":"Lesion patterns and stroke mechanism in atherosclerotic middle cerebral artery disease: early diffusion-weighted imaging study","volume":"36","author":"Lee","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2008.06.039_bib26","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1161\/hs1201.99821","article-title":"Time course of tissue plasminogen activator-induced recanalization in acute cardioembolic stroke: a case-control study","volume":"32","author":"Molina","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2008.06.039_bib27","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1161\/01.STR.0000239696.61545.4b","article-title":"Proof-of-principle phase II MRI studies in stroke: sample size estimates from dichotomous and continuous data","volume":"37","author":"Phan","year":"2006","journal-title":"Stroke"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X08003146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X08003146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T15:39:47Z","timestamp":1758382787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X08003146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":27,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S0022510X08003146"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2008.06.039","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential patterns of evolution in acute middle cerebral artery infarction with perfusion\u2013diffusion mismatch: Atherosclerotic vs. cardioembolic occlusion","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2008.06.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}