{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:16:36Z","timestamp":1791209796274,"version":"4.1.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1016\/j.jns.2008.08.002","type":"journal-article","created":{"date-parts":[[2008,11,29]],"date-time":"2008-11-29T04:59:27Z","timestamp":1227934767000},"page":"98-100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["The intrathecal, polyspecific antiviral immune response: Specific for MS or a general marker of CNS autoimmunity?"],"prefix":"10.1016","volume":"280","author":[{"given":"Sven","family":"Jarius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Eichhorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Jacobi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Wildemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Wick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Voltz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2008.08.002_bib1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0165-5728(94)90233-X","article-title":"The intrathecal synthesis of virus-specific oligoclonal IgG in multiple sclerosis","volume":"54","author":"Sindic","year":"1994","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.jns.2008.08.002_bib2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1177\/135245859800400304","article-title":"The intrathecal, polyspecific and oligoclonal immune response in multiple sclerosis","volume":"4","author":"Reiber","year":"1998","journal-title":"Mult Scler"},{"key":"10.1016\/j.jns.2008.08.002_bib3","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/ana.20890","article-title":"B lineage cells in the inflammatory central nervous system environment: migration, maintenance, local antibody production, and therapeutic modulation","volume":"59","author":"Meinl","year":"2006","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jns.2008.08.002_bib4","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/BF00422934","article-title":"The diagnostic significance of antibody specificity indices in multiple sclerosis and herpes virus induced diseases of the nervous system","volume":"70","author":"Felgenhauer","year":"1992","journal-title":"Clin Investig"},{"key":"10.1016\/j.jns.2008.08.002_bib5","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/135245859800400106","article-title":"Intrathecal synthesis of virus-specific oligoclonal IgG, and of free kappa and free lambda oligoclonal bands in acute monosymptomatic optic neuritis. Comparison with brain MRI","volume":"4","author":"Frederiksen","year":"1998","journal-title":"Mult Scler"},{"key":"10.1016\/j.jns.2008.08.002_bib6","first-page":"587","article-title":"Polyspecific immune reaction in the central nervous system in autoimmune diseases with CNS involvement","volume":"88","author":"Graef","year":"1994","journal-title":"Z Arztl Fortbild (Jena)"},{"key":"10.1016\/j.jns.2008.08.002_bib7","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0022-510X(85)90067-X","article-title":"Cerebrospinal fluid virus antibodies. A diagnostic indicator for multiple sclerosis?","volume":"71","author":"Felgenhauer","year":"1985","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.jns.2008.08.002_bib8","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S1474-4422(02)00135-7","article-title":"Paraneoplastic neurological syndromes: an update on diagnosis, pathogenesis, and therapy","volume":"1","author":"Voltz","year":"2002","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jns.2008.08.002_bib9","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S1474-4422(08)70060-7","article-title":"Paraneoplastic syndromes of the CNS","volume":"7","author":"Dalmau","year":"2008","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jns.2008.08.002_bib10","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1474-4422(07)70216-8","article-title":"The spectrum of neuromyelitis optica","volume":"6","author":"Wingerchuk","year":"2007","journal-title":"Lancet Neurol"},{"issue":"10","key":"10.1016\/j.jns.2008.08.002_bib11","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1136\/jnnp.2007.133330","article-title":"Polyspecific, antiviral immune response distinguishes multiple sclerosis and neuromyelitis optica","volume":"79","author":"Jarius","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jns.2008.08.002_bib12","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1136\/jnnp.2003.034447","article-title":"Recommended diagnostic criteria for paraneoplastic neurological syndromes","volume":"75","author":"Graus","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jns.2008.08.002_bib13","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/ana.1032","article-title":"Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis","volume":"50","author":"McDonald","year":"2001","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jns.2008.08.002_bib14","first-page":"99","article-title":"Cerebrospinal fluid\u2014physiology, analysis and interpretation of protein patterns for diagnosis of neurological diseases","volume":"4","author":"Reiber","year":"1998","journal-title":"Mult Scler"},{"key":"10.1016\/j.jns.2008.08.002_bib15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1600-0404.2005.00418.x","article-title":"Relevance of immunological variables in neuroborreliosis and multiple sclerosis","volume":"112","author":"Bednarova","year":"2005","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.jns.2008.08.002_bib16","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1590\/S0004-282X1995000500008","article-title":"The value of CSF analysis for the differential diagnosis of HTLV-I associated myelopathy and multiple sclerosis","volume":"53","author":"Puccioni-Sohler","year":"1995","journal-title":"Arq Neuropsiquiatr"},{"key":"10.1016\/j.jns.2008.08.002_bib17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1084\/jem.163.1.41","article-title":"Temporal invariance and clonal uniformity of brain and cerebrospinal IgG, IgA, and IgM in multiple sclerosis","volume":"163","author":"Walsh","year":"1986","journal-title":"J Exp Med"},{"key":"10.1016\/j.jns.2008.08.002_bib18","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1600-0404.2006.00755.x","article-title":"Intrathecal polyspecific immune response to neurotropic viruses in multiple sclerosis: a comparative report from Cuban patients","volume":"115","author":"Robinson-Agramonte","year":"2007","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.jns.2008.08.002_bib19","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/ana.410320317","article-title":"Absence of measles, mumps, and rubella viral genomic sequences from multiple sclerosis brain tissue by polymerase chain reaction","volume":"32","author":"Godec","year":"1992","journal-title":"Ann Neurol"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X08003808?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X08003808?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T15:39:56Z","timestamp":1758382796000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X08003808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":19,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S0022510X08003808"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2008.08.002","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The intrathecal, polyspecific antiviral immune response: Specific for MS or a general marker of CNS autoimmunity?","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2008.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}