{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:39:16Z","timestamp":1792679956387,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1016\/j.jns.2009.02.370","type":"journal-article","created":{"date-parts":[[2009,3,18]],"date-time":"2009-03-18T08:43:02Z","timestamp":1237365782000},"page":"153-157","source":"Crossref","is-referenced-by-count":82,"title":["Dendritic pathology in Alzheimer's disease"],"prefix":"10.1016","volume":"283","author":[{"given":"S.J.","family":"Baloyannis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2009.02.370_bib1","first-page":"78","article-title":"Synaptic alterations in the molecular layer of the cerebellum in Alzheimer's disease","volume":"22","author":"Baloyannis","year":"1996","journal-title":"Neuropath Appl Neurobiol"},{"key":"10.1016\/j.jns.2009.02.370_bib2","first-page":"26","article-title":"Abnormal synapses in the granule cell layer of the cerebellum in Alzheimer's disease: a Golgi and electron microscope study","volume":"5","author":"Baloyannis","year":"1998","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.jns.2009.02.370_bib3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/ana.410140502","article-title":"Senile dementia of the Alzheimer type","volume":"14","author":"Terry","year":"1983","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jns.2009.02.370_bib4","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1097\/00005072-199655100-00001","article-title":"The pathogenesis of Alzheimer's disease: an alternative to the amyloid hypothesis","volume":"55","author":"Terry","year":"1996","journal-title":"J Neuropath Exp Neurol"},{"key":"10.1016\/j.jns.2009.02.370_bib5","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment","volume":"30","author":"Terry","year":"1991","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jns.2009.02.370_bib6","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/ana.410270502","article-title":"Synapse loss in frontal lobe biopsies in Alzheimer's disease: correlation with cognitive severity","volume":"27","author":"De Kosky","year":"1990","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jns.2009.02.370_bib7","first-page":"150","article-title":"Neocortical synapses in a presenile dementia","volume":"26","author":"Gonatas","year":"1967","journal-title":"J Neuropath exp Neurol"},{"key":"10.1016\/j.jns.2009.02.370_bib8","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1126\/science.1533953","article-title":"Mitochondrial genetics: a paradigm for aging and degenerative diseases?","volume":"256","author":"Wallace","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.jns.2009.02.370_bib9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0005-2728(98)00165-0","article-title":"Mitochondria involvement in Alzheimer's disease","volume":"1410","author":"Bonilla","year":"1999","journal-title":"Biochem Biophys Acta"},{"key":"10.1016\/j.jns.2009.02.370_bib10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/002383099300600101","article-title":"Brain oxidative energy and related metabolism, neuronal stress, and Alzheimer's disease: a speculative synthesis","volume":"6","author":"Hoyer","year":"1993","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"10.1016\/j.jns.2009.02.370_bib11","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0197-4580(00)83140-1","article-title":"Oxidative stress and mitochondrial alterations in Alzheimer's disease","volume":"21","author":"Baloyannis","year":"2000","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jns.2009.02.370_bib12","first-page":"10","article-title":"Mitochondrial alterations in neurons of various areas of the brain in Parkinson's disease: an electron microscopy study","volume":"7","author":"Baloyannis","year":"2001","journal-title":"Parkinson Rel Disord"},{"key":"10.1016\/j.jns.2009.02.370_bib13","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1126\/science.292.5517.624","article-title":"The mitochondrion: is it central to apoptosis?","volume":"292","author":"Finkel","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.jns.2009.02.370_bib14","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1126\/science.1060885","article-title":"Apoptosis: death of a monopoly?","volume":"292","author":"Hunot","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.jns.2009.02.370_bib15","first-page":"917","article-title":"Hollenbeck PJ","volume":"104","author":"Morris","year":"1993","journal-title":"The regulation of bidirectional mitochondrial transport is coordinated with axonal outgrowth. J Cell Sci"},{"key":"10.1016\/j.jns.2009.02.370_bib16","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2004.11.003","article-title":"The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses","volume":"119","author":"Zheng","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.jns.2009.02.370_bib17","first-page":"155","article-title":"The staining of nervous elements by the Bodian method I. The influence of factors preceding impregnation","volume":"s3-103","author":"Williams","year":"1962","journal-title":"Q J Microsc Sci"},{"key":"10.1016\/j.jns.2009.02.370_bib18","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1177\/002215540205000403","article-title":"Comparative analysis of an improved thioflavin-S stain, Gallyas silver stain, and immunohistochemistry for neurofibrillary tangle demonstration on the same sections","volume":"50","author":"Sun","year":"2002","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.jns.2009.02.370_bib19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/00207450701591115","article-title":"The combination of silver techniques for studying the pathology of Alzheimer's disease","volume":"118","author":"Tsamis","year":"2008","journal-title":"Int J Neurosci"},{"key":"10.1016\/j.jns.2009.02.370_bib20","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1369\/jhc.2008.950246","article-title":"A rapid method combining Golgi and Nissl staining to study neuronal morphology and cytoarchitecture","volume":"56","author":"Pilati","year":"2008","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.jns.2009.02.370_bib21_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2818.1989.tb04294.x","article-title":"On the structure of nerve cells","volume":"155","author":"Golgi","year":"1989","journal-title":"1898 J Microsc"},{"key":"10.1016\/j.jns.2009.02.370_bib21_2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological staging of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol (Berlin)"},{"key":"10.1016\/j.jns.2009.02.370_bib22_1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.7705\/biomedica.v26i4.315","article-title":"La technica de impregnacion argentica de Golgi. Conmemoracion del centenario de premio Nobel de Medicina (1906), Compartido por Camillo Golgi y Santiago Ramon y Cajal","volume":"26","author":"Torres-Fernandez","year":"2006","journal-title":"Biomedica"},{"key":"10.1016\/j.jns.2009.02.370_bib22_2","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/S0002-9440(10)63518-3","article-title":"Subiculum dendritic arborization in Alzheimer's disease correlates with neurofibrillary tangle density","volume":"163","author":"Falke","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jns.2009.02.370_bib23_1","first-page":"387","article-title":"Dendritic organization in the neurons of the visual and motor cortices on the cat","volume":"87","author":"Sholl","year":"1953","journal-title":"J Anat"},{"key":"10.1016\/j.jns.2009.02.370_bib23_2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/00016480601126986","article-title":"Dendritic and spinal pathology in the acoustic cortex in Alzheimer's disease: morphological and morphometric estimation by Golgi technique and electron microscopy","volume":"127","author":"Baloyannis","year":"2007","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.jns.2009.02.370_bib24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/00001756-200101220-00043","article-title":"Early loss of dendritic spines in murine scrapie revealed by confocal analysis","volume":"12","author":"Brown","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.jns.2009.02.370_bib25","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0304-3940(90)90420-E","article-title":"Neuronal alterations in patients with dementia: a Golgi study on biopsy samples","volume":"114","author":"Ferrer","year":"1990","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jns.2009.02.370_bib26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0304-3940(79)96076-2","article-title":"Experimental modification of cerebellar development in tissue culture: x-irradiation induces granular degeneration and unattached Purkinje cell dendritic spines","volume":"12","author":"Baloyannis","year":"1979","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jns.2009.02.370_bib27","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0736-5748(93)90079-S","article-title":"Reactive astroglia\u2013neuron relationships in the human cerebellar cortex: a quantitative, morphological and immunocytochemical study in Creutzfeldt Jakob disease","volume":"11","author":"Lafarga","year":"1993","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.jns.2009.02.370_bib28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0165-0173(02)00158-3","article-title":"Dendritic spine pathology: cause or consequence of neurological disorders","volume":"39","author":"Fiala","year":"2002","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.jns.2009.02.370_bib29","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0301-0082(98)00022-7","article-title":"Dendritic changes in Alzheimer's disease and factors that may underlie these changes","volume":"55","author":"Anderton","year":"1998","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.jns.2009.02.370_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.104.2.e21","article-title":"Dendritic spine pathology in infants with severe protein-calorie malnutrition","volume":"104","author":"Ben\u00edtez-Bribiesca","year":"1999","journal-title":"Pediatrics"},{"key":"10.1016\/j.jns.2009.02.370_bib31","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/jnen\/60.8.759","article-title":"Oxidative damage is the earliest event in Alzheimer's disease","volume":"60","author":"Nunomura","year":"2001","journal-title":"J Neuropath exp Neurol"},{"key":"10.1016\/j.jns.2009.02.370_bib32","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1016\/S0024-3205(01)01074-8","article-title":"The reduction of NADH-ubiquinol oxidoredyctase 24- and 75\u00a0kDa subunit in brain of patients with Down syndrome and Alzheimer's disease","volume":"68","author":"Kim","year":"2000","journal-title":"Life Sciences"},{"key":"10.1016\/j.jns.2009.02.370_bib33","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1177\/153331750401900205","article-title":"Mitochondrial alterations in Alzheimer's disease","volume":"19","author":"Baloyannis","year":"2004","journal-title":"Am J Alzheimer's Dis"},{"key":"10.1016\/j.jns.2009.02.370_bib34","doi-asserted-by":"crossref","first-page":"9046","DOI":"10.1523\/JNEUROSCI.23-27-09046.2003","article-title":"Mechanisms of mitochondria\u2013neurofilament interactions","volume":"23","author":"Lifshitz","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.jns.2009.02.370_bib35","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1083\/jcb.200207030","article-title":"Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells","volume":"161","author":"Anandatheerthavarada","year":"2003","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jns.2009.02.370_bib36","first-page":"160","article-title":"The mossy fibers of the cerebellar cortex in Alzheimer's disease. An electron microscopy study","volume":"2","author":"Baloyannis","year":"1997","journal-title":"Neurosc"},{"key":"10.1016\/j.jns.2009.02.370_bib37","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3233\/JAD-2006-9204","article-title":"Mitochondrial alteration in Alzheimer's disease","volume":"9","author":"Baloyannis","year":"2006","journal-title":"J Alzh Dis"},{"key":"10.1016\/j.jns.2009.02.370_bib38","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/nbdi.1996.0022","article-title":"Rapid alterations in dendritic morphology during sublethal hypoxic glutamate activation","volume":"3","author":"Park","year":"1996","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jns.2009.02.370_bib39","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/BF00453489","article-title":"Synaptic alterations in the acoustic cortex of the rat following insulin-induced hypoglycemia","volume":"244","author":"Baloyannis","year":"1987","journal-title":"Arch Otorhinolaryng"},{"key":"10.1016\/j.jns.2009.02.370_bib40","first-page":"5440","article-title":"d-\u03b2-Hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease","volume":"97","author":"Kashiwaya","year":"1999","journal-title":"Med Sci"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X09004298?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X09004298?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T22:05:35Z","timestamp":1558217135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X09004298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":43,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["S0022510X09004298"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2009.02.370","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]}}}