{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:37:00Z","timestamp":1791225420419,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS039422"],"award-info":[{"award-number":["R01 NS039422"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS042859"],"award-info":[{"award-number":["R01 NS042859"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008061","name":"Fundaci\u00f3n Mutua Madrile\u00f1a","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.jns.2009.08.037","type":"journal-article","created":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T04:25:16Z","timestamp":1251779116000},"page":"138-142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":133,"title":["Brain structural changes in essential tremor: Voxel-based morphometry at 3-Tesla"],"prefix":"10.1016","volume":"287","author":[{"given":"Juli\u00e1n","family":"Benito-Le\u00f3n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Alvarez-Linera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Antonio","family":"Hern\u00e1ndez-Tamames","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hortensia","family":"Alonso-Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix Javier","family":"Jim\u00e9nez-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elan D.","family":"Louis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2009.08.037_bib1","doi-asserted-by":"crossref","unstructured":"Benito-Le\u00f3n J, Bermejo-Pareja F, Morales JM, Vega S, Molina JA. Prevalence of essential tremor in three elderly populations of central Spain. Mov Disord 2003;18:389\u201394.","DOI":"10.1002\/mds.10376"},{"key":"10.1016\/j.jns.2009.08.037_bib2","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1212\/01.WNL.0000161852.70374.01","article-title":"Incidence of essential tremor in three elderly populations of central Spain","volume":"64","author":"Benito-Le\u00f3n","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2009.08.037_bib3","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/ncpneuro0347","article-title":"Essential tremor: emerging views of a common disorder","volume":"2","author":"Benito-Le\u00f3n","year":"2006","journal-title":"Nat Clin Pract Neurol"},{"key":"10.1016\/j.jns.2009.08.037_bib4","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/S0140-6736(07)60544-3","article-title":"Clinical update: diagnosis and treatment of essential tremor","volume":"369","author":"Benito-Le\u00f3n","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.jns.2009.08.037_bib5","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/mds.21731","article-title":"The emerging neuropathology of essential tremor","volume":"23","author":"Louis","year":"2007","journal-title":"Mov Disord"},{"key":"10.1016\/j.jns.2009.08.037_bib6","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1093\/brain\/awm266","article-title":"Neuropathological changes in essential tremor: 33 cases compared with 21 controls","volume":"130","author":"Louis","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.jns.2009.08.037_bib7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1001\/archneurol.2007.8","article-title":"Reduced Purkinje cell number in essential tremor: a postmortem study","volume":"65","author":"Axelrad","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jns.2009.08.037_bib8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/nimg.2001.0786","article-title":"A voxel-based morphometric study of ageing in 465 normal adult human brains","volume":"14","author":"Good","year":"2001","journal-title":"NeuroImage"},{"key":"10.1016\/j.jns.2009.08.037_bib9","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1212\/01.wnl.0000240130.94408.99","article-title":"Voxel-based morphometry shows no decreases in cerebellar gray matter volume in essential tremor","volume":"67","author":"Daniels","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2009.08.037_bib10","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.3174\/ajnr.A1190","article-title":"Essential head tremor is associated with cerebellar vermis atrophy: a volumetric and voxel-based morphometry MR imaging study","volume":"29","author":"Quattrone","year":"2008","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.jns.2009.08.037_bib11","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1552-6569.2008.00263.x","article-title":"Predicting the histopathological grade of cerebral gliomas using high b value MR DW imaging at 3-Tesla","volume":"18","author":"Alvarez-Linera","year":"2008","journal-title":"J Neuroimaging"},{"key":"10.1016\/j.jns.2009.08.037_bib12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ejrad.2007.11.006","article-title":"Clinical advantages of 3.0T MRI over 1.5T","volume":"65","author":"Willinek","year":"2008","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.jns.2009.08.037_bib13","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1046\/j.1528-1157.2001.0420081021.x","article-title":"Comparison of hippocampal volumetry at 1.5Tesla and at 3Tesla","volume":"42","author":"Briellmann","year":"2001","journal-title":"Epilepsia"},{"key":"10.1016\/j.jns.2009.08.037_bib14","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/ana.1022","article-title":"Risk of tremor and impairment from relatives of patients with essential tremor: a community-based family study","volume":"49","author":"Louis","year":"2001","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jns.2009.08.037_bib15","series-title":"DSM-IV. Diagnostic and Statistical Manual of Mental Disorders","year":"1994"},{"key":"10.1016\/j.jns.2009.08.037_bib16","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1006\/nimg.2000.0582","article-title":"Voxel-based morphometry\u2014the methods","volume":"11","author":"Ashburner","year":"2000","journal-title":"NeuroImage"},{"key":"10.1016\/j.jns.2009.08.037_bib17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1006\/nimg.2002.1202","article-title":"Automatic differentiation of anatomical patterns in the human brain: validation with studies of degenerative dementias","volume":"17","author":"Good","year":"2002","journal-title":"Neuroimage"},{"key":"10.1016\/j.jns.2009.08.037_bib18","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1006\/nimg.1995.1032","article-title":"A voxel-based method for the statistical analysis of gray and white matter density applied to schizophrenia","volume":"2","author":"Wright","year":"1995","journal-title":"Neuroimage"},{"key":"10.1016\/j.jns.2009.08.037_bib19","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8","article-title":"Automated Talairach atlas labels for functional brain mapping","volume":"10","author":"Lancaster","year":"2000","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.jns.2009.08.037_bib20","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/ana.410360413","article-title":"Red nuclear and cerebellar but no olivary activation associated with essential tremor: a positron emission tomographic study","volume":"36","author":"Wills","year":"1994","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jns.2009.08.037_bib21","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1212\/01.WNL.0000065885.15875.0D","article-title":"Evaluation of essential tremor with multi-voxel magnetic resonance spectroscopy","volume":"60","author":"Pagan","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2009.08.037_bib22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0304-3940(02)00966-7","article-title":"Metabolic abnormality in the cerebellum in patients with essential tremor: a proton magnetic resonance spectroscopic imaging study","volume":"333","author":"Louis","year":"2002","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jns.2009.08.037_bib23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/ana.410410108","article-title":"Activation mapping in essential tremor with functional magnetic resonance imaging","volume":"41","author":"Bucher","year":"1997","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jns.2009.08.037_bib24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3174\/ajnr.A0744","article-title":"Diffusion tensor imaging in patients with essential tremor","volume":"29","author":"Shin","year":"2008","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.jns.2009.08.037_bib25","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.eurpsy.2007.02.006","article-title":"Insular cortex and neuropsychiatric disorders: a review of recent literature","volume":"22","author":"Nagai","year":"2007","journal-title":"Eur Psychiatr"},{"key":"10.1016\/j.jns.2009.08.037_bib26","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0165-0173(96)00011-2","article-title":"Circuitry and functional aspects of the insular lobe in primates including humans","volume":"22","author":"Augustine","year":"1996","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1016\/j.jns.2009.08.037_bib27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1212\/01.wnl.0000192393.05850.ec","article-title":"Population-based case\u2013control study of cognitive function in essential tremor","volume":"66","author":"Benito-Le\u00f3n","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2009.08.037_bib28","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1212\/01.wnl.0000216134.88617.de","article-title":"Elderly-onset essential tremor is associated with dementia","volume":"66","author":"Benito-Le\u00f3n","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2009.08.037_bib29","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1002\/mds.21553","article-title":"Risk of incident dementia in essential tremor: a population-based study","volume":"22","author":"Bermejo-Pareja","year":"2007","journal-title":"Mov Disord"},{"key":"10.1016\/j.jns.2009.08.037_bib30","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1111\/j.1468-1331.2007.01923.x","article-title":"Self-reported depression and anti-depressant medication use in essential tremor: cross-sectional and prospective analyses in a population-based study","volume":"14","author":"Louis","year":"2007","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.jns.2009.08.037_bib31","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1002\/mds.22124","article-title":"Philadelphia Geriatric Morale Scale in essential tremor: a population-based study in three Spanish communities","volume":"23","author":"Louis","year":"2008","journal-title":"Mov Disord"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X09007606?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X09007606?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T15:39:28Z","timestamp":1758382768000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X09007606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":31,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0022510X09007606"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2009.08.037","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain structural changes in essential tremor: Voxel-based morphometry at 3-Tesla","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2009.08.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier B.V. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}