{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T23:01:25Z","timestamp":1788735685539,"version":"build-2803163510"},"reference-count":15,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Nature Science Foundation of China","award":["30730096"],"award-info":[{"award-number":["30730096"]}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program","doi-asserted-by":"crossref","award":["2007CB94790"],"award-info":[{"award-number":["2007CB94790"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Chinese Science & Technology Commission","award":["2007AA02Z460"],"award-info":[{"award-number":["2007AA02Z460"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.jns.2010.02.024","type":"journal-article","created":{"date-parts":[[2010,3,25]],"date-time":"2010-03-25T06:09:50Z","timestamp":1269497390000},"page":"102-105","source":"Crossref","is-referenced-by-count":28,"title":["Decreased level of 5-methyltetrahydrofolate: A potential biomarker for pre-symptomatic amyotrophic lateral sclerosis"],"prefix":"10.1016","volume":"293","author":[{"given":"X.","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jns.2010.02.024_bib1","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1517\/13543784.16.8.1197","article-title":"Current clinical trials in amyotrophic lateral sclerosis","volume":"16","author":"Bhatt","year":"2007","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.jns.2010.02.024_bib2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/14660820050515692","article-title":"Immunosuppression and anti-inflammatory agents in ALS","volume":"4","author":"Smith","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"issue":"9","key":"10.1016\/j.jns.2010.02.024_bib3","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nrn1971","article-title":"Molecular biology of amyotrophic lateral sclerosis: insights from genetics","volume":"7","author":"Pasinelli","year":"2006","journal-title":"Nat Rev Neurosci"},{"issue":"7","key":"10.1016\/j.jns.2010.02.024_bib4","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.neuropharm.2008.02.020","article-title":"Folic acid protects motor neurons against the increased homocysteine, inflammation and apoptosis in SOD1 G93A transgenic mice","volume":"54","author":"Zhang","year":"2008","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.jns.2010.02.024_bib5","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1212\/01.wnl.0000297193.53986.6f","article-title":"Elevated plasma homocysteine levels in patients with amyotrophic lateral sclerosis","volume":"70","author":"Zoccolella","year":"2008","journal-title":"Neurology"},{"issue":"22","key":"10.1016\/j.jns.2010.02.024_bib6","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.1021\/ac010741y","article-title":"Determination of folates in human plasma using hydrophilic interaction chromatography\u2013tandem mass spectrometry","volume":"73","author":"Garbis","year":"2001","journal-title":"Anal Chem"},{"issue":"4","key":"10.1016\/j.jns.2010.02.024_bib7","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nm1021","article-title":"Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice","volume":"10","author":"Kieran","year":"2004","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.jns.2010.02.024_bib8","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1179\/016164103101201193","article-title":"Glial cell line-derived neurotrophic factor protein prevents motor neuron loss of transgenic model mice for amyotrophic lateral sclerosis","volume":"25","author":"Manabe","year":"2003","journal-title":"Neurol Res"},{"issue":"1\u20132","key":"10.1016\/j.jns.2010.02.024_bib9","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0006-8993(98)01351-1","article-title":"Selective impairment of fast anterograde axonal transport in the peripheral nerves of asymptomatic transgenic mice with a G93A mutant SOD1 gene","volume":"819","author":"Warita","year":"1999","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.jns.2010.02.024_bib10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0047-6374(01)00365-7","article-title":"Folic acid and homocysteine in age-related disease","volume":"1","author":"Mattson","year":"2002","journal-title":"Ageing Res Rev"},{"issue":"6","key":"10.1016\/j.jns.2010.02.024_bib11","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.pediatrneurol.2007.09.001","article-title":"Folate-responsive neurologic diseases","volume":"37","author":"Djukic","year":"2007","journal-title":"Pediatric Neurol"},{"issue":"1","key":"10.1016\/j.jns.2010.02.024_bib12","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0969-9961(03)00070-6","article-title":"Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine","volume":"14","author":"Ho","year":"2003","journal-title":"Neurobiol Dis"},{"issue":"1","key":"10.1016\/j.jns.2010.02.024_bib13","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/cne.21160","article-title":"Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death","volume":"500","author":"Martin","year":"2007","journal-title":"J Comp Neurol"},{"issue":"1","key":"10.1016\/j.jns.2010.02.024_bib14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0021-9150(99)00036-2","article-title":"Hyperhomocysteinemia in high-aged subjects: relation of B-vitamins, folic acid, renal function and the methyleneterahydrofolate reductase mutation","volume":"144","author":"Herrmann","year":"1999","journal-title":"Atherosclerosis"},{"issue":"15","key":"10.1016\/j.jns.2010.02.024_bib15","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1016\/j.lfs.2005.02.014","article-title":"Increase of total homocysteine concentration in cerebrospinal fluid in patients with Alzheimer's disease and Parkinson's disease","volume":"77","author":"Isobe","year":"2005","journal-title":"Life Sci"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X10001000?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X10001000?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T19:12:13Z","timestamp":1588792333000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X10001000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":15,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0022510X10001000"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2010.02.024","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}