{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:40:25Z","timestamp":1758476425408},"reference-count":45,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.jns.2010.08.031","type":"journal-article","created":{"date-parts":[[2010,9,23]],"date-time":"2010-09-23T00:46:08Z","timestamp":1285202768000},"page":"11-14","source":"Crossref","is-referenced-by-count":6,"title":["New development in diagnosis of vascular cognitive impairment"],"prefix":"10.1016","volume":"299","author":[{"given":"Margherita","family":"Cavalieri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhold","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jns.2010.08.031_bb0005","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/WNL.43.2.250","article-title":"Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop","volume":"43","author":"Roman","year":"1993","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.jns.2010.08.031_bb0010","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.jns.2010.08.031_bb0015","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/jama.277.10.813","article-title":"Brain infarction and the clinical expression of Alzheimer disease. The Nun Study","volume":"277","author":"Snowdon","year":"1997","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.jns.2010.08.031_bb0020","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1532-5415.1998.tb01076.x","article-title":"Absence of vascular dementia in an autopsy series from a dementia clinic","volume":"46","author":"Nolan","year":"1998","journal-title":"J Am Geriatr Soc"},{"issue":"suppl2","key":"10.1016\/j.jns.2010.08.031_bb0025","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1159\/000049150","article-title":"Small vessel disease and Alzheimer's dementia : pathological considerations","volume":"13","author":"Kalaria","year":"2002","journal-title":"Cerebrovasc Dis"},{"issue":"9251","key":"10.1016\/j.jns.2010.08.031_bb0030","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0140-6736(00)03589-3","article-title":"Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales","volume":"357","author":"Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.jns.2010.08.031_bb0035","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1212\/WNL.43.10.2159-a","article-title":"Vascular dementia","volume":"43","author":"Hachinski","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2010.08.031_bb0040","series-title":"Vascular cognitive impairment in clinical practice","author":"Wahlund","year":"2009"},{"key":"10.1016\/j.jns.2010.08.031_bb0045","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/bmb\/ldm021","article-title":"Modern concept of vascular cognitive impairment","volume":"83","author":"Bowler","year":"2007","journal-title":"Br Med Bull"},{"key":"10.1016\/j.jns.2010.08.031_bb0050","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1161\/01.STR.19.10.1285","article-title":"White matter signal abnormalities in normal individuals: correlation with carotid ultrasonography, cerebral flow measurements, and cerebrovascular risk factors","volume":"19","author":"Fazekas","year":"1988","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2010.08.031_bb0055","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/brain\/awf077","article-title":"Hypertension and cerebral white matter lesion in a prospective cohort study","volume":"125","author":"de Leeuw","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.jns.2010.08.031_bb0060","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1161\/01.STR.0000135226.53499.85","article-title":"Stroke risk profile predicts white matter hyperintensity volume: the Framingham Study","volume":"35","author":"Jeerakathil","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2010.08.031_bb0065","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1212\/WNL.43.9.1683","article-title":"Pathologic correlates of incidental MRI white matter signal hyperintensities","volume":"43","author":"Fazekas","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2010.08.031_bb0070","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/BF00612126","article-title":"MRI and pathological examination of post-mortem brains: the problem of white matter high signal areas","volume":"36","author":"Scarpelli","year":"1994","journal-title":"Neuroradiology"},{"key":"10.1016\/j.jns.2010.08.031_bb0075","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1212\/WNL.45.5.883","article-title":"Histopathologic correlates of white matter changes on MRI in Alzheimer's disease and normal aging","volume":"45","author":"Scheltens","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2010.08.031_bb0080","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1212\/WNL.57.6.990","article-title":"A prospective study of cerebral white matter abnormalities in older people with gait dysfunction","volume":"57","author":"Whitman","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2010.08.031_bb0085","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00234-008-0489-0","article-title":"Longitudinal follow-up of individual white matter hyperintensities in a large cohort of elderly","volume":"51","author":"Maillard","year":"2009","journal-title":"Neuroradiology"},{"key":"10.1016\/j.jns.2010.08.031_bb0090","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1161\/STROKEAHA.107.498535","article-title":"Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period. The Leukoaraiosis and Disability Study","volume":"39","author":"Gouw","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2010.08.031_bb0095","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1161\/01.STR.0000149625.99732.69","article-title":"Incidence, manifestations, and predictors of worsening white matter on serial cranial magnetic resonance imaging in the elderly. The Cardiovascular Health Study","volume":"36","author":"Longstreth","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2010.08.031_bb0100","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/S0140-6736(00)02604-0","article-title":"Relation between age-related decline in intelligence and cerebral white-matter hyperintensities in healthy octogenarians: a longitudinal study","volume":"356","author":"Garde","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jns.2010.08.031_bb0105","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1136\/jnnp.2005.070193","article-title":"Increase in periventricular white matter hyperintensities parallels decline in mental processing speed in a non-demented elderly population","volume":"77","author":"van den Heuvel","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"10.1016\/j.jns.2010.08.031_bb0110","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1037\/0894-4105.21.4.412","article-title":"Longitudinal MRI and cognitive change in healthy elderly","volume":"21","author":"Kramer","year":"2007","journal-title":"Neuropsychology"},{"key":"10.1016\/j.jns.2010.08.031_bb0115","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/ana.20630","article-title":"White matter lesion progression, brain atrophy, and cognitive decline: the Austrian Stroke Prevention Study","volume":"58","author":"Schmidt","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jns.2010.08.031_bb0120","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1161\/STROKEAHA.107.513176","article-title":"Progression of cerebral small vessel disease in relation to risk factors and cognitive consequences. Rotterdam Scan Study","volume":"39","author":"van Dijk","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2010.08.031_bb0125","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1212\/01.wnl.0000316799.86917.37","article-title":"Impact of white matter hyperintensitiey volume progression on rate of cognitive and motor decline","volume":"71","author":"Silbert","year":"2008","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.jns.2010.08.031_bb0130","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1001\/archneur.61.10.1531","article-title":"Cerebral white matter lesions and the risk of dementia","volume":"61","author":"Prins","year":"2004","journal-title":"Arch Neurol"},{"issue":"1","key":"10.1016\/j.jns.2010.08.031_bb0135","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1001\/archneurol.2007.23","article-title":"Magnetic resonance imaging white matter hyperintensities and brain volume in prediction of mild cognitive impairment and dementia","volume":"65","author":"Smith","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jns.2010.08.031_bb0140","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1007\/s00415-008-0874-y","article-title":"Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia","volume":"255","author":"van Straaten ECW","year":"2008","journal-title":"J Neurol"},{"key":"10.1016\/j.jns.2010.08.031_bb0145","doi-asserted-by":"crossref","first-page":"b2477","DOI":"10.1136\/bmj.b2477","article-title":"Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort","volume":"339","author":"Inzitari","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.jns.2010.08.031_bb0150","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1474-4422(07)70170-9","article-title":"Silent brain infarcts: a systematic review","volume":"6","author":"Vermeer","year":"2007","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jns.2010.08.031_bb0155","first-page":"1683","article-title":"Lacunes: small, deep cerebral infarcts","volume":"43","author":"Fisher","year":"1965","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2010.08.031_bb0160","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1161\/01.STR.0000032241.58727.49","article-title":"Incidence, manifestations, and predictors of brain infarcts defined by serial cranial magnetic resonance imaging in the elderly. The Cardiovascular Health Study","volume":"33","author":"Longstreth","year":"2002","journal-title":"Stroke"},{"issue":"14","key":"10.1016\/j.jns.2010.08.031_bb0165","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1212\/01.wnl.0000307750.41970.d9","article-title":"Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study","volume":"70","author":"Vernooij","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2010.08.031_bb0170","first-page":"637","article-title":"Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds","volume":"20","author":"Fazekas","year":"1999","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/j.jns.2010.08.031_bb0175","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1161\/01.STR.30.8.1637","article-title":"Small chronic hemorrhages and ischemic lesions in association with spontaneous intracerebral hematomas","volume":"30","author":"Tanaka","year":"1999","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2010.08.031_bb0180","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1093\/brain\/awh253","article-title":"Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI","volume":"127","author":"Werring","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.jns.2010.08.031_bb0185","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1212\/01.wnl.0000339038.65508.96","article-title":"MRI correlates of cognitive decline in CADASIL. A 7-year follow-up study","volume":"72","author":"Liem","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2010.08.031_bb0190","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1212\/01.wnl.0000216271.96364.50","article-title":"Brain volume changes in CADASIL: a serial MRI study in pure subcortical ischemic vascular disease","volume":"66","author":"Peters","year":"2006","journal-title":"Neurology"},{"issue":"20","key":"10.1016\/j.jns.2010.08.031_bb0195","doi-asserted-by":"crossref","first-page":"11050","DOI":"10.1073\/pnas.200033797","article-title":"Measuring the thickness of the human cerebral cortex from magnetic resonance images","volume":"97","author":"Fischl","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jns.2010.08.031_bb0200","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1161\/01.STR.0000189696.70989.a4","article-title":"Diffusion magnetic resonance histograms as a surrogate marker and predictor of disease progression in CADASIL. A two-year follow-up study","volume":"36","author":"Holtmannspotter","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2010.08.031_bb0205","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1136\/jnnp.2003.014910","article-title":"Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis","volume":"75","author":"O'Sullivan","year":"2004","journal-title":"J Neurol Neurosurg Neuropsychiatry"},{"key":"10.1016\/j.jns.2010.08.031_bb0210","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1159\/000087930","article-title":"Cognitive correlates of cerebral white matter lesions and water diffusion tensor parameters in community-dwelling older people","volume":"20","author":"Shenkin","year":"2005","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.jns.2010.08.031_bb0215","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.3174\/ajnr.A0555","article-title":"Whole-brain histogram and voxel-based analysis of diffusion tensor imaging in patients with leukoaraiosis: correlation with motor and cognitive impairment","volume":"28","author":"Della Nave","year":"2007","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.jns.2010.08.031_bb0220","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1001\/archgenpsychiatry.2009.5","article-title":"White matter microstructural integrity and cognitive function in a general elderly population","volume":"66","author":"Vernooij","year":"2009","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.jns.2010.08.031_bb0225","doi-asserted-by":"crossref","unstructured":"Schmidt R, Ropele S, Ferro J, Madureira S, Verdelho A, Petrovic K, Gouw A, van der Flier WM, Enzinger C, Pantoni L, Inzitari D, Erkinjuntti T, Scheltens P, Wahlund LO, Waldemar G, Rostrup E, Wallin A, Barkhof F, Fazekas F; on behalf of the LADIS study group. Diffusion-weighted imaging and cognition in the leukoariosis and disability in the elderly study. Stroke. 2010 Mar 4. [Epub ahead of print].","DOI":"10.1161\/STROKEAHA.109.576629"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X10003989?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X10003989?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T21:01:13Z","timestamp":1559682073000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X10003989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":45,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0022510X10003989"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2010.08.031","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}