{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:50:59Z","timestamp":1779335459190,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.jns.2011.06.048","type":"journal-article","created":{"date-parts":[[2011,7,23]],"date-time":"2011-07-23T22:21:42Z","timestamp":1311459702000},"page":"90-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Dopamine-depletion and increased \u03b1-synuclein load induce degeneration of cortical cholinergic fibers in mice"],"prefix":"10.1016","volume":"310","author":[{"given":"\u00c9va M.","family":"Szeg\u0151","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Gerhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago F.","family":"Outeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawel","family":"Kermer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jns.2011.06.048_bb0005","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1001\/archneurol.2008.561","article-title":"Overview of the extranigral aspects of Parkinson disease","volume":"66","author":"Lim","year":"2009","journal-title":"Arch Neurol"},{"issue":"6","key":"10.1016\/j.jns.2011.06.048_bb0010","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0896-6273(03)00568-3","article-title":"Parkinson's disease: mechanisms and models","volume":"39","author":"Dauer","year":"2003","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.jns.2011.06.048_bb0015","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1001\/archneur.60.3.387","article-title":"Prevalence and characteristics of dementia in Parkinson disease \u2014 an 8-year prospective study","volume":"60","author":"Aarsland","year":"2003","journal-title":"Arch Neurol"},{"issue":"5\u20136","key":"10.1016\/j.jns.2011.06.048_bb0020","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s007020050176","article-title":"Dementia with Lewy bodies: choline acetyltransferase parallels nucleus basalis pathology","volume":"106","author":"Lippa","year":"1999","journal-title":"J Neural Transm"},{"issue":"2","key":"10.1016\/j.jns.2011.06.048_bb0025","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson's disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol Aging"},{"issue":"6","key":"10.1016\/j.jns.2011.06.048_bb0030","article-title":"Cholinergic denervation is associated with more severe depression in Parkinson's disease","volume":"64","author":"Bohnen","year":"2005","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.jns.2011.06.048_bb0035","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s004019900168","article-title":"Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease","volume":"100","author":"Mattila","year":"2000","journal-title":"Acta Neuropathol"},{"issue":"6","key":"10.1016\/j.jns.2011.06.048_bb0040","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1007\/s004010050843","article-title":"Cortical Lewy bodies and Alzheimer-type changes in patients with Parkinson's disease","volume":"95","author":"Mattila","year":"1998","journal-title":"Acta Neuropathol"},{"issue":"10","key":"10.1016\/j.jns.2011.06.048_bb0045","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1212\/WNL.54.10.1916","article-title":"Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease","volume":"54","author":"Hurtig","year":"2000","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.jns.2011.06.048_bb0050","first-page":"S27","article-title":"Clues to how alpha-synuclein damages neurons in Parkinson's disease","volume":"25","author":"Sulzer","year":"2010","journal-title":"Mov Disord"},{"issue":"44","key":"10.1016\/j.jns.2011.06.048_bb0055","doi-asserted-by":"crossref","first-page":"34328","DOI":"10.1074\/jbc.M004345200","article-title":"Alpha-synuclein membrane interactions and lipid specificity","volume":"275","author":"Jo","year":"2000","journal-title":"J Biol Chem"},{"issue":"1\u20132","key":"10.1016\/j.jns.2011.06.048_bb0060","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jns.2009.08.015","article-title":"Are genetic and sporadic Parkinson's disease patients equally susceptible to develop dementia?","volume":"289","author":"Inzelberg","year":"2010","journal-title":"J Neurol Sci"},{"issue":"3","key":"10.1016\/j.jns.2011.06.048_bb0065","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1212\/01.wnl.0000299387.59159.db","article-title":"Clinicopathologic study of a SNCA gene duplication patient with Parkinson disease and dementia","volume":"70","author":"Obi","year":"2008","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.jns.2011.06.048_bb0070","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neulet.2008.11.065","article-title":"Effects of endurance exercise on ventral tegmental area neurons in the chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and probenecid-treated mice","volume":"450","author":"Ahmad","year":"2009","journal-title":"Neurosci Lett"},{"issue":"3","key":"10.1016\/j.jns.2011.06.048_bb0075","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/1055-8330(95)90015-2","article-title":"Time-course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine","volume":"4","author":"Jacksonlewis","year":"1995","journal-title":"Neurodegeneration"},{"issue":"5","key":"10.1016\/j.jns.2011.06.048_bb0080","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ijdevneu.2009.05.004","article-title":"Dopaminergic signals in primary motor cortex","volume":"27","author":"Luft","year":"2009","journal-title":"Int J Dev Neurosci"},{"issue":"5","key":"10.1016\/j.jns.2011.06.048_bb0085","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.neuron.2005.05.002","article-title":"The hippocampal-VTA loop: controlling the entry of information into long-term memory","volume":"46","author":"Lisman","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.jns.2011.06.048_bb0090","first-page":"21","article-title":"Confocal Analysis of Cholinergic and Dopaminergic Inputs onto Pyramidal Cells in the Prefrontal Cortex of Rodents","volume":"4","author":"Zhang","year":"2010","journal-title":"Front Neuroanat"},{"issue":"2","key":"10.1016\/j.jns.2011.06.048_bb0095","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0006-8993(90)90701-C","article-title":"Dopaminergic modulation of cholinergic responses in rat medial prefrontal cortex \u2014 an electrophysiological study","volume":"524","author":"Yang","year":"1990","journal-title":"Brain Res"},{"key":"10.1016\/j.jns.2011.06.048_bb0100","first-page":"112","article-title":"Accumulation of detergent-insoluble alpha-synuclein in Lewy body diseases and transgenic mice","volume":"78","author":"Kahle","year":"2001","journal-title":"J Neurochem"},{"issue":"17","key":"10.1016\/j.jns.2011.06.048_bb0105","doi-asserted-by":"crossref","first-page":"6365","DOI":"10.1523\/JNEUROSCI.20-17-06365.2000","article-title":"Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha-synuclein in human and transgenic mouse brain","volume":"20","author":"Kahle","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.jns.2011.06.048_bb0110","series-title":"Maps and Guide to Microdissection of the Rat Brain","author":"Palkovits","year":"1988"},{"issue":"50","key":"10.1016\/j.jns.2011.06.048_bb0115","doi-asserted-by":"crossref","first-page":"20049","DOI":"10.1073\/pnas.0706177104","article-title":"RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals","volume":"104","author":"Kowsky","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"issue":"15","key":"10.1016\/j.jns.2011.06.048_bb0120","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.1523\/JNEUROSCI.0222-06.2006","article-title":"Estrogen induces estrogen receptor alpha-dependent cAMP response element-binding protein phosphorylation via mitogen activated protein kinase pathway in basal forebrain cholinergic neurons in vivo","volume":"26","author":"Szego","year":"2006","journal-title":"J Neurosci"},{"issue":"2","key":"10.1016\/j.jns.2011.06.048_bb0125","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1177\/33.2.2578498","article-title":"A modified histochemical technique to visualize acetylcholinesterase-containing axons","volume":"33","author":"Hedreen","year":"1985","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.jns.2011.06.048_bb0130","article-title":"Effects of estrogen on beta-Amyloid-induced cholinergic cell death in the nucleus basalis magnocellularis","author":"Szego","year":"2010","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.jns.2011.06.048_bb0135","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2001"},{"issue":"4","key":"10.1016\/j.jns.2011.06.048_bb0140","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1046\/j.1471-4159.2001.00366.x","article-title":"Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice","volume":"77","author":"Rathke-Hartlieb","year":"2001","journal-title":"J Neurochem"},{"issue":"2","key":"10.1016\/j.jns.2011.06.048_bb0145","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000321119","article-title":"Effects of estrogen on beta-amyloid-induced cholinergic cell death in the nucleus basalis magnocellularis","volume":"93","author":"Szeg\u0151","year":"2010","journal-title":"Neuroendocrinology"},{"issue":"2","key":"10.1016\/j.jns.2011.06.048_bb0150","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1006\/nlme.1996.3757","article-title":"The nucleus basalis magnocellularis cholinergic system: one hundred years of progress","volume":"67","author":"Wenk","year":"1997","journal-title":"Neurobiol Learn Mem"},{"issue":"12","key":"10.1016\/j.jns.2011.06.048_bb0155","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.tins.2010.09.004","article-title":"Alpha-synuclein and dopamine at the crossroads of Parkinson's disease","volume":"33","author":"Venda","year":"2004","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.jns.2011.06.048_bb0160","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1196\/annals.1332.016","article-title":"The role of alpha-synuclein in both neuroprotection and neurodegeneration","volume":"1035","author":"Sidhu","year":"2004","journal-title":"Ann N Y Acad Sci"},{"issue":"7","key":"10.1016\/j.jns.2011.06.048_bb0165","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1002\/mds.23043","article-title":"Two Parkinson's disease patients with alpha-synuclein gene duplication and rapid cognitive decline","volume":"25","author":"Shin","year":"2010","journal-title":"Mov Disord"},{"issue":"14","key":"10.1016\/j.jns.2011.06.048_bb0170","doi-asserted-by":"crossref","first-page":"5782","DOI":"10.1523\/JNEUROSCI.19-14-05782.1999","article-title":"Alpha-synuclein shares physical and functional homology with 14-3-3 proteins","volume":"19","author":"Ostrerova","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.jns.2011.06.048_bb0175","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.33549\/physiolres.931598","article-title":"14-3-3 proteins: a family of versatile molecular regulators","volume":"57","author":"Obsilova","year":"2008","journal-title":"Physiol Res"},{"issue":"30","key":"10.1016\/j.jns.2011.06.048_bb0180","doi-asserted-by":"crossref","first-page":"28281","DOI":"10.1074\/jbc.M011549200","article-title":"The chaperone protein 14-3-3 eta interacts with the nicotinic acetylcholine receptor alpha 4 subunit \u2014 evidence for a dynamic role in subunit stabilization","volume":"276","author":"Jeanclos","year":"2001","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.jns.2011.06.048_bb0185","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nn.2322","article-title":"Regulation of acetylcholine receptor clustering by ADF\/cofilin-directed vesicular trafficking","volume":"12","author":"Lee","year":"2009","journal-title":"Nat Neurosci"},{"issue":"1","key":"10.1016\/j.jns.2011.06.048_bb0190","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1038\/cddis.2009.4","article-title":"Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease","volume":"1","author":"Yacoubian","year":"2010","journal-title":"Cell Death Dis"},{"issue":"4","key":"10.1016\/j.jns.2011.06.048_bb0195","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0301-0082(98)00059-8","article-title":"Distribution and retrograde transport of trophic factors in the central nervous system: functional implications for the treatment of neurodegenerative diseases","volume":"57","author":"Mufson","year":"1999","journal-title":"Prog Neurobiol"},{"issue":"10","key":"10.1016\/j.jns.2011.06.048_bb0200","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1023\/A:1020952704398","article-title":"Gene expression profiles of cholinergic nucleus basalis neurons in Alzheimer's disease","volume":"27","author":"Mufson","year":"2002","journal-title":"Neurochem Res"},{"key":"10.1016\/j.jns.2011.06.048_bb0205","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1601-183X.2007.00378.x","article-title":"Neurotrophic factors in Alzheimer's disease: role of axonal transport","volume":"7","author":"Schindowski","year":"2008","journal-title":"Genes Brain Behav"},{"issue":"1","key":"10.1016\/j.jns.2011.06.048_bb0210","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0006-8993(95)00357-V","article-title":"Cultured basal forebrain cholinergic neurons from postnatal rats show both overlapping and nonoverlapping responses to the neurotrophins","volume":"683","author":"Nonomura","year":"1995","journal-title":"Brain Res"},{"issue":"3","key":"10.1016\/j.jns.2011.06.048_bb0215","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s12031-010-9377-2","article-title":"Muscarinic Acetylcholine Receptors (mAChRs) in the nervous system: some functions and mechanisms","volume":"41","author":"Brown","year":"2010","journal-title":"J Mol Neurosci"},{"issue":"2","key":"10.1016\/j.jns.2011.06.048_bb0220","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1471-4159.2006.03764.x","article-title":"Down regulation of trk but not p75(NTR) gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease","volume":"97","author":"Ginsberg","year":"2006","journal-title":"J Neurochem"},{"issue":"22","key":"10.1016\/j.jns.2011.06.048_bb0225","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/0024-3205(96)00193-2","article-title":"Neurotrophins and Alzheimer's disease: beyond the cholinergic neurons","volume":"58","author":"Knusel","year":"1996","journal-title":"Life Sci"},{"issue":"1","key":"10.1016\/j.jns.2011.06.048_bb0230","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0306-4522(00)00542-X","article-title":"Involvement of dopamine D-2 receptors in complex maze learning and acetylcholine release in ventral hippocampus of rats","volume":"103","author":"Umegaki","year":"2001","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.jns.2011.06.048_bb0235","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1515\/REVNEURO.2007.18.1.37","article-title":"Insights into the role of dopamine receptor systems in learning and memory","volume":"18","author":"El-Ghundi","year":"2007","journal-title":"Rev Neurosci"},{"issue":"6","key":"10.1016\/j.jns.2011.06.048_bb0240","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1046\/j.1471-4159.1994.63062086.x","article-title":"Dopaminergic regulation of septohippocampal cholinergic neurons","volume":"63","author":"Day","year":"1994","journal-title":"J Neurochem"},{"issue":"3","key":"10.1016\/j.jns.2011.06.048_bb0245","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1017\/S1461145706007103","article-title":"Activation of dopamine D-1 receptors enhances cholinergic transmission and social cognition: a parallel dialysis and behavioural study in rats","volume":"10","author":"Di Cara","year":"2007","journal-title":"Int J Neuropsychopharmacol"},{"issue":"1","key":"10.1016\/j.jns.2011.06.048_bb0250","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.nbd.2009.10.004","article-title":"Dual response of BDNF to sublethal concentrations of beta-amyloid peptides in cultured cortical neurons","volume":"37","author":"Aliaga","year":"2010","journal-title":"Neurobiol Dis"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X11003832?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X11003832?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T15:41:42Z","timestamp":1758382902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X11003832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":50,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0022510X11003832"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2011.06.048","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dopamine-depletion and increased \u03b1-synuclein load induce degeneration of cortical cholinergic fibers in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2011.06.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}