{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:37:08Z","timestamp":1789627028893,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.jns.2011.11.025","type":"journal-article","created":{"date-parts":[[2011,12,13]],"date-time":"2011-12-13T04:29:28Z","timestamp":1323750568000},"page":"77-81","source":"Crossref","is-referenced-by-count":12,"title":["Hypoperfusion in caudate nuclei in patients with brain\u2013lung\u2013thyroid syndrome"],"prefix":"10.1016","volume":"315","author":[{"given":"Mitsugu","family":"Uematsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Haginoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuo","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tojo","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousuke","family":"Kakisaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurika","family":"Numata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Hino-Fukuyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuma","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Kure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2011.11.025_bb0005","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S0167-4781(97)00210-8","article-title":"Structure of the human Nkx2.1 gene","volume":"1396","author":"Hamdan","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jns.2011.11.025_bb0010","doi-asserted-by":"crossref","first-page":"8108","DOI":"10.1074\/jbc.270.14.8108","article-title":"Gene structure and expression of human thyroid transcription factor-1 in respiratory epithelial cells","volume":"270","author":"Ikeda","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jns.2011.11.025_bb0015","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1242\/dev.113.4.1093","article-title":"The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain","volume":"113","author":"Lazzaro","year":"1991","journal-title":"Development"},{"key":"10.1016\/j.jns.2011.11.025_bb0020","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1101\/gad.10.1.60","article-title":"The T\/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary","volume":"10","author":"Kimura","year":"1996","journal-title":"Genes Dev"},{"key":"10.1016\/j.jns.2011.11.025_bb0025","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/1096-9861(20000828)424:3<409::AID-CNE3>3.0.CO;2-7","article-title":"Pallial and subpallial derivatives in the embryonic chick and mouse telencephalon, traced by the expression of the genes Dlx-2, Emx-1, Nkx-2.1, Pax-6, and Tbr-1","volume":"424","author":"Puelles","year":"2000","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.jns.2011.11.025_bb0030","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1172\/JCI118123","article-title":"Congenital human thyroglobulin defect due to low expression of the thyroid-specific transcription factor TTF-1","volume":"96","author":"Acebron","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jns.2011.11.025_bb0035","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1093\/hmg\/11.8.971","article-title":"Mutations in TITF-1 are associated with benign hereditary chorea","volume":"11","author":"Breedveld","year":"2002","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jns.2011.11.025_bb0040","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1172\/JCI0214341","article-title":"Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency","volume":"109","author":"Krude","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jns.2011.11.025_bb0045","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1212\/WNL.59.4.579","article-title":"Clinical and genetic heterogeneity in benign hereditary chorea","volume":"59","author":"Breedveld","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2011.11.025_bb0050","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s00431-004-1559-x","article-title":"Brain\u2013thyroid\u2013lung syndrome: a patient with a severe multi-system disorder due to a de novo mutation in the thyroid transcription factor 1 gene","volume":"164","author":"Willemsen","year":"2005","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jns.2011.11.025_bb0055","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1002\/mds.21644","article-title":"Benign hereditary chorea revisited: a journey to understanding","volume":"22","author":"Kleiner-Fisman","year":"2007","journal-title":"Mov Disord"},{"key":"10.1016\/j.jns.2011.11.025_bb0060","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1093\/hmg\/ddp162","article-title":"Five new TTF1\/NKX2.1 mutations in brain\u2013lung\u2013thyroid syndrome: rescue by PAX8 synergism in one case","volume":"18","author":"Carre","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jns.2011.11.025_bb0065","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.parkreldis.2011.01.002","article-title":"Benign hereditary chorea: an update","volume":"17","author":"Inzelberg","year":"2011","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.jns.2011.11.025_bb0070","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10048-005-0013-1","article-title":"Nonsense mutation in TITF1 in a Portuguese family with benign hereditary chorea","volume":"6","author":"Carmo Costa","year":"2005","journal-title":"Neurogenetics"},{"key":"10.1016\/j.jns.2011.11.025_bb0075","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1002\/mds.23065","article-title":"Benign hereditary chorea: clinical and neuroimaging features in an Italian family","volume":"25","author":"Salvatore","year":"2010","journal-title":"Mov Disord"},{"key":"10.1016\/j.jns.2011.11.025_bb0080","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.neuron.2008.07.031","article-title":"The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes","volume":"59","author":"Butt","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.jns.2011.11.025_bb0085","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1210\/jc.2004-1358","article-title":"PAX8, TITF1, and FOXE1 gene expression patterns during human development: new insights into human thyroid development and thyroid dysgenesis-associated malformations","volume":"90","author":"Trueba","year":"2004","journal-title":"J Clin Endocrinol Metabol"},{"key":"10.1016\/j.jns.2011.11.025_bb0090","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1152\/physrev.00028.2006","article-title":"Transcriptional control of lung morphogenesis","volume":"87","author":"Maeda","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jns.2011.11.025_bb0095","doi-asserted-by":"crossref","first-page":"E1146","DOI":"10.1002\/humu.21183","article-title":"NKX2-1mutations leading to surfactant protein promoter dysregulation cause interstitial lung disease in \u201cBrain\u2013Lung\u2013Thyroid Syndrome\u201d","volume":"31","author":"Guillot","year":"2010","journal-title":"Hum Mutat"},{"key":"10.1016\/j.jns.2011.11.025_bb0100","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1002\/mds.22215","article-title":"Psychosis, short stature in benign hereditary chorea: a novel thyroid transcription factor-1 mutation","volume":"23","author":"Glik","year":"2008","journal-title":"Mov Disord"},{"key":"10.1016\/j.jns.2011.11.025_bb0105","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1242\/dev.126.15.3359","article-title":"Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum","volume":"126","author":"Sussel","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.jns.2011.11.025_bb0110","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1523\/JNEUROSCI.4228-09.2010","article-title":"The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons","volume":"30","author":"Flandin","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.jns.2011.11.025_bb0115","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1177\/0883073807306261","article-title":"Benign hereditary chorea: clinical, neuroimaging, and genetic findings","volume":"22","author":"Mahajnah","year":"2007","journal-title":"J Child Neurol"},{"key":"10.1016\/j.jns.2011.11.025_bb0120","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s00259-004-1491-3","article-title":"Effects of partial volume correction on discrimination between very early Alzheimer's dementia and controls using brain perfusion SPECT","volume":"31","author":"Kanetaka","year":"2004","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.jns.2011.11.025_bb0125","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.mce.2010.03.009","article-title":"Genetics and phenomics of hypothyroidism and thyroid dys- and agenesis due to PAX8 and TTF1 mutations","volume":"322","author":"Montanelli","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.jns.2011.11.025_bb0130","first-page":"731","article-title":"Automated discrimination between very early Alzheimer disease and controls using an easy Z-score imaging system for multicenter brain perfusion single-photon emission tomography","volume":"28","author":"Matsuda","year":"2007","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.jns.2011.11.025_bb0135","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/13554790802269984","article-title":"The effect of donepezil on increased regional cerebral blood flow in the posterior cingulate cortex of a patient with Parkinson's disease dementia","volume":"14","author":"Imamura","year":"2008","journal-title":"Neurocase"},{"key":"10.1016\/j.jns.2011.11.025_bb0140","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.braindev.2010.06.003","article-title":"Brain perfusion SPECT and EEG findings in children with autism spectrum disorders and medically intractable epilepsy","volume":"32","author":"Sasaki","year":"2010","journal-title":"Brain Dev"},{"key":"10.1016\/j.jns.2011.11.025_bb0145","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.brainres.2009.09.050","article-title":"Ongoing expression of Nkx2.1 in the postnatal mouse forebrain: potential for understanding NKX2.1 haploinsufficiency in humans?","volume":"1304","author":"Magno","year":"2009","journal-title":"Brain Res"},{"key":"10.1016\/j.jns.2011.11.025_bb0150","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1136\/jnnp.55.11.1018","article-title":"Reduced regional cerebral blood flow in Huntington's disease studied by SPECT","volume":"55","author":"Hasselbalch","year":"1992","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jns.2011.11.025_bb0155","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/00006231-200201000-00004","article-title":"Single photon emission computerized tomography (SPECT) in detecting neurodegeneration in Huntington's disease","volume":"23","author":"Reynolds","year":"2002","journal-title":"Nucl Med Commun"},{"key":"10.1016\/j.jns.2011.11.025_bb0160","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1212\/01.WNL.0000164000.75046.CC","article-title":"A novel TITF-1 mutation causes benign hereditary chorea with response to levodopa","volume":"64","author":"Asmus","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2011.11.025_bb0165","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1136\/jnnp.2009.202903","article-title":"Long-term follow-up of pallidal deep brain stimulation in two cases of Huntington's disease","volume":"82","author":"Kang","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X11006770?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X11006770?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,12,19]],"date-time":"2021-12-19T22:08:06Z","timestamp":1639951686000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X11006770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":33,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0022510X11006770"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2011.11.025","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}