{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:31:11Z","timestamp":1789957871131,"version":"4.0.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.jns.2012.04.019","type":"journal-article","created":{"date-parts":[[2012,5,23]],"date-time":"2012-05-23T14:23:08Z","timestamp":1337782988000},"page":"105-110","source":"Crossref","is-referenced-by-count":29,"title":["MRI mean diffusivity detects widespread brain degeneration in multiple sclerosis"],"prefix":"10.1016","volume":"319","author":[{"given":"Joe","family":"Senda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohisa","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Tsuboi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazuki","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoichi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Atsuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiaki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Naganawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Sobue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2012.04.019_bb0005","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1212\/01.wnl.0000250267.85698.7a","article-title":"Gray matter involvement in multiple sclerosis","volume":"68","author":"Pirko","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2012.04.019_bb0010","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00415-003-0992-5","article-title":"A study of the mechanisms of normal-appearing white matter damage in multiple sclerosis using diffusion tensor imaging","volume":"250","author":"Ciccarelli","year":"2003","journal-title":"J Neurol"},{"key":"10.1016\/j.jns.2012.04.019_bb0015","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/jmri.20564","article-title":"Altered diffusion tensor in multiple sclerosis normal-appearing brain tissue: cortical diffusion changes seem related to clinical deterioration","volume":"23","author":"Vrenken","year":"2006","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jns.2012.04.019_bb0020","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1212\/WNL.52.8.1626","article-title":"Diffusion tensor imaging of lesions and normal-appearing white matter in multiple sclerosis","volume":"52","author":"Werring","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2012.04.019_bb0025","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1191\/1352458504ms1050oa","article-title":"Progressive grey matter atrophy in clinically early relapsing\u2013remitting multiple sclerosis","volume":"10","author":"Chard","year":"2004","journal-title":"Mult Scler"},{"key":"10.1016\/j.jns.2012.04.019_bb0030","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/brain\/awh126","article-title":"Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes","volume":"127","author":"Dalton","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.jns.2012.04.019_bb0035","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1212\/01.WNL.0000129544.79539.D5","article-title":"Neocortical volume decrease in relapsing\u2013remitting MS patients with mild cognitive impairment","volume":"63","author":"Amato","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2012.04.019_bb0040","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1212\/01.WNL.0000055926.69643.03","article-title":"Evidence of early cortical atrophy in MS: relevance to white matter changes and disability","volume":"60","author":"De Stefano","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2012.04.019_bb0045","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.neuroimage.2005.03.008","article-title":"The relationship between whole brain volume and disability in multiple sclerosis: a comparison of normalized gray vs. white matter with misclassification correction","volume":"26","author":"Sanfilipo","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.jns.2012.04.019_bb0050","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1212\/01.wnl.0000201238.93586.d9","article-title":"Gray and white matter brain atrophy and neuropsychological impairment in multiple sclerosis","volume":"66","author":"Sanfilipo","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2012.04.019_bb0055","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1212\/WNL.46.4.907","article-title":"Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis","volume":"46","author":"Lublin","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2012.04.019_bb0060","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1212\/01.wnl.0000251302.55202.73","article-title":"Progression of white matter hyperintensities in elderly individuals over 3 years","volume":"68","author":"Sachdev","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2012.04.019_bb0065","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1001\/archneurol.2010.280","article-title":"Functional impact of white matter hyperintensities in cognitively normal elderly subjects","volume":"67","author":"Murray","year":"2010","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jns.2012.04.019_bb0070","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/ana.1032","article-title":"Recommended diagnostic criteria for multiple sclerosis: guidelines from the international panel on the diagnosis of multiple sclerosis","volume":"50","author":"McDonald","year":"2010","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jns.2012.04.019_bb0075","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1212\/01.wnl.0000216139.44259.74","article-title":"Revised diagnostic criteria for neuromyelitis optica","volume":"66","author":"Wingerchuk","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2012.04.019_bb0080","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/ncpneuro0764","article-title":"Mechanisms of disease: aquaporin-4 antibodies in neuromyelitis optica","volume":"4","author":"Jarius","year":"2008","journal-title":"Nat Clin Pract Neurol"},{"key":"10.1016\/j.jns.2012.04.019_bb0085","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.jns.2012.04.019_bb0090","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS)","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2012.04.019_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0022-510X(95)00261-Y","article-title":"Clinical scales for multiple sclerosis","volume":"135","author":"Sharrak","year":"1996","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.jns.2012.04.019_bb0100","first-page":"189","article-title":"Statistical parametric maps in functional imaging: a general linear approach","volume":"2","author":"Poline","year":"1995","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.jns.2012.04.019_bb0105","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuroimage.2007.07.007","article-title":"A fast diffeomorphic image registration algorithm","volume":"38","author":"Ashburner","year":"2007","journal-title":"Neuroimage"},{"key":"10.1016\/j.jns.2012.04.019_bb0110","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1148\/radiol.10100626","article-title":"Gray- and white-matter changes 1 year after first clinical episode of multiple sclerosis: MR imaging","volume":"257","author":"Raz","year":"2010","journal-title":"Radiology"},{"key":"10.1016\/j.jns.2012.04.019_bb0115","doi-asserted-by":"crossref","DOI":"10.1002\/hbm.21402","article-title":"The effect of hypointense white matter lesions on automated gray matter segmentation in multiple sclerosis","author":"Gelineau-Morel","year":"2011","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.jns.2012.04.019_bb0120","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1006\/nimg.2000.0582","article-title":"Voxel-based morphometry \u2014 the methods","volume":"11","author":"Ashburner","year":"2000","journal-title":"Neuroimage"},{"key":"10.1016\/j.jns.2012.04.019_bb0125","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0720-048X(02)00328-5","article-title":"MR diffusion tensor imaging: recent advance and new techniques for diffusion tensor visualization","volume":"46","author":"Masutani","year":"2003","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.jns.2012.04.019_bb0130","series-title":"Pattern classification","author":"Duda","year":"2000"},{"key":"10.1016\/j.jns.2012.04.019_bb0135","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s00415-003-0192-3","article-title":"High field MRI correlates of myelin content and axonal density in multiple sclerosis \u2014 a post-mortem study of the spinal cord","volume":"250","author":"Mottershead","year":"2003","journal-title":"J Neurol"},{"key":"10.1016\/j.jns.2012.04.019_bb0140","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1212\/WNL.50.5.1282","article-title":"Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis","volume":"50","author":"van Walderveen","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2012.04.019_bb0145","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.neuroimage.2006.12.010","article-title":"Diffusion tensor imaging of post mortem multiple sclerosis brain","volume":"35","author":"Schmierer","year":"2007","journal-title":"Neuroimage"},{"key":"10.1016\/j.jns.2012.04.019_bb0150","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/S0022-510X(01)00487-7","article-title":"Acute and chronic changes of the apparent diffusion coefficient in neurological disorders\u2014biophysical mechanisms and possible underlying histopathology","volume":"186","author":"Gass","year":"2001","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.jns.2012.04.019_bb0155","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1001\/archneur.57.7.1017","article-title":"A quantitative study of water diffusion in multiple sclerosis lesions and normal-appearing white matter using echo-planar imaging","volume":"57","author":"Filippi","year":"2000","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jns.2012.04.019_bb0160","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00415-006-0408-4","article-title":"Normal-appearing white and grey matter damage in MS. A volumetric and diffusion tensor MRI study at 3.0 Tesla","volume":"254","author":"Ceccarelli","year":"2007","journal-title":"J Neurol"},{"key":"10.1016\/j.jns.2012.04.019_bb0165","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-3-540-73677-6_2","article-title":"Pathological heterogeneity of idiopathic central nervous system inflammatory demyelinating disorders","volume":"318","author":"Lucchinetti","year":"2008","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.jns.2012.04.019_bb0170","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1600-0404.2006.00615.x","article-title":"Grey matter pathology in multiple sclerosis","volume":"183","author":"B\u00f6","year":"2006","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.jns.2012.04.019_bb0175","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S1474-4422(08)70191-1","article-title":"Grey matter pathology in multiple sclerosis","volume":"7","author":"Geurts","year":"2008","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jns.2012.04.019_bb0180","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1136\/jnnp.2009.188748","article-title":"Atrophy mainly affects the limbic system and the deep grey matter at the first stage of multiple sclerosis","volume":"81","author":"Audoin","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jns.2012.04.019_bb0185","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1001\/archneur.63.8.1175","article-title":"Regional gray matter atrophy in early primary progressive multiple sclerosis: a voxel-based morphometry study","volume":"63","author":"Sepulcre","year":"2006","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jns.2012.04.019_bb0190","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1212\/01.wnl.0000237551.26858.39","article-title":"Neocortical neuronal, synaptic, and glial loss in multiple sclerosis","volume":"67","author":"Wegner","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2012.04.019_bb0195","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S1474-4422(05)70071-5","article-title":"Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis","volume":"4","author":"Miller","year":"2005","journal-title":"Lancet Neurol"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X12002109?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X12002109?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T01:39:50Z","timestamp":1561772390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X12002109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":39,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0022510X12002109"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2012.04.019","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}