{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:49:34Z","timestamp":1790844574208,"version":"4.1.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.jns.2012.06.005","type":"journal-article","created":{"date-parts":[[2012,7,21]],"date-time":"2012-07-21T03:12:05Z","timestamp":1342840325000},"page":"45-51","source":"Crossref","is-referenced-by-count":33,"title":["Phosphodiesterase inhibitor modulation of brain microvascular endothelial cell barrier properties"],"prefix":"10.1016","volume":"320","author":[{"given":"Shuo","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanhui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annlia","family":"Paganini-Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jns.2012.06.005_bb0005","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neurobiolaging.2007.07.015","article-title":"Blood\u2013brain barrier: ageing and microvascular disease\u2014systematic review and meta-analysis","volume":"30","author":"Farrall","year":"2009","journal-title":"Neurobiol Aging"},{"issue":"2","key":"10.1016\/j.jns.2012.06.005_bb0010","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1365-2796.2009.02199.x","article-title":"The neurovascular unit in the setting of stroke","volume":"267","author":"del Zoppo","year":"2010","journal-title":"J Intern Med"},{"issue":"9","key":"10.1016\/j.jns.2012.06.005_bb0015","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1111\/j.1532-5415.2010.03011.x","article-title":"The blood\u2013brain barrier: geriatric relevance of a critical brain\u2013body interface","volume":"58","author":"Zeevi","year":"2010","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.jns.2012.06.005_bb0020","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1749-6632.2010.05758.x","article-title":"The challenge of mixed cerebrovascular disease","volume":"1207","author":"Fisher","year":"2010","journal-title":"Ann N Y Acad Sci"},{"issue":"12","key":"10.1016\/j.jns.2012.06.005_bb0025","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1161\/STROKEAHA.110.593657","article-title":"Cerebral microbleeds in the elderly: a pathological analysis","volume":"41","author":"Fisher","year":"2010","journal-title":"Stroke"},{"issue":"12","key":"10.1016\/j.jns.2012.06.005_bb0030","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1038\/sj.jcbfm.9600155","article-title":"Pericapillary haem-rich deposits: evidence for microhaemorrhages in aging human cerebral cortex","volume":"25","author":"Cullen","year":"2005","journal-title":"J Cereb Blood Flow Metab"},{"issue":"11","key":"10.1016\/j.jns.2012.06.005_bb0035","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1212\/01.wnl.0000319691.50117.54","article-title":"Neuropathologic correlates of white matter hyperintensities","volume":"71","author":"Young","year":"2008","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.jns.2012.06.005_bb0040","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1001\/archneurol.2009.42","article-title":"Use of antithrombotic drugs and the presence of cerebral microbleeds: the Rotterdam Scan Study","volume":"66","author":"Vernooij","year":"2009","journal-title":"Arch Neurol"},{"issue":"4","key":"10.1016\/j.jns.2012.06.005_bb0045","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.atherosclerosissup.2005.09.003","article-title":"Cilostazol in secondary prevention of stroke: impact of the Cilostazol Stroke Prevention Study","volume":"6","author":"Matsumoto","year":"2005","journal-title":"Atheroscler Suppl"},{"issue":"2","key":"10.1016\/j.jns.2012.06.005_bb0050","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1527-3458.2008.00042.x","article-title":"Protective effects of cilostazol against transient focal cerebral ischemia and chronic cerebral hypoperfusion injury","volume":"14","author":"Lee","year":"2008","journal-title":"CNS Neurosci Ther"},{"issue":"10","key":"10.1016\/j.jns.2012.06.005_bb0055","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S1474-4422(10)70198-8","article-title":"Cilostazol for prevention of secondary stroke (CSPS 2): an aspirin-controlled, double-blind, randomised non-inferiority trial","volume":"9","author":"Shinohara","year":"2010","journal-title":"Lancet Neurol"},{"issue":"4","key":"10.1016\/j.jns.2012.06.005_bb0060","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2174\/156802607779941224","article-title":"Re-discovering PDE3 inhibitors\u2014new opportunities for a long neglected target","volume":"7","author":"Thompson","year":"2007","journal-title":"Curr Top Med Chem"},{"issue":"3","key":"10.1016\/j.jns.2012.06.005_bb0065","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.pharmthera.2005.07.003","article-title":"Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents","volume":"109","author":"Lugnier","year":"2006","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jns.2012.06.005_bb0070","doi-asserted-by":"crossref","first-page":"12590","DOI":"10.1074\/jbc.M110.203604","article-title":"PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts","volume":"286","author":"Blackman","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jns.2012.06.005_bb0075","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev.biochem.76.060305.150444","article-title":"Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling","volume":"76","author":"Conti","year":"2007","journal-title":"Annu Rev Biochem"},{"issue":"3 Suppl 3","key":"10.1016\/j.jns.2012.06.005_bb0080","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1212\/WNL.51.3_Suppl_3.S17","article-title":"Dipyridamole trials in stroke prevention","volume":"51","author":"Diener","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2012.06.005_bb0085","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1749-6632.2010.05801.x","article-title":"Effect of dipyridamole during acute stroke: exploring antithrombosis and neuroprotective benefits","volume":"1207","author":"d'Esterre","year":"2010","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"10.1016\/j.jns.2012.06.005_bb0090","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.brainres.2006.08.028","article-title":"Tadalafil, a long-acting type 5 phosphodiesterase isoenzyme inhibitor, improves neurological functional recovery in a rat model of embolic stroke","volume":"1118","author":"Zhang","year":"2006","journal-title":"Brain Res"},{"issue":"17","key":"10.1016\/j.jns.2012.06.005_bb0095","doi-asserted-by":"crossref","first-page":"6317","DOI":"10.1523\/JNEUROSCI.20-17-06317.2000","article-title":"Both protein kinase A and mitogen-activated protein kinase are required in the amygdala for the macromolecular synthesis-dependent late phase of long-term potentiation","volume":"20","author":"Huang","year":"2000","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.jns.2012.06.005_bb0100","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0165-0270(03)00206-1","article-title":"A simple method for isolation and characterization of mouse brain microvascular endothelial cells","volume":"130","author":"Wu","year":"2003","journal-title":"J Neurosci Methods"},{"issue":"1","key":"10.1016\/j.jns.2012.06.005_bb0105","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1085\/jgp.200910339","article-title":"Epac1 mediates protein kinase A-independent mechanism of forskolin-activated intestinal chloride secretion","volume":"135","author":"Hoque","year":"2010","journal-title":"J Gen Physiol"},{"issue":"1","key":"10.1016\/j.jns.2012.06.005_bb0110","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1128\/MCB.25.1.136-146.2005","article-title":"Cyclic AMP potentiates vascular endothelial cadherin-mediated cell\u2013cell contact to enhance endothelial barrier function through an Epac\u2013Rap1 signaling pathway","volume":"25","author":"Fukuhara","year":"2005","journal-title":"Mol Cell Biol"},{"issue":"2","key":"10.1016\/j.jns.2012.06.005_bb0115","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.phrs.2006.10.010","article-title":"Cilostazol inhibits the redistribution of the actin cytoskeleton and junctional proteins on the blood\u2013brain barrier under hypoxia\/reoxygenation","volume":"55","author":"Torii","year":"2007","journal-title":"Pharmacol Res"},{"issue":"5","key":"10.1016\/j.jns.2012.06.005_bb0120","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1111\/j.1476-5381.2010.01134.x","article-title":"Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3\u2013L1 adipocytes via the endothelial NO synthase\u2013cGMP\u2013protein kinase G signalling pathway","volume":"162","author":"Shen","year":"2011","journal-title":"Br J Pharmacol"},{"issue":"3","key":"10.1016\/j.jns.2012.06.005_bb0125","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.niox.2011.02.004","article-title":"Activation of MEK1\/ERK1\/2\/iNOS\/sGC\/PKG pathway associated with peroxynitrite formation contributes to hypotension and vascular hyporeactivity in endotoxemic rats","volume":"24","author":"Korkmaz","year":"2011","journal-title":"Nitric Oxide"},{"issue":"13","key":"10.1016\/j.jns.2012.06.005_bb0130","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1002\/cbic.200800216","article-title":"8-pCPT-2\u2032-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue","volume":"9","author":"Vliem","year":"2008","journal-title":"Chembiochem"},{"issue":"2","key":"10.1016\/j.jns.2012.06.005_bb0135","doi-asserted-by":"crossref","first-page":"C488","DOI":"10.1152\/ajpcell.00537.2007","article-title":"Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells","volume":"294","author":"Pastor-Soler","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1\u20133","key":"10.1016\/j.jns.2012.06.005_bb0140","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0169-409X(96)00435-8","article-title":"In vitro models to predict blood\u2013brain barrier permeability","volume":"23","author":"Eddy","year":"1997","journal-title":"Adv Drug Deliv Rev"},{"issue":"1","key":"10.1016\/j.jns.2012.06.005_bb0145","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s10571-004-1377-8","article-title":"Permeability studies on in vitro blood\u2013brain barrier models: physiology, pathology, and pharmacology","volume":"25","author":"Deli","year":"2005","journal-title":"Cell Mol Neurobiol"},{"issue":"6","key":"10.1016\/j.jns.2012.06.005_bb0150","doi-asserted-by":"crossref","first-page":"H2427","DOI":"10.1152\/ajpheart.00556.2004","article-title":"cAMP protects endothelial barrier functions by preventing Rac-1 inhibition","volume":"287","author":"Waschke","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"6","key":"10.1016\/j.jns.2012.06.005_bb0155","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s00418-008-0422-y","article-title":"cAMP induced Rac 1-mediated cytoskeletal reorganization in microvascular endothelium","volume":"129","author":"Baumer","year":"2008","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.jns.2012.06.005_bb0160","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.vph.2009.12.008","article-title":"Molecular mechanisms involved in adenosine-induced endothelial cell barrier enhancement","volume":"52","author":"Umapathy","year":"2010","journal-title":"Vascul Pharmacol"},{"issue":"3","key":"10.1016\/j.jns.2012.06.005_bb0165","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1526-4610.2009.01512.x","article-title":"Nitric oxide-induced changes in endothelial expression of phosphodiesterases 2, 3, and 5","volume":"50","author":"Schankin","year":"2010","journal-title":"Headache"},{"issue":"4","key":"10.1016\/j.jns.2012.06.005_bb0170","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0006-2952(99)00346-9","article-title":"Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity","volume":"59","author":"Sudo","year":"2000","journal-title":"Biochem Pharmacol"},{"issue":"4","key":"10.1016\/j.jns.2012.06.005_bb0175","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1527-3466.2001.tb00076.x","article-title":"Cilostazol (pletal): a dual inhibitor of cyclic nucleotide phosphodiesterase type 3 and adenosine uptake","volume":"19","author":"Liu","year":"2001","journal-title":"Cardiovasc Drug Rev"},{"issue":"1\u20132","key":"10.1016\/j.jns.2012.06.005_bb0180","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ejphar.2004.02.038","article-title":"Analysis of the effects of phosphodiesterase type 3 and 4 inhibitors in cerebral arteries","volume":"489","author":"Birk","year":"2004","journal-title":"Eur J Pharmacol"},{"issue":"6","key":"10.1016\/j.jns.2012.06.005_bb0185","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/09537100310001598819","article-title":"Phosphorylation of the vasodilator-stimulated phosphoprotein (VASP) by the anti-platelet drug, cilostazol, in platelets","volume":"14","author":"Sudo","year":"2003","journal-title":"Platelets"},{"issue":"3","key":"10.1016\/j.jns.2012.06.005_bb0190","doi-asserted-by":"crossref","first-page":"s39","DOI":"10.1161\/ATVBAHA.107.160226","article-title":"Translational therapeutics of dipyridamole","volume":"28","author":"Kim","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"10.1016\/j.jns.2012.06.005_bb0195","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1083\/jcb.115.6.1725","article-title":"A cell culture model of the blood\u2013brain barrier","volume":"115","author":"Rubin","year":"1991","journal-title":"J Cell Biol"},{"issue":"2","key":"10.1016\/j.jns.2012.06.005_bb0200","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2174\/157488911795933910","article-title":"Patented in vitro blood\u2013brain barrier models in CNS drug discovery","volume":"6","author":"Toth","year":"2011","journal-title":"Recent Pat CNS Drug Discov"},{"issue":"2 Pt 1","key":"10.1016\/j.jns.2012.06.005_bb0205","doi-asserted-by":"crossref","first-page":"C495","DOI":"10.1152\/ajpcell.1996.271.2.C495","article-title":"Signal transduction and glial cell modulation of cultured brain microvessel endothelial cell tight junctions","volume":"271","author":"Raub","year":"1996","journal-title":"Am J Physiol"},{"issue":"Pt 3","key":"10.1016\/j.jns.2012.06.005_bb0210","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1113\/jphysiol.2003.045880","article-title":"Human blood-derived macrophages enhance barrier function of cultured primary bovine and human brain capillary endothelial cells","volume":"551","author":"Zenker","year":"2003","journal-title":"J Physiol"},{"issue":"2","key":"10.1016\/j.jns.2012.06.005_bb0215","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2174\/156720211795495385","article-title":"Blockade of phosphodiesterase-III protects against oxygen\u2013glucose deprivation in endothelial cells by upregulation of VE-cadherin","volume":"8","author":"Ishiguro","year":"2011","journal-title":"Curr Neurovasc Res"},{"issue":"12","key":"10.1016\/j.jns.2012.06.005_bb0220","doi-asserted-by":"crossref","first-page":"e15178","DOI":"10.1371\/journal.pone.0015178","article-title":"Phosphodiesterase-III inhibitor prevents hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tPA","volume":"5","author":"Ishiguro","year":"2010","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jns.2012.06.005_bb0225","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1006\/mvre.2001.2350","article-title":"The kinetics, function, and regulation of P-selectin expressed by human brain microvessel endothelial cells in primary culture","volume":"62","author":"Easton","year":"2001","journal-title":"Microvasc Res"},{"issue":"1\u20132","key":"10.1016\/j.jns.2012.06.005_bb0230","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0165-5728(99)00063-6","article-title":"Treatment with BBB022A or rolipram stabilizes the blood\u2013brain barrier in experimental autoimmune encephalomyelitis: an additional mechanism for the therapeutic effect of type IV phosphodiesterase inhibitors","volume":"97","author":"Folcik","year":"1999","journal-title":"J Neuroimmunol"},{"issue":"3","key":"10.1016\/j.jns.2012.06.005_bb0235","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1159\/000319072","article-title":"Amelioration of inflammation and cytotoxicity by dipyridamole in brain endothelial cells","volume":"30","author":"Guo","year":"2010","journal-title":"Cerebrovasc Dis"},{"issue":"9","key":"10.1016\/j.jns.2012.06.005_bb0240","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1023\/A:1018938722768","article-title":"Cereport (RMP-7) increases the permeability of human brain microvascular endothelial cell monolayers","volume":"16","author":"Mackic","year":"1999","journal-title":"Pharm Res"},{"issue":"4","key":"10.1016\/j.jns.2012.06.005_bb0245","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1159\/000335785","article-title":"Tissue plasminogen activator expression and barrier properties of human brain microvascular endothelial cells","volume":"28","author":"Yang","year":"2011","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.jns.2012.06.005_bb0250","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/jnr.22558","article-title":"Cilostazol enhances integrin-dependent homing of progenitor cells by activation of cAMP-dependent protein kinase in synergy with Epac1","volume":"89","author":"Lee","year":"2011","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.jns.2012.06.005_bb0255","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.thromres.2011.12.008","article-title":"PDE4 regulates tissue plasminogen activator expression of human brain microvascular endothelial cells","volume":"129","author":"Yang","year":"2012","journal-title":"Thromb Res"},{"issue":"9","key":"10.1016\/j.jns.2012.06.005_bb0260","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1210\/mend.14.9.0534","article-title":"Phosphodiesterases and cyclic nucleotide signaling in endocrine cells","volume":"14","author":"Conti","year":"2000","journal-title":"Mol Endocrinol"},{"issue":"6","key":"10.1016\/j.jns.2012.06.005_bb0265","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1091\/mbc.E09-08-0655","article-title":"Compartmentalized cyclic adenosine 3\u2032,5\u2032-monophosphate at the plasma membrane clusters PDE3A and cystic fibrosis transmembrane conductance regulator into microdomains","volume":"21","author":"Penmatsa","year":"2010","journal-title":"Mol Biol Cell"},{"issue":"Pt 6","key":"10.1016\/j.jns.2012.06.005_bb0270","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1042\/BST0331319","article-title":"Compartmentalization of adenylate cyclase and cAMP signalling","volume":"33","author":"Cooper","year":"2005","journal-title":"Biochem Soc Trans"},{"issue":"6","key":"10.1016\/j.jns.2012.06.005_bb0275","doi-asserted-by":"crossref","first-page":"L1309","DOI":"10.1152\/ajplung.2001.280.6.L1309","article-title":"Role of cAMP-dependent protein kinase A activity in endothelial cell cytoskeleton rearrangement","volume":"280","author":"Liu","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"1","key":"10.1016\/j.jns.2012.06.005_bb0280","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.mvr.2008.09.012","article-title":"The actin cytoskeleton in endothelial cell phenotypes","volume":"77","author":"Prasain","year":"2009","journal-title":"Microvasc Res"},{"issue":"1","key":"10.1016\/j.jns.2012.06.005_bb0285","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte-endothelial interactions at the blood\u2013brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"10.1016\/j.jns.2012.06.005_bb0290","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0014-4827(03)00354-9","article-title":"Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood\u2013brain-barrier endothelial cells via protein kinase A-dependent and -independent pathways","volume":"290","author":"Ishizaki","year":"2003","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jns.2012.06.005_bb0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2007.02.091","article-title":"A functional in vitro model of rat blood\u2013brain barrier for molecular analysis of efflux transporters","volume":"1150","author":"Perri\u00e8re","year":"2007","journal-title":"Brain Res"},{"issue":"4\u20135","key":"10.1016\/j.jns.2012.06.005_bb0300","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1537-1891(03)00007-7","article-title":"Role of Ca2+ signaling in the regulation of endothelial permeability","volume":"39","author":"Tiruppathi","year":"2002","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.jns.2012.06.005_bb0305","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/clpt.2010.256","article-title":"Histamine: new thoughts about a familiar mediator","volume":"89","author":"Jones","year":"2011","journal-title":"Clin Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.jns.2012.06.005_bb0310","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1023\/A:1007074420772","article-title":"Inflammatory mediators and modulation of blood\u2013brain barrier permeability","volume":"20","author":"Abbott","year":"2000","journal-title":"Cell Mol Neurobiol"},{"issue":"11","key":"10.1016\/j.jns.2012.06.005_bb0315","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1161\/01.RES.83.11.1115","article-title":"Transient and prolonged increase in endothelial permeability induced by histamine and thrombin: role of protein kinases, calcium, and RhoA","volume":"83","author":"van Nieuw Amerongen","year":"1998","journal-title":"Circ Res"},{"issue":"9","key":"10.1016\/j.jns.2012.06.005_bb0320","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1167\/iovs.05-1127","article-title":"Histamine-induced phosphorylation of the regulatory light chain of myosin II disrupts the barrier integrity of corneal endothelial cells","volume":"47","author":"Srinivas","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"10.1016\/j.jns.2012.06.005_bb0325","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/sj.bjp.0705530","article-title":"Histamine induces cytoskeletal changes in human eosinophils via the H(4) receptor","volume":"140","author":"Buckland","year":"2003","journal-title":"Br J Pharmacol"},{"issue":"10","key":"10.1016\/j.jns.2012.06.005_bb0330","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1007\/s11095-007-9309-1","article-title":"Histamine-induced myosin light chain phosphorylation breaks down the barrier integrity of cultured corneal epithelial cells","volume":"24","author":"Guo","year":"2007","journal-title":"Pharm Res"},{"issue":"5","key":"10.1016\/j.jns.2012.06.005_bb0335","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/sj.bjp.0701699","article-title":"Effect of cilostazol, a phosphodiesterase type III inhibitor, on histamine-induced increase in [Ca2+]i and force in middle cerebral artery of the rabbit","volume":"123","author":"Shiraishi","year":"1998","journal-title":"Br J Pharmacol"},{"issue":"5","key":"10.1016\/j.jns.2012.06.005_bb0340","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1242\/jcs.107.5.1347","article-title":"Modulation of tight junction structure in blood\u2013brain barrier endothelial cells. Effects of tissue culture, second messengers and cocultured astrocytes","volume":"107","author":"Wolburg","year":"1994","journal-title":"J Cell Sci"},{"issue":"9","key":"10.1016\/j.jns.2012.06.005_bb0345","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1161\/ATVBAHA.108.164368","article-title":"Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells","volume":"28","author":"Ota","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"Suppl. 2","key":"10.1016\/j.jns.2012.06.005_bb0350","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1046\/j.1463-1326.2002.0040s2s14.x","article-title":"The pharmacology of cilostazol","volume":"4","author":"Schror","year":"2002","journal-title":"Diabetes Obes Metab"},{"issue":"2","key":"10.1016\/j.jns.2012.06.005_bb0355","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.atherosclerosis.2006.01.022","article-title":"Activation of endothelial nitric oxide synthase by cilostazol via a cAMP\/protein kinase A-and phosphatidylinositol 3-kinase\/Akt-dependent mechanism","volume":"189","author":"Hashimoto","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jns.2012.06.005_bb0360","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/978-1-4419-1241-1_12","article-title":"The effects of cilostazol on tissue oxygenation upon an ischemic\u2013reperfusion injury in the mouse cerebrum","volume":"662","author":"Morikawa","year":"2010","journal-title":"Adv Exp Med Biol"},{"issue":"5","key":"10.1016\/j.jns.2012.06.005_bb0365","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1097\/CCM.0b013e31819deb6a","article-title":"Lipopolysaccharide-induced endothelial barrier breakdown is cyclic adenosine monophosphate dependent in vivo and in vitro","volume":"37","author":"Schlegel","year":"2009","journal-title":"Crit Care Med"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X12003139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X12003139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T14:37:05Z","timestamp":1642862225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X12003139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":73,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0022510X12003139"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2012.06.005","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}