{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:30:08Z","timestamp":1762176608243},"reference-count":32,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.jns.2012.07.001","type":"journal-article","created":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T13:45:35Z","timestamp":1344001535000},"page":"87-91","source":"Crossref","is-referenced-by-count":14,"title":["Cerebrovascular lesions in elderly Japanese patients with Alzheimer's disease"],"prefix":"10.1016","volume":"322","author":[{"given":"Ken","family":"Nagata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiki","family":"Takano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taizen","family":"Nakase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuko","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2012.07.001_bb0005","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/jama.1997.03540340047031","article-title":"Brain infarction and the clinical expression of Alzheimer disease. The Nun Study","volume":"277","author":"Snowdon","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.jns.2012.07.001_bb0010","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0140-6736(99)02355-7","article-title":"Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer's disease","volume":"354","author":"Esiri","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jns.2012.07.001_bb0015","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1001\/archneur.57.10.1474","article-title":"Small concomitant vascular lesions do not influence rates of cognitive decline in patients with Alzheimer disease","volume":"57","author":"Lee","year":"2000","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jns.2012.07.001_bb0020","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00401-001-0493-5","article-title":"Degenerative and vascular lesions of the brain have synergistic effects in dementia of the elderly","volume":"103","author":"Zekry","year":"2002","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.jns.2012.07.001_bb0025","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1136\/bmj.322.7300.1447","article-title":"Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study","volume":"322","author":"Kivipelto","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.jns.2012.07.001_bb0030","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0140-6736(96)09328-2","article-title":"Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study","volume":"349","author":"Hofman","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.jns.2012.07.001_bb0035","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/S0140-6736(96)90608-X","article-title":"15-year longitudinal study of blood pressure and dementia","volume":"347","author":"Skoog","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.jns.2012.07.001_bb0040","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/ana.21009","article-title":"Cognitive impact of subcortical vascular and Alzheimer's disease pathology","volume":"60","author":"Chui","year":"2006","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jns.2012.07.001_bb0045","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S1474-4422(08)70021-8","article-title":"Cognition and diabetes: a lifespan perspective","volume":"7","author":"Biessels","year":"2008","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jns.2012.07.001_bb0050","first-page":"665","article-title":"Differential diagnosis of Alzheimer-type dementia and vascular dementia based on neuroimaging study","volume":"47","author":"Hanyu","year":"1995","journal-title":"No To Shinkei"},{"key":"10.1016\/j.jns.2012.07.001_bb0055","first-page":"1104","article-title":"Differences of neuroimaging between early-onset and late-onset Alzheimer-type dementia","volume":"35","author":"Hanyu","year":"1995","journal-title":"Rinsho Shinkeigaku"},{"key":"10.1016\/j.jns.2012.07.001_bb0060","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2012.07.001_bb0065","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1161\/01.STR.19.10.1285","article-title":"White matter signal abnormalities in normal individuals: correlation with carotid ultrasonography, cerebral blood flow measurements, and cerebrovascular risk factors","volume":"19","author":"Fazekas","year":"1988","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2012.07.001_bb0070","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1474-4422(09)70340-0","article-title":"Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis","volume":"9","author":"van Asch","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jns.2012.07.001_bb0075","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1212\/WNL.0b013e318221ad36","article-title":"AIBL Research Group: cerebral microhemorrhage and brain \u03b2-amyloid in aging and Alzheimer disease","volume":"77","author":"Yates","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2012.07.001_bb0080","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1212\/WNL.57.7.1222","article-title":"Cardiovascular Health Study Collaborative Reseach Group: silent MRI infarcts and the risk of future stroke: the cardiovascular health study","volume":"57","author":"Bernick","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2012.07.001_bb0085","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1161\/01.STR.0000166052.89772.b5","article-title":"Cognitive consequences of thalamic, basal ganglia, and deep white matter lacunes in brain aging and dementia","volume":"36","author":"Gold","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2012.07.001_bb0090","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1136\/jnnp.2008.160440","article-title":"Location of lacunar infarcts correlates with cognition in a sample of non-disabled subjects with age-related white-matter changes: the LADIS study","volume":"80","author":"Benisty","year":"2009","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jns.2012.07.001_bb0095","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.neurobiolaging.2008.09.011","article-title":"Contribution of vascular pathology to the clinical expression of dementia","volume":"31","author":"Strozyk","year":"2010","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jns.2012.07.001_bb0100","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1159\/000368814","article-title":"The prevalence and severity of white matter lesions, their relationship with age, ethnicity, gender, and cardiovascular disease risk factors: The ARIC study","volume":"16","author":"Liao","year":"1997","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.jns.2012.07.001_bb0105","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1161\/01.STR.27.8.1274","article-title":"Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people: the cardiovascular health study","volume":"27","author":"Longstreth","year":"1996","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2012.07.001_bb0110","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1212\/WNL.51.1.319","article-title":"Progression of cerebral white matter hyperintensities on MRI is related to diastolic blood pressure","volume":"51","author":"Longstreth","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2012.07.001_bb0115","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1001\/archneurol.2010.284","article-title":"Alzheimer's Disease Neuroimaging Initiative: longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative","volume":"67","author":"Carmichael","year":"2010","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jns.2012.07.001_bb0120","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1161\/01.STR.0000199847.96188.12","article-title":"Cerebral microhemorrhage","volume":"37","author":"Viswanathan","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2012.07.001_bb0125","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1161\/STROKEAHA.110.595181","article-title":"Prevalence and risk factors of cerebral microbleeds: an update of the Rotterdam scan study","volume":"41","author":"Poels","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2012.07.001_bb0130","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1161\/01.STR.0000131809.35202.1b","article-title":"Cerebral microbleeds: prevalence and associations with cardiovascular risk factors in the Framingham Study","volume":"35","author":"Jeerakathil","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2012.07.001_bb0135","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1212\/WNL.52.5.991","article-title":"MRI evidence of past cerebral microbleeds in a healthy elderly population","volume":"52","author":"Roob","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2012.07.001_bb0140","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s002340100649","article-title":"MR detection of microhemorrhages in neurologically healthy adults","volume":"44","author":"Tsushima","year":"2002","journal-title":"Neuroradiology"},{"key":"10.1016\/j.jns.2012.07.001_bb0145","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1212\/WNL.0b013e3181e396ea","article-title":"Incidence of cerebral microbleeds","volume":"74","author":"Goos","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2012.07.001_bb0150","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1001\/archneur.65.6.790","article-title":"Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study","volume":"65","author":"Pettersen","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jns.2012.07.001_bb0155","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S1474-4422(09)70013-4","article-title":"Microbleed Study Group: cerebral microbleeds: a guide to detection and interpretation","volume":"8","author":"Greenberg","year":"2009","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jns.2012.07.001_bb0160","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1212\/01.wnl.0000307750.41970.d9","article-title":"Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study","volume":"70","author":"Vernooij","year":"2008","journal-title":"Neurology"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X12003346?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X12003346?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T18:25:33Z","timestamp":1542824733000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X12003346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":32,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0022510X12003346"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2012.07.001","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}