{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:20:49Z","timestamp":1793146849405,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"1-2","content-domain":{"domain":["jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.jns.2013.03.019","type":"journal-article","created":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T08:33:28Z","timestamp":1366965208000},"page":"18-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Mitochondria, motor neurons and aging"],"prefix":"10.1016","volume":"330","author":[{"given":"M.L.","family":"Garc\u00eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.T.","family":"Solas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2013.03.019_bb0005","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jns.2013.03.019_bb0010","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s12017-008-8044-z","article-title":"Mitochondrial medicine for aging and neurodegenerative diseases","volume":"10","author":"Reddy","year":"2008","journal-title":"Neuromolecular Med"},{"key":"10.1016\/j.jns.2013.03.019_bb0015","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1002\/jnr.21167","article-title":"Mitochondria in cybrids containing mtDNA from persons with mitochondriopathies","volume":"85","author":"Swerdlow","year":"2007","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.jns.2013.03.019_bb0020","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev.genet.39.110304.095751","article-title":"A mitochondrial paradigm of metabolic & degenerative diseases, aging and cancer: a dawn for evolutionary medicine","volume":"39","author":"Wallace","year":"2005","journal-title":"Annu Rev Genet"},{"key":"10.1016\/j.jns.2013.03.019_bb0025","first-page":"223","article-title":"Programmed cell death and apoptosis in aging and life span regulation","volume":"8","author":"Shen","year":"2009","journal-title":"Discov Med"},{"key":"10.1016\/j.jns.2013.03.019_bb0030","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1126\/science.288.5464.335","article-title":"Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model","volume":"288","author":"Li","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jns.2013.03.019_bb0035","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1056\/NEJMra022366","article-title":"Apoptosis and caspases in neurodegenerative diseases","volume":"348","author":"Friedlander","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jns.2013.03.019_bb0040","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1038\/sj.onc.1207517","article-title":"Role of AIF in caspase-dependent and caspase-independent cell death","volume":"23","author":"Cregan","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.jns.2013.03.019_bb0045","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1590\/S0001-37652009000300011","article-title":"Calcium and cell death signaling in neurodegeneration and aging","volume":"81","author":"Smaili","year":"2009","journal-title":"An Acad Bras Cienc"},{"key":"10.1016\/j.jns.2013.03.019_bb0050","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1242\/jcs.03381","article-title":"Mitochondrial bioenergetics and structural network organization","volume":"120","author":"Bernard","year":"2007","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jns.2013.03.019_bb0055","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/jcp.20753","article-title":"Formation of elongated giant mitochondria in DFO-induced cellular senescence: Involvement of enhanced fusion process through modulation of Fis1","volume":"209","author":"Yoon","year":"2006","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jns.2013.03.019_bb0060","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0024-3205(96)00322-0","article-title":"Cytosolic and mitochondrial calcium in synaptosomes during aging","volume":"59","author":"Satrustegui","year":"1996","journal-title":"Life Sci"},{"key":"10.1016\/j.jns.2013.03.019_bb0065","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1474-9728.2003.00073.x","article-title":"Mitochondria and aging: a role for the permeability transition?","volume":"3","author":"Crompton","year":"2004","journal-title":"Aging Cell"},{"key":"10.1016\/j.jns.2013.03.019_bb0070","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/ana.20624","article-title":"Mitochondria take center stage in aging and neurodegeneration","volume":"58","author":"Beal","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jns.2013.03.019_bb0075","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1017\/S1092852900024901","article-title":"Role of mitochondria in neurodegenerative diseases: mitochondria as a therapeutic target in Alzheimer's disease","volume":"14","author":"Reddy","year":"2009","journal-title":"CNS Spectr"},{"key":"10.1016\/j.jns.2013.03.019_bb0080","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/364584a0","article-title":"ALS, SOD and peroxynitrite","volume":"364","author":"Beckman","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.jns.2013.03.019_bb0085","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1126\/science.286.5449.2498","article-title":"Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase","volume":"24","author":"Est\u00e9vez","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jns.2013.03.019_bb0090","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1126\/science.271.5248.515","article-title":"Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis","volume":"271","author":"Wiedau-Pazos","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.jns.2013.03.019_bb0095","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/sj.sc.3101674","article-title":"Increased production of reactive oxygen species contributes to motor neuron death in a compression mouse model of spinal cord injury","volume":"43","author":"Xu","year":"2005","journal-title":"Spinal Cord"},{"key":"10.1016\/j.jns.2013.03.019_bb0100","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1096\/fj.09-146308","article-title":"Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration","volume":"24","author":"Youngmok","year":"2010","journal-title":"FASEB J"},{"key":"10.1016\/j.jns.2013.03.019_bb0105","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.mito.2005.01.002","article-title":"Mitochondrial dysfunction and its role in motor neuron degeneration in ALS","volume":"5","author":"Manfredi","year":"2005","journal-title":"Mitochondrion"},{"key":"10.1016\/j.jns.2013.03.019_bb0110","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1523\/JNEUROSCI.20-07-02534.2000","article-title":"Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases","volume":"20","author":"Frey","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.jns.2013.03.019_bb0115","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.nbd.2007.07.003","article-title":"Time course of preferential motor unit loss in the SOD1G93A mouse model of amyotrophic lateral sclerosis","volume":"28","author":"Hegedus","year":"2007","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jns.2013.03.019_bb0120","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.expneurol.2003.10.004","article-title":"Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man","volume":"185","author":"Fisher","year":"2004","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jns.2013.03.019_bb0125","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1126\/science.1083129","article-title":"Mutations in dynein link motor neuron degeneration to defects in retrograde transport","volume":"300","author":"Hafezparast","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.jns.2013.03.019_bb0130","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0896-6273(02)00696-7","article-title":"Disruption of dynein\/dynactin inhibits axonal transport in motor neurons causing late-onset progressive deterioration","volume":"34","author":"LaMonte","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.jns.2013.03.019_bb0135","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/ng1123","article-title":"Mutant dynactin in motor neuron disease","volume":"33","author":"Puls","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.jns.2013.03.019_bb0140","doi-asserted-by":"crossref","first-page":"11658","DOI":"10.1074\/jbc.M510303200","article-title":"Synaptic mitochondria are more susceptible to Ca2+ overload than non-synaptic mitochondria","volume":"281","author":"Brown","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jns.2013.03.019_bb0145","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1474-9726.2005.00156.x","article-title":"Age-related changes in regional brain mitochondria from Fischer 344 rats","volume":"4","author":"LaFrance","year":"2005","journal-title":"Aging Cell"},{"key":"10.1016\/j.jns.2013.03.019_bb0150","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.molmed.2007.12.002","article-title":"Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease","volume":"14","author":"Reddy","year":"2008","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.jns.2013.03.019_bb0155","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.bbabio.2008.05.011","article-title":"Correlated light and electron microscopy illuminates the role of mitochondrial inner membrane remodeling during apoptosis","volume":"1777","author":"Frey","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jns.2013.03.019_bb0160","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.281.5381.1309","article-title":"Mitochondria and apoptosis","volume":"281","author":"Green","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jns.2013.03.019_bb0165","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/74994","article-title":"Mitochondrial control of cell death","volume":"6","author":"Kroemer","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.jns.2013.03.019_bb0170","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S1097-2765(00)80095-7","article-title":"Autoactivation of procaspase-9 by Apaf-1 mediated oligomerization","volume":"1","author":"Srinivasula","year":"1998","journal-title":"Mol Cell"},{"key":"10.1016\/j.jns.2013.03.019_bb0175","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1093\/emboj\/18.13.3586","article-title":"Role of cytochrome c and dATP\/ATP hydrolysis in Apaf-1 mediated caspase-9 activation and apoptosis","volume":"18","author":"Hu","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/j.jns.2013.03.019_bb0180","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1101\/gad.13.24.3179","article-title":"Caspase-9 and Apaf-1 form an active holoenzyme","volume":"13","author":"Rodriguez","year":"1999","journal-title":"Genes Dev"},{"key":"10.1016\/j.jns.2013.03.019_bb0185","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S1097-2765(02)00442-2","article-title":"Three-dimensional structure of the apoptosome: implications for assembly","volume":"9","author":"Acehan","year":"2002","journal-title":"Mol Cell"},{"key":"10.1016\/j.jns.2013.03.019_bb0190","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1159\/000094602","article-title":"Caspase-3 immunoreactivity in different cortical areas of young and aging macaque (Macaca mulatta) monkeys","volume":"15","author":"Zhang","year":"2006","journal-title":"Neurosignals"},{"key":"10.1016\/j.jns.2013.03.019_bb0195","doi-asserted-by":"crossref","first-page":"6092","DOI":"10.1523\/JNEUROSCI.0707-05.2005","article-title":"Axonal dynactin p150 Glued transports caspase-8 to drive retrograde olfactory receptor neuron apoptosis","volume":"25","author":"Carson","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.jns.2013.03.019_bb0200","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1582-4934.2002.tb00452.x","article-title":"Megamitochondria formation \u2014 physiology and pathology","volume":"6","author":"Wakabayashi","year":"2002","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jns.2013.03.019_bb0205","doi-asserted-by":"crossref","first-page":"22704","DOI":"10.1074\/jbc.M312366200","article-title":"Ca2+ homeostasis during mitochondrial fragmentation and perinuclear clustering induced by hFis1","volume":"279","author":"Frieden","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jns.2013.03.019_bb0210","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.bbabio.2009.03.010","article-title":"Mitochondrial calcium function and dysfunction in the central nervous system","volume":"1787","author":"Nicholls","year":"2009","journal-title":"BBA \u2014 Bioenergetics"},{"key":"10.1016\/j.jns.2013.03.019_bb0215","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1111\/j.1471-4159.2007.04626.x","article-title":"Calcium-induced precipitate formation in brain mitochondria: composition, calcium capacity, and retention","volume":"102","author":"Kristian","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.jns.2013.03.019_bb0220","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.1523\/JNEUROSCI.0531-04.2004","article-title":"Excitotoxic calcium overload in a subpopulation of mitochondria triggers delayed death in hippocampal neurons","volume":"24","author":"Pivarova","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.jns.2013.03.019_bb0225","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1756-0500-3-67","article-title":"A mathematical model of mitochondrial swelling","volume":"3","author":"Eisenhofer","year":"2010","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.jns.2013.03.019_bb0230","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1006\/jsbi.1999.4188","article-title":"Quantitative energy-dispersive X-ray microanalysis of calcium dynamics in cell suspensions during stimulation on a subsecond time scale: preparative and analytical aspects as exemplified with paramecium cells","volume":"128","author":"Hardt","year":"1999","journal-title":"J Struct Biol"},{"key":"10.1016\/j.jns.2013.03.019_bb0235","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1016\/j.febslet.2007.01.095","article-title":"New insights into mitochondrial fusion","volume":"581","author":"Zhang","year":"2007","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jns.2013.03.019_bb0240","doi-asserted-by":"crossref","first-page":"52726","DOI":"10.1074\/jbc.M408910200","article-title":"Fzo1, a protein involved in mitochondrial fusion, inhibits apoptosis","volume":"279","author":"Sugioka","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jns.2013.03.019_bb0245","doi-asserted-by":"crossref","first-page":"25060","DOI":"10.1074\/jbc.M501599200","article-title":"Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization","volume":"280","author":"Neuspiel","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jns.2013.03.019_bb0250","first-page":"45","article-title":"Mitochondrial dysfunction in amyotrophic lateral sclerosis","volume":"2010","author":"Shi","year":"1802","journal-title":"BBA-Mol Basis Dis"},{"key":"10.1016\/j.jns.2013.03.019_bb0255","doi-asserted-by":"crossref","first-page":"e5390","DOI":"10.1371\/journal.pone.0005390","article-title":"Muscle mitochondrial uncopling dismantles neuromuscular junction and triggers distal degeneration of motor neurons","volume":"4","author":"Dupuis","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jns.2013.03.019_bb0260","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4081\/ni.2009.e16","article-title":"Early detachment of neuromuscular junction proteins in ALS mice with SODG93A mutation","volume":"1","author":"Narai","year":"2009","journal-title":"Neurol Int"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X13001433?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X13001433?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T21:13:59Z","timestamp":1644873239000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X13001433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":52,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S0022510X13001433"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2013.03.019","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondria, motor neurons and aging","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2013.03.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}