{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:43:48Z","timestamp":1791438228870,"version":"4.3.3"},"reference-count":34,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Korea Healthcare Technology R & D Project, Ministry of Health & Welfare, Republic of Korea","award":["A092042"],"award-info":[{"award-number":["A092042"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jns-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.jns.2014.01.029","type":"journal-article","created":{"date-parts":[[2014,2,2]],"date-time":"2014-02-02T06:22:46Z","timestamp":1391322166000},"page":"91-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["CR1, ABCA7, and APOE genes affect the features of cognitive impairment in Alzheimer's disease"],"prefix":"10.1016","volume":"339","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4118-8233","authenticated-orcid":false,"given":"Sun Ju","family":"Chung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juyeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sooyeoun","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Hye","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Yoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Hong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2014.01.029_bb0005","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.jns.2014.01.029_bb0010","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0197-4580(00)00183-4","article-title":"Cognitive and behavioral heterogeneity in Alzheimer's disease: seeking the neurobiological basis","volume":"21","author":"Cummings","year":"2000","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jns.2014.01.029_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/alzrt155","article-title":"Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome","volume":"5","author":"Lam","year":"2013","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.jns.2014.01.029_bb0020","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease","volume":"41","author":"Lambert","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.jns.2014.01.029_bb0025","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease","volume":"41","author":"Harold","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.jns.2014.01.029_bb0030","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1001\/jama.2010.574","article-title":"Genome-wide analysis of genetic loci associated with Alzheimer disease","volume":"303","author":"Seshadri","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.jns.2014.01.029_bb0035","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1001\/archneurol.2010.292","article-title":"Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals","volume":"68","author":"Lee","year":"2011","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jns.2014.01.029_bb0040","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng.803","article-title":"Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease","volume":"43","author":"Hollingworth","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.jns.2014.01.029_bb0045","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/WAD.0b013e31826d7281","article-title":"Association of GWAS top hits with late-onset Alzheimer disease in Korean population","volume":"27","author":"Chung","year":"2013","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.1016\/j.jns.2014.01.029_bb0050","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS\u2013ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2014.01.029_bb0055","series-title":"Seoul Neuropsychological Screening Battery (SNSB)","author":"Kang","year":"2003"},{"key":"10.1016\/j.jns.2014.01.029_bb0060","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/ng.305","article-title":"Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease","volume":"41","author":"Carrasquillo","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.jns.2014.01.029_bb0065","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/gm249","article-title":"The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease","volume":"3","author":"Antunez","year":"2011","journal-title":"Genome Med"},{"key":"10.1016\/j.jns.2014.01.029_bb0070","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ng.801","article-title":"Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease","volume":"43","author":"Naj","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.jns.2014.01.029_bb0075","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nature04226","article-title":"A haplotype map of the human genome","volume":"437","author":"International HapMap Consortium","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jns.2014.01.029_bb0080","first-page":"5","article-title":"Statistical methods in cancer research. Volume I \u2014 the analysis of case\u2013control studies","author":"Breslow","year":"1980","journal-title":"IARC Sci Publ"},{"key":"10.1016\/j.jns.2014.01.029_bb0085","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1001\/archneurol.2010.147","article-title":"Replication of CLU, CR1, and PICALM associations with Alzheimer disease","volume":"67","author":"Carrasquillo","year":"2010","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jns.2014.01.029_bb0090","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1084\/jem.155.5.1427","article-title":"Complement receptor (CR1) deficiency in erythrocytes from patients with systemic lupus erythematosus","volume":"155","author":"Iida","year":"1982","journal-title":"J Exp Med"},{"key":"10.1016\/j.jns.2014.01.029_bb0095","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0162-3109(00)80303-3","article-title":"Complement and innate immunity","volume":"49","author":"Song","year":"2000","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.jns.2014.01.029_bb0100","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.molimm.2008.09.026","article-title":"Complement receptor 1: disease associations and therapeutic implications","volume":"46","author":"Khera","year":"2009","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jns.2014.01.029_bb0105","doi-asserted-by":"crossref","first-page":"10837","DOI":"10.1073\/pnas.162350199","article-title":"Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice","volume":"99","author":"Wyss-Coray","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jns.2014.01.029_bb0110","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/ana.22277","article-title":"CR1 is associated with amyloid plaque burden and age-related cognitive decline","volume":"69","author":"Chibnik","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jns.2014.01.029_bb0115","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1001\/jama.2013.2973","article-title":"Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E 4, and the risk of late-onset Alzheimer disease in African Americans","volume":"309","author":"Reitz","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.jns.2014.01.029_bb0120","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1074\/jbc.M412602200","article-title":"Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels","volume":"280","author":"Kim","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jns.2014.01.029_bb0125","doi-asserted-by":"crossref","first-page":"274","DOI":"10.5551\/jat.6726","article-title":"Roles of ATP-binding cassette transporter A7 in cholesterol homeostasis and host defense system","volume":"18","author":"Tanaka","year":"2011","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.jns.2014.01.029_bb0130","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1083\/jcb.200601030","article-title":"ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages","volume":"174","author":"Jehle","year":"2006","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jns.2014.01.029_bb0135","series-title":"Neuropsychological assessment","author":"Lezak","year":"2004"},{"key":"10.1016\/j.jns.2014.01.029_bb0140","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0140-6736(93)91705-Q","article-title":"Apolipoprotein E polymorphism and Alzheimer's disease","volume":"342","author":"Poirier","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.jns.2014.01.029_bb0145","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1212\/WNL.0b013e31827f0889","article-title":"Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia","volume":"80","author":"Ossenkoppele","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2014.01.029_bb0150","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1212\/01.wnl.0000311446.61861.e3","article-title":"Whole-brain atrophy rate in Alzheimer disease: identifying fast progressors","volume":"70","author":"Sluimer","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2014.01.029_bb0155","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1001\/archneur.63.1.155","article-title":"Apolipoprotein e genotype modifies the phenotype of Alzheimer disease","volume":"63","author":"Schott","year":"2006","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jns.2014.01.029_bb0160","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000104467","article-title":"Cognitive impairment in Alzheimer's disease is modified by APOE genotype","volume":"24","author":"van der Vlies","year":"2007","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.jns.2014.01.029_bb0165","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1212\/WNL.46.2.413","article-title":"Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: relation to apolipoprotein E polymorphism","volume":"46","author":"Lehtovirta","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2014.01.029_bb0170","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.neuroimage.2009.01.009","article-title":"Mapping the effect of APOE epsilon4 on gray matter loss in Alzheimer's disease in vivo","volume":"45","author":"Pievani","year":"2009","journal-title":"Neuroimage"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X14000537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X14000537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T19:51:11Z","timestamp":1538855471000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X14000537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":34,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S0022510X14000537"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2014.01.029","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CR1, ABCA7, and APOE genes affect the features of cognitive impairment in Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2014.01.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}