{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:26:23Z","timestamp":1773213983126,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.jns.2014.07.044","type":"journal-article","created":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T18:15:43Z","timestamp":1406571343000},"page":"189-192","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cardiac involvement in chronic progressive external ophthalmoplegia"],"prefix":"10.1016","volume":"345","author":[{"given":"Fabio","family":"Galetta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinando","family":"Franzoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelangelo","family":"Mancuso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Orsucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Tocchini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Papi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Speziale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Gaudio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Siciliano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gino","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2014.07.044_bb0005","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1056\/NEJMra022567","article-title":"Mitochondrial respiratory-chain diseases","volume":"348","author":"Di Mauro","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jns.2014.07.044_bb0010","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/ana.21217","article-title":"Prevalence of mitochondrial DNA disease in adults","volume":"63","author":"Schaefer","year":"2008","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jns.2014.07.044_bb0015","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1600-0404.2006.00777.x","article-title":"Mitochondrial diseases: a nosological update","volume":"115","author":"Filosto","year":"2007","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.jns.2014.07.044_bb0020","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1093\/brain\/awm067","article-title":"Chronic progressive ophthalmoplegia with large-scale mtDNA rearrangement: can we predict progression?","volume":"130","author":"Aur\u00e9","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.jns.2014.07.044_bb0025","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/clc.4960200310","article-title":"Cardiac dysfunction in patients with chronic progressive external ophthalmoplegia","volume":"20","author":"Akaike","year":"1997","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jns.2014.07.044_bb0030","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1161\/01.CIR.91.4.955","article-title":"Cardiac involvement in mitochondrial diseases. A study on 17 patients with documented mitochondrial DNA defects","volume":"91","author":"Anan","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.jns.2014.07.044_bb0035","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0002-9149(97)00015-5","article-title":"Clinical application of pulsed Doppler tissue imaging for assessing abnormal left ventricular relaxation","volume":"79","author":"Oki","year":"1997","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jns.2014.07.044_bb0040","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1136\/heart.87.4.336","article-title":"Is Doppler tissue velocity during early left ventricular filling preload independent?","volume":"87","author":"Yalcin","year":"2002","journal-title":"Heart"},{"key":"10.1016\/j.jns.2014.07.044_bb0045","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0894-7317(14)80001-1","article-title":"Color Doppler myocardial imaging: a new technique for the assessment of myocardial function","volume":"7","author":"Sutherland","year":"1994","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jns.2014.07.044_bb0050","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1212\/01.WNL.0000033795.17156.00","article-title":"Diagnostic criteria for respiratory chain disorders in adults and children","volume":"59","author":"Bernier","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2014.07.044_bb0055","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/ana.410220409","article-title":"Cytochrome c oxidase deficiency in Leigh syndrome","volume":"22","author":"Di Mauro","year":"1987","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jns.2014.07.044_bb0060","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0960-8966(02)00221-3","article-title":"Autosomal dominant external ophthalmoplegia and bipolar affective disorder associated with a mutation in the ANT1 gene","volume":"13","author":"Siciliano","year":"2003","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.jns.2014.07.044_bb0065","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1161\/01.CIR.58.6.1072","article-title":"The committee on M-mode Standardization of the American Society of Echocardiography: recommendations regarding quantitation in M-mode echocardiography. Results of a survey of echocardiographic measurements","volume":"58","author":"Sahn","year":"1978","journal-title":"Circulation"},{"key":"10.1016\/j.jns.2014.07.044_bb0070","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1161\/01.CIR.55.4.613","article-title":"Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method","volume":"55","author":"Devereux","year":"1977","journal-title":"Circulation"},{"key":"10.1016\/j.jns.2014.07.044_bb0075","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1651-2227.2003.tb00549.x","article-title":"Ultrasonic tissue characterization of the myocardium in anorexia nervosa","volume":"92","author":"Franzoni","year":"2003","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jns.2014.07.044_bb0080","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/ana.410010104","article-title":"Lumping or splitting? \u2018Ophthalmoplegia-plus\u2019 or Kearns\u2013Sayre syndrome?","volume":"1","author":"Berenberg","year":"1977","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jns.2014.07.044_bb0085","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/hrt.38.5.526","article-title":"Cardiac abnormalities in chronic progressive external ophthalmoplegia","volume":"38","author":"McComish","year":"1976","journal-title":"Br Heart J"},{"key":"10.1016\/j.jns.2014.07.044_bb0090","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/S0735-1097(97)00344-6","article-title":"Doppler tissue imaging: a non-invasive technique for evaluation of left ventricular relaxation and filling pressures","volume":"30","author":"Nagueh","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jns.2014.07.044_bb0095","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S0735-1097(97)88335-0","article-title":"Assessment of mitral annulus velocity by Doppler tissue imaging in the evaluation of left ventricular diastolic function","volume":"30","author":"Sohn","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jns.2014.07.044_bb0100","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1067\/mje.2000.106206","article-title":"Myocardial longitudinal motion by tissue velocity imaging in the evaluation of patients with myocardial infarction","volume":"13","author":"Palmes","year":"2000","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jns.2014.07.044_bb0105","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0002-9149(96)00033-1","article-title":"Mitral annular descent velocity by tissue Doppler echocardiography as an index of global left ventricular function","volume":"77","author":"Gulati","year":"1996","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jns.2014.07.044_bb0110","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0894-7317(97)70028-2","article-title":"Echocardiographic patterns of myocardial fibrosis in hypertensive patients: endomyocardial biopsy versus ultrasonic tissue characterization","volume":"10","author":"Ciulla","year":"1997","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jns.2014.07.044_bb0115","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1161\/01.RES.47.1.49","article-title":"The dependence of ultrasonic attenuation and backscatter on collagen content in dog and rabbit hearts","volume":"47","author":"Mimbs","year":"1980","journal-title":"Circ Res"},{"key":"10.1016\/j.jns.2014.07.044_bb0120","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0735-1097(84)80323-X","article-title":"Applicability of ultrasonic tissue characterisation for longitudinal assessment and differentiation of calcification and fibrosis in cardiomyopathy","volume":"4","author":"Pe\u00b4rez","year":"1984","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jns.2014.07.044_bb0125","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1212\/WNL.46.5.1329","article-title":"Multiple mitochondrial DNA deletions associated with autosomal recessive ophthalmoplegia and severe cardiomyopathy","volume":"46","author":"Bohlega","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2014.07.044_bb0130","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.jacc.2007.06.035","article-title":"Induction of mitochondrial biogenesis is a maladaptive mechanism in mitochondrial cardiomyopathies","volume":"50","author":"Sebastiani","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jns.2014.07.044_bb0135","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/BF00705340","article-title":"Fatal mitochondrial cardiomyopathy in Kearns\u2013Sayre syndrome","volume":"408","author":"H\u00fcbner","year":"1986","journal-title":"Virchows Arch A Pathol Anat Histopathol"},{"key":"10.1016\/j.jns.2014.07.044_bb0140","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1161\/01.STR.0000147045.71923.18","article-title":"Do normal d-dimer levels reliably exclude cerebral sinus thrombosis?","volume":"35","author":"Kosinski","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2014.07.044_bb0145","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1212\/WNL.46.3.826","article-title":"Cerebral infarction associated with Kearns\u2013Sayre syndrome-related cardiomyopathy","volume":"46","author":"Provenzale","year":"1996","journal-title":"Neurology"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X14004900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X14004900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T09:25:15Z","timestamp":1538385915000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X14004900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":29,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0022510X14004900"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2014.07.044","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiac involvement in chronic progressive external ophthalmoplegia","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2014.07.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}