{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T08:03:08Z","timestamp":1789545788218,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.jns.2014.12.002","type":"journal-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T07:05:28Z","timestamp":1418022328000},"page":"195-200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["The susceptibility vessel sign at the proximal M1: A strong predictor for poor outcome after intravenous thrombolysis"],"prefix":"10.1016","volume":"348","author":[{"given":"Junya","family":"Aoki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensaku","family":"Shibazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Saji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.jns.2014.12.002_bb0005","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1056\/NEJM199512143332401","article-title":"Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group","volume":"333","year":"1995","journal-title":"N Engl J Med"},{"issue":"13","key":"10.1016\/j.jns.2014.12.002_bb0010","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJMoa0804656","article-title":"Thrombolysis with alteplase 3 to 4.5hours after acute ischemic stroke","volume":"359","author":"Hacke","year":"2008","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.jns.2014.12.002_bb0015","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1161\/STROKEAHA.109.552588","article-title":"M1 susceptibility vessel sign on T2* as a strong predictor for no early recanalization after IV-t-PA in acute ischemic stroke","volume":"40","author":"Kimura","year":"2009","journal-title":"Stroke"},{"issue":"11","key":"10.1016\/j.jns.2014.12.002_bb0020","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1161\/STROKEAHA.111.623207","article-title":"Clinical and MRI predictors of no early recanalization within 1hour after tissue-type plasminogen activator administration","volume":"42","author":"Kimura","year":"2011","journal-title":"Stroke"},{"issue":"5","key":"10.1016\/j.jns.2014.12.002_bb0025","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1159\/000327690","article-title":"Clinical and MRI scale to predict very poor outcome in tissue plasminogen activator patients","volume":"65","author":"Kimura","year":"2011","journal-title":"Eur Neurol"},{"key":"10.1016\/j.jns.2014.12.002_bb0030","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000354848","article-title":"Location of the susceptibility vessel sign on T2*-weighted MRI and early recanalization within 1hour after t-PA administration","volume":"3","author":"Aoki","year":"2013","journal-title":"Cerebrovasc. Dis. Ext."},{"issue":"10","key":"10.1016\/j.jns.2014.12.002_bb0035","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1056\/NEJMoa1214300","article-title":"Endovascular therapy after intravenous t-PA versus t-PA alone for stroke","volume":"368","author":"Broderick","year":"2013","journal-title":"N Engl J Med"},{"issue":"10","key":"10.1016\/j.jns.2014.12.002_bb0040","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1056\/NEJMoa1213701","article-title":"Endovascular treatment for acute ischemic stroke","volume":"368","author":"Ciccone","year":"2013","journal-title":"N Engl J Med"},{"issue":"10","key":"10.1016\/j.jns.2014.12.002_bb0045","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1056\/NEJMoa1212793","article-title":"A trial of imaging selection and endovascular treatment for ischemic stroke","volume":"368","author":"Kidwell","year":"2013","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.jns.2014.12.002_bb0050","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1747-4949.2008.00178.x","article-title":"Outline of the Japanese Guidelines for the Management of Stroke 2004 and subsequent revision","volume":"3","author":"Shinohara","year":"2008","journal-title":"Int J Stroke"},{"issue":"5","key":"10.1016\/j.jns.2014.12.002_bb0055","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1159\/000323850","article-title":"Intravenous thrombolysis based on diffusion-weighted imaging and fluid-attenuated inversion recovery mismatch in acute stroke patients with unknown onset time","volume":"31","author":"Aoki","year":"2011","journal-title":"Cerebrovasc Dis"},{"issue":"6","key":"10.1016\/j.jns.2014.12.002_bb0060","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/ana.21651","article-title":"Negative fluid-attenuated inversion recovery imaging identifies acute ischemic stroke at 3hours or less","volume":"65","author":"Thomalla","year":"2009","journal-title":"Ann Neurol"},{"issue":"1","key":"10.1016\/j.jns.2014.12.002_bb0065","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","article-title":"Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment","volume":"24","author":"Adams","year":"1993","journal-title":"Stroke"},{"issue":"9216","key":"10.1016\/j.jns.2014.12.002_bb0070","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/S0140-6736(00)02237-6","article-title":"Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy. ASPECTS Study Group. Alberta Stroke Programme Early CT Score","volume":"355","author":"Barber","year":"2000","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.jns.2014.12.002_bb0075","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1136\/jnnp.2004.059261","article-title":"Imaging of the brain in acute ischaemic stroke: comparison of computed tomography and magnetic resonance diffusion-weighted imaging","volume":"76","author":"Barber","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"6","key":"10.1016\/j.jns.2014.12.002_bb0080","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1159\/000311736","article-title":"Recanalization within one hour after intravenous tissue plasminogen activator is associated with favorable outcome in acute stroke patients","volume":"63","author":"Kimura","year":"2010","journal-title":"Eur Neurol"},{"issue":"7","key":"10.1016\/j.jns.2014.12.002_bb0085","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1212\/WNL.55.7.952","article-title":"Predicting prognosis after stroke: a placebo group analysis from the National Institute of Neurological Disorders and Stroke rt-PA Stroke Trial","volume":"55","author":"Frankel","year":"2000","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.jns.2014.12.002_bb0090","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1161\/01.STR.0000185932.73486.7a","article-title":"Significance of susceptibility vessel sign on T2*-weighted gradient echo imaging for identification of stroke subtypes","volume":"36","author":"Cho","year":"2005","journal-title":"Stroke"},{"issue":"11","key":"10.1016\/j.jns.2014.12.002_bb0095","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1161\/STROKEAHA.109.562991","article-title":"Routine use of intravenous low-dose recombinant tissue plasminogen activator in Japanese patients: general outcomes and prognostic factors from the SAMURAI register","volume":"40","author":"Toyoda","year":"2009","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.jns.2014.12.002_bb0100","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1161\/01.STR.0000105396.93273.72","article-title":"Predicting major neurological improvement with intravenous recombinant tissue plasminogen activator treatment of stroke","volume":"35","author":"Brown","year":"2004","journal-title":"Stroke"},{"issue":"9558","key":"10.1016\/j.jns.2014.12.002_bb0105","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0140-6736(07)60149-4","article-title":"Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study","volume":"369","author":"Wahlgren","year":"2007","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.jns.2014.12.002_bb0110","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1161\/01.STR.0000021001.18101.A5","article-title":"Clinical and vascular outcome in internal carotid artery versus middle cerebral artery occlusions after intravenous tissue plasminogen activator","volume":"33","author":"Linfante","year":"2002","journal-title":"Stroke"},{"issue":"11","key":"10.1016\/j.jns.2014.12.002_bb0115","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1161\/01.STR.0000143728.45516.c6","article-title":"Impact of admission hyperglycemia on stroke outcome after thrombolysis: risk stratification in relation to time to reperfusion","volume":"35","author":"Alvarez-Sabin","year":"2004","journal-title":"Stroke"},{"issue":"8","key":"10.1016\/j.jns.2014.12.002_bb0120","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1161\/STROKEAHA.107.510917","article-title":"Large ischemic lesions on diffusion-weighted imaging done before intravenous tissue plasminogen activator thrombolysis predicts a poor outcome in patients with acute stroke","volume":"39","author":"Kimura","year":"2008","journal-title":"Stroke"},{"issue":"7","key":"10.1016\/j.jns.2014.12.002_bb0125","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1161\/STROKEAHA.113.001026","article-title":"Clot burden score on admission T2*-MRI predicts recanalization in acute stroke","volume":"44","author":"Legrand","year":"2013","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.jns.2014.12.002_bb0130","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1148\/radiology.215.2.r00ma09476","article-title":"Middle cerebral artery (MCA) susceptibility sign at susceptibility-based perfusion MR imaging: clinical importance and comparison with hyperdense MCA sign at CT","volume":"215","author":"Flacke","year":"2000","journal-title":"Radiology"},{"issue":"3","key":"10.1016\/j.jns.2014.12.002_bb0135","first-page":"618","article-title":"Diagnostic and prognostic value of early MR Imaging vessel signs in hyperacute stroke patients imaged <3hours and treated with recombinant tissue plasminogen activator","volume":"26","author":"Schellinger","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"issue":"7","key":"10.1016\/j.jns.2014.12.002_bb0140","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1161\/01.STR.30.7.1444","article-title":"Reliability and validity of noninvasive imaging of internal carotid artery pseudo-occlusion","volume":"30","author":"F\u00fcrst","year":"1999","journal-title":"Stroke"},{"issue":"3 Pt 2","key":"10.1016\/j.jns.2014.12.002_bb0145","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1148\/radiology.174.3.174-3-1013","article-title":"Optimization of gradient-echo imaging parameters for intracaval filters and trapped thromboemboli","volume":"174","author":"Teitelbaum","year":"1990","journal-title":"Radiology"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X14007679?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X14007679?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T04:52:09Z","timestamp":1538023929000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X14007679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":29,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S0022510X14007679"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2014.12.002","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The susceptibility vessel sign at the proximal M1: A strong predictor for poor outcome after intravenous thrombolysis","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2014.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}