{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:08:55Z","timestamp":1791198535900,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100005725","name":"CHDI Foundation Inc.","doi-asserted-by":"crossref","award":["A \u2013 3433"],"award-info":[{"award-number":["A \u2013 3433"]}],"id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["606650"],"award-info":[{"award-number":["606650"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jns-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.jns.2016.03.021","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T18:02:11Z","timestamp":1457805731000},"page":"148-153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Subjective sleep problems in Huntington's disease: A pilot investigation of the relationship to brain structure, neurocognitive, and neuropsychiatric function"],"prefix":"10.1016","volume":"364","author":[{"given":"Chaya Rochel","family":"Baker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Dom\u00ednguez D","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie C.","family":"Stout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanaz","family":"Gabery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Churchyard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis","family":"Chua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary F.","family":"Egan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa","family":"Peters\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nellie","family":"Georgiou-Karistianis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govinda R.","family":"Poudel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2016.03.021_bb0005","doi-asserted-by":"crossref","DOI":"10.1002\/ana.24495","article-title":"Sleep, but no metabolic, deficits in pre-manifest huntington's disease","author":"Lazar","year":"2015","journal-title":"Ann. Neurol."},{"issue":"6","key":"10.1016\/j.jns.2016.03.021_bb0010","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","volume":"72","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.jns.2016.03.021_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/currents.RRN1189","article-title":"Identifying sleep disturbances in Huntington's disease using a simple disease-focused questionnaire","volume":"2","author":"Goodman","year":"2010","journal-title":"PLoS Curr."},{"key":"10.1016\/j.jns.2016.03.021_bb0020","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.expneurol.2012.10.014","article-title":"Circadian and sleep disorder in Huntington's disease","volume":"243","author":"Morton","year":"2013","journal-title":"Exp. Neurol."},{"issue":"9","key":"10.1016\/j.jns.2016.03.021_bb0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074131","article-title":"Multi-modal neuroimaging in premanifest and early Huntington's disease: 18month longitudinal data from the IMAGE-HD study","volume":"8","author":"Dominguez","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jns.2016.03.021_bb0030","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.nbd.2012.10.001","article-title":"Automated differentiation of pre-diagnosis Huntington's disease from healthy control individuals based on quadratic discriminant analysis of the basal ganglia: the IMAGE-HD study","volume":"51","author":"Georgiou-Karistianis","year":"2013","journal-title":"Neurobiol. Dis."},{"issue":"9","key":"10.1016\/j.jns.2016.03.021_bb0035","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S1474-4422(09)70170-X","article-title":"Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data","volume":"8","author":"Tabrizi","year":"2009","journal-title":"Lancet Neurol."},{"issue":"4","key":"10.1016\/j.jns.2016.03.021_bb0040","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.neuroimage.2006.05.057","article-title":"Distribution of grey matter atrophy in Huntington's disease patients: a combined ROI-based and voxel-based morphometric study","volume":"32","author":"Douaud","year":"2006","journal-title":"NeuroImage"},{"issue":"4","key":"10.1016\/j.jns.2016.03.021_bb0045","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/00005072-199007000-00002","article-title":"Atrophy of the hypothalamic lateral tuberal nucleus in Huntington's disease","volume":"49","author":"Kremer","year":"1990","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"1","key":"10.1016\/j.jns.2016.03.021_bb0050","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1523\/JNEUROSCI.3842-04.2005","article-title":"Disintegration of the sleep-wake cycle and circadian timing in Huntington's disease","volume":"25","author":"Morton","year":"2005","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"issue":"6","key":"10.1016\/j.jns.2016.03.021_bb0055","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00401-010-0742-6","article-title":"Changes in key hypothalamic neuropeptide populations in Huntington disease revealed by neuropathological analyses","volume":"120","author":"Gabery","year":"2010","journal-title":"Acta Neuropathol."},{"issue":"1","key":"10.1016\/j.jns.2016.03.021_bb0060","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/hmg\/ddi004","article-title":"Orexin loss in Huntington's disease","volume":"14","author":"Petersen","year":"2005","journal-title":"Hum. Mol. Genet."},{"issue":"4","key":"10.1016\/j.jns.2016.03.021_bb0065","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF00314781","article-title":"Nocturnal sleep in Huntington's disease","volume":"238","author":"Wiegand","year":"1991","journal-title":"J. Neurol."},{"issue":"29","key":"10.1016\/j.jns.2016.03.021_bb0070","doi-asserted-by":"crossref","first-page":"7869","DOI":"10.1523\/JNEUROSCI.0649-07.2007","article-title":"Pharmacological imposition of sleep slows cognitive decline and reverses dysregulation of circadian gene expression in a transgenic mouse model of Huntington's disease","volume":"27","author":"Pallier","year":"2007","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.jns.2016.03.021_bb0075","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.parkreldis.2010.02.009","article-title":"Sleep and circadian rhythm alterations correlate with depression and cognitive impairment in Huntington's disease","volume":"16","author":"Aziz","year":"2010","journal-title":"Parkinsonism Relat. Disord."},{"issue":"3","key":"10.1016\/j.jns.2016.03.021_bb0080","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.sleep.2006.08.007","article-title":"The effects of sleep deprivation on symptoms of psychopathology in healthy adults","volume":"8","author":"Kahn-Greene","year":"2007","journal-title":"Sleep Med."},{"issue":"2","key":"10.1016\/j.jns.2016.03.021_bb0085","first-page":"87","article-title":"Abnormal synchrony of resting state networks in premanifest and symptomatic Huntington disease: the IMAGE-HD study","volume":"39","author":"Poudel","year":"2014","journal-title":"J. Psychiatry Neurosci. JPN."},{"issue":"1","key":"10.1016\/j.jns.2016.03.021_bb0090","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00429-013-0670-z","article-title":"Functional changes during working memory in Huntington's disease: 30-month longitudinal data from the IMAGE-HD study","volume":"220","author":"Poudel","year":"2015","journal-title":"Brain Struct. Funct."},{"issue":"5","key":"10.1016\/j.jns.2016.03.021_bb0095","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1002\/hbm.22296","article-title":"Functional magnetic resonance imaging of working memory in Huntington's disease: cross-sectional data from the IMAGE-HD study","volume":"35","author":"Georgiou-Karistianis","year":"2014","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.jns.2016.03.021_bb0100","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.nbd.2014.12.009","article-title":"Longitudinal change in white matter microstructure in Huntington's disease: the IMAGE-HD study","volume":"74","author":"Poudel","year":"2015","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.jns.2016.03.021_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0117593","article-title":"Volumetric analysis of the hypothalamus in Huntington disease using 3T MRI: the IMAGE-HD study","volume":"10","author":"Gabery","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jns.2016.03.021_bb0110","article-title":"Automated differentiation of pre-diagnosis Huntington's disease from healthy control individuals based on quadratic discriminant analysis of the basal ganglia: the IMAGE-HD study","author":"Georgiou-Karistianis","year":"2012","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.jns.2016.03.021_bb0115","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.bandc.2013.07.004","article-title":"Functional and connectivity changes during working memory in Huntington's disease: 18month longitudinal data from the IMAGE-HD study","volume":"83","author":"Georgiou-Karistianis","year":"2013","journal-title":"Brain Cogn."},{"issue":"1","key":"10.1016\/j.jns.2016.03.021_bb0120","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00429-013-0670-z","article-title":"Functional changes during working memory in Huntington's disease: 30-month longitudinal data from the IMAGE-HD study","volume":"220","author":"Poudel","year":"2015","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.jns.2016.03.021_bb0125","first-page":"406","article-title":"Longitudinal change in white matter microstructure in Huntington's disease: the IMAGE-HD study","volume":"74C","author":"Poudel","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jns.2016.03.021_bb0130","first-page":"218","article-title":"Prefrontal activity in Huntington's disease reflects cognitive and neuropsychiatric disturbances: the IMAGE-HD study","volume":"239C","author":"Gray","year":"2012","journal-title":"Exp. Neurol."},{"issue":"4","key":"10.1016\/j.jns.2016.03.021_bb0135","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1399-0004.2004.00241.x","article-title":"A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length","volume":"65","author":"Langbehn","year":"2004","journal-title":"Clin. Genet."},{"key":"10.1016\/j.jns.2016.03.021_bb0140","series-title":"Manual for the Beck Depression Inventory-II","author":"Beck","year":"1996"},{"issue":"9","key":"10.1016\/j.jns.2016.03.021_bb0145","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/da.22064","article-title":"Relationship between sleep disturbance and depression, anxiety, and functioning in college students","volume":"30","author":"Nyer","year":"2013","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.jns.2016.03.021_bb0150","series-title":"Symbol Digit Modality Test (SDMT): Manual (Revised)","author":"Smith","year":"1982"},{"issue":"6","key":"10.1016\/j.jns.2016.03.021_bb0155","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1037\/h0054651","article-title":"Studies of interference in serial verbal reactions","volume":"18","author":"Stroop","year":"1935","journal-title":"J. Exp. Psychol."},{"issue":"4","key":"10.1016\/j.jns.2016.03.021_bb0160","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.jns.2016.03.021_bb0165","series-title":"Frontal Systems Behavior Scale: Professional Manual","author":"Grace","year":"2001"},{"issue":"1","key":"10.1016\/j.jns.2016.03.021_bb0170","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1177\/1073191104271483","article-title":"Development and validation of the schedule of compulsions, obsessions, and pathological impulses (SCOPI)","volume":"12","author":"Watson","year":"2005","journal-title":"Assessment"},{"key":"10.1016\/j.jns.2016.03.021_bb0175","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3389\/fnins.2014.00356","article-title":"The power-proportion method for intracranial volume correction in volumetric imaging analysis","volume":"8","author":"Liu","year":"2014","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.jns.2016.03.021_bb0180","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/sleep\/28.1.47","article-title":"The effects of sleep loss on medical residents' emotional reactions to work events: a cognitive-energy model","volume":"28","author":"Zohar","year":"2005","journal-title":"Sleep"},{"issue":"1","key":"10.1016\/j.jns.2016.03.021_bb0185","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/hbm.22178","article-title":"Losing the struggle to stay awake: divergent thalamic and cortical activity during microsleeps","volume":"35","author":"Poudel","year":"2014","journal-title":"Hum. Brain Mapp."},{"issue":"3","key":"10.1016\/j.jns.2016.03.021_bb0190","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1212\/WNL.58.3.341","article-title":"Emerging views of dopamine in modulating sleep\/wake state from an unlikely source: PD","volume":"58","author":"Rye","year":"2002","journal-title":"Neurology"},{"issue":"Pt 2","key":"10.1016\/j.jns.2016.03.021_bb0195","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1093\/brain\/awt329","article-title":"The caudate: a key node in the neuronal network imbalance of insomnia?","volume":"137","author":"Stoffers","year":"2014","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.jns.2016.03.021_bb0200","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/13803390600718958","article-title":"Patients with Huntington's disease have impaired awareness of cognitive, emotional, and functional abilities","volume":"29","author":"Hoth","year":"2007","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"10.1016\/j.jns.2016.03.021_bb0205","first-page":"161","article-title":"Sleep problems in anxious and depressive older adults","volume":"8","author":"Leblanc","year":"2015","journal-title":"Psychol. Res. Behav. Manag."},{"key":"10.1016\/j.jns.2016.03.021_bb0210","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.brainres.2009.03.072","article-title":"Management of sleep\/wake cycles improves cognitive function in a transgenic mouse model of Huntington's disease","volume":"1279","author":"Pallier","year":"2009","journal-title":"Brain Res."}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X16301538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X16301538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T09:58:16Z","timestamp":1567677496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X16301538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":42,"alternative-id":["S0022510X16301538"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2016.03.021","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Subjective sleep problems in Huntington's disease: A pilot investigation of the relationship to brain structure, neurocognitive, and neuropsychiatric function","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2016.03.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}