{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:14:12Z","timestamp":1789161252865,"version":"build-2803163510"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100008723","name":"Finnish Medical Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004092","name":"Kuopio University Hospital","doi-asserted-by":"publisher","award":["5252614"],"award-info":[{"award-number":["5252614"]}],"id":[{"id":"10.13039\/501100004092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004092","name":"Kuopio University Hospital","doi-asserted-by":"publisher","award":["5772708"],"award-info":[{"award-number":["5772708"]}],"id":[{"id":"10.13039\/501100004092","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sigrid Juselius Foundation"},{"name":"Strategic Funding of the University of Eastern Finland (UEF-Brain)"},{"DOI":"10.13039\/501100004963","name":"FP7","doi-asserted-by":"publisher","award":["601055"],"award-info":[{"award-number":["601055"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"name":"JPND Program"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jns-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.jns.2016.06.052","type":"journal-article","created":{"date-parts":[[2016,6,26]],"date-time":"2016-06-26T14:47:42Z","timestamp":1466952462000},"page":"11-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Familial idiopathic normal pressure hydrocephalus"],"prefix":"10.1016","volume":"368","author":[{"given":"Joel","family":"Huovinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Kastinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simo","family":"Komulainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minna","family":"Oinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Avellan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janek","family":"Frantzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaakko","family":"Rinne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Ronkainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Kauppinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimmo","family":"L\u00f6nnrot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Perola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okko T.","family":"Pyykk\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Koivisto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Remes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilkka","family":"Soininen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Hiltunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo","family":"Helisalmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitja","family":"Kurki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha E.","family":"J\u00e4\u00e4skel\u00e4inen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ville","family":"Leinonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2016.06.052_bb0005","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJM196507152730301","article-title":"Symptomatic occult hydrocephalus with normal cerebrospinal-fluid pressure","volume":"273","author":"Adams","year":"1965","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jns.2016.06.052_bb0010","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1097\/00006123-200509001-00001","article-title":"The value of supplemental prognostic tests for the preoperative assessment of idiopathic normal-pressure hydrocephalus","volume":"57","author":"Marmarou","year":"2005","journal-title":"Neurosurgery"},{"key":"10.1016\/j.jns.2016.06.052_bb0015","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1227\/01.NEU.0000168185.29659.C5","article-title":"Diagnosing idiopathic normal-pressure hydrocephalus","volume":"57","author":"Relkin","year":"2005","journal-title":"Neurosurgery"},{"key":"10.1016\/j.jns.2016.06.052_bb0020","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/jnnp-2013-306117","article-title":"Natural course of idiopathic normal pressure hydrocephalus","volume":"85","author":"Andr\u00e9n","year":"2014","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jns.2016.06.052_bb0025","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s00701-013-1835-5","article-title":"Systematic review of the outcome of shunt surgery in idiopathic normal-pressure hydrocephalus","volume":"155","author":"Toma","year":"2013","journal-title":"Acta Neurochir."},{"key":"10.1016\/j.jns.2016.06.052_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1227\/NEU.0b013e31827414b3","article-title":"Poor cognitive outcome in shunt-responsive idiopathic normal pressure hydrocephalus","volume":"72","author":"Koivisto","year":"2013","journal-title":"Neurosurgery"},{"key":"10.1016\/j.jns.2016.06.052_bb0035","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1600-0404.2007.00982.x","article-title":"Prevalence of probable idiopathic normal pressure hydrocephalus in a Norwegian population","volume":"118","author":"Brean","year":"2008","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.jns.2016.06.052_bb0040","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jns.2008.10.004","article-title":"Asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus on MRI (AVIM) in the elderly: a prospective study in a Japanese population","volume":"277","author":"Iseki","year":"2009","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jns.2016.06.052_bb0045","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1212\/WNL.0000000000000342","article-title":"Prevalence of idiopathic normal-pressure hydrocephalus","volume":"82","author":"Jaraj","year":"2014","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.jns.2016.06.052_bb0050","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000186501","article-title":"Prevalence of possible idiopathic normal-pressure hydrocephalus in Japan: the Osaki-Tajiri project","volume":"32","author":"Tanaka","year":"2009","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.jns.2016.06.052_bb0055","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1365-2990.2011.01195.x","article-title":"Post-mortem findings in 10 patients with presumed normal-pressure hydrocephalus and review of the literature","volume":"38","author":"Leinonen","year":"2012","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.jns.2016.06.052_bb0060","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/ana.22100","article-title":"Amyloid and tau proteins in cortical brain biopsy and Alzheimer's disease","volume":"68","author":"Leinonen","year":"2010","journal-title":"Ann. Neurol."},{"issue":"8","key":"10.1016\/j.jns.2016.06.052_bb0065","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S1474-4422(03)00487-3","article-title":"Alzheimer's disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis","volume":"2","author":"Silverberg","year":"2003","journal-title":"Lancet Neurol."},{"issue":"3","key":"10.1016\/j.jns.2016.06.052_bb0070","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1212\/01.wnl.0000316197.04157.6f","article-title":"Continuous CSF drainage in AD: results of a double-blind, randomized, placebo-controlled study","volume":"71","author":"Silverberg","year":"2008","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.jns.2016.06.052_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119973","article-title":"Impact of cerebrospinal fluid shunting for idiopathic normal pressure hydrocephalus on the amyloid cascade","volume":"10","author":"Moriya","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jns.2016.06.052_bb0080","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1001\/archneur.1984.04050150117029","article-title":"Familial occurrence of idiopathic normal-pressure hydrocephalus","volume":"41","author":"Portenoy","year":"1984","journal-title":"Arch. Neurol."},{"issue":"4","key":"10.1016\/j.jns.2016.06.052_bb0085","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/ajmg.a.31958","article-title":"Heritable essential tremor-idiopathic normal pressure hydrocephalus (ETINPH)","volume":"146","author":"Zhang","year":"2008","journal-title":"Am. J. Med. Genet. A"},{"issue":"4","key":"10.1016\/j.jns.2016.06.052_bb0090","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1159\/000288711","article-title":"Genome-wide linkage scan maps ETINPH gene to chromosome 19q12-13.31","volume":"69","author":"Zhang","year":"2010","journal-title":"Hum. Hered."},{"key":"10.1016\/j.jns.2016.06.052_bb0095","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1017\/S031716710001146X","article-title":"Normal-pressure hydrocephalus: is there a genetic predisposition?","volume":"38","author":"Cusimano","year":"2011","journal-title":"Can. J. Neurol. Sci."},{"issue":"1","key":"10.1016\/j.jns.2016.06.052_bb0100","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jns.2012.07.062","article-title":"Familial aggregation of idiopathic normal pressure hydrocephalus: novel familial case and a family study of the NPH triad in an iNPH patient cohort","volume":"321","author":"McGirr","year":"2012","journal-title":"J. Neurol. Sci."},{"issue":"1","key":"10.1016\/j.jns.2016.06.052_bb0105","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jns.2011.06.018","article-title":"Familial normal pressure hydrocephalus (NPH) with an autosomal-dominant inheritance: a novel subgroup of NPH","volume":"308","author":"Takahashi","year":"2011","journal-title":"J. Neurol. Sci."},{"issue":"7","key":"10.1016\/j.jns.2016.06.052_bb0110","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/pcn.12176","article-title":"Novel case of familial normal pressure hydrocephalus","volume":"68","author":"Liouta","year":"2014","journal-title":"Psychiatry Clin. Neurosci."},{"issue":"4","key":"10.1016\/j.jns.2016.06.052_bb0115","doi-asserted-by":"crossref","DOI":"10.3171\/foc.2007.22.4.2","article-title":"Estimated incidence of normal pressure hydrocephalus and shunt outcome in patients residing in assisted-living and extended-care facilities","volume":"22","author":"Marmarou","year":"2007","journal-title":"Neurosurg. Focus."},{"issue":"1\u20132","key":"10.1016\/j.jns.2016.06.052_bb0120","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.mrfmmm.2005.01.008","article-title":"Assessment of two flexible and compatible SNP genotyping platforms: TaqMan SNP genotyping assays and the SNPlex genotyping system","volume":"573","author":"De la Vega","year":"2005","journal-title":"Mutat. Res."},{"key":"10.1016\/j.jns.2016.06.052_bb0125","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/2045-8118-11-19","article-title":"Increased prevalence of cardiovascular disease in idiopathic normal pressure hydrocephalus patients compared to a population-based cohort from the HUNT3 survey","volume":"11","author":"Eide","year":"2014","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.jns.2016.06.052_bb0130","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/2045-8118-11-11","article-title":"Cerebrospinal fluid absorption block at the vertex in chronic hydrocephalus: obstructed arachnoid granulations or elevated venous pressure","volume":"11","author":"Bateman","year":"2014","journal-title":"Fluids Barriers CNS"},{"issue":"1","key":"10.1016\/j.jns.2016.06.052_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-008-0457-0","article-title":"Lymphatic drainage of the brain and the pathophysiology of neurological disease","volume":"117","author":"Weller","year":"2009","journal-title":"Acta Neuropathol."},{"issue":"18","key":"10.1016\/j.jns.2016.06.052_bb0140","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1001\/jama.1989.03430180093036","article-title":"Prevalence of Alzheimer's disease in a community population of older persons: higher than previously reported","volume":"262","author":"Evans","year":"1989","journal-title":"JAMA"},{"issue":"26","key":"10.1016\/j.jns.2016.06.052_bb0145","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1093\/hmg\/10.26.2961","article-title":"Dissecting a population genome for targeted screening of disease mutations","volume":"10","author":"Pastinen","year":"2001","journal-title":"Hum. Mol. Genet."},{"issue":"11","key":"10.1016\/j.jns.2016.06.052_bb0150","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1136\/jnnp-2011-303849","article-title":"APOE4 predicts amyloid-beta in cortical brain biopsy but not idiopathic normal pressure hydrocephalus","volume":"83","author":"Pyykko","year":"2012","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"3","key":"10.1016\/j.jns.2016.06.052_bb0155","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0022-2275(20)43170-0","article-title":"Apolipoprotein E phenotypes in Finnish youths: a cross-sectional and 6-year follow-up study","volume":"31","author":"Lehtimaki","year":"1990","journal-title":"J. Lipid Res."},{"issue":"4","key":"10.1016\/j.jns.2016.06.052_bb0160","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2169\/internalmedicine.50.4505","article-title":"Segmental copy number loss of SFMBT1 gene in elderly individuals with ventriculomegaly: a community-based study","volume":"50","author":"Kato","year":"2011","journal-title":"Intern. Med."},{"issue":"1","key":"10.1016\/j.jns.2016.06.052_bb0165","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng1934","article-title":"Systematic meta-analyses of alzheimer disease genetic association studies: the AlzGene database","volume":"39","author":"Bertram","year":"2007","journal-title":"Nat. Genet."},{"issue":"5","key":"10.1016\/j.jns.2016.06.052_bb0170","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng.803","article-title":"Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease","volume":"43","author":"Hollingworth","year":"2011","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.jns.2016.06.052_bb0175","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat. Genet."},{"issue":"5","key":"10.1016\/j.jns.2016.06.052_bb0180","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1227\/00006123-199311000-00001","article-title":"Familial subarachnoid hemorrhage in East Finland, 1977\u20131990","volume":"33","author":"Ronkainen","year":"1993","journal-title":"Neurosurgery"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X16303847?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X16303847?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T05:49:00Z","timestamp":1656740940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X16303847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":36,"alternative-id":["S0022510X16303847"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2016.06.052","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Familial idiopathic normal pressure hydrocephalus","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2016.06.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}