{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:24:22Z","timestamp":1778883862228,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.jns.2016.09.009","type":"journal-article","created":{"date-parts":[[2016,9,11]],"date-time":"2016-09-11T17:41:57Z","timestamp":1473615717000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Retinal imaging and axonal degeneration in later onset multiple sclerosis"],"prefix":"10.1016","volume":"370","author":[{"given":"Konstantin","family":"Huhn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"L\u00e4mmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"L\u00e4mmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Waschbisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Utz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9 Markus","family":"Gie\u00df","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedemann","family":"Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf A.","family":"Linker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-Hyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jns.2016.09.009_bb0005","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/brain\/103.2.281","article-title":"Course and prognosis of multiple sclerosis assessed by the computerized data processing of 349 patients","volume":"103","author":"Confavreux","year":"1980","journal-title":"Brain"},{"issue":"Pt 1","key":"10.1016\/j.jns.2016.09.009_bb0010","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/brain\/112.1.133","article-title":"The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability","volume":"112","author":"Weinshenker","year":"1989","journal-title":"Brain"},{"issue":"12","key":"10.1016\/j.jns.2016.09.009_bb0015","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1212\/WNL.33.12.1537","article-title":"Multiple sclerosis after age 50","volume":"33","author":"Noseworthy","year":"1983","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.jns.2016.09.009_bb0020","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.msard.2014.02.004","article-title":"Late onset multiple sclerosis: is it really late onset?","volume":"3","author":"Roohani","year":"2014","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"6","key":"10.1016\/j.jns.2016.09.009_bb0025","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1212\/01.wnl.0000237475.01655.9d","article-title":"Is late-onset multiple sclerosis associated with a worse outcome?","volume":"67","author":"Tremlett","year":"2006","journal-title":"Neurology"},{"issue":"Suppl 4","key":"10.1016\/j.jns.2016.09.009_bb0030","doi-asserted-by":"crossref","first-page":"S350","DOI":"10.1007\/s10072-004-0339-8","article-title":"Late onset multiple sclerosis: clinical characteristics, prognostic factors and differential diagnosis","volume":"25","author":"Martinelli","year":"2004","journal-title":"Neurol. Sci."},{"issue":"11","key":"10.1016\/j.jns.2016.09.009_bb0035","first-page":"1082","article-title":"Late onset multiple sclerosis","volume":"158","author":"Delalande","year":"2002","journal-title":"Rev. Neurol. (Paris)."},{"issue":"2","key":"10.1016\/j.jns.2016.09.009_bb0040","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1046\/j.1532-5415.2001.49038.x","article-title":"Late-onset multiple sclerosis","volume":"49","author":"Polliack","year":"2001","journal-title":"J. Am. Geriatr. Soc."},{"issue":"10","key":"10.1016\/j.jns.2016.09.009_bb0045","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1212\/WNL.42.10.1907","article-title":"Multiple sclerosis with very late onset","volume":"42","author":"Hooge","year":"1992","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.jns.2016.09.009_bb0050","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s00415-008-0778-x","article-title":"Clinical characteristics of patients with late-onset multiple sclerosis","volume":"255","author":"Kis","year":"2008","journal-title":"J. Neurol."},{"issue":"5","key":"10.1016\/j.jns.2016.09.009_bb0055","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.nrl.2010.09.008","article-title":"Late onset multiple sclerosis","volume":"26","author":"Arias","year":"2011","journal-title":"Neurologia"},{"issue":"1\u20133","key":"10.1016\/j.jns.2016.09.009_bb0060","first-page":"58","article-title":"Late onset multiple sclerosis: clinical pattern of optic nerve involvement","volume":"12","author":"Safran","year":"1989","journal-title":"Metab. Pediatr. Syst. Ophthalmol."},{"issue":"4","key":"10.1016\/j.jns.2016.09.009_bb0065","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1468-1331.2004.01103.x","article-title":"Brain MRI in late-onset multiple sclerosis","volume":"12","author":"de Seze","year":"2005","journal-title":"Eur. J. Neurol."},{"issue":"4","key":"10.1016\/j.jns.2016.09.009_bb0070","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S1474-4422(12)70003-0","article-title":"Association between pathological and MRI findings in multiple sclerosis","volume":"11","author":"Filippi","year":"2012","journal-title":"Lancet Neurol."},{"issue":"9","key":"10.1016\/j.jns.2016.09.009_bb0075","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1056\/NEJMra052130","article-title":"Multiple sclerosis\u2013the plaque and its pathogenesis","volume":"354","author":"Frohman","year":"2006","journal-title":"N. Engl. J. Med."},{"issue":"12","key":"10.1016\/j.jns.2016.09.009_bb0080","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/S1474-4422(12)70230-2","article-title":"Measurement and clinical effect of grey matter pathology in multiple sclerosis","volume":"11","author":"Geurts","year":"2012","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.jns.2016.09.009_bb0085","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s13311-010-0005-1","article-title":"Optical coherence tomography (OCT): imaging the visual pathway as a model for neurodegeneration","volume":"8","author":"Galetta","year":"2011","journal-title":"Neurotherapeutics"},{"issue":"1","key":"10.1016\/j.jns.2016.09.009_bb0090","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1001\/jamaneurol.2013.573","article-title":"Relationships between retinal axonal and neuronal measures and global central nervous system pathology in multiple sclerosis","volume":"70","author":"Saidha","year":"2013","journal-title":"JAMA Neurol."},{"issue":"12","key":"10.1016\/j.jns.2016.09.009_bb0095","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/ncpneuro0950","article-title":"Optical coherence tomography: a window into the mechanisms of multiple sclerosis","volume":"4","author":"Frohman","year":"2008","journal-title":"Nat. Clin. Pract. Neurol."},{"issue":"9","key":"10.1016\/j.jns.2016.09.009_bb0100","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S1474-4422(10)70168-X","article-title":"Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis","volume":"9","author":"Petzold","year":"2010","journal-title":"Lancet Neurol."},{"issue":"11","key":"10.1016\/j.jns.2016.09.009_bb0105","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1001\/archneurol.2009.230","article-title":"Macular volume determined by optical coherence tomography as a measure of neuronal loss in multiple sclerosis","volume":"66","author":"Burkholder","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jns.2016.09.009_bb0110","article-title":"Optical coherence tomography reflects brain atrophy in MS: a four year study","volume":"18","author":"Saidha","year":"2015","journal-title":"Ann. Neurol."},{"issue":"4","key":"10.1016\/j.jns.2016.09.009_bb0115","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1177\/1352458512457844","article-title":"Optic neuritis interferes with optical coherence tomography and magnetic resonance imaging correlations","volume":"19","author":"Zimmermann","year":"2013","journal-title":"Mult. Scler."},{"issue":"4","key":"10.1016\/j.jns.2016.09.009_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018132","article-title":"Association of retinal and macular damage with brain atrophy in multiple sclerosis","volume":"6","author":"Dorr","year":"2011","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jns.2016.09.009_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018019","article-title":"Metabolic changes in the visual cortex are linked to retinal nerve fiber layer thinning in multiple sclerosis","volume":"6","author":"Pfueller","year":"2011","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.jns.2016.09.009_bb0130","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nrneurol.2009.41","article-title":"Imaging outcomes for neuroprotection and repair in multiple sclerosis trials","volume":"5","author":"Barkhof","year":"2009","journal-title":"Nat. Rev. Neurol."},{"issue":"2","key":"10.1016\/j.jns.2016.09.009_bb0135","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000000018","article-title":"Randomized phase I trials of the safety\/tolerability of anti-LINGO-1 monoclonal antibody BIIB033","volume":"1","author":"Tran","year":"2014","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"issue":"4","key":"10.1016\/j.jns.2016.09.009_bb0140","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1136\/jnnp-2014-308189","article-title":"Bidirectional trans-synaptic axonal degeneration in the visual pathway in multiple sclerosis","volume":"86","author":"Balk","year":"2015","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"6","key":"10.1016\/j.jns.2016.09.009_bb0145","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/ana.20851","article-title":"Quantifying axonal loss after optic neuritis with optical coherence tomography","volume":"59","author":"Costello","year":"2006","journal-title":"Ann. Neurol."},{"issue":"6","key":"10.1016\/j.jns.2016.09.009_bb0150","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/ana.20703","article-title":"Diagnostic criteria for multiple sclerosis: 2005 revisions to the \u201cMcDonald Criteria\u201d","volume":"58","author":"Polman","year":"2005","journal-title":"Ann. Neurol."},{"issue":"11","key":"10.1016\/j.jns.2016.09.009_bb0155","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS)","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.jns.2016.09.009_bb0160","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1167\/iovs.03-0514","article-title":"Reproducibility of nerve fiber thickness, macular thickness, and optic nerve head measurements using StratusOCT","volume":"45","author":"Paunescu","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.jns.2016.09.009_bb0165","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/ene.12532","article-title":"Optical coherence tomography in patients with a history of juvenile multiple sclerosis reveals early retinal damage","volume":"22","author":"Huhn","year":"2015","journal-title":"Eur. J. Neurol."},{"issue":"8","key":"10.1016\/j.jns.2016.09.009_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022947","article-title":"The impact of utilizing different optical coherence tomography devices for clinical purposes and in multiple sclerosis trials","volume":"6","author":"Warner","year":"2011","journal-title":"PLoS One"},{"issue":"14","key":"10.1016\/j.jns.2016.09.009_bb0175","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1177\/1352458513489757","article-title":"Retinal ganglion cell and inner plexiform layer thinning in clinically isolated syndrome","volume":"19","author":"Oberwahrenbrock","year":"2013","journal-title":"Mult. Scler."},{"issue":"4","key":"10.1016\/j.jns.2016.09.009_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034823","article-title":"The OSCAR-IB consensus criteria for retinal OCT quality assessment","volume":"7","author":"Tewarie","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jns.2016.09.009_bb0185","first-page":"530305","article-title":"Retinal damage in multiple sclerosis disease subtypes measured by high-resolution optical coherence tomography","volume":"2012","author":"Oberwahrenbrock","year":"2012","journal-title":"Mult. Scler. Int."}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X16305639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X16305639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T12:12:17Z","timestamp":1710331937000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X16305639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":37,"alternative-id":["S0022510X16305639"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2016.09.009","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retinal imaging and axonal degeneration in later onset multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2016.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}