{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:42:32Z","timestamp":1761597752296},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jns-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.jns.2016.10.033","type":"journal-article","created":{"date-parts":[[2016,10,23]],"date-time":"2016-10-23T05:00:45Z","timestamp":1477198845000},"page":"363-368","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Functional impairment of precerebral arteries in Huntington disease"],"prefix":"10.1016","volume":"372","author":[{"given":"Jan","family":"Kobal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ksenija","family":"Cankar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janja","family":"Pretnar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjan","family":"Zaletel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucijan","family":"Kobal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasa","family":"Teran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziva","family":"Melik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2016.10.033_bb0005","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1021\/pr050244o","article-title":"Metabolic characterization of the R6\/2 transgenic mouse model of Huntington's disease by high-resolution MAS 1H NMR spectroscopy","volume":"5","author":"Tsang","year":"2006","journal-title":"J. Proteome. Res."},{"key":"10.1016\/j.jns.2016.10.033_bb0010","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.brainresbull.2009.07.010","article-title":"Role of mitochondrial dysfunction in the pathogenesis of Huntington's disease","volume":"80","author":"Quintanilla","year":"2009","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jns.2016.10.033_bb0015","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1172\/JCI17742","article-title":"Huntingtin in health and disease","volume":"111","author":"Young","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jns.2016.10.033_bb0020","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/hmg\/8.5.813","article-title":"Formation of polyglutamine inclusions in non-CNS tissue","volume":"8","author":"Sathasivam","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jns.2016.10.033_bb0025","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.expneurol.2009.05.012","article-title":"Huntington's disease: the current state of research with peripheral tissues","volume":"219","author":"Sassone","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jns.2016.10.033_bb0030","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.nbd.2006.09.016","article-title":"Cardiac dysfunction in the R&\/2 mouse model of Huntington's disease","volume":"25","author":"Mihm","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jns.2016.10.033_bb0035","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1002\/mds.21540","article-title":"Clinical correlates of mitochondrial function in Huntington's disease","volume":"22","author":"Turner","year":"2007","journal-title":"Mov. Disord."},{"key":"10.1016\/j.jns.2016.10.033_bb0040","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1212\/WNL.38.5.769","article-title":"Huntington's disease mortality in the United States","volume":"38","author":"Lanska","year":"1988","journal-title":"Neurology"},{"issue":"8","key":"10.1016\/j.jns.2016.10.033_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004550","article-title":"Dysfunction of the CNS-heart axis in mouse models of Huntington's disease","volume":"10","author":"Mielcarek","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jns.2016.10.033_bb0050","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.expneurol.2013.08.019","article-title":"Neurovascular abnormalities in humans and mice with Huntington's disease","volume":"250","author":"Lin","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jns.2016.10.033_bb0055","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2174\/157016106777698414","article-title":"Hyperhomocystinemia in movement disorders: current evidence and hypotheses","volume":"4","author":"Zoccolella","year":"2006","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.jns.2016.10.033_bb0060","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.ejphar.2012.10.026","article-title":"Late onset vascular dysfunction in the R6\/1 model of Huntington's disease","volume":"698","author":"Rahman","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jns.2016.10.033_bb0065","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.nbd.2011.09.003","article-title":"Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington's disease","volume":"45","author":"Franciosi","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jns.2016.10.033_bb0070","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1038\/jcbfm.2011.60","article-title":"Magnetic resonance perfusion imaging of resting-state cerebral blood flow in preclinical Huntington's disease","volume":"31","author":"Wolf","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.jns.2016.10.033_bb0075","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.neuroimage.2011.08.112","article-title":"Complex relationships between cerebral blood flow and brain atrophy in early Huntington's disease","volume":"59","author":"Chen","year":"2012","journal-title":"NeuroImage"},{"key":"10.1016\/j.jns.2016.10.033_bb0080","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1152\/ajpcell.1997.273.1.C205","article-title":"Energy turnover of vascular endothelial cells","volume":"273","author":"Culic","year":"1997","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.jns.2016.10.033_bb0085","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev-physiol-030212-183804","article-title":"Mitochondria in vascular health and disease","volume":"75","author":"Dromparis","year":"2013","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.jns.2016.10.033_bb0090","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.1073\/pnas.0601026103","article-title":"Mitochondria as signalling organelles in the vascular endothelium","volume":"103","author":"Quinteiro","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jns.2016.10.033_bb0095","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJM199201093260207","article-title":"Case 2-1992 \u2014 chorea and progressive dementia in an 88-year-old woman","volume":"326","author":"Sax","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jns.2016.10.033_bb0100","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1161\/STROKEAHA.107.502732","article-title":"Morphological but not functional changes of the carotid artery are associated with the extent of coronary artery disease in patients with preserved left ventricular function","volume":"39","author":"Sugioka","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2016.10.033_bb0105","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2147\/vhrm.1.2.131.64077","article-title":"Carotid ultrasound assessment of patients with coronary artery disease: a useful index for risk stratification","volume":"1","author":"Komorovsky","year":"2005","journal-title":"Vasc. Health Risk Manag."},{"key":"10.1016\/j.jns.2016.10.033_bb0110","doi-asserted-by":"crossref","first-page":"797","DOI":"10.2459\/JCM.0000000000000185","article-title":"How arterial stiffness may affect coronary blood flow: a challenging pathophysiological link","volume":"14","author":"Cusma-Piccione","year":"2014","journal-title":"J. Cardiovasc. Med."},{"key":"10.1016\/j.jns.2016.10.033_bb0115","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/hmg\/2.6.635","article-title":"A PCR method for accurate assessment of trinucleotide repeat expansion in Huntington's disease","volume":"2","author":"Goldberg","year":"1993","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jns.2016.10.033_bb0120","first-page":"265","article-title":"Global risk of coronary heart disease: Assesment and application","volume":"82","author":"Viera","year":"2010","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.jns.2016.10.033_bb0125","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1159\/000343145","volume":"34","author":"Touboul","year":"2012","journal-title":"Cerebrovasc. Dis."},{"key":"10.1016\/j.jns.2016.10.033_bb0130","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/S0300-8932(10)70295-5","article-title":"Carotid artery stiffness as an early marker of Vascular lesions in children with cardiovascular risk factors","volume":"63","author":"N\u00fa\u00f1ez","year":"2010","journal-title":"Rev. Esp. Cardiol."},{"key":"10.1016\/j.jns.2016.10.033_bb0135","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1161\/circ.106.25.3143","volume":"106","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jns.2016.10.033_bb0140","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1161\/HYPERTENSIONAHA.111.182766","article-title":"Arterial baroreflex modulation of sympathetic activity and arterial wall properties: new evidence","volume":"59","author":"Parati","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.jns.2016.10.033_bb0145","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1600-0404.2009.01251.x","article-title":"Autonomic dysfunction in presymptomatic and early symptomatic Huntington's disease","volume":"121","author":"Kobal","year":"2010","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.jns.2016.10.033_bb0150","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00415-011-6279-3","article-title":"Microcirculation response to local cooling in patients with Huntington's disease","volume":"259","author":"Melik","year":"2012","journal-title":"J. Neurol."},{"key":"10.1016\/j.jns.2016.10.033_bb0155","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.jacc.2003.12.047","article-title":"The patophysiology of cigarette smoking and cardiovascular disease. An update","volume":"43","author":"Ambrose","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jns.2016.10.033_bb0160","series-title":"Harrison's Principles of Internal Medicine","first-page":"1611","article-title":"Hypertensive vascular disease","author":"Kotchen","year":"2015"},{"key":"10.1016\/j.jns.2016.10.033_bb0165","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1161\/01.STR.0000223048.70103.F1","volume":"37","author":"Goldstein","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2016.10.033_bb0170","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.parkreldis.2012.09.012","article-title":"The influence of gender on phenotype and disease progression in patients with Huntington's disease","volume":"19","author":"Zielonka","year":"2013","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.jns.2016.10.033_bb0175","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1447-0594.2009.00572.x","article-title":"Hypertrophic cardiomyopathy in the elderly","volume":"10","author":"Kubo","year":"2010","journal-title":"Geriatr. Gerontol. Int."},{"key":"10.1016\/j.jns.2016.10.033_bb0180","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/S0025-6196(12)62272-1","article-title":"The central autonomic network: functional organization, dysfunction, and prespective","volume":"68","author":"Benarroch","year":"1993","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.jns.2016.10.033_bb0185","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/j.1468-1331.2004.00894.x","article-title":"Early sympathetic hyperactivity in Huntington's disease","volume":"11","author":"Kobal","year":"2004","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.jns.2016.10.033_bb0190","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.4088\/JCP.08m04446yel","article-title":"Effects of olanzapine and risperidone on glucose metabolism and insulin sensitivity in chronic schizophrenic patients with long-term antipsychotic treatment: a randomized 5-month study","volume":"70","author":"Smith","year":"2009","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.jns.2016.10.033_bb0195","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s12872-015-0111-4","article-title":"Malnutrition and associated factors among heart failure patients on follow up at Jimma university specialized hospital, Ethiopia","volume":"15","author":"Amare","year":"2015","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.jns.2016.10.033_bb0200","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1007\/s00415-015-7700-0","article-title":"Progress in Huntington's disease: the search for markers of disease onset and progression","volume":"262","author":"Mason","year":"2015","journal-title":"J. Neurol."},{"key":"10.1016\/j.jns.2016.10.033_bb0205","article-title":"An in vitro perspective on the molecular mechanisms underlying mutant huntingtin protein toxicity","volume":"30","author":"Cisbani","year":"2012","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jns.2016.10.033_bb0210","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jns.2016.05.021","article-title":"The incidence of post-mortem neurodegenerative and cerebrovascular pathology in mixed dementia","volume":"366","author":"De Reuck","year":"2016","journal-title":"J. Neurol. Sci."}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X16306748?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X16306748?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T19:14:43Z","timestamp":1568488483000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X16306748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":42,"alternative-id":["S0022510X16306748"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2016.10.033","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional impairment of precerebral arteries in Huntington disease","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2016.10.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}