{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T05:16:30Z","timestamp":1772082990180,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jns-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.jns.2017.02.045","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T10:00:20Z","timestamp":1487930420000},"page":"404-410","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Profile of von Willebrand factor antigen and von Willebrand factor propeptide in an overall TIA and ischaemic stroke population and amongst subtypes"],"prefix":"10.1016","volume":"375","author":[{"given":"WO","family":"Tobin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JA","family":"Kinsella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GF","family":"Kavanagh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JS","family":"O'Donnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RT","family":"McGrath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Tierney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Egan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TM","family":"Feeley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Coughlan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DR","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"O'Neill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SJX","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SJ","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RP","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DJH","family":"McCabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jns.2017.02.045_bb0005","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1111\/j.1538-7836.2010.03863.x","article-title":"Von Willebrand factor propeptide and the occurrence of a first ischemic stroke","volume":"8","author":"van Schie","year":"2010","journal-title":"J. Thromb. Haemost."},{"issue":"4","key":"10.1016\/j.jns.2017.02.045_bb0010","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1182\/blood-2007-12-130740","article-title":"Basal secretion of von Willebrand factor from human endothelial cells","volume":"112","author":"Giblin","year":"2008","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.jns.2017.02.045_bb0015","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1182\/blood.V92.2.529","article-title":"Binding of factor VIII to von willebrand factor is enabled by cleavage of the von Willebrand factor propeptide and enhanced by formation of disulfide-linked multimers","volume":"92","author":"Bendetowicz","year":"1998","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.jns.2017.02.045_bb0020","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1161\/STROKEAHA.111.628867","article-title":"Von Willebrand factor: an emerging target in stroke therapy","volume":"43","author":"De Meyer","year":"2012","journal-title":"Stroke"},{"issue":"11","key":"10.1016\/j.jns.2017.02.045_bb0025","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1161\/01.STR.0000244767.39962.f7","article-title":"High von Willebrand factor levels increase the risk of first ischemic stroke: influence of ADAMTS13, inflammation, and genetic variability","volume":"37","author":"Bongers","year":"2006","journal-title":"Stroke"},{"issue":"1\u20132","key":"10.1016\/j.jns.2017.02.045_bb0030","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jns.2014.10.035","article-title":"Relationship between ADAMTS13 activity, von Willebrand factor antigen levels and platelet function in the early and late phases after TIA or ischaemic stroke","volume":"348","author":"McCabe","year":"2015","journal-title":"J. Neurol. Sci."},{"issue":"10","key":"10.1016\/j.jns.2017.02.045_bb0035","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1161\/STROKEAHA.112.657007","article-title":"IL1B and VWF variants are associated with fibrinolytic early recanalization in patients with ischemic stroke","volume":"43","author":"Fernandez-Cadenas","year":"2012","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.jns.2017.02.045_bb0040","first-page":"37","article-title":"Comparison between von Willebrand factor (VWF) and VWF antigen II in normal individuals and patients with von Willebrand disease","volume":"80","author":"de Romeuf","year":"1998","journal-title":"Thromb. Haemost."},{"issue":"1","key":"10.1016\/j.jns.2017.02.045_bb0045","first-page":"164","article-title":"Romani de Wit T. Von Willebrand factor propeptide in vascular disorders","volume":"86","author":"van Mourik","year":"2001","journal-title":"Thromb. Haemost."},{"issue":"3\u20134","key":"10.1016\/j.jns.2017.02.045_bb0050","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/09537109876618","article-title":"Von Willebrand factor, P-selectin and fibrinogen levels in patients with acute ischaemic and haemorrhagic stroke, and their relationship with stroke sub-type and functional outcome","volume":"9","author":"Bath","year":"1998","journal-title":"Platelets"},{"issue":"6","key":"10.1016\/j.jns.2017.02.045_bb0055","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1055\/s-0038-1656120","article-title":"Von Willebrand factor and factor VIII: C in acute cerebrovascular disease. Relationship to stroke subtype and mortality","volume":"77","author":"Catto","year":"1997","journal-title":"Thromb. Haemost."},{"issue":"2","key":"10.1016\/j.jns.2017.02.045_bb0060","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1538-7836.2010.04134.x","article-title":"Plasma levels of von Willebrand factor in the etiologic subtypes of ischemic stroke","volume":"9","author":"Hanson","year":"2011","journal-title":"J. Thromb. Haemost."},{"issue":"5","key":"10.1016\/j.jns.2017.02.045_bb0065","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jstrokecerebrovasdis.2007.05.001","article-title":"Clopidogrel-induced platelet inhibition cannot be detected by the platelet function analyzer-100 system in stroke patients","volume":"16","author":"Kotzailias","year":"2007","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"1","key":"10.1016\/j.jns.2017.02.045_bb0070","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0021-9150(01)00635-9","article-title":"Endothelial markers and adhesion molecules in acute ischemic stroke\u2014sequential change and differences in stroke subtype","volume":"161","author":"Kozuka","year":"2002","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.jns.2017.02.045_bb0075","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1161\/01.STR.0000105927.62344.4C","article-title":"Novel diagnostic test for acute stroke","volume":"35","author":"Lynch","year":"2004","journal-title":"Stroke"},{"issue":"6","key":"10.1016\/j.jns.2017.02.045_bb0080","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1365-2141.2004.04983.x","article-title":"Platelet degranulation and monocyte-platelet complex formation are increased in the acute and convalescent phases after ischaemic stroke or transient ischaemic attack","volume":"125","author":"McCabe","year":"2004","journal-title":"Br. J. Haematol."},{"issue":"4","key":"10.1016\/j.jns.2017.02.045_bb0085","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1160\/TH04-12-0795","article-title":"Circulating endothelial cells in acute ischaemic stroke","volume":"94","author":"Nadar","year":"2005","journal-title":"Thromb. Haemost."},{"issue":"2","key":"10.1016\/j.jns.2017.02.045_bb0090","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0021-9150(02)00025-4","article-title":"Increased fibrinogen, von Willebrand factor and tissue plasminogen activator levels in insulin resistant South Asian patients with ischaemic stroke","volume":"163","author":"Kain","year":"2002","journal-title":"Atherosclerosis"},{"issue":"7","key":"10.1016\/j.jns.2017.02.045_bb0095","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1007\/s00415-014-7362-3","article-title":"Longitudinal assessment of von Willebrand factor antigen and von Willebrand factor propeptide in response to alteration of antiplatelet therapy after TIA or ischaemic stroke","volume":"261","author":"Tobin","year":"2014","journal-title":"J. Neurol."},{"issue":"7","key":"10.1016\/j.jns.2017.02.045_bb0100","doi-asserted-by":"crossref","first-page":"969-e55","DOI":"10.1111\/ene.12403","article-title":"Increased endothelial activation in recently symptomatic versus asymptomatic carotid artery stenosis and in cerebral microembolic-signal-negative patient subgroups","volume":"21","author":"Kinsella","year":"2014","journal-title":"Eur. J. Neurol."},{"issue":"5","key":"10.1016\/j.jns.2017.02.045_bb0105","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1159\/000131083","article-title":"Guidelines for management of ischaemic stroke and transient ischaemic attack 2008","volume":"25","author":"ESO","year":"2008","journal-title":"Cerebrovasc. Dis."},{"issue":"1","key":"10.1016\/j.jns.2017.02.045_bb0110","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","article-title":"Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment","volume":"24","author":"Adams","year":"1993","journal-title":"Stroke"},{"issue":"7","key":"10.1016\/j.jns.2017.02.045_bb0115","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1111\/jth.12277","article-title":"Increased platelet activation in early symptomatic vs. asymptomatic carotid stenosis and relationship with microembolic status: results from the Platelets and Carotid Stenosis Study","volume":"11","author":"Kinsella","year":"2013","journal-title":"J. Thromb. Haemost."},{"issue":"5","key":"10.1016\/j.jns.2017.02.045_bb0120","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1080\/09537100400020567","article-title":"Assessment of the antiplatelet effects of low to medium dose aspirin in the early and late phases after ischaemic stroke and TIA","volume":"16","author":"McCabe","year":"2005","journal-title":"Platelets"},{"issue":"6","key":"10.1016\/j.jns.2017.02.045_bb0125","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1111\/j.1365-2141.2004.05137.x","article-title":"Circulating reticulated platelets in the early and late phases after ischaemic stroke and transient ischaemic attack","volume":"126","author":"McCabe","year":"2004","journal-title":"Br. J. Haematol."},{"issue":"9","key":"10.1016\/j.jns.2017.02.045_bb0130","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1136\/jnnp.2004.051003","article-title":"Increased platelet count and leucocyte-platelet complex formation in acute symptomatic compared with asymptomatic severe carotid stenosis","volume":"76","author":"McCabe","year":"2005","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"2","key":"10.1016\/j.jns.2017.02.045_bb0135","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1468-1331.2012.03861.x","article-title":"High on-treatment platelet reactivity on commonly prescribed antiplatelet agents following transient ischaemic attack or ischaemic stroke: results from the Trinity Antiplatelet Responsiveness (TRAP) study","volume":"20","author":"Tobin","year":"2013","journal-title":"Eur. J. Neurol."},{"issue":"5","key":"10.1016\/j.jns.2017.02.045_bb0140","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/j.1365-2141.2010.08539.x","article-title":"Enhanced ex vivo inhibition of platelet function following addition of dipyridamole to aspirin after transient ischaemic attack or ischaemic stroke: first results from the TRinity AntiPlatelet responsiveness (TrAP) study","volume":"152","author":"Tobin","year":"2011","journal-title":"Br. J. Haematol."},{"issue":"2","key":"10.1016\/j.jns.2017.02.045_bb0145","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1046\/j.1365-2141.2001.03101.x","article-title":"Increased circulating platelet-leucocyte complexes and platelet activation in patients with antiphospholipid syndrome, systemic lupus erythematosus and rheumatoid arthritis","volume":"115","author":"Joseph","year":"2001","journal-title":"Br. J. Haematol."},{"issue":"1","key":"10.1016\/j.jns.2017.02.045_bb0150","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1182\/blood.V70.1.307.307","article-title":"Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow cytometry","volume":"70","author":"Shattil","year":"1987","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.jns.2017.02.045_bb0155","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1182\/blood-2005-02-0792","article-title":"Bombay phenotype is associated with reduced plasma-VWF levels and an increased susceptibility to ADAMTS13 proteolysis","volume":"106","author":"O'Donnell","year":"2005","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.jns.2017.02.045_bb0160","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1111\/j.1365-2141.2008.07550.x","article-title":"The protein C omega-loop substitution Asn2Ile is associated with reduced protein C anticoagulant activity","volume":"144","author":"Preston","year":"2009","journal-title":"Br. J. Haematol."},{"issue":"2","key":"10.1016\/j.jns.2017.02.045_bb0165","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.atherosclerosis.2013.07.046","article-title":"Relationship of von Willebrand factor with carotid artery and aortic arch calcification in ischemic stroke patients","volume":"230","author":"Sonneveld","year":"2013","journal-title":"Atherosclerosis"},{"issue":"2","key":"10.1016\/j.jns.2017.02.045_bb0170","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0008-6363(97)00039-4","article-title":"Von Willebrand factor: a marker of endothelial dysfunction in vascular disorders?","volume":"34","author":"Lip","year":"1997","journal-title":"Cardiovasc. Res."}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X17301417?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X17301417?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T10:39:25Z","timestamp":1692700765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X17301417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":34,"alternative-id":["S0022510X17301417"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2017.02.045","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Profile of von Willebrand factor antigen and von Willebrand factor propeptide in an overall TIA and ischaemic stroke population and amongst subtypes","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2017.02.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}