{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:26:32Z","timestamp":1790555192503,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Shanghai Municipal Commission of Health and Family Planning","award":["201540392"],"award-info":[{"award-number":["201540392"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jns-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.jns.2018.01.008","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T12:56:35Z","timestamp":1515761795000},"page":"46-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"special_numbering":"C","title":["Quantifying iron deposition within the substantia nigra of Parkinson's disease by quantitative susceptibility mapping"],"prefix":"10.1016","volume":"386","author":[{"given":"Hedi","family":"An","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengfei","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaiying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanlan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongya","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2018.01.008_bb0005","article-title":"Quantitative Susceptibility Mapping (QSM) as a means to measure brain iron? A postmortem validation study[C]","volume":"2368","author":"Langkammer","year":"2012","journal-title":"Proc. Intl. Soc. Mag. Reson. Med."},{"issue":"8","key":"10.1016\/j.jns.2018.01.008_bb0010","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1093\/brain\/awt192","article-title":"Disease duration and the integrity of the nigrostriatal system in Parkinson's disease","volume":"136","author":"Kordower","year":"2013","journal-title":"Brain"},{"issue":"10","key":"10.1016\/j.jns.2018.01.008_bb0015","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S1474-4422(14)70117-6","article-title":"The role of iron in brain ageing and neurodegenerative disorders","volume":"13","author":"Ward","year":"2014","journal-title":"Lancet Neurol."},{"issue":"8","key":"10.1016\/j.jns.2018.01.008_bb0020","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nrn3453","article-title":"Iron metabolism in the CNS: implications for neurodegenerative diseases","volume":"14","author":"Rouault","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jns.2018.01.008_bb0025","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nrn1537","article-title":"Iron, brain ageing and neurodegenerative disorders","volume":"5","author":"Zecca","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"issue":"6","key":"10.1016\/j.jns.2018.01.008_bb0030","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nrneurol.2010.55","article-title":"Restless legs syndrome: pathophysiology, clinical presentation and management","volume":"6","author":"Trenkwalder","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jns.2018.01.008_bb0035","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.brainres.2010.03.036","article-title":"Characterizing iron deposition in Parkinson's disease using susceptibility- weighted imaging: an in vivo MR study","volume":"1330","author":"Zhang","year":"2010","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.jns.2018.01.008_bb0040","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.3489","article-title":"Regionally progressive accumulation of iron in Parkinson's disease as measured by quantitative susceptibility mapping","volume":"30","author":"Guan","year":"2017","journal-title":"NMR Biomed."},{"issue":"7","key":"10.1016\/j.jns.2018.01.008_bb0045","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1111\/j.1468-1331.2011.03658.x","article-title":"Nigral iron deposition occurs across motor phenotypes of Parkinson's disease","volume":"19","author":"Jin","year":"2012","journal-title":"Eur. J. Neurol."},{"issue":"12","key":"10.1016\/j.jns.2018.01.008_bb0050","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.parkreldis.2013.08.011","article-title":"Motor phenotype and magnetic resonance measures of basal ganglia iron levels in Parkinson's disease","volume":"19","author":"Bunzeck","year":"2013","journal-title":"Parkinsonism Relat. Disord."},{"issue":"6","key":"10.1016\/j.jns.2018.01.008_bb0055","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nrn1119","article-title":"Looking into the functional architecture of the brain with diffusion MRI","volume":"4","author":"Le","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"issue":"Pt 4","key":"10.1016\/j.jns.2018.01.008_bb0060","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1093\/brain\/aww022","article-title":"Iron and dopamine: a toxic couple","volume":"139","author":"Hare","year":"2016","journal-title":"Brain A J. Neurol."},{"issue":"1","key":"10.1016\/j.jns.2018.01.008_bb0065","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.neuroimage.2012.09.055","article-title":"Toward in vivo, histology: a comparison of quantitative susceptibility mapping (QSM) with magnitude-, phase-, and R 2* -imaging at ultra-high magnetic field strength","volume":"65","author":"Deistung","year":"2013","journal-title":"NeuroImage"},{"issue":"3","key":"10.1016\/j.jns.2018.01.008_bb0070","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1016\/j.neuroimage.2011.08.077","article-title":"MRI estimates of brain iron concentration in normal aging using quantitative susceptibility mapping","volume":"59","author":"Bilgic","year":"2012","journal-title":"NeuroImage"},{"issue":"3","key":"10.1016\/j.jns.2018.01.008_bb0075","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","article-title":"Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinicopathological study of 100 cases","volume":"55","author":"Hughes","year":"1992","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"5","key":"10.1016\/j.jns.2018.01.008_bb0080","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1212\/WNL.37.5.893","article-title":"Recent Developments in Parkinson's disease","volume":"37","author":"Hurtig","year":"1987","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.jns.2018.01.008_bb0085","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.50.2.318","article-title":"Parkinsonism: onset, progression, and mortality","volume":"50","author":"Hoehn","year":"1998","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.jns.2018.01.008_bb0090","first-page":"710","article-title":"Progression of Parkinson's disease as evaluated by Hoehn and Yahr stage transition times","volume":"25","author":"Zhao","year":"2010","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.jns.2018.01.008_bb0095","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1192\/bjp.134.4.382","article-title":"A new depression scale designed to be sensitive to change","volume":"134","author":"Montgomery","year":"1979","journal-title":"Br. J. Psychiatry"},{"issue":"1","key":"10.1016\/j.jns.2018.01.008_bb0100","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1148\/radiol.13121991","article-title":"Improved subthalamic nucleus depiction with quantitative susceptibility mapping","volume":"269","author":"Liu","year":"2013","journal-title":"Radiology"},{"issue":"4","key":"10.1016\/j.jns.2018.01.008_bb0105","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/brain\/114.4.1953","article-title":"Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting basal ganglia","volume":"114","author":"Dexter","year":"1991","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.jns.2018.01.008_bb0110","doi-asserted-by":"crossref","DOI":"10.3174\/ajnr.A4260","article-title":"Usefulness of quantitative susceptibility mapping for the diagnosis of Parkinson disease","volume":"36","author":"Murakami","year":"2015","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.jns.2018.01.008_bb0115","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1148\/radiol.12120707","article-title":"Quantitative susceptibility mapping in multiple sclerosis","volume":"267","author":"Langkammer","year":"2013","journal-title":"Radiology"},{"issue":"3","key":"10.1016\/j.jns.2018.01.008_bb0120","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.parkreldis.2014.11.017","article-title":"Longitudinal midbrain changes in early Parkinson's disease: iron content estimated from R2*\/MRI","volume":"21","author":"Wieler","year":"2015","journal-title":"Parkinsonism Relat. Disord."},{"issue":"3","key":"10.1016\/j.jns.2018.01.008_bb0125","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1007\/s00330-014-3472-7","article-title":"Internal structures of the globus pallidus in patients with Parkinson's disease: evaluation with quantitative susceptibility mapping (QSM)","volume":"25","author":"Ide","year":"2015","journal-title":"Eur. Radiol."},{"issue":"3","key":"10.1016\/j.jns.2018.01.008_bb0130","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/mds.26417","article-title":"Quantitative susceptibility mapping of the midbrain in Parkinson's disease","volume":"31","author":"Du","year":"2016","journal-title":"Mov. Disord."},{"key":"10.1016\/j.jns.2018.01.008_bb0135","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/mds.20897","article-title":"Changes in motor subtype and risk for incident dementia in Parkinson's disease","volume":"21","author":"Alves","year":"2006","journal-title":"Mov. Disord."},{"issue":"11","key":"10.1016\/j.jns.2018.01.008_bb0140","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1002\/hbm.22928","article-title":"Region-specific disturbed iron distribution in early idiopathic Parkinson's disease measured by quantitative susceptibility mapping","volume":"36","author":"He","year":"2015","journal-title":"Hum. Brain Mapp."}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X1830008X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X1830008X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T14:26:18Z","timestamp":1535120778000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X1830008X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":28,"alternative-id":["S0022510X1830008X"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2018.01.008","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantifying iron deposition within the substantia nigra of Parkinson's disease by quantitative susceptibility mapping","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2018.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}