{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T10:42:51Z","timestamp":1770892971145,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004543","name":"Chinese Scholarship Council","doi-asserted-by":"crossref","award":["201206170169"],"award-info":[{"award-number":["201206170169"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004543","name":"Chinese Scholarship Council","doi-asserted-by":"crossref","award":["201306170014"],"award-info":[{"award-number":["201306170014"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jns-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.jns.2018.01.015","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T17:56:58Z","timestamp":1515779818000},"page":"56-63","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Lovastatin promotes myelin formation in NPC1 mutant oligodendrocytes"],"prefix":"10.1016","volume":"386","author":[{"given":"Fan","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arndt","family":"Rolfs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiankai","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5323","key":"10.1016\/j.jns.2018.01.015_bb0005","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1126\/science.277.5323.228","article-title":"Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis","volume":"277","author":"Carstea","year":"1997","journal-title":"Science"},{"issue":"5323","key":"10.1016\/j.jns.2018.01.015_bb0010","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1126\/science.277.5323.232","article-title":"Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene","volume":"277","author":"Loftus","year":"1997","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jns.2018.01.015_bb0015","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10545-014-9794-4","article-title":"Complex lipid trafficking in Niemann-Pick disease type C","volume":"38","author":"Vanier","year":"2015","journal-title":"J. Inherit. Metab. Dis."},{"issue":"2","key":"10.1016\/j.jns.2018.01.015_bb0020","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nn1620","article-title":"Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage","volume":"9","author":"Kessaris","year":"2006","journal-title":"Nat. Neurosci."},{"issue":"6","key":"10.1016\/j.jns.2018.01.015_bb0025","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.devcel.2013.05.013","article-title":"Individual oligodendrocytes have only a few hours in which to generate new myelin sheaths in vivo","volume":"25","author":"Czopka","year":"2013","journal-title":"Dev. Cell"},{"issue":"10","key":"10.1016\/j.jns.2018.01.015_bb0030","doi-asserted-by":"crossref","first-page":"4386","DOI":"10.1523\/JNEUROSCI.4962-14.2015","article-title":"Olig1 function is required for oligodendrocyte differentiation in the mouse brain","volume":"35","author":"Dai","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jns.2018.01.015_bb0035","first-page":"E46","article-title":"Myrf promotes oligodendrocyte maturation both through positive regulation of myelin genes and negative regulation of OPC genes via induction of key micro-RNAs","volume":"63","author":"Emery","year":"2015","journal-title":"Glia"},{"issue":"10","key":"10.1016\/j.jns.2018.01.015_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003907","article-title":"The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes","volume":"9","author":"Hornig","year":"2013","journal-title":"PLoS Genet."},{"issue":"19","key":"10.1016\/j.jns.2018.01.015_bb0045","doi-asserted-by":"crossref","first-page":"8454","DOI":"10.1523\/JNEUROSCI.2453-12.2013","article-title":"Stage-specific deletion of Olig2 conveys opposing functions on differentiation and maturation of oligodendrocytes","volume":"33","author":"Mei","year":"2013","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.jns.2018.01.015_bb0050","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1111\/j.1471-4159.2010.06831.x","article-title":"Axon-oligodendrocyte interactions during developmental myelination, demyelination and repair","volume":"114","author":"Piaton","year":"2010","journal-title":"J. Neurochem."},{"issue":"12","key":"10.1016\/j.jns.2018.01.015_bb0055","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1007\/s00018-010-0616-z","article-title":"From axon-glial signalling to myelination: the integrating role of oligodendroglial Fyn kinase","volume":"68","author":"Kramer-Albers","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.jns.2018.01.015_bb0060","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41593-017-0040-x","article-title":"Ca (2+) activity signatures of myelin sheath formation and growth in vivo","volume":"21","author":"Baraban","year":"2018","journal-title":"Nat. Neurosci."},{"issue":"5","key":"10.1016\/j.jns.2018.01.015_bb0065","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nn.3991","article-title":"Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo","volume":"18","author":"Mensch","year":"2015","journal-title":"Nat. Neurosci."},{"issue":"4","key":"10.1016\/j.jns.2018.01.015_bb0070","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/nn1426","article-title":"High cholesterol level is essential for myelin membrane growth","volume":"8","author":"Saher","year":"2005","journal-title":"Nat. Neurosci."},{"issue":"6","key":"10.1016\/j.jns.2018.01.015_bb0075","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1007\/s00415-003-1070-8","article-title":"Therapeutic potential of lovastatin in multiple sclerosis","volume":"250","author":"Sena","year":"2003","journal-title":"J. Neurol."},{"issue":"9421","key":"10.1016\/j.jns.2018.01.015_bb0080","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0140-6736(04)16205-3","article-title":"Oral simvastatin treatment in relapsing-remitting multiple sclerosis","volume":"363","author":"Vollmer","year":"2004","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.jns.2018.01.015_bb0085","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1023\/A:1018975928974","article-title":"In vivo and in vitro blood-brain barrier transport of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors","volume":"11","author":"Saheki","year":"1994","journal-title":"Pharm. Res."},{"issue":"4","key":"10.1016\/j.jns.2018.01.015_bb0090","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrn1652","article-title":"Statins\u2014a cure-all for the brain?","volume":"6","author":"Menge","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"issue":"2","key":"10.1016\/j.jns.2018.01.015_bb0095","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/ncpneuro0047","article-title":"Drug insight: using statins to treat neuroinflammatory disease","volume":"1","author":"Weber","year":"2005","journal-title":"Nat. Clin. Pract. Neurol."},{"issue":"1","key":"10.1016\/j.jns.2018.01.015_bb0100","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.expneurol.2008.09.010","article-title":"Simvastatin induces cell death in a mouse cerebellar slice culture (CSC) model of developmental myelination","volume":"215","author":"Xiang","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jns.2018.01.015_bb0105","doi-asserted-by":"crossref","DOI":"10.1038\/srep45780","article-title":"A staged screening of registered drugs highlights remyelinating drug candidates for clinical trials","volume":"7","author":"Eleuteri","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.jns.2018.01.015_bb0110","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1124\/mol.107.044230","article-title":"Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis","volume":"73","author":"Paintlia","year":"2008","journal-title":"Mol. Pharmacol."},{"issue":"14","key":"10.1016\/j.jns.2018.01.015_bb0115","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1002\/glia.21039","article-title":"Activation of PPAR-gamma and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells","volume":"58","author":"Paintlia","year":"2010","journal-title":"Glia"},{"issue":"5","key":"10.1016\/j.jns.2018.01.015_bb0120","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/nprot.2007.149","article-title":"Isolation and culture of rat and mouse oligodendrocyte precursor cells","volume":"2","author":"Chen","year":"2007","journal-title":"Nat. Protoc."},{"issue":"54","key":"10.1016\/j.jns.2018.01.015_bb0125","doi-asserted-by":"crossref","DOI":"10.3791\/3324","article-title":"Derivation of enriched oligodendrocyte cultures and oligodendrocyte\/neuron myelinating co-cultures from post-natal murine tissues","author":"O'Meara","year":"2011","journal-title":"J. Vis. Exp."},{"issue":"5","key":"10.1016\/j.jns.2018.01.015_bb0130","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1111\/j.1471-4159.2011.07474.x","article-title":"Inhibition of neuronal cholesterol biosynthesis with lovastatin leads to impaired synaptic vesicle release even in the presence of lipoproteins or geranylgeraniol","volume":"119","author":"Mailman","year":"2011","journal-title":"J. Neurochem."},{"issue":"6","key":"10.1016\/j.jns.2018.01.015_bb0135","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1038\/nprot.2007.207","article-title":"Isolation and culture of adult neurons and neurospheres","volume":"2","author":"Brewer","year":"2007","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.jns.2018.01.015_bb0140","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s12031-007-0052-1","article-title":"Roundtable discussion of session 2: lipoproteins and polyunsaturated fatty acids","volume":"33","author":"Watkins","year":"2007","journal-title":"J. Mol. Neurosci."},{"issue":"4","key":"10.1016\/j.jns.2018.01.015_bb0145","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.neuron.2008.09.011","article-title":"Distinct stages of myelination regulated by gamma-secretase and astrocytes in a rapidly myelinating CNS coculture system","volume":"60","author":"Watkins","year":"2008","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.jns.2018.01.015_bb0150","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.bbrc.2010.08.066","article-title":"Differentiation of human neural progenitor cells regulated by Wnt-3a","volume":"400","author":"Hubner","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.jns.2018.01.015_bb0155","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s11011-011-9263-9","article-title":"Decreased expression of myelin gene regulatory factor in Niemann-pick type C 1 mouse","volume":"26","author":"Yan","year":"2011","journal-title":"Metab. Brain Dis."},{"issue":"7","key":"10.1016\/j.jns.2018.01.015_bb0160","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1194\/jlr.M012377","article-title":"Requirement of Npc1 and availability of cholesterol for early embryonic cell movements in zebrafish","volume":"52","author":"Schwend","year":"2011","journal-title":"J. Lipid Res."},{"issue":"2","key":"10.1016\/j.jns.2018.01.015_bb0165","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/BF01067791","article-title":"The dysmyelinating mouse mutations shiverer (shi) and myelin deficient (shimld)","volume":"20","author":"Readhead","year":"1990","journal-title":"Behav. Genet."},{"issue":"4","key":"10.1016\/j.jns.2018.01.015_bb0170","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1083\/jcb.200706164","article-title":"Activation of oligodendroglial Fyn kinase enhances translation of mRNAs transported in hnRNP A2-dependent RNA granules","volume":"181","author":"White","year":"2008","journal-title":"J. Cell Biol."},{"issue":"9","key":"10.1016\/j.jns.2018.01.015_bb0175","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/embor.2012.97","article-title":"Myelin basic protein synthesis is regulated by small non-coding RNA 715","volume":"13","author":"Bauer","year":"2012","journal-title":"EMBO Rep."},{"issue":"12","key":"10.1016\/j.jns.2018.01.015_bb0180","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nrn3386","article-title":"Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2","volume":"13","author":"Meijer","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jns.2018.01.015_bb0185","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.expneurol.2014.12.012","article-title":"Voltage-gated Ca2+ entry promotes oligodendrocyte progenitor cell maturation and myelination in vitro","volume":"265","author":"Cheli","year":"2015","journal-title":"Exp. Neurol."},{"issue":"3","key":"10.1016\/j.jns.2018.01.015_bb0190","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1523\/JNEUROSCI.1423-14.2015","article-title":"Oligodendroglial maturation is dependent on intracellular protein shuttling","volume":"35","author":"Gottle","year":"2015","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.jns.2018.01.015_bb0195","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1083\/jcb.200509022","article-title":"Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites","volume":"172","author":"Trajkovic","year":"2006","journal-title":"J. Cell Biol."},{"issue":"Pt A","key":"10.1016\/j.jns.2018.01.015_bb0200","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.brainres.2015.10.013","article-title":"Evolution of the CNS myelin gene regulatory program","volume":"1641","author":"Li","year":"2016","journal-title":"Brain Res."},{"issue":"6","key":"10.1016\/j.jns.2018.01.015_bb0205","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1093\/nar\/gkw1222","article-title":"Interplay between H1 and HMGN epigenetically regulates OLIG1&2 expression and oligodendrocyte differentiation","volume":"45","author":"Deng","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.jns.2018.01.015_bb0210","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0306-4522(01)00517-6","article-title":"Neurodegeneration in the Niemann-pick C mouse: glial involvement","volume":"109","author":"German","year":"2002","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.jns.2018.01.015_bb0215","doi-asserted-by":"crossref","first-page":"e1003462","DOI":"10.1371\/journal.pgen.1003462","article-title":"Npc1 acting in neurons and glia is essential for the formation and maintenance of CNS myelin","volume":"9","author":"Yu","year":"2013","journal-title":"PLoS Genet."},{"issue":"4","key":"10.1016\/j.jns.2018.01.015_bb0220","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/jnr.490150409","article-title":"Regulation of myelin basic protein in oligodendrocytes by a soluble neuronal factor","volume":"15","author":"Bologa","year":"1986","journal-title":"J. Neurosci. Res."},{"issue":"2","key":"10.1016\/j.jns.2018.01.015_bb0225","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/glia.20441","article-title":"Simvastatin regulates oligodendroglial process dynamics and survival","volume":"55","author":"Miron","year":"2007","journal-title":"Glia"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X18300236?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X18300236?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T13:19:41Z","timestamp":1719753581000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X18300236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":45,"alternative-id":["S0022510X18300236"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2018.01.015","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lovastatin promotes myelin formation in NPC1 mutant oligodendrocytes","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2018.01.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}