{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:30:34Z","timestamp":1788877834908,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Research Foundation of KoreaNational Research Foundation of Korea (NRF)"},{"name":"Korea government","award":["2017R1A2B2009086"],"award-info":[{"award-number":["2017R1A2B2009086"]}]},{"name":"Korea government","award":["2017R1A2B4007254"],"award-info":[{"award-number":["2017R1A2B4007254"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jns-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.jns.2019.01.039","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T23:29:35Z","timestamp":1548372575000},"page":"204-209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Paradoxical association between age and cerebrovascular reactivity in migraine: A cross-sectional study"],"prefix":"10.1016","volume":"398","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1364-1969","authenticated-orcid":false,"given":"Mi Ji","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soohyun","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sook-Young","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Sang","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2019.01.039_bb0005","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/bmj.38302.504063.8F","article-title":"Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies","volume":"330","author":"Etminan","year":"2005","journal-title":"BMJ"},{"key":"10.1016\/j.jns.2019.01.039_bb0010","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1001\/jama.296.3.283","article-title":"Migraine and risk of cardiovascular disease in women","volume":"296","author":"Kurth","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.jns.2019.01.039_bb0015","doi-asserted-by":"crossref","first-page":"146","DOI":"10.5853\/jos.2015.01683","article-title":"The migraine-stroke connection","volume":"18","author":"Lee","year":"2016","journal-title":"J. Stroke"},{"key":"10.1016\/j.jns.2019.01.039_bb0020","doi-asserted-by":"crossref","first-page":"b3914","DOI":"10.1136\/bmj.b3914","article-title":"Migraine and cardiovascular disease: systematic review and meta-analysis","volume":"339","author":"Schurks","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.jns.2019.01.039_bb0025","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1161\/STROKEAHA.113.002465","article-title":"Migraine and hemorrhagic stroke: a meta-analysis","volume":"44","author":"Sacco","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2019.01.039_bb0030","article-title":"Migraine and risk of cardiovascular disease in women: prospective cohort study","volume":"353","author":"Kurth","year":"2016","journal-title":"BMJ"},{"key":"10.1016\/j.jns.2019.01.039_bb0035","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S1474-4422(11)70266-6","article-title":"Migraine and stroke: a complex association with clinical implications","volume":"11","author":"Kurth","year":"2012","journal-title":"Lancet Neurol."},{"issue":"4","key":"10.1016\/j.jns.2019.01.039_bb0040","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1177\/0333102416642602","article-title":"Migraine and incidence of ischemic stroke: a nationwide population-based study","volume":"37","author":"Peng","year":"2017","journal-title":"Cephalalgia"},{"key":"10.1016\/j.jns.2019.01.039_bb0045","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1474-4422(03)00266-7","article-title":"Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century","volume":"2","author":"Feigin","year":"2003","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jns.2019.01.039_bb0050","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1212\/01.wnl.0000294329.93565.94","article-title":"Decreased number and function of endothelial progenitor cells in patients with migraine","volume":"70","author":"Lee","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2019.01.039_bb0055","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1136\/jnnp-2014-309571","article-title":"Interictal cerebral and systemic endothelial dysfunction in patients with migraine: a case-control study","volume":"86","author":"Rajan","year":"2015","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jns.2019.01.039_bb0060","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1212\/WNL.0b013e31826170ce","article-title":"Endothelial progenitor cells: a new key for endothelial dysfunction in migraine","volume":"79","author":"Rodriguez-Osorio","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2019.01.039_bb0065","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1161\/STROKEAHA.109.547901","article-title":"Migraine and biomarkers of endothelial activation in young women","volume":"40","author":"Tietjen","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2019.01.039_bb0070","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1600-0404.2010.01468.x","article-title":"Cerebrovascular reactivity to l-arginine in the anterior and posterior cerebral circulation in migraine patients","volume":"124","author":"Perko","year":"2011","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.jns.2019.01.039_bb0075","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1177\/0333102415607857","article-title":"Systemic and cerebral endothelial dysfunction in chronic migraine. A case-control study with an active comparator","volume":"36","author":"Gonzalez-Quintanilla","year":"2016","journal-title":"Cephalalgia"},{"key":"10.1016\/j.jns.2019.01.039_bb0080","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1001\/jama.291.4.427","article-title":"Migraine as a risk factor for subclinical brain lesions","volume":"291","author":"Kruit","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.jns.2019.01.039_bb0085","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/ana.24712","article-title":"Development of White matter hyperintensity is preceded by reduced cerebrovascular reactivity","volume":"80","author":"Sam","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jns.2019.01.039_bb0090","series-title":"S. Headache Classification Committee of the International Headache, The International Classification of Headache Disorders, 3rd edition (beta version), Cephalalgia","first-page":"629","volume":"33","year":"2013"},{"key":"10.1016\/j.jns.2019.01.039_bb0095","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1129-2377-14-80","article-title":"Peripheral vascular dysfunction in migraine: a review","volume":"14","author":"Sacco","year":"2013","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.jns.2019.01.039_bb0100","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1111\/j.1526-4610.2011.01960.x","article-title":"Pulse wave velocity study in middle-aged migraineurs at low cardiovascular disease risk","volume":"51","author":"Ikeda","year":"2011","journal-title":"Headache"},{"key":"10.1016\/j.jns.2019.01.039_bb0105","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1046\/j.1468-2982.2003.00465.x","article-title":"Cranial and peripheral interictal vascular changes in migraine patients","volume":"23","author":"de Hoon","year":"2003","journal-title":"Cephalalgia"},{"key":"10.1016\/j.jns.2019.01.039_bb0110","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1471-2377-10-119","article-title":"Endothelial function in migraine: a cross-sectional study","volume":"10","author":"Vanmolkot","year":"2010","journal-title":"BMC Neurol."},{"key":"10.1016\/j.jns.2019.01.039_bb0115","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1177\/0333102414564890","article-title":"Markers of endothelial function in migraine patients: results from a bi-center prospective study","volume":"35","author":"Fischer","year":"2015","journal-title":"Cephalalgia"},{"key":"10.1016\/j.jns.2019.01.039_bb0120","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1177\/0333102416631961","article-title":"Migraine and endothelial function: the HUNT3 Study","volume":"36","author":"Larsen","year":"2016","journal-title":"Cephalalgia"},{"key":"10.1016\/j.jns.2019.01.039_bb0125","doi-asserted-by":"crossref","first-page":"e434","DOI":"10.1161\/STROKEAHA.109.569855","article-title":"A systematic review of dynamic cerebral and peripheral endothelial function in lacunar stroke versus controls","volume":"41","author":"Stevenson","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2019.01.039_bb0130","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1161\/CIRCULATIONAHA.106.652859","article-title":"Endothelial function and dysfunction: testing and clinical relevance","volume":"115","author":"Deanfield","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jns.2019.01.039_bb0135","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1161\/01.CIR.0000089191.72957.ED","article-title":"Endothelial function testing as a biomarker of vascular disease","volume":"108","author":"Verma","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jns.2019.01.039_bb0140","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jcin.2011.10.012","article-title":"Endothelial and smooth muscle cells dysfunction distal to recanalized chronic total coronary occlusions and the relationship with the collateral connection grade","volume":"5","author":"Brugaletta","year":"2012","journal-title":"JACC Cardiovasc. Interv."},{"key":"10.1016\/j.jns.2019.01.039_bb0145","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1161\/CIRCRESAHA.111.250126","article-title":"Induction of vascular progenitor cells from endothelial cells stimulates coronary collateral growth","volume":"110","author":"Yin","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.jns.2019.01.039_bb0150","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1212\/WNL.0000000000000888","article-title":"Cerebrovascular reactivity predicts stroke in high-grade carotid artery disease","volume":"83","author":"Reinhard","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2019.01.039_bb0155","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1001\/jamaneurol.2016.5704","article-title":"Association between migraine and cervical artery dissection: the Italian project on stroke in young adults","volume":"74","author":"De Giuli","year":"2017","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.jns.2019.01.039_bb0160","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1212\/WNL.0000000000003428","article-title":"Ischemic stroke subtypes and migraine with visual aura in the ARIC study","volume":"87","author":"Androulakis","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2019.01.039_bb0165","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1161\/01.STR.0000019511.81583.A8","article-title":"Cerebrovascular reactivity to acetazolamide and outcome in patients with symptomatic internal carotid or middle cerebral artery occlusion: a xenon-133 single-photon emission computed tomography study","volume":"33","author":"Ogasawara","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2019.01.039_bb0170","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1111\/head.12386","article-title":"Spreading depolarization may link migraine and stroke","volume":"54","author":"Eikermann-Haerter","year":"2014","journal-title":"Headache"},{"key":"10.1016\/j.jns.2019.01.039_bb0175","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1161\/STROKEAHA.118.020554","article-title":"Vulnerability to infarction during cerebral ischemia in migraine sufferers","volume":"49","author":"Pezzini","year":"2018","journal-title":"Stroke"},{"key":"10.1016\/j.jns.2019.01.039_bb0180","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.amjmed.2009.12.021","article-title":"Migraine headache and ischemic stroke risk: an updated meta-analysis","volume":"123","author":"Spector","year":"2010","journal-title":"Am. J. Med."},{"key":"10.1016\/j.jns.2019.01.039_bb0185","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1093\/brain\/awx223","article-title":"Migraine and risk of stroke: a national population-based twin study","volume":"140","author":"Lantz","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.jns.2019.01.039_bb0190","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1093\/brain\/awf007","article-title":"Endothelin-1 potently induces Leao's cortical spreading depression in vivo in the rat: a model for an endothelial trigger of migrainous aura?","volume":"125","author":"Dreier","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.jns.2019.01.039_bb0195","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1001\/jama.2012.14276","article-title":"Structural brain changes in migraine","volume":"308","author":"Palm-Meinders","year":"2012","journal-title":"JAMA"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X19300474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X19300474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T11:22:35Z","timestamp":1550834555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X19300474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":39,"alternative-id":["S0022510X19300474"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2019.01.039","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Paradoxical association between age and cerebrovascular reactivity in migraine: A cross-sectional study","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2019.01.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}