{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T19:40:57Z","timestamp":1783366857491,"version":"3.54.6"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501450"],"award-info":[{"award-number":["81501450"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fujian Provincial Science","award":["2018\u202fJ06023"],"award-info":[{"award-number":["2018\u202fJ06023"]}]},{"name":"Distinguished Young Scholars","award":["2017B023"],"award-info":[{"award-number":["2017B023"]}]},{"name":"Fujian Provincial Health Commission Project for Scientific Research Talents","award":["2018-ZQN-28"],"award-info":[{"award-number":["2018-ZQN-28"]}]},{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"crossref","award":["2018QH103"],"award-info":[{"award-number":["2018QH103"]}],"id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.jns.2019.116438","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T12:24:54Z","timestamp":1567081494000},"page":"116438","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Brain white matter abnormalities and correlation with severity in amyotrophic lateral sclerosis: An atlas-based diffusion tensor imaging study"],"prefix":"10.1016","volume":"405","author":[{"given":"Xiao-Qiang","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Xiu","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nao-Xin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8277-1110","authenticated-orcid":false,"given":"Zhang-Yu","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Jing","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jns.2019.116438_bb0005","doi-asserted-by":"crossref","first-page":"17071","DOI":"10.1038\/nrdp.2017.71","article-title":"Amyotrophic lateral sclerosis","volume":"3","author":"Hardiman","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"2","key":"10.1016\/j.jns.2019.116438_bb0010","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.clineuro.2009.10.014","article-title":"Diagnostic problems and delay of diagnosis in amyotrophic lateral sclerosis","volume":"112","author":"Kraemer","year":"2010","journal-title":"Clin. Neurol. Neurosurg."},{"issue":"4","key":"10.1016\/j.jns.2019.116438_bb0015","doi-asserted-by":"crossref","first-page":"4379","DOI":"10.3892\/mmr.2017.7186","article-title":"Implications of white matter damage in amyotrophic lateral sclerosis (review)","volume":"16","author":"Zhou","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"4","key":"10.1016\/j.jns.2019.116438_bb0020","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1136\/jnnp.23.4.269","article-title":"Nerve fibre degeneration in the brain in amyotrophic lateral sclerosis","volume":"23","author":"Smith","year":"1960","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"Pt 11","key":"10.1016\/j.jns.2019.116438_bb0025","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1093\/brain\/123.11.2289","article-title":"Extramotor involvement in ALS: PET studies with the GABA(a) ligand [(11)C]flumazenil","volume":"123","author":"Lloyd","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.jns.2019.116438_bb0030","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3389\/fneur.2019.00193","article-title":"White matter microstructure breakdown in the motor neuron disease spectrum: recent advances using diffusion magnetic resonance imaging","volume":"10","author":"Basaia","year":"2019","journal-title":"Front. Neurol."},{"issue":"8","key":"10.1016\/j.jns.2019.116438_bb0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104894","article-title":"Voxel-based MRI intensitometry reveals extent of cerebral white matter pathology in amyotrophic lateral sclerosis","volume":"9","author":"Hartung","year":"2014","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.jns.2019.116438_bb0040","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.clineuro.2012.11.031","article-title":"Diffusion tensor imaging patterns differ in bulbar and limb onset amyotrophic lateral sclerosis","volume":"115","author":"Prell","year":"2013","journal-title":"Clin. Neurol. Neurosurg."},{"issue":"1","key":"10.1016\/j.jns.2019.116438_bb0045","doi-asserted-by":"crossref","first-page":"102","DOI":"10.4103\/0976-3147.165423","article-title":"Advanced magnetic resonance neuroimaging in bulbar and limb onset early amyotrophic lateral sclerosis","volume":"7","author":"Vora","year":"2016","journal-title":"J Neurosci Rural Pract"},{"issue":"1","key":"10.1016\/j.jns.2019.116438_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0168424","article-title":"Relationship between clinical parameters and brain structure in sporadic amyotrophic lateral sclerosis patients according to onset type: a voxel-based morphometric study","volume":"12","author":"Kim","year":"2017","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jns.2019.116438_bb0055","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"Neuroimage"},{"issue":"10","key":"10.1016\/j.jns.2019.116438_bb0060","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1007\/s00415-004-0526-9","article-title":"Combined MR spectroscopic imaging and diffusion tensor MRI visualizes corticospinal tract degeneration in amyotrophic lateral sclerosis","volume":"251","author":"Yin","year":"2004","journal-title":"J. Neurol."},{"issue":"12","key":"10.1016\/j.jns.2019.116438_bb0065","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1212\/WNL.0000000000000792","article-title":"Functional pattern of brain FDG-PET in amyotrophic lateral sclerosis","volume":"83","author":"Pagani","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2019.116438_bb0070","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.3389\/fneur.2018.01005","article-title":"Clinical and radiological markers of extra-motor deficits in amyotrophic lateral sclerosis","volume":"9","author":"Christidi","year":"2018","journal-title":"Front. Neurol."},{"issue":"Pt 6","key":"10.1016\/j.jns.2019.116438_bb0075","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1093\/brain\/awu090","article-title":"Diffusion tensor imaging analysis of sequential spreading of disease in amyotrophic lateral sclerosis confirms patterns of TDP-43 pathology","volume":"137","author":"Kassubek","year":"2014","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.jns.2019.116438_bb0080","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/ana.23937","article-title":"Stages of pTDP-43 pathology in amyotrophic lateral sclerosis","volume":"74","author":"Brettschneider","year":"2013","journal-title":"Ann. Neurol."},{"issue":"5","key":"10.1016\/j.jns.2019.116438_bb0085","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1212\/WNL.53.5.1051","article-title":"Diffusion tensor MRI assesses corticospinal tract damage in ALS","volume":"53","author":"Ellis","year":"1999","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.jns.2019.116438_bb0090","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1136\/jnnp.74.9.1250","article-title":"Diffusion tensor imaging detects corticospinal tract involvement at multiple levels in amyotrophic lateral sclerosis","volume":"74","author":"Toosy","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"11","key":"10.1016\/j.jns.2019.116438_bb0095","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1212\/01.WNL.0000145766.03057.E7","article-title":"Diffusion tensor imaging for the assessment of upper motor neuron integrity in ALS","volume":"63","author":"Graham","year":"2004","journal-title":"Neurology"},{"issue":"Pt 2","key":"10.1016\/j.jns.2019.116438_bb0100","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1093\/brain\/awh041","article-title":"Diffusion tensor MRI of early upper motor neuron involvement in amyotrophic lateral sclerosis","volume":"127","author":"Sach","year":"2004","journal-title":"Brain"},{"issue":"7","key":"10.1016\/j.jns.2019.116438_bb0105","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1212\/01.wnl.0000299186.72374.19","article-title":"Evaluation of corticospinal tracts in ALS with diffusion tensor MRI and brainstem stimulation","volume":"70","author":"Iwata","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.jns.2019.116438_bb0110","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.brainres.2010.05.067","article-title":"Utility of axial and radial diffusivity from diffusion tensor MRI as markers of neurodegeneration in amyotrophic lateral sclerosis","volume":"1348","author":"Metwalli","year":"2010","journal-title":"Brain Res."},{"issue":"8","key":"10.1016\/j.jns.2019.116438_bb0115","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.3174\/ajnr.A2105","article-title":"Assessment of white matter tract damage in patients with amyotrophic lateral sclerosis: a diffusion tensor MR imaging tractography study","volume":"31","author":"Agosta","year":"2010","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.jns.2019.116438_bb0120","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/1471-2202-13-141","article-title":"Longitudinal diffusion tensor imaging in amyotrophic lateral sclerosis","volume":"13","author":"Keil","year":"2012","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.jns.2019.116438_bb0125","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.nicl.2015.11.019","article-title":"Translating state-of-the-art spinal cord MRI techniques to clinical use: a systematic review of clinical studies utilizing DTIMT, MWF, MRS, and fMRI","volume":"10","author":"Martin","year":"2016","journal-title":"Neuroimage. Clin"},{"key":"10.1016\/j.jns.2019.116438_bb0130","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.nicl.2016.03.011","article-title":"Structural and diffusion imaging versus clinical assessment to monitor amyotrophic lateral sclerosis","volume":"11","author":"Cardenas-Blanco","year":"2016","journal-title":"Neuroimage. Clin"},{"issue":"4","key":"10.1016\/j.jns.2019.116438_bb0135","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/jmri.1076","article-title":"Diffusion tensor imaging: concepts and applications","volume":"13","author":"Le Bihan","year":"2001","journal-title":"J. Magn. Reson. Imaging"},{"issue":"3","key":"10.1016\/j.jns.2019.116438_bb0140","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1016\/j.neuroimage.2011.09.086","article-title":"The influence of complex white matter architecture on the mean diffusivity in diffusion tensor MRI of the human brain","volume":"59","author":"Vos","year":"2012","journal-title":"Neuroimage"},{"issue":"7\u20138","key":"10.1016\/j.jns.2019.116438_bb0145","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/nbm.1940080707","article-title":"Inferring microstructural features and the physiological state of tissues from diffusion-weighted images","volume":"8","author":"Basser","year":"1995","journal-title":"NMR Biomed."},{"issue":"4","key":"10.1016\/j.jns.2019.116438_bb0150","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/1522-2594(200010)44:4<625::AID-MRM17>3.0.CO;2-O","article-title":"In vivo fiber tractography using DT-MRI data","volume":"44","author":"Basser","year":"2000","journal-title":"Magn. Reson. Med."},{"issue":"6","key":"10.1016\/j.jns.2019.116438_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0066366","article-title":"Local diffusion homogeneity (LDH): an inter-voxel diffusion MRI metric for assessing inter-subject white matter variability","volume":"8","author":"Gong","year":"2013","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.jns.2019.116438_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162656","article-title":"Schizophrenia patients demonstrate both inter-voxel level and intra-voxel level white matter alterations","volume":"11","author":"Zhuo","year":"2016","journal-title":"PLoS One"},{"issue":"30","key":"10.1016\/j.jns.2019.116438_bb0165","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000004032","article-title":"Reduced local diffusion homogeneity as a biomarker for temporal lobe epilepsy","volume":"95","author":"Liu","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jns.2019.116438_bb0170","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fnana.2018.00053","article-title":"Diffusion tensor imaging with tract-based spatial statistics reveals white matter abnormalities in patients with vascular cognitive impairment","volume":"12","author":"Chen","year":"2018","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.jns.2019.116438_bb0175","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3389\/fnins.2019.00063","article-title":"Local diffusion homogeneity provides supplementary information in T2DM-related WM microstructural abnormality detection","volume":"13","author":"Liang","year":"2019","journal-title":"Front. Neurosci."},{"issue":"5","key":"10.1016\/j.jns.2019.116438_bb0180","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/146608200300079536","article-title":"El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis","volume":"1","author":"Brooks","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord."},{"key":"10.1016\/j.jns.2019.116438_bb0185","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fnhum.2013.00042","article-title":"PANDA: a pipeline toolbox for analyzing brain diffusion images","volume":"7","author":"Cui","year":"2013","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.jns.2019.116438_bb0190","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.nicl.2018.04.005","article-title":"Altered white matter microarchitecture in amyotrophic lateral sclerosis: a voxel-based meta-analysis of diffusion tensor imaging","volume":"19","author":"Zhang","year":"2018","journal-title":"NeuroImage. Clinical"},{"key":"10.1016\/j.jns.2019.116438_bb0195","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.pnpbp.2018.01.007","article-title":"White matter volume loss in amyotrophic lateral sclerosis: a meta-analysis of voxel-based morphometry studies","volume":"83","author":"Chen","year":"2018","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"12","key":"10.1016\/j.jns.2019.116438_bb0200","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/S1474-4422(14)70167-X","article-title":"Neuroimaging in amyotrophic lateral sclerosis: insights into structural and functional changes","volume":"13","author":"Chio","year":"2014","journal-title":"The Lancet. Neurol"},{"issue":"6","key":"10.1016\/j.jns.2019.116438_bb0205","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.3174\/ajnr.A2918","article-title":"Widespread microstructural white matter involvement in amyotrophic lateral sclerosis: a whole-brain DTI study","volume":"33","author":"Cirillo","year":"2012","journal-title":"AJNR Am. J. Neuroradiol."},{"issue":"5","key":"10.1016\/j.jns.2019.116438_bb0210","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1590\/0004-282x20170032","article-title":"Usefulness of diffusion tensor imaging in amyotrophic lateral sclerosis: potential biomarker and association with the cognitive profile","volume":"75","author":"Chaves","year":"2017","journal-title":"Arq. Neuropsiquiatr."},{"issue":"1","key":"10.1016\/j.jns.2019.116438_bb0215","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1136\/jnnp.2008.154252","article-title":"A longitudinal diffusion tensor MRI study of the cervical cord and brain in amyotrophic lateral sclerosis patients","volume":"80","author":"Agosta","year":"2009","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"2","key":"10.1016\/j.jns.2019.116438_bb0220","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.expneurol.2003.10.004","article-title":"Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man","volume":"185","author":"Fischer","year":"2004","journal-title":"Exp. Neurol."},{"issue":"3","key":"10.1016\/j.jns.2019.116438_bb0225","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2217\/nmt.14.21","article-title":"The role of oligodendroglial dysfunction in amyotrophic lateral sclerosis","volume":"4","author":"Nonneman","year":"2014","journal-title":"Neurodegener Dis Manag"},{"issue":"1","key":"10.1016\/j.jns.2019.116438_bb0230","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1148\/radiol.2371041506","article-title":"Diffusion-tensor MR imaging of corticospinal tract in amyotrophic lateral sclerosis and progressive muscular atrophy","volume":"237","author":"Cosottini","year":"2005","journal-title":"Radiology"},{"issue":"7","key":"10.1016\/j.jns.2019.116438_bb0235","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/dneu.22455","article-title":"The corticospinal tract: evolution, development, and human disorders","volume":"77","author":"Welniarz","year":"2017","journal-title":"Dev Neurobiol"},{"issue":"7","key":"10.1016\/j.jns.2019.116438_bb0240","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.3174\/ajnr.A3389","article-title":"Different characteristics of the corticospinal tract according to the cerebral origin: DTI study","volume":"34","author":"Seo","year":"2013","journal-title":"AJNR Am. J. Neuroradiol."},{"issue":"8","key":"10.1016\/j.jns.2019.116438_bb0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0043993","article-title":"Grey and white matter changes across the amyotrophic lateral sclerosis-frontotemporal dementia continuum","volume":"7","author":"Lillo","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.jns.2019.116438_bb0250","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3109\/17482968.2011.593036","article-title":"Progression of white matter degeneration in amyotrophic lateral sclerosis: a diffusion tensor imaging study","volume":"12","author":"Zhang","year":"2011","journal-title":"Amyotroph. Lateral Scler."},{"issue":"5","key":"10.1016\/j.jns.2019.116438_bb0255","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1002\/jmri.24073","article-title":"Quantitative tractography and tract shape modeling in amyotrophic lateral sclerosis","volume":"38","author":"Bastin","year":"2013","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.jns.2019.116438_bb0260","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jneumeth.2013.12.014","article-title":"Tractography in amyotrophic lateral sclerosis using a novel probabilistic tool: a study with tract-based reconstruction compared to voxel-based approach","volume":"224","author":"Sarica","year":"2014","journal-title":"J. Neurosci. Methods"},{"issue":"2","key":"10.1016\/j.jns.2019.116438_bb0265","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.neuroimage.2006.09.025","article-title":"Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis","volume":"34","author":"Sage","year":"2007","journal-title":"Neuroimage"},{"issue":"2","key":"10.1016\/j.jns.2019.116438_bb0270","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00062-009-8040-1","article-title":"Linear longitudinal decline in fractional anisotropy in patients with amyotrophic lateral sclerosis: preliminary results","volume":"19","author":"Nickerson","year":"2009","journal-title":"Klin. Neuroradiol."},{"issue":"1","key":"10.1016\/j.jns.2019.116438_bb0275","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1001\/archneurol.2008.527","article-title":"Diffusion tensor imaging in sporadic and familial (D90A SOD1) forms of amyotrophic lateral sclerosis","volume":"66","author":"Stanton","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jns.2019.116438_bb0280","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.clineuro.2019.04.015","article-title":"Deterministic-tractography-based approach for diagnosis and disease monitoring of amyotrophic lateral sclerosis","volume":"181","author":"Sako","year":"2019","journal-title":"Clin. Neurol. Neurosurg."},{"issue":"5","key":"10.1016\/j.jns.2019.116438_bb0285","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/ana.23969","article-title":"Aggregation of neurologic and neuropsychiatric disease in amyotrophic lateral sclerosis kindreds: a population-based case-control cohort study of familial and sporadic amyotrophic lateral sclerosis","volume":"74","author":"Byrne","year":"2013","journal-title":"Ann. Neurol."},{"issue":"1\u20132","key":"10.1016\/j.jns.2019.116438_bb0290","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/21678421.2016.1248976","article-title":"Identifying behavioural changes in ALS: validation of the Beaumont Behavioural Inventory (BBI)","volume":"18","author":"Elamin","year":"2017","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"10.1016\/j.jns.2019.116438_bb0295","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.pscychresns.2019.04.001","article-title":"Microstructural correlates of Edinburgh cognitive and behavioural ALS screen (ECAS) changes in amyotrophic lateral sclerosis","volume":"288","author":"Trojsi","year":"2019","journal-title":"Psychiatry Res. Neuroimaging"},{"issue":"8","key":"10.1016\/j.jns.2019.116438_bb0300","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1136\/jnnp-2016-314912","article-title":"Semantic dementia, progressive non-fluent aphasia and their association with amyotrophic lateral sclerosis","volume":"88","author":"Saxon","year":"2017","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"1\u20132","key":"10.1016\/j.jns.2019.116438_bb0305","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3109\/21678421.2014.987301","article-title":"Semantic deficits in amyotrophic lateral sclerosis","volume":"16","author":"Leslie","year":"2015","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"issue":"3","key":"10.1016\/j.jns.2019.116438_bb0310","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/BF00248903","article-title":"Projections from inferior temporal cortex to prefrontal cortex via the uncinate fascicle in rhesus monkeys","volume":"76","author":"Ungerleider","year":"1989","journal-title":"Exp. Brain Res."},{"issue":"8","key":"10.1016\/j.jns.2019.116438_bb0315","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.cortex.2008.05.004","article-title":"A diffusion tensor imaging tractography atlas for virtual in vivo dissections","volume":"44","author":"Catani","year":"2008","journal-title":"Cortex"},{"issue":"Pt 6","key":"10.1016\/j.jns.2019.116438_bb0320","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1093\/brain\/awt094","article-title":"Dissecting the uncinate fasciculus: disorders, controversies and a hypothesis","volume":"136","author":"Von Der Heide","year":"2013","journal-title":"Brain"},{"issue":"5","key":"10.1016\/j.jns.2019.116438_bb0325","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1177\/1073858413513502","article-title":"The language connectome: new pathways, new concepts","volume":"20","author":"Dick","year":"2014","journal-title":"Neuroscientist"},{"issue":"8","key":"10.1016\/j.jns.2019.116438_bb0330","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1161\/STROKEAHA.117.017060","article-title":"Motor recovery prediction with clinical assessment and local diffusion homogeneity after acute subcortical infarction","volume":"48","author":"Liu","year":"2017","journal-title":"Stroke"}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X19303703?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X19303703?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T15:48:04Z","timestamp":1758383284000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X19303703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":66,"alternative-id":["S0022510X19303703"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2019.116438","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain white matter abnormalities and correlation with severity in amyotrophic lateral sclerosis: An atlas-based diffusion tensor imaging study","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2019.116438","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116438"}}