{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T21:59:50Z","timestamp":1773266390513,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T00:00:00Z","timestamp":1573689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014468","name":"Mallinckrodt Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014468","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jns-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Neurological Sciences"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.jns.2019.116505","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T02:03:15Z","timestamp":1571709795000},"page":"116505","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Change in visual acuity and retinal structures following Repository Corticotropin Injection (RCI) therapy in patients with acute demyelinating optic neuritis: Improvement in low contrast visual acuity in both affected and contralateral eyes in a single-armed open-label study"],"prefix":"10.1016","volume":"407","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1030-3155","authenticated-orcid":false,"given":"Molly","family":"Scannell Bryan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Sergott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jns.2019.116505_bb0005","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1600-0404.2010.01388.x","article-title":"Bilateral and recurrent optic neuritis in multiple sclerosis","volume":"123","author":"Burman","year":"2011","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.jns.2019.116505_bb0010","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2147\/EB.S54131","article-title":"Optic neuritis as an early sign of multiple sclerosis","volume":"8","author":"Kale","year":"2016","journal-title":"Eye Brain."},{"issue":"8","key":"10.1016\/j.jns.2019.116505_bb0015","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0161-6420(87)33349-4","article-title":"Deficits in visual function after resolution of optic neuritis","volume":"94","author":"Fleishman","year":"1987","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.jns.2019.116505_bb0020","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1111\/aos.12215","article-title":"Analysis of spectral domain optical coherence tomography measurements in optic neuritis: differences in neuromyelitis optica, multiple sclerosis, isolated optic neuritis and normal healthy controls","volume":"92","author":"Park","year":"2014","journal-title":"Acta Ophthalmol."},{"issue":"5","key":"10.1016\/j.jns.2019.116505_bb0025","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/ana.20448","article-title":"Adaptive cortical plasticity in higher visual areas after acute optic neuritis","volume":"57","author":"Toosy","year":"2005","journal-title":"Ann. Neurol."},{"issue":"2","key":"10.1016\/j.jns.2019.116505_bb0030","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1177\/1756285611400658","article-title":"Symptomatic therapy in multiple sclerosis","volume":"4","author":"Frohman","year":"2011","journal-title":"Ther. Adv. Neurol. Disord."},{"issue":"1","key":"10.1016\/j.jns.2019.116505_bb0035","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1474-4422(13)70259-X","article-title":"Optic neuritis","volume":"13","author":"Toosy","year":"2014","journal-title":"Lancet Neurol."},{"issue":"11","key":"10.1016\/j.jns.2019.116505_bb0040","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.jocn.2011.04.008","article-title":"Reduced retinal nerve fiber layer and macular thickness in patients with multiple sclerosis with no history of optic neuritis identified by the use of spectral domain high-definition optical coherence tomography","volume":"18","author":"Fjeldstad","year":"2011","journal-title":"J. Clin. Neurosci."},{"issue":"3","key":"10.1016\/j.jns.2019.116505_bb0045","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-010956","article-title":"Treatment of optic neuritis with erythropoietin (TONE): a randomised, double-blind, placebo-controlled trial-study protocol","volume":"6","author":"Diem","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.jns.2019.116505_bb0050","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/1874364101206010065","article-title":"Optic neuritis, its differential diagnosis and management","volume":"6","author":"Hoorbakht","year":"2012","journal-title":"Open Ophthalmol J."},{"issue":"24","key":"10.1016\/j.jns.2019.116505_bb0055","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1056\/NEJM199312093292403","article-title":"The effect of corticosteroids for acute optic neuritis on the subsequent development of multiple sclerosis","volume":"329","author":"Beck","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jns.2019.116505_bb0060","article-title":"Corticosteroids for treating optic neuritis","volume":"8","author":"Gal","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"issue":"9665","key":"10.1016\/j.jns.2019.116505_bb0065","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/S0140-6736(09)60442-6","article-title":"Sustained-release oral fampridine in multiple sclerosis: a randomised, double-blind, controlled trial","volume":"373","author":"Goodman","year":"2009","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.jns.2019.116505_bb0070","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S1474-4422(16)00004-1","article-title":"Phenytoin for neuroprotection in patients with acute optic neuritis: a randomised, placebo-controlled, phase 2 trial","volume":"15","author":"Raftopoulos","year":"2016","journal-title":"Lancet Neurol."},{"issue":"8","key":"10.1016\/j.jns.2019.116505_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci7080104","article-title":"Melanocortin receptors and multiple sclerosis","volume":"7","author":"Lisak","year":"2017","journal-title":"Brain Sci."},{"issue":"3","key":"10.1016\/j.jns.2019.116505_bb0085","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/jnr.24141","article-title":"Melanocortin receptor subtypes are expressed on cells in the oligodendroglial lineage and signal ACTH protection","volume":"96","author":"Benjamins","year":"2018","journal-title":"J. Neurosci. Res."},{"issue":"2","key":"10.1016\/j.jns.2019.116505_bb0090","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/jcph.582","article-title":"Pharmacodynamics and tolerability of repository corticotropin injection in healthy human subjects: a comparison with intravenous methylprednisolone","volume":"56","author":"Lal","year":"2016","journal-title":"J. Clin. Pharmacol."},{"issue":"6","key":"10.1016\/j.jns.2019.116505_bb0095","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1136\/bjo.2008.150698","article-title":"Agreement between spectral-domain and time-domain OCT for measuring RNFL thickness","volume":"93","author":"Vizzeri","year":"2009","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.jns.2019.116505_bb0100","author":"Lidster"},{"issue":"7","key":"10.1016\/j.jns.2019.116505_bb0105","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0161-6420(87)33527-4","article-title":"Treatment techniques and clinical guidelines for photocoagulation of diabetic macular edema. Early Treatment Diabetic Retinopathy Study Report Number 2","volume":"94","author":"Early Treatment Diabetic Retinopathy Study Research Group","year":"1987","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jns.2019.116505_bb0110","series-title":"ggplot2: Elegant Graphics for Data Analysis","first-page":"211","author":"Wickham","year":"2009"},{"key":"10.1016\/j.jns.2019.116505_bb0115","series-title":"R: A Language and Environment for Statistical Computing, version3.2.2","author":"R Core Team","year":"2015"},{"key":"10.1016\/j.jns.2019.116505_bb0120","author":"Fox"},{"issue":"8","key":"10.1016\/j.jns.2019.116505_bb0125","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1167\/iovs.15-17328","article-title":"Retinal ganglion cell and inner plexiform layer loss correlate with visual acuity loss in LHON: a longitudinal, segmentation OCT analysis","volume":"57","author":"Moster","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jns.2019.116505_bb0130","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2377-14-31","article-title":"Relations of low contrast visual acuity, quality of life and multiple sclerosis functional composite: a cross-sectional analysis","volume":"14","author":"Schinzel","year":"2014","journal-title":"BMC Neurol."},{"issue":"7","key":"10.1016\/j.jns.2019.116505_bb0135","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1177\/1352458510397414","article-title":"Effect of optic neuritis on progressive axonal damage in multiple sclerosis patients","volume":"17","author":"Garcia-Martin","year":"2011","journal-title":"Mult. Scler. J."},{"issue":"2","key":"10.1016\/j.jns.2019.116505_bb0140","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1177\/1352458512458844","article-title":"Mechanisms of action of adrenocorticotropic hormone and other melanocortins relevant to the clinical management of patients with multiple sclerosis","volume":"19","author":"Arnason","year":"2013","journal-title":"Mult. Scler."},{"issue":"5","key":"10.1016\/j.jns.2019.116505_bb0145","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.bbi.2007.11.001","article-title":"The diminishment of experimental autoimmune encephalomyelitis (EAE) by neuropeptide alpha-melanocyte stimulating hormone (\u03b1-MSH) therapy","volume":"22","author":"Taylor","year":"2008","journal-title":"Brain Behav. Immun."}],"container-title":["Journal of the Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X1930437X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022510X1930437X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T15:50:21Z","timestamp":1758383421000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022510X1930437X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":28,"alternative-id":["S0022510X1930437X"],"URL":"https:\/\/doi.org\/10.1016\/j.jns.2019.116505","relation":{},"ISSN":["0022-510X"],"issn-type":[{"value":"0022-510X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Change in visual acuity and retinal structures following Repository Corticotropin Injection (RCI) therapy in patients with acute demyelinating optic neuritis: Improvement in low contrast visual acuity in both affected and contralateral eyes in a single-armed open-label study","name":"articletitle","label":"Article Title"},{"value":"Journal of the Neurological Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jns.2019.116505","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116505"}}